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Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Published by Universitas Muhammadiyah Surabaya
ISSN : 25412272     EISSN : 25489526     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 301 Documents
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Acute kidney injury induced by beta-lactam antibiotics in children: A scoping review Tania, Astalitha Lorel; Alya Ayu Tazkia
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.20376

Abstract

Antibiotics are the agents that cause Acute Kidney Injuries (AKI) in children. A recent study has shown the incidence of nephrotoxicity by antibiotics reaches 16% in children. Beta-lactam types are not widely known for their nephrotoxic effect. This study aims to examine beta-lactam antibiotics' role in inducing children's renal failure. This search for a scoping review on the effect of beta-lactam antibiotics in children was carried out in December-January 2022-2023. We used some search engines with the year of publication 2012-2022 then extracted. The keyword combinations used are: “beta-lactams” OR “β-lactams” AND “acute renal failure” OR “acute renal injury” OR “nephrotoxic” OR “nephrotoxicity” AND “children” OR “pediatric” OR “neonate” NOT “adult”. Studies were excluded if the: (i) adult; (ii) were a review, systematic review, or meta-analysis; (iii) written in a language other than English; (iv) not available in full text; (v) have kidney disease before (vi) in vitro or in vivo. The article selection process was based on PRISMA-ScR. From 4032 articles that met the search criteria, 3 studies met the inclusion criteria. The result shows that beta-lactam increases the risk of acute renal injury in children. This review emphasizes the importance of choosing kidney-safe antibiotics for children.
Exploring cytokine levels in pregnancy, preeclampsia, and sepsis-complicated preeclampsia Wardhani, Mira Kusuma; Gondo, Harry Kurniawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.20427

Abstract

Around the world, preeclampsia (PE) influences five to eight percent of pregnancies and contributes significantly to maternal mortality. This study applies a scientific observational cross-sectional review to examine how TNF-α, TNF-R1, and TNF-R2 play their roles in normal pregnancy, preeclampsia, and preeclampsia associated with sepsis. Blood tests were gathered from subjects at a local medical clinic in Malang, Indonesia, and TNF-α, TNF-R1, and TNF-R2 levels were surveyed utilizing the Enzyme-linked Immunosorbent Assay (ELISA) strategy. The results demonstrate raised TNF-α levels in both preeclampsia and preeclampsia with sepsis, along with expanded TNF-R1 and TNF-R2 receptor levels, signifying their association in these circumstances. Validation through bigger scope studies is basic, possibly situating TNF-α as an early indicative biomarker for sepsis. This study highlights the importance of TNF-α in pregnant mothers with preeclampsia and preeclampsia muddled by sepsis, uncovering possible analytic and remedial avenues.
Determination of ABO blood group based on secretors or non-secretors analysis in body fluids Setiawan, Fery; Yudianto, Ahmad; Nurdianto, Arif Rahman; Sunariani, Jenny; Mooduto, Latief
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.20561

Abstract

Criminal acts often leave traces analyzed by law enforcement, especially by the Indonesian National Police (POLRI). Sometimes, various items were found and analyzed to link the victim and the perpetrator. Blood, the most abundant body fluid, found in crime scenes, consists of cellular and liquid elements. The forensic focuses on red blood, which can be wet or dried at the crime scene. Sometimes, there was no blood or bloodstains found, but objects related to other body fluids, such as: condoms, toothbrushes, the mouth of glass cups, straws, etc, could be found. Blood group analysis could still be carried out based on secretor gene (Se) considering that 80% of the population was of the secretor group. There are two chromosomes related to blood regulation, namely: chromosomes no. 9 and 19. The former relates to the ABO blood group and the latter relates to the secretory phenotype. The basic principle of secretors was antigens found on the surface of red blood cells and all body fluids, except cerebrospinal fluid. The pattern of inheritance on chromosomes 9 and 19 is based on the probability law by Mendell. It stated that all of genotypes (homozygous dominant-recessive or heterozygous) would be passed on to their offspring.
The body mass index profiles in chronic pulmonary aspergillosis: trend and variability in post tuberculosis patients Setianingrum, Findra; Rozaliyani, Anna
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 01 (2024): Qanun Medika Vol 08 No 01 January 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i01.20763

Abstract

Tuberculosis (TB) is the main risk factor for chronic pulmonary aspergillosis, especially in patients with residual cavitary lesions after completion of TB therapy. The body mass index (BMI) is one of the established markers in predicting the mortality of CPA. However, the data regarding BMI profiles of CPA patients in Indonesia is still limited. We evaluated the BMI profiles of CPA patients among post-TB patients. Patients diagnosed as CPA based on clinical, radiology and the Aspergillus IgG test. 50 patients were included with a mean age of 35 years; 13 patients met the criteria of CPA. The overall median of BMI in these patients was 21. The median BMI in the CPA group was 19,3. The lowest (19,8) median BMI value was observed in the positive Aspergillus IgG group (11,5 – 30 mg/L) with a minimum BMI of 14,7 and a maximum BMI of 29,2. The differences in median BMI across CPA and non CPA groups and Aspergillus IgG level were not statistically significant. However, there is a trend that lower BMI were distributed among patients with positive Aspergillus IgG. More than one third of CPA patients in this study were classified as underweight. Future study is necessary to better depict the BMI profiles in larger scale of populations of CPA in Indonesia in order to achieve better diagnosis and management of CPA.
Osteopontin and Its Clinical Correlation to Type 1 Cardiorenal Syndrome: A Literature Review Welliam, Yongki; Wungu, Citrawati Dyah Kencono; Susilo, Hendri
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.20878

Abstract

Cardiorenal syndrome (CRS) is a spectrum of disorders involving both the heart and the kidneys, either acutely or chronically, in one organ that can lead to dysfunction in the other. Type 1 CRS, the most common CRS, is when acute heart dysfunction impacts acute kidney dysfunction, commonly known as acute kidney injury. Comorbidities involving these two significant organs contribute to a high patient mortality rate that requires a new potential diagnostic method. Biomarkers are one of the diagnostic modalities widely used in various diseases. Osteopontin (OPN) is a phosphorylated glycoprotein found primarily in bones and teeth that regulates mineralization. Osteopontin is known to be involved in describing various pathological changes in the body, including cardiovascular diseases. This review aims to evaluate the clinical correlation of OPN level changes with the occurrence of Type 1 CRS. The results indicate that OPN also plays a role in detecting the progression of cardiovascular disease towards renal injury. The imbalance in the function of OPN as a pro-inflammatory and anti-inflammatory agent increases the progression of kidney disease in patients. Further findings suggest that, more specifically, urinary OPN describes renal injury events in type 1 CRS patients.
Unraveling the intricacies: understanding the complexities of obesity, body image, and demographic influences among Indonesian high school adolescents Wiradinata, Harsono
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.20883

Abstract

This research addresses Indonesia's significant obesity issue among teenagers, highlighted by the 2022 Indonesian Health Survey. It explores the correlation between overweight-obesity prevalence and body image disturbances in high school adolescents, with a sample of 185 individuals selected through random sampling. Inclusion criteria involve parental consent for overweight-obese adolescents, while exclusion criteria consider specific health conditions or unwillingness to participate. Ethically, respondent anonymity and the lack of biological materials alleviate concerns. BSQ-34 prevalence rate analysis reveals a complex landscape influencing body image disturbances. While age and gender show limited associations, Body Mass Index correlates significantly, emphasizing its role. Conversely, no notable correlation is found with bullying, parenting styles, and social comparison, highlighting the independence of body image disturbances. Media influence stands out, warranting comprehensive investigations. In conclusion, these findings stress the complexity of body image concerns, advocating for holistic comprehension and interventions beyond singular influences, emphasizing the multifaceted nature of factors affecting high school adolescents' body image perceptions.
The effect of using the smartphone blue light filter feature on tear production Ikliluddin, Ahmad; Rahmat Saputra, Adey
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.21060

Abstract

Smartphones today have been used to support human activities. It makes the human eye always exposed to smartphone screens that use light-emitting diodes (LEDs) that emit light with a blue electromagnetic spectrum known as blue light. The effect of blue light on human eyes is still being studied. This study aims to determine the effect of using smartphone blue light filter features on tear production. This was a quasi-experimental, pre-post study, involving 40 samples who met the inclusion and exclusion criteria. Subjects were asked to use a smartphone within 1 week without activating a blue light filter. After this, tear production was measured using the Schirmer test under topical anesthesia. Then, subjects were asked to use a smartphone again within 1 week by activating the blue light filter and being measured again using the Schirmer test under topical anesthesia. Data obtained were analyzed using SPSS 25 software. There was a statistically significant (sig=0.000) difference in Schirmer test values before and after the usage of smartphone blue light filters. Each increase in the duration of smartphone usage for one minute will decrease Schirmer test results by 0.000625 mm, and so will the multiplication. The duration of smartphone usage has a 21.6% contribution of influence on the results of the Schirmer test. In conclusion, there is an effect of using the blue light filter feature on tear production between the use of a smartphone without activating the blue light filter with the use of a smartphone that activates the blue light filter feature.
Medical education in clerkship: From here and out Prananjaya, Bintang Arroyantri; Syulthoni, Zain Budi; Maritska, Ziske; Nudhar, Lathifah; Aini, Syarifah; Suryani, Puji Rizki; Ikhsan, Diyaz Syauki
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.21094

Abstract

The COVID-19 pandemic has changed many things in the medical education system. This change requires adaptation and modification from education providers, teachers, and students. A virtual learning system has been implemented instead of a face-to-face learning system. However, this makes several challenges and issues that must be considered. Virtual learning is considered less attractive and interactive and not effective in teaching clinical skills. For student clerks, the reduced time to undergo education in the hospital leads to fewer case exposures. Another problem is the facilities and infrastructure. Several ways to solve this problem have been implemented while minimizing risk and taking strict precautions. Some institutions modify and innovate to maximize the effectiveness of learning activities. In addition to technical and effectiveness issues, changes in the education system also have an impact on the mental health of medical students, therefore it is important for institutions to be sensitive to changes and risks to students' mental health during the pandemic.
Analysis of Neutrophil, Leukocyte, Lymphocyte, and NLR Cell Profiles in Patients Diagnosed with Chronic Gastritis Affected by Helicobacter pylori and Non-Helicobacter pylori Infection at Dr. Soetomo Hospital in Surabaya, Indonesia Aziz, Nahdah Aulia; Wahyunitisari, Manik Retno; Susilo, Imam
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.21260

Abstract

Helicobacter pylori (HP) is a prevalent cause of bacterial infections, particularly chronic gastritis in the human body. The diagnosis of gastritis relied on gastric biopsy examination, where inflammation is characterized by an increase in various inflammatory cells, including macrophage, neutrophil, lymphocyte, or plasma cells. Therefore, this research aimed to determine the profiles of neutrophil, leukocyte, lymphocyte, and neutrophil lymphocyte ratio (NLR) in chronic gastritis patients, distinguishing between those with Helicobacter pylori and non-Helicobacter pylori infection at Dr. Soetomo Hospital in Surabaya. This research adopted a retrospective method, using medical records for chronic gastritis patients at Dr. Soetomo Hospital between 2018 and 2022. The variables analyzed included Helicobacter pylori infections and values of neutrophil, leukocyte, lymphocyte, and NLR cells. The obtained data were subjected to analysis using descriptive statistics. The results showed that the majority of participants were females (61.9%), senior high school graduates (52.38%), and aged 45-59 (pre-elderly) (32.14%). In non-Helicobacter pylori group, the average values of neutrophil, leukocyte, lymphocyte, and NLR cells were 62.29 (SD = 12.17), 8.155 (SD = 4.02), 29.165 (SD = 12.31), and 3.68 (SD=4.865), respectively. In conclusion, females showed a propensity for chronic gastritis with Helicobacter pylori. It was observed that non-Helicobacter pylori chronic gastritis tended to have elevated neutrophil and leukocyte values. Meanwhile, Helicobacter pylori-related chronic gastritis tended to show increased lymphocyte and NLR values due to systemic inflammation. Helicobacter pylori was associated with conditions such as iron deficiency anemia, cardiovascular disease, diabetes, thyroid disease, and malnutrition.
Pilihan Antibiotik Pada Pasien Abses Hