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Hesti Lina Wiraswati
Universitas Padjadjaran
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Dysobinol from Chisocheton macrophyllus Selectively Induces G1 Cell Cycle Arrest in MCF-7 Breast Cancer Cells Gaffar, Shabarni; Tambunan, Ghina Uli Felicia; Hafiz, Ersanda; Herlina, Tati; Wiraswati, Hesti Lina; Nurlelasari, Nurlelasari; Ma'ruf, Ilma Fauziah
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.100479

Abstract

Chisocheton macrophyllus is a medicinal plant that contains sesquiterpenoids, triterpenoids, limonoids, steroids, and phenolic compounds. This research aimed to assess the effect of Dysobinol, a limonoid compound from the seed of C. macrophyllus, on MCF-7 cell growth. Cell viability was evaluated using the MTS colorimetric assay, DNA fragmentation was assessed by agarose electrophoresis, apoptosis and cell cycle arrest were determined by flow cytometry, and gene expression levels were evaluated using qRT-PCR. Dysobinol was also analyzed in silico using drug-likeness, pharmacokinetic, and molecular docking analysis. Dysobinol demonstrated moderate cytotoxicity against MCF-7 cells, with an IC50 of 148.20 μg/mL. Dysobinol induced G1 phase cell cycle arrest that was not accompanied by the induction of apoptosis in MCF-7 cells. In silico studies showed that the EGFR/AKT/cyclin D1 proteins were affected by Dysobinol. Furthermore, drug-likeness and pharmacokinetics analysis showed that Dysobinol is bioavailable orally and has high gastrointestinal absorption and low penetration into the blood-brain barrier. Together, these results indicate that Dysobinol can regulate breast cancer cell proliferation through cell cycle arrest rather than apoptosis, and its pharmacological profile highlights its potential as a promising lead compound for anticancer drug development.
Co-Authors Ade Zuhrotun Adesandika, Egidia Listi Akbari, Anamika Lingga Anjani Andri Rezano Arimdayu, Annisa Retno Arimdayu, Annissa Retno Asep Wiryasa Astri Gloria Larwuy Baasin, Rusdi Toriq Dewi, Sumartini Dini Oktaviani Dini Wahyuni Ekawardani, Savira Enny Rohmawaty Erlangga Ing Geni Bisma Pratama Ersanda Hafiz Faiza, Tiara Fernanda, Keisha Arizka Florine, Angela Chrisabel Hafiz, Ersanda Hansen Wangsa Herman Khaq, Arina Al Laurence, Christopher Lia Faridah Liana Awalia Lutfunnisa Ma'ruf, Ilma Fauziah Marhendra Satria Utama Melia Juwita Adha Meri Alex Sandra Muhammad Begawan Bestari Muhammad Saifuddin B. S. Arif Muhammad Yudha Nugraha Nenny Agustanti Nurfitri, Fauzia Nurlelasari Nurlelasari Nurul Mufliha Patahuddin Permana, Noah Jefferson Permatasari, Priska Dewi PUTRI, RAFIKA Putri, Rafika Nanda Rachmawati, Nadya Rini Hendriani Rosdianto, Aziiz Mardanarian Safri Ishmayana Salma Nur Raidah Saragih, Winda A. M. Sarasati Windria Savira Ekawardhani Shabarni Gaffar Shabarni Gaffar -, Shabarni Gaffar Shabrinna, Hanif Siti Silvia Nur Shofa Shamantri Suharman, Khuznul Khatimah Sukamto, Charissa Otniel Supriyadi, Isma Yustifania Syafrizal Saragih Tambunan, Ghina Uli Felicia Tati Herlina Tati Herlina Usman, Hermin A. Veronica Oladitha Siagian Wijaya, Muhammad Palar Yasfira Aradella Yeni Wahyuni Hartati Yoga Windhu Wardhana