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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
Published by Universitas Tadulako
ISSN : 24427284     EISSN : 24428744     DOI : https://doi.org/10.22487/j24428744
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 247 Documents
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Relationship between Knowledge and adherence to Use of TB Drugs in adults in Idaman Banjarbaru Hospital: Hubungan Pengetahuan terhadap Kepatuhan Minum Obat TBC Dewasa di RSD Idaman Banjarbaru Wati, Helmina; Kurniawan, Guntur; Abdurrahman, Faizah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.17014

Abstract

Background: Tuberculosis (TB) is the disease that causes the highest mortality worldwide. One of the causes is the bacteria Mycobacterium tuberculosis. Knowledge and adherence are very important in TB treatment to achieve therapeutic success. Objectives: This study aims to see the relationship between the level of knowledge and adherence to taking medication for adult TB patients at Idaman Banjarbaru Hospital. Methods: This type of research is descriptive research with a cross-sectional research design, prospectively taken in March–June 2023. The total sampling technique was employed to select 42 patients. The data were collected via a validated online questionnaire and subsequently analysed using the Fisher Exact SPSS test with a 95% confidence level. Results: The results showed that patients had a good level of knowledge of as many as 32 people (76.2%) and had less knowledge of as many as 10 people (23.8%). The value of patient compliance in taking medication was 29 people (69%), and disobedient as many as 13 people (31%). Conclusion: The statistical analysis results indicated a statistically significant relationship between knowledge and compliance with medication in TB patients at Idaman Banjarbaru Hospital (p < 0.05). This implies that an individual's willingness to comply with medication regimens is significantly influenced by their knowledge about the prescribed treatment.
Toxicity Effect Test of Matoa (Pometia pinnata) Plant Fractions as Raw Materials for Anticancer Drugs: Uji Efek Toksisitas Fraksi Tanaman Matoa (Pometia pinnata) Sebagai Bahan Baku Obat Antikanker Hasan, Hamsidar; Taupik, Muhammad; Andi Suryadi, A. Mu’thi; Ihsan, Muh.
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.17016

Abstract

Background:The prevalence of cancer in Indonesia increases every year. Medical treatments such as chemotherapy, surgery, and radiation require significant costs with considerable side effects. Therefore, there is a need for chemopreventive agents from natural sources such as plants. One plant with potential as a chemopreventive agent is the matoa tree (Pometia pinnata), which is empirically used to treat suppurating wounds.Objectives: This research aims to test the toxicity of leaf and stem bark fractions of matoa using shrimp larvae Artemia salina Leach. Methods: The parameter for this study is the LC50 value. The extraction method involves successive maceration using solvents based on increasing polarity, starting with n-hexane, chloroform, ethyl acetate, and methanol. Phytochemical screening is conducted using colour tests, and toxicity is assessed through the brine shrimp lethality test. The research indicates that all fractions of matoa leaves and stem bark are toxic with respective LC50 values for leaf fractions: n-hexane (394.8 µg/mL), chloroform (244.3 µg/mL), ethyl acetate (180.6 µg/mL), and methanol (303.2 µg/mL). Stem bark fractions exhibit LC50 values in the order of n-hexane (203.9 µg/mL), chloroform (244.3 µg/mL), ethyl acetate (144.8 µg/mL), and methanol (58.3 µg/mL). Conclusions: All fractions fall into the toxic category and have the potential as raw materials for anti-cancer drugs.
Effect of Levonorgestrel Implant on Lactation and Infant Growth: A Review: Review : Pengaruh Implan Levonorgestrel pada Laktasi dan Pertumbuhan Bayi Febrianti, Yosi; Hanifah, Suci; Febrian, M. Pandoman; Annisa, Lily; Azza, Lintang Prava; Mafruhah, Okti Ratna; Medisa, Dian; Sari, Chynthia Pradiftha
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.17045

