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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmascience IDJP (Indonesian Journal of Pharmaceutics) Chimica et Natura Acta Jurnal Pengabdian Pada Masyarakat SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Journal of Pharmacopolium JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JURNAL FARMASI GALENIKA Indonesia Natural Research Pharmaceutical Journal (INRPJ) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Masyarakat (Jupemas) Prosiding Seminar Nasional Unimus Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika
Soni Muhsinin
Universitas Bakti Kencana
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Pembinaan Kelompok Istri & Kader Posyandu Sebagai Kader Toga Di Lingkungan Bendega Dalam Upaya Primary Health Care Saat Pandemi Covid-19 I Gusti Agung Ayu Hari Triandini; Hairani Hairani; Diana Hidayati; Widhya Aligita; Nur Intan Hayati; Soni Muhsinin; ED. Yunisa Mega Pasha
Prosiding Seminar Nasional Unimus Vol 4 (2021): Inovasi Riset dan Pengabdian Masyarakat Post Pandemi Covid-19 Menuju Indonesia Tangguh
Publisher : Universitas Muhammadiyah Semarang

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Abstract

Kementerian Kesehatan telah mencanangkan beberapa program terkait pengembangan kesehatantradisional melalui teknologi tanaman obat keluarga (TOGA) yaitu saintifikasi jamu, asuhan mandiri(selfcare), serta perawatan herbal dan terapi tradisional akupresur yang bertujuan untukmeningkatkan akses dan keterjangkauan masyarakat terhadap obat-obatan. Peran keluarga sebagaigarda terdepan dalam upaya PHC membuat ibu/istri sebagai sosok yang berperan penting dalamkesehatan keluarga yang diharapkan akan membawa perubahan ke komunitas kecil di sekitarnyadan perlahan diterapkan ke dalam komunitas yang lebih besar dan beragam. Kader Posyandu yangsehari-harinya berinteraksi dalam mendampingi ibu dalam membangun kesehatan keluarga jugamenjadi sosok yang berperan dalam program asuhan mandiri keluarga yang telah dicanangkanpemerintah. Lingkungan Bendega merupakan salah satu lingkungan yang ada di Kelurahan TanjungKarang Kecamatan Sekarbela, Kota Mataram Provinsi Nusa Tenggara Barat. Lingkungan tersebutmerupakan lingkungan binaan kesehatan ibu dan anak dari Universitas Bhakti Kencana PSDKUMataram, IBI Tanjung Karang dan Puskesmas Tanjung Karang. Sebelumnya, telah dilakukanpengabdian masyarakat dengan mengangkat sosialisasi pembuatan vertical garden TOGA dilingkungan tersebut. Selama ini belum ada program khusus tentang TOGA ataupun pembentukankader TOGA di lingkungan Bendega. Tujuan kegiatan pengabdian kepada masyarakat kali ini adalahuntuk melakukan perekrutan kader TOGA pada mitra, sosialisasi tupoksi kader serta meningkatkanpengetahuan dan keterampilan mitra dalam mengolah jenis TOGA yang secara ilmiah berfungsimencegah COVID-19. Metode pelaksanaan: persiapan, sosialisasi, evaluasi dan dokumentasi.Kegiatan dilaksanakan secara daring dan luring. Berdasarkan hasil yang diperoleh, didapatkanbahwa mitra telah mendapatkan peningkatan pengetahuan dan keterampilan tentang TOGA danpemanfaatannya. Selain itu, telah dibentuk organisasi Kader TOGA di lingkungan Bendega yangberfungsi mengembangkan TOGA di lingkungan Bendega.  Kata kunci : Bendega, COVID-19, herbal, istri, kader, TOGA.
FORMULATION AND EVALUATION OF EFFERVESCENT GRANULE OF WHITE TEMU RHIZOME EXTRACT (Curcuma zedoaria (Christm.) Roscoe.) AS ANTIOXIDANT Reza Pratama; Deny Puriyani Azhary; Soni Muhsinin; Adinda Khumairani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1050

Abstract

More than 9,606 plant species have medicinal properties, but only around 3-4% of these have been cultivated commercially and used in traditional medicine in Indonesia. One of the natural ingredients believed to have properties is the white temu rhizome. White Curcuma rhizomes are usually processed into food and drinks. White ginger rhizome has antioxidant activity. Antioxidants are secondary metabolites found in herbal plants and have pharmacological activities that can minimize free radicals. Several studies have shown that white ginger rhizomes have antioxidant activities that can remove free radicals. This research aims to formulate an effervescent granule preparation. for white temu rhizome extract (Curcuma zedoaria (Christm.) Roscoe) using the wet granulation method, which meets the requirements for the physical properties of granules and has antioxidant activity. Several formulae were selected from various combinations. Next, an evaluation was performed to determine the physical properties and activities of the formulated granules. The evaluation results showed that all formulations met the requirements of the physical properties of the granules. Qualitative antioxidant activity testing using TLC plates showed positive antioxidant results in the extract and effervescent granule preparation of white curcuma rhizome extract and in quantitative testing it was found that the IC50 value of white curcuma rhizome extract was in the strong category and in the effervescent granule preparation of white curcuma rhizome extract, the granules were found to be in the strong category. Keywords: Effervescent Granule, Extracts, White Temu Rhizome (Curcuma zedoaria (Christm.) Roscoe), Antioxidants
FORMULASI PRODUK MINUMAN PROBIOTIK (YOGHURT) DARI SARI JAGUNG MANIS (Zea mays L.) DENGAN PENAMBAHAN BAKTERI PROBIOTIK Lactobacillus bulgaricus DAN Streptococcus thermophilus Soni Muhsinin
JURNAL FARMASI GALENIKA Vol 3 No 01 (2016): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Abstract

To prepare sweet corn probiotic beverage (Yoghurt) will be required Lactobacillus bulgaricus and Streptococcus thermophilus. The purpose of the is research is to produce probiotic beverage (Yoghurt) containing sweet corn base on the Indonesia National Standard (SNI), which has the antimicrobial activity and a good taste and a good preparations that can be accepted by society. The evaluation used were the analysis of antimicrobial activity and Indonesia National Standard (SNI) for analysis of sweet corn extract which includes water content analysis, total sugar analysis, and the ash content analysis. Meanwhile, the sweet corn probiotic beverage (Yoghurt) evaluation were analysis of lactic acid level, pH, viscosity, total LAB, protein, levels of fats, fondness, and total sugar. While Hedonic test showed the best formula was formula II (25% of the sweet corn), with 0,78% of lactic acid, pH 3,85, viscosity 236,7 cP, total LAB 10,0 × 107 cfu/mL, 4,467% protein, 2,12% fats, 13,42% total sugar. While antimicrobial activity towards Salmonella typhi was 9,567 mm ± 0,65. Thus, it can be cloncuded than the product complied with the requirments of Indonesia National Standard (SNI) except for the fats content.
Formulation and Characterization of Tretinoin Nanostructured Lipid Carriers Using Apifil and Cremophore Jafar, Garnadi; Putriyanti, Al-fira; Muhsinin, Soni
Indonesian Journal of Pharmaceutics Vol 5, Issue 3, Sept - Dec 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i3.54349

Abstract

The most widely used vitamin A derivative for mild to severe acne is tretinoin. However, it is lipophilic (LogP 6.3). Tretinoin must be transformed into liquid lipids and NLC (nanostructured lipid carriers) based on Apifil® and stabilized by surfactants to address permeability and stability concerns. Heat homogenization and sonication with a sonicator probe were used to formulate tretinoin into NLC. Apifil®, Myritol®, and Chremophore® RH 40 were the materials utilized. Particle size, polydispersity index, zeta potential, adsorption effectiveness, and morphological measurements were then used to describe NLC. The characterization results showed that NLC tretinoin has a particle size of <200 nm for 2 measurements over 30 days, a polydispersity index value of 0.5, a zeta potential range of -7 mV to -19.3 mV, and an efficiency entrapment value of >80% for all formulas. Spherical shape emerged from the morphology data. Conclusion: The findings demonstrate that tretinoin's nanostructured lipid carriers provide favorable characterization outcomes. Keywords: Diabetes, Metformin HCl, Extended release, Direct compressed,                     Hypromellose, Carboxymethylcellulose natrium.
REVIEW ARTIKEL: PENGEMBANGAN NANOSTRUCTURED LIPID CARRIERS UNTUK PENGOBATAN ALOPESIA Jafar, Garnadi; Pebriawati, Silpi; Latifah, Zahra Alfa; Pratama, Reza; Muhsinin, Soni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.53560

Abstract

Alopesia androgenetik adalah bentuk kebotakan yang umum terjadi pada pria dan wanita, dipicu oleh faktor genetik dan hormonal, terutama dihidrotestosteron (DHT). Minoksidil dan finasterid adalah terapi yang paling sering direkomendasikan untuk mengatasi alopecia androgenetik; namun, pengobatan ini sering kali menghasilkan efek samping dermatologis, termasuk iritasi kulit, ruam, dan dermatitis kontak. Selain itu, metode pengobatan konvensional memiliki keterbatasan dalam penetrasi kulit dan efektivitas optimal. Oleh karena itu, dibutuhkan sistem penghantaran obat yang lebih efektif, seperti Nanostructured Lipid Carriers (NLC). Penelitian ini bertujuan untuk mengeksplorasi potensi NLC sebagai sistem penghantaran obat inovatif untuk alopecia androgenetik. Metode yang digunakan melibatkan literatur yang diperoleh dari platform seperti Google Scholar, ScienceDirect, dan PubMed. Data yang dikumpulkan dianalisis dan dikelola menggunakan Mendeley® untuk tujuan referensi. Temuan dari literatur menunjukkan bahwa NLC dapat meningkatkan penetrasi obat ke dalam folikel rambut, meningkatkan retensi obat di kulit, dan mengurangi efek samping. Temuan ini menegaskan potensi NLC sebagai sistem penghantaran obat yang menjanjikan untuk meningkatkan respons terapeutik dalam mengobati alopecia dan berbagai kondisi kulit lainnya.
Efek Kombinasi Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) dan Daun Pegagan (Centella asiatica (L.) Urb) terhadap Ekspresi Gen eNOS pada Jaringan Hati Tikus Obes Sulaeman, Agus; Agustian, Salim; Susilawati, Elis; Muhsinin, Soni; Kaniawati, Marita; Feliana, Marita
Journal of Pharmascience Vol 12, No 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23813

Abstract

Obesitas adalah kondisi patologis akibat akumulasi lemak berlebih yang meningkatkan risiko gangguan metabolik, termasuk disfungsi endotel yang ditandai oleh penurunan produksi Nitric Oxide (NO) sintesis oleh enzim Endothelial Nitric Oxide Synthase (eNOS). Penelitian ini bertujuan mengevaluasi efek kombinasi ekstrak etanol rimpang kunyit (Curcuma longa L.) dan daun pegagan (Centella asiatica (L.) Urb) terhadap kadar NO serum dan ekspresi gen eNOS pada jaringan hati tikus obesitas. Penelitian eksperimental ini menggunakan tikus jantan yang diinduksi obesitas dengan pakan tinggi lemak dan karbohidrat selama 60 hari. Tikus dibagi enam kelompok: normal (kontrol negative), obesitas (kontrol positif), pembanding orlistat 10,8 mg/kgBB, ekstrak kunyit 200 mg/kgBB, ekstrak pegagan 20 mg/kgBB, dan kombinasi kunyit-pegagan 200:100 mg/kgBB. Parameter yang diukur meliputi berat badan, kadar NO serum (metode Griess), ekspresi gen eNOS (qPCR), kadar SGOT dan  SGPT. Hasil menunjukkan kombinasi ekstrak secara signifikan menurunkan berat badan dan meningkatkan kadar NO dibandingkan kelompok obesitas (p < 0,05), meningkatkan ekspresi gen eNOS serta secara (p< 0,05) signifikan menurunkan kadar SGOT dan SGPT . Penelitian ini mengindikasikan potensi kombinasi ekstrak kunyit dan pegagan sebagai agen preventif disfungsi endotel pada obesitas melalui peningkatan produksi NO dan regulasi ekspresi gen eNOS serta berperan sebagai hepatoprotektor. Kata Kunci: Ekstrak Kunyit, Ekstrak Pegagan, Ekspresi Gen eNOS, Jaringan Hati, Obesitas  Obesity is a pathological condition caused by excessive fat accumulation that increases the risk of metabolic disorders, including endothelial dysfunction characterized by decreased Nitric Oxide (NO) synthesis by the enzyme Endothelial Nitric Oxide Synthase (eNOS). This study aims to evaluate the effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa L.) and gotu kola leaves (Centella asiatica (L.) Urb) on serum NO levels and eNOS gene expression in the liver tissue of obese rats. This experimental study used male rats induced to become obese with a high-fat and high-carbohydrate diet for 60 days. The rats were divided into six groups: normal (negative control), obese (positive control), orlistat 10.8 mg/kgBW, turmeric extract 200 mg/kgBW, gotu kola extract 20 mg/kgBW, and turmeric-gotu kola combination 200:100 mg/kgBW. The measured parameters included body weight, serum NO levels (Griess method), eNOS gene expression (qPCR), SGOT and SGPT levels. The results showed that the combination of extracts significantly reduced body weight and increased NO levels compared to the obesity group (p < 0.05), increased eNOS gene expression, and significantly (p < 0.05) decreased SGOT and SGPT levels. This study indicates the potential of the combination of turmeric and pegagan extracts as a preventive agent for endothelial dysfunction in obesity through the enhancement of NO production and regulation of eNOS gene expression as well as acting as a hepatoprotector.
Co-Authors Adinda Khumairani Agus Sulaeman Agustian, Salim Aiyi Asnawi Aiyi Asnawi Algofar, Muhammad Alif Aziz Anne Yuliantini claudio Ananda Boby Dadang Juanda Dadih Supriadi Deden Indra Dinata Deny Puriyani Azhary Dewi, Winasari Diana Hidayati Diana Hidayati ED. Yunisa Mega Pasha ED. Yunisa Mega Pasha Eki Pratidina Ellin Febrina Etika Emaliyawati Fatmawati, Fenti Fauzan Z Muttaqin Fauzan Zein Mutaqin Fauzan Zein Muttaqin Feliana, Marita Garnadi Jafar, Garnadi Ginayah, Gina Hairani Hairani Hairani Hairani I Gusti Agung Ayu Hari Triandini Iceu Mulyati Iceu Mulyati Idar Idar Ika Kana Trisnawati Ina Sugiharti Ivan Andriansyah Ivan Andriyansyah Latifah, Zahra Alfa Lia Marliani Maria Martina Sulastri Marita Kaniawati Muhammad Yusuf Muttaqin, Fauzan Zein Noprianty, Richa Nur Intan Hayati Nur Intan Hayati Nur Intan Hayati Husnul Khotimah Nur Intan Hayati Husnul Khotimah Pebriawati, Silpi Pratama, Reza Prayoga Prayoga Putriyanti, Al-fira Rahma Ziska Reza Pratama Roni, Asep Rosmansyah, Hurryatul Fikri Rum, Ira Adiyati Sri Soleha Susilawati, Elis Umi Baroroh Untung Sudharmono Widhya Aligita Widhya Aligita Widhya Aligita Yulianti Anjayani Yulianti Anjayani Yuyun Yuyun