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All Journal Journal Pharmaceutical Science and Application (JPSA) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Endurance: Kajian Ilmiah Problema Kesehatan Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Bali Medika Jurnal Jurnal Riset Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Ilmiah Medicamento Widya Kesehatan Medfarm: Jurnal Farmasi dan Kesehatan Tropical Health and Medical Research Journal Jurnal Farmasi Indonesia Benzena Pharmaceutical Scientific Journal Bali International Scientific Forum
Wintariani, Ni Putu
Universitas Bali Internasional
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGETAHUAN, SIKAP DAN PRAKTIK MASYARAKAT KECAMATAN KINTAMANI TERHADAP PENGGUNAAN OBAT TRADISIONAL Dewi Puspita Apsari; Ni Putu Wintariani
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 11 No 2 (2022): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v11i2.95

Abstract

Background: Complementary Alternative Medicine (CAM) is very popular among people. Nevertheless, an inappropriate combination of CAM and conventional medicine can lead to adverse drug reactions (ADR). This is very limited known by the public. Therefore, it is necessary to conduct research on the knowledge, attitudes, and practices of using CAM in Kintamani District. Methods: This cross-sectional quantitative study was conducted from June to Agustus 2021. The target population in this study was 102 people in Kintamani District who were more than or equal to 18 years old and using CAM maximum of a year before. Descriptive data were processed using SPSS (21.0) to describe the knowledge, attitudes, and practices of CAM. Pearson correlation test was conducted to determine the relationship between demographic characteristics on knowledge and attitudes to use CAM. Results: The level of knowledge Kintamani District regarding the use of CAM is sufficient as many as 71 (69.61%) people. In addition, 95 (93%) people have a positive attitude about using CAM. In practice, 44 (42.3%) people use herbs in the category of CAM that is often used. Information about CAM they got from the family was 37 (29.6%) and was used to treat hypertension as many as 35 (32.8%) respondents. Conclusion: People in Kintamani District, Bangli have sufficient knowledge and a positive attitude towards the use of CAM. In addition, most people use traditional medicine to treat hypertension
FORMULASI SEDIAAN SABUN CAIR EKSTRAK LIDAH BUAYA (Aloe vera L.) Made Galih Dwi Mahayuni; I Gusti Ngurah Agung Windra Wartana Putra; Ni Putu Wintariani
Jurnal Riset Kefarmasian Indonesia Vol 5 No 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.309

Abstract

Skin is the external part of body which protects internal organs from external interference, such as bacteria, viruses, cold air, hot sun, exposure to UV radiation, pressure, etc. Maintain clean skin is an important thing to do to prevent skin diseases. The way to keep our skin clean is use a mild soap which is good for the skin. Soap is one of the preparations commonly used in daily life. The ingredients of liquid soap are made up of surfactants, thickeners, preservatives and pH regulators. The presence of surface-active agents in soap is important for cleansing the dirt from the skin. Thickeners are important in the soap to obtain the required viscosity of the formulation. The aim of this study was to determine the characteristics of aloe vera (Aloe Vera L.) liquid soap. This type of research is an experimental study with a completely randomized design. The formula will be tested for physical and chemical properties which include organoleptic tests, viscosity tests, specific gravity tests, foam stability tests, and pH tests. Aloe vera liquid soap in all formulas has physical and chemical characteristics that meet the standards where the viscosity values obtained are 2616-4188 cP, specific gravity 1.067-1.082, foam resistance 61-70%, and pH 6.1-7
Aktivitas Antiradikal Krim Ekstrak Tanaman Gonda (Sphenoclea zeylanica Gaertn) dengan Metode DPPH (1,1-diphenyl-2-picrylhydrazyl) Ni Kadek Vinka Lionita; Ni Putu Wintariani; Dewi Puspita Apsari
Jurnal Ilmiah Medicamento Vol 9 No 1 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i1.4575

Abstract

Free radicals are compounds that trigger the premature aging process. The development of Gonda plant extract cream (Sphenoclea zeylanica Gaertn), which contains active antioxidant substances that can fight free radicals, is carried out. The aims of this study were to determine the phytochemical compounds of the 96% ethanol extract of the Gonda (Sphenoclea zeylanica Gaertn) plant, to observe the physical and chemical properties of the cream of the Gonda (Sphenoclea zeylanica Gaertn) plant extract and its potential as an antioxidant through an antiradical test using the DPPH method. This study was an experimental study with four cream formulations and various extract concentrations consisting of 0% (F0), 5% (F1), 10% (F2), and 15% (F3). Evaluation of the physical and chemical properties carried out was the organoleptic test, homogeneity test, spreadability test, viscosity test, adhesion test, pH test, and antiradical activity, which was tested using the DPPH method. The results showed that the 96% ethanol extract of the Gonda plant (Sphenoclea zeylanica Gaertn) positively contained flavonoids, saponins, tannins, steroids, and alkaloids. Gonda plant extract cream (Sphenoclea zeylanica Gaertn) has good physical-chemical properties based on cream evaluation tests. It shows anti-radical activity on average F0 is 596.08 in the very weak category, F1 (5%) is 95.32 in the strong category, F2 (10%), i.e., 64.58 in the strong category, F3 (15%), i.e., 40.96 in the very strong category, and the average positive control is 22.74 in the very strong category. The 96% ethanol extract of the gonda plant as an active ingredient in cream preparations has the potential to be developed into a topical antioxidant, and its antioxidant activity needs to be further investigated in vitro and in vivo.
Uji Efektivitas Antibakteri Ekstrak Etanol 96% Tanaman Gonda (Sphenoclea zeylanica Gaertn) terhadap Staphylococcus aureus Pande I Ketut Sukadiasa; Ni Putu Wintariani; I Gusti Ngurah Agung Windra Wartana Putra
Jurnal Ilmiah Medicamento Vol 9 No 1 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i1.4644

Abstract

Staphylococcus aureus is a gram-positive bacterium that is the leading cause of infections of the skin, soft tissue, respiratory tract, bones, and joints. The use of traditional medicine is generally considered safer than the use of modern medicine. One of the plants in Indonesia that can be used as medicine is the Gonda plant (Sphenoclea zeylanica Gaertn). The phytochemical compounds in the gonda plant are saponins, flavonoids, phenols, alkaloids, and steroids, which have antibacterial activity. This study aims to determine the content of secondary metabolites and the antibacterial activity of 96% ethanol extract of Gonda plants with different concentration variations against Staphylococcus aureus bacteria. This research is quantitative research with an experimental research design. The results showed that the 96% ethanol extract of the gonda plant contained flavonoids, saponins, tannins, steroids, and alkaloids and showed antibacterial activity. The average inhibition zone concentration of the extract was 5%, 10%, 15%, and 20%, respectively, 9.4 ± 0.19 mm, 12.56 ± 0.18 mm, 14.63 ± 0.30 mm, 17.45 ± 0.36 mm in the medium to strong category. There was a significant difference (P<0.05) between the inhibition zone values of each concentration, where the increase in the inhibition zone value was directly proportional to the increase in the extract concentration. The extract with a concentration of 20% had an immense inhibition zone value of 17.45 mm.
Effect of Black Garlic Extract in Feminine Liquid Soap as Antibacterial (Escherichia coli): Effect of Black Garlic Extract in Feminine Liquid Soap as Antibacterial (Escherichia coli) Herliawati, Putu Arik; Wintariani, Ni Putu; Olivia, Brigita; Hildayanti, Rezha Alivia; Pratiwi, Nanda Agnesia Jati
Tropical Health and Medical Research Vol. 5 No. 2 (2023): Tropical Health and Medical Research
Publisher : Baiman Bauntung Batuah Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35916/thmr.v5i1.100

Abstract

One of the causes of infection is pathological vaginal discharge caused by Escherichia coli. Handling of this infectious disease is still limited to giving antibiotics. So, an alternative therapy is needed using herbs. Black garlic is a fermented product that has stronger antibacterial properties. Based on this, it is necessary to test the potential of liquid soap with black garlic extract as antibacterial as scientific evidence. Research Objectives: To analyze the effect of black garlic extract on women's liquid soap on the growth of Escherichia coli. This research is quantitative research with an experimental research design. In this study, the intervention given was giving black garlic extract in feminism hygiene liquid soap preparations with various doses for bacteria Escherichia coli with disc diffusion technique. Black garlic extract was tested for phytochemicals to determine the content of active compounds. The results showed that black garlic extract in feminine hygiene liquid soap inhibited the growth of Escherichia coli bacteria; at a concentration of 40%, black garlic had the highest antibacterial activity with an average inhibition zone of 12.7mm. Therefore, it is proven that black garlic extract is effective as an antibacterial Escherichia coli in the formulation of feminine hygiene liquid soap.
Analisis Nilai Sun Protection Factor Krim Tabir Surya Ekstrak Tanaman Gonda (Sphenoclea zeylanica Gaertner) dengan Metode Spektrofotometri UV-Vis Wintariani, Ni Putu; Lionita, Ni Kadek Vinka
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.6600

Abstract

Free radicals are unstable atoms that can damage cells, causing disease and aging of the skin. Ultraviolet rays cause skin to darken and wrinkle as free radicals produce excess melanin. One of the anti-radical substances is found in the Gonda plant (Sphenoclea zeylanica Gaertner). The plant extract is made into a sunscreen cream dosage form to protect the skin from the dangers of free radicals from sunlight. The aim of this study was to determine the compounds contained in Gonda plant extract and the SPF value of Gonda plant extract sunscreen cream by in vitro method using UV-Vis spectrophotometry. The results showed that Gonda plant extract contains flavonoids, saponins, tannins, steroids, and alkaloids. The SPF value of the cream with 4 concentrations of Gonda plant extract in the formula, namely cream base (0%), F1 (5%), F2 (10%) and F3 (15%) showed the protection category of "none" (1.510), "maximum" (13.488), "ultra" (20.129) and "ultra" (22.921), respectively. The SPF values of the creams of the four formulas were significantly different (p<0.05), and there was a significant (p<0.001) and strong relationship between extract concentration and SPF value. Gonda plant extract cream had SPF value with maximum protection level at 5% concentration and ultra at 10% and 15% concentration. There was a significant and strong relationship between extract concentration and SPF of the cream.
Knowledge, Attitude, and Compliance with Hypertension Patients at The Manggis I Karangasem Health Centre Oktayanti, Leny; Widowati, I Gusti Ayu Rai; Tunas, I Ketut; Wintariani, Ni Putu
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 1 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i1.171

Abstract

High blood pressure or hypertension is a serious medical condition that significantly increases the risk of heart, brain, kidney, and other organ diseases. Most people with hypertension do not show specific symptoms and remain in good condition to perform routine activities. This study aimed to evaluate the knowledge, attitude, and compliance of hypertensive patients. A cross-sectional observational study was conducted at Puskesmas Manggis I Karangasem from March to May 2023 using a validated questionnaire. Data were analyzed using SPSS software version 25.0. A total of 120 respondents participated (100% response rate). Most of respondents were >65 years old (37.5%); male (61.7%); had secondary education (65.8%); not working (28.3%); had grade 1 hypertension (70.8%), and had no comorbidities (80.8%). Patient knowledge was categorized as good (109 [90.8%]), attitude was positive (75 [62.5%]), and medication compliance was high (79 [65.9%]). The results of the chi-square test showed that there was a significant relationship between knowledge and compliance (p-value=0.002), and there was a significant relationship between attitude and compliance (p-value=0.006). Knowledge and attitudes of hypertensive patients must continue to be improved so that patients comply to their medication therapy. Pharmacists are advised to conduct counseling on lifestyle, dietary patterns, and information related to complications in hypertensive patients.
FORMULATION AND CHARACTERIZATION EFFERVESCENT TABLETS OF GAMBIER LEAF EXTRACT (Uncaria gambier Roxb) Putra, I Gusti Ngurah Agung Windra Wartana; Rismayanti Putri, Putu; Wintariani, Ni Putu; Suryaningsih, Ni Putu Aryati
Journal Pharmaceutical Science and Application Vol 6 No 1 (2024): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2024.v06.i01.p04

Abstract

Background: Gambier, also known as the term (Uncaria gambier Roxb), is a plant that has long been cultivated in Indonesia. The components of flavonoid compounds in gambier plants have been widely reported as antioxidants. Using the gambier plant will be more accessible and more practical if it is made in dosage form, one of which is in the form of effervescent tablets. Objective: To determine the physical and chemical characteristics of effervescent tablets of gambier leaf extract (Uncaria gambier Roxb). Methods: Descriptive design, which includes phytochemical screening research, extract quality test, physical and chemical characteristics test of effervescent tablets formulation. Results: Positive gambier leaf extracts contain flavonoid compounds, alkaloids, tannins, and saponins. The average weight uniformity test of the tablet is 1.57 ± 0.02 grams, the average tablet thickness test of the tablet is 0.5±0 cm while a tablet's average diameter is 1.6±0 cm, the fragility test obtained <1%, the average hardness test of the tablet is 4.34±0.02 kg, the solubility time of the tablet obtaining is 1.6 ±0.4 minutes and tablets pH is 5.5±0.2. Conclusion: It is possible to draw the conclusion that the positive gambier leaf extract includes flavonoid components, alkaloids, tannins, and saponins based on the findings of the data previously gathered. The quality test of gambier leaf extract is already qualified, and the test of the characteristics of the physical and chemical properties produced is suitable based on Pharmacopeia Indonesia Standard. Keywords: Gambier; Extract; Tablet Effervescent
ANALISIS KESESUAIAN BIAYA RIIL PASIEN KEMOTERAPI KANKER SERVIKS DENGAN TARIF INA-CBG’s PADA PASIEN JKN RAWAT INAP DI RSUP SANGLAH DENPASAR TAHUN 2014 Wintariani, Ni Putu; Suwantara, I Putu Tangkas; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 3 No 1 (2017): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v3i1.1053

Abstract

Kanker payudara adalah penyakit urutan pertama yang menyerang wanita di Indonesia. Tingginya biaya perawatan dan penggunaan sistem satu tarif Indonesia Case Base Group (INA-CBG) yang saat ini diikuti oleh semua rumah sakit di Indonesia. Tarif yang diputuskan oleh INA-CBG terkadang tidak sesuai dengan biaya sebenarnya yang dikeluarkan rumah sakit sehingga terjadi perbedaan. Penelitian ini bertujuan untuk mengetahui perbedaan biaya riil tanpa kemoterapi dan tarif INA-CBGs, komponen biaya tertinggi dengan biaya riil tanpa kemoterapi, dan untuk mengetahui jumlah biaya riil tanpa kemoterapi yang terkait dengan keteraturan siklus kemoterapi pada pasien rawat inap di serviks. Di Rumah Sakit Umum Sanglah Denpasar pada bulan Januari-Juli 2014. Penelitian ini menggunakan desain analisis deskriptif dengan mengumpulkan data dokumen klaim dan rekam medis penderita kemoterapi kanker payudara di RSUP Sanglah. Diambil secara purposive sampling secara retrospektif dengan desain cross-sectional menurut perspektif rumah sakit; Sampel terdiri dari 161 episode dari 50 pasien. Analisis dilakukan dengan menggunakan satu sampel uji-t untuk mengetahui perbedaan biaya riil dan tarif INA-CBG dan analisis multivariat untuk mengetahui faktor-faktor yang mempengaruhi biaya sebenarnya. Perbedaan antara biaya riil dan tarif paket INA-CBGs pada tingkat keparahan pertama sebesar Rp. 77.021.099 untuk yang pertama, Rp. 40.924.685 untuk yang kedua, dan Rp 248.472.471 untuk kelas ketiga pengobatan; Pada tingkat keparahan kedua sebesar Rp 29.467.328 untuk yang pertama, Rp. 58.917.239 untuk yang kedua, dan Rp 170.277.952 untuk kelas ketiga perawatan, dan pada tingkat keparahan ketiga sebesar Rp 20.903.495 untuk yang pertama, Rp. 19.591.972 untuk yang kedua, dan Rp. 72.467.699 untuk kelas ketiga pengobatan. Faktor-faktor yang mempengaruhi biaya sebenarnya di kelas pertama, kedua, dan kelas ketiga adalah LOS (p = 0.000), prosedur (0.000), dan diagnosis sekunder (p = 0,030). Pola siklus tidak teratur memiliki biaya rata-rata yang nyata tanpa kemoterapi yang lebih rendah daripada yang tidak teratur.
Aktivitas Antioksidan Ekstrak Etanol 96% Kulit Kedelai Edamame (Glycine Max L. Merr) menggunakan metode peredaman radikal bebas DPPH (2,2-diphenyl-1- picrilhidrazyl). Oktaviani, Fatikhatul Putri; Setiawan, Putu Yudhistira Budhi; widayanti, ni putu; wintariani, ni putu
BENZENA Pharmaceutical Scientific Journal Vol 3 No 02 (2024): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v3i02.5073

Abstract

Radikal bebas merupakan suatu permasalahan yang menimbulkan penyakit generative yang dapat membahayakan tubuh, dengan begitu tubuh memerlukan untuk menetralisir kerusakan yang ditimbulkan oleh radikal bebas adalah dengan antioksidan. Antioksidan membantu tubuh untuk melawan produksi radikal bebas berlebihan yang dapat terjadinya stres oksidatif maka tubuh harus mendapat tambahan antioksidan dari luar tubuh (antioksidan eksogen) seperti antioksidan alami yang berasal dari buah-buahan dan tanaman. Tanaman kedelai edamame (Glycine Max L. Merr) merupakan salah satu tanaman yang mengandung senyawa isoflavon yang berfungsi sebagai antioksidan. Tujuan Penelitian ini mengetahui aktivitas antioksidan ekstrak etanol 96% kulit kedelai edamame menggunakan metode peredaman radikal bebas DPPH (2,2-diphenyl-1- picrilhidrazyl). Pengujian aktivitas antioksidan menggunakan metode peredaman radikal bebas DPPH dengan dihitung berdasarkan nilai Inhibitor Consentration (IC50). Penentuan kadar senyawa fenol dan flavonoid dengan metode spektrofotometri UV-Vis dan skrining fitokimia menggunakan metode kromatografi lapis tipis (KLT). Hasil dari penelitian uji aktivitas antioksidan ekstrak etanol 96% kulit kedelai edamame memiliki nilai IC50 685,39 ±19,38 ppm. Hasil penetapan kadar flavonoid total memiliki nilai 0,3511 ± 0,03 %. Hasil penetepan kadar fenol total memiliki nilai 1,3428 ± 0,01 %. Hasil pengujian evaluasi simplisia kulit kedelai edamame meliputi uji kadar abu total dengan hasil 5,5357 ± 0,12 %, susut pengeringan dengan hasil 8,4740 ± 0,11 %. Hasil pengujian evaluasi ekstrak etanol 96% kulit kedelai edamame meliputi uji rendemen dengan hasil 13,427 %. Kesimpulan dari pengujian aktivitas antioksidan ekstrak etanol 96% kulit kedelai edamame memiliki hasil IC50 yang sangat lemah. Hasil dari evaluasi simplisia dan ekstrak memiliki hasil parameter yang sesuai standar dan skrining fitokimia ekstrak kulit kedelai edamame memiliki hasil positif kandungan senyawa metabolit sekunder seperti flavonoid, fenol, steroid, terpenoid, dan saponin.
Co-Authors Agustini, Ni Putu Dewi Andyani, Ni Kadek Ayu Surya Dewa Ayu Putu Satrya Dewi Dewi Puspita Apsari Dewi Puspita Apsari Dharma, I Putu Handika Dwicandra, Ni Made Oka Fitria Megawati Fitria Megawati Fitria Megawati Gangga, I Made Putra Herleeyana Meriyani Herliawati, Putu Arik Hildayanti, Rezha Alivia I Ketut Tunas I Made Putra Gangga I Putu Tangkas Suwantara I Putu Tangkas Suwantara Jaelani, Abdul Khodir Lionita, Ni Kadek Vinka Made Galih Dwi Mahayuni Made Krisna Adi Jaya Mahartha, I Ketut Panji Megawati, Fitria Mei, Fransiska Oktaviana Meriyani, Herleeyana Ni Kadek Vinka Lionita Ni Made Dharma Shantini Suena Ni Putu Aryanti Suryaningsih Ni Putu Aryati Suryaningsih Ni Putu Dewi Agustini Ni Putu Widayanti Oktaviani, Fatikhatul Putri Oktayanti, Leny Olivia, Brigita Pande I Ketut Sukadiasa Parthasutema, Ida Ayu Manik Pratiwi, Nanda Agnesia Jati Putri, Dhiancinantyan Windydaca Brata Putu Eka Arimbawa Putu Eka Arimbawa Putu Yudhistira Budhi Setiawan Rismayanti Putri, Putu Suwantara, I Putu Tangkas Wardani, I Gusti Agung Ayu Kusuma Wartana Putra, I Gusti Ngurah Agung Windra Widowati, I Gusti Ayu Rai -