Abstract

Background: Family Planning is a way to regulate the number of children born and the spacing of pregnancies through information, education, and the use of contraceptives. Postpartum contraception is important to obtain an optimal interpregnancy interval. Postpartum contraception should be initiated early; one of which is Long-Acting Reversible Contraception (LARC). Levonorgestrel can be used to prevent pregnancy because it interferes with ovulation, implantation, and fertilization. Objectives: This study aimed to assess the efficacy and effects of using levonorgestrel implants on breastfeeding and infant growth. Methods: Primary data were in the form of research papers obtained from PubMed®, and Google Scholar® published from the period 2010-2018. The keywords for the searches included: “levonorgestrel”, “levonorgestrel (LNG)-releasing implant”, “levonorgestrel on lactogenesis”, “levonorgestrel on infant growth”, and “levonorgestrel on breastfeeding”, which were used alone or in combination. Results: The 20 selected articles were reviewed based on five identified phrases. Levonorgestrel subdermal implants were shown to be a good choice for women who wanted effective contraception. When used by breastfeeding mothers, levonorgestrel subdermal implants affected neither infant growth (0-1 year of age) nor lactation duration. Conclusions: Levonorgestrel subdermal implants can be effective long-term contraception. These implants are safe for breastfeeding mothers and do not affect infant growth.
Antibacterial Activity Assay on Escherichia coli of The Active Fraction Matoa Seeds (Pometia Pinnata J.R Forst & G. Forst.) Karnelasatri, Karnelasatri; Yacob, Iren Anggreni; Andareas, Pangeran; Santoso, Feronia Reni Cyrena; Novia, Jessica
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16283

Abstract

One of the plants had been used as a medicinal plant in Papua is Pometia Pinnata J.R Forst & G. Forst or the Matoa plant. The aim of this study is to determine the antibacterial activity of the active fraction of Matoa seeds against Escherichia coli bacteria. The positive control and negative control used were ciprofloxacin and dimethyl sulfoxide, respectively. 96% ethanol solvent was used to extract the simplicia of Matoa seeds. Fractionation was carried out using n-hexane, ethyl acetate and water as solvents. The Kirby Bauer diffusion method was used in the antibacterial activity assay at concentrations of 100 mg/mL, 200 mg/mL, 300 mg/mL, 400 mg/mL, and 500 mg/mL. Overall, the inhibition zones obtained from the sequential concentrations above were 8.89 mm, 10.18 mm, 10.34 mm, 10.84 mm, and 11.76 mm respectively. Further, data analysis was performed with One Way ANOVA and the results showed significant differences between concentrations. Data analysis was then continued with the post hoc Tukey HSD test and a concentration of 500 mg/mL was concluded as the optimum concentration.
Evaluation of Drug Accuracy and Cardiac Drug Dose Accuracy in Heart Failure Patients Hospitalized in Samarinda: Evaluasi Ketepatan Obat Dan Dosis Obat Jantung Pada Pasien Gagal Jantung Di Instalasi Rawat Inap Rumah Sakit Samarinda Hanifa, Deasy Nur Chairin; Riansyah, Novita Angelia
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16504

Abstract

Background: Heart failure is a condition where the heart is unable to pump blood to the tissues to meet the body's metabolic needs. Heart failure has a variety of therapies and drug options available, so careful consideration is needed in selecting drugs for heart failure patients. Evaluation is carried out to identify problems with the accuracy of drug use and dosage accuracy. The many types of drugs available present its their problems in the use of drugs, especially in the selection and use of drugs that are effective, correct, and safe. Inappropriate and rational use of drugs can increase morbidity and mortality. Objectives: To determine the accuracy of drugs and heart drug dosages in patients with heart failure at the inpatient installation of Samarinda Medika Citra Hospital. Material and Methods: This research is a descriptive observational study with retrospective data collection in 2022. The sample consisted of all adult heart failure inpatients who met the inclusion criteria of 60 patients. Results: The results of the study showed that out of 60 patients, the accuracy of therapy included 93% of the correct drug and 88% of the correct dose. The heart failure drugs used were furosemide (39%), spironolactone (19%), digoxin (18%), candesartan (15%), captopril (4%), bisoprolol (3%), and lisinopril (2%). Conclusions: From the research results, it was found that 93% of the drug accuracy and 88% of the drug dose accuracy in heart failure patients.
The Effect of Different Soxhlet Extraction Solvents Towards AntiPropionibacterium acnes Activity of Balik Angin Leaves (Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz) : Pengaruh Perbedaan Pelarut Ekstraksi Soxhlet Terhadap Aktivitas AntiPropionibacterium acnes dari Daun Balik Angin (Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz) Ramadhan, Hafiz; Forestryana, Dyera; Subareng, Ahmad Rizal Maulana; Vebruati, Vebruati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 1 (2025): (March 2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i1.16634

Abstract

Background: Acne is a skin infection that may be induced by Propionibacterium acnes. Treatment of acne infection from natural ingredients native to Kalimantan such as Balik Angin or Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz can be an alternative therapy. Prior research indicates that leaves macerated with methanol and 70% ethanol solvents can inhibit the growth of P. acnes in the medium category with a Minimum Inhibitory Concentration (MIC) of 3.2%. Objectives: The research purpose is to compare the effect of the different solvents of soxhlet extraction on the antibacterial activity of Balik Angin leaves in inhibiting the growth of P. acnes. Material and Methods: Balik Angin leaves were extracted using the Soxhlet with two different solvents, which were methanol and 70% ethanol, then followed by phytochemical screening. The antibacterial activity assay was carried out by using well diffusion with each sample concentrations of 25.6%; 12.8%; 6.4%; 3.2%; 1.6%; 0.8%; 0.4%; and 0.2%. Results: Both extracts contained the same phytochemical groups, which were phenols, flavonoids, alkaloids, tannins, saponins, and triterpenoids. The antibacterial activity test results showed that both extracts had the same MIC of 0.8%. however, the 70% ethanol extract of Balik Angin leaves was able to provide a larger inhibition diameter average of 9.61±0.35 mm compared to the methanol extract of 9.20±0.22 mm. Nonetheless, there was no significant difference (p>0.05) between both concentrations, when compared to the range of 1.6-25.6%. Conclusions: The conclusion of this research is that differences in Soxhlet extraction solvents in Balik Angin leaves can affect its activity as an anti-Propionibacterium acnes agent.
Bioactivity of Songga Wood (Strychnos ligustrina) methanol extract: Antioxidant and Anti-inflammatory against Interleukin-8 (IL-8) levels in Vivo: Bioaktivitas ekstrak metanol Kayu Songga (Strychnos ligustrina): antioksidan dan Antiinflamasi terhadap kadar Interleukin-8 (Il-8) secara in Vivo Jabbar, Asriullah; Wahyuni, Wahyuni; Nasrudin, Nasrudin
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 1 (2025): (March 2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i1.17342

Abstract

Background: Songga wood (Strychnos ligustrina) from the genus Loganiaceae is a plant that is empirically used as a traditional medicine by people in several regions in Indonesia. This plant serves as a medicine for fever, malaria, as an antidote, and for treating wounds, boils, acne and scabies. Objectives: This study aims to determine the antioxidant and anti-inflammatory activity of methanol extract of songga wood with Interleukin-8 (IL-8) parameter. Material and Methods: Songga wood was macerated with methanol for 3x24 hours until a thick extract was obtained. Antioxidant activity test was conducted using the DPPH method and anti-inflammatory test was performed using ELISA with IL-8 parameter. Test animals were divided into six groups:the normal group, negative control (Na-CMC), positive control (diclofenac sodium) and treatment with three dose variations, 50, 100, and 200 mg/kgBB. Results: The results showed that the antioxidant activity value of Songga wood was IC50 84.51 µg/ml. Furthermore, anti-inflammatory activity showed IL-8 levels at doses of 50 mg/kgBB extract (494.8 pg/ml), 100 mg/kgBB (216.2 pg/ml) and 200 mg/kgBB (118.7 pg/ml). Conclusions: This study concluded that methanol extract of songga wood has strong antioxidant activity and anti-inflammatory activity. The most effective dose to reduce IL-8 levels was 200 mg/kgBB, which was not significantly different from the positive control (p>0.05).
In Vitro Evaluation of Sunscreen Activity of Extract and Fraction of Kedabu Fruit (Sonneratia ovata Backer) : Uji Aktivitas Tabir Surya Ekstrak dan Fraksi Buah Kedabu (Sonneratia ovata Backer) Secara In Vitro Lestari, Putri; Furi, Mustika; Fernando, Armon; Amin, Syahrul; Irfan, Nawwar
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 1 (2025): (March 2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i1.17347

Abstract

The Kedabu fruit, scientifically known as Sonneratia ovata Backer, is a mangrove plant commonly found in Indonesia. This fruit is valued for its antioxidant properties and shows potential as a natural sunscreen. This study was conducted to determine the in-vitro activity of the extract and fractions of Kedabu fruit (Sonneratia ovata Backer) as a sunscreen, with the potential for development into a natural sunscreen preparation. Experiments were conducted on extracts and various fractions, including n-hexane, ethyl acetate, n-butanol, and water. The extracts and fractions of Kedabu fruit were prepared at concentrations of 200, 400, 600, 800, and 1000 µg/mL. Their absorbance was then measured in the UV A (320-375 nm) and UV B (290-320 nm) wavelength ranges. The n-butanol fraction, at a concentration of 1000 µg/mL, appears to be the most effective sunscreen, demonstrating a %Te value of 8.369% and %Tp of 50.345%. This performance places it in the standard Suntan range for UV B protection. Additionally, it has an SPF value of 10.58, categorizing it within the highest level of sun protection.
Antiseptic Gel Formulation Uses Eco-Enzyme from Rambutan (Nephelium lappaceum) Peels Substitute the Active Ingredient Alcohol : Formulasi Gel Antiseptik Menggunakan Eco-Enzyme Dari Kulit Buah Rambutan (Nephelium lappaceum) Untuk Mensubstitusi Bahan Aktif Alkohol Razak, Abd. Rahman; Maqnalia, Maura Maqnalia; Lauende, Sarah Hapritasya; Ainun, Sri; Setiawan, Muh. Risky
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 1 (2025): (March 2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i1.16625

Abstract

Background: Eco-enzyme is the result of fermenting organic waste that possesses antibacterial properties. Objectives: This research aims to develop the best formula for an environmentally friendly antiseptic gel. Methods: The analysis carried out in this research includes testing the physical parameters and antibacterial activity of preparation. Results: The liquid eco-enzyme product produced has a distinct strong acid aroma with a pH of 3.1. Antiseptic gels were created in five formulations (F1-F5) by substituting the active alcohol ingredient traditionally used as an antibacterial agent. Test results showed that F1, F2, and F3 met all the requirements for the physical parameters of the gel, including pH (4.5-6.5), viscosity (2000-4000 Cp), spreadability (5-7 cm), and homogeneity (homogeneous). Meanwhile, F4 did not meet the physical parameter of viscosity, and F5 did not meet the parameters for viscosity and spreadability. Antiseptic gel made from eco-enzyme extracted from rambutan fruit peels exhibited higher antibacterial activity against S. aureus and E. coli bacteria compared to two commercial antiseptic gels and F1, which served as the negative control. Conclusion: An antiseptic gel preparation containing rambutan peel eco-enzyme with a concentration of 50% and 50% alcohol (F3) is the best formula.
Cost Effectiveness Analysis of Hypertensive Therapy in Hypertensive Patients with Type 2 of Diabetes Mellitus at RSUD Dr. Soehadi Prijonegoro Sragen: Analisis Efektivitas Biaya Terapi Hipertensi pada Pasien Hipertensi dengan Diabetes Melitus Tipe 2 di RSUD dr. Soehadi Prijonegoro Sragen Jati, Alpian Rona Asmoro; Sugihantoro, Hajar; Syahrir, Ach.
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 1 (2025): (March 2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i1.16955

Abstract

Background: Hypertension followed by type 2 diabetes mellitus is a major risk factor for various cardiovascular diseases and is one of the chronic degenerative diseases Hence, it requires long-lasting treatment therapy and high costs. Based on this, hypertensive patients with DM type 2 need special attention in order to get effective hypertensive therapy at minimum cost. Cost-effectiveness analysis is an analytical method for making decisions on the best alternative to the therapy used. Objectives: To determine the most cost-effective hypertensive therapy in hypertensive patients with DM type 2 diabetes who underwent pharmacoeconomic hospitalization with a cost-effectiveness analysis approach. Methods: This type of study is descriptive observational with a retrospective data collection method from January 2021 - June 2023. The data taken was 31 medical records data and bill fees that met the inclusion criteria. Results: The description of drug use in hypertensive patients with DM type 2 diabetes at RSUD Soehadi Prijonegoro Sragen consists of monotherapy (19.35%) and combination (80.65%). The effectiveness of monotherapy was highest in patients receiving amlodipine therapy (12.42 mmHg), while the effectiveness of the combination was highest in patients taking adalat oros + candesartan + bisoprolol + furosemide + clonidine (22,38 mmHg). From the calculation of the ACER value, it was found that the most cost-effective drug was amlodipine, which had an ACER value of Rp. 289,962 in monotherapy and amlodipine + candesartan with an ACER value of Rp. 262,626. Conclusions: The most widely used hypertension therapy is combination therapy; the drug with the highest effectiveness is adalat oros + candesartan + bisoprolol + furosemide + clonidine and the drug with the highest cost-effectiveness is amlodipine monotherapy and the combination of amlodipine + candesartan.

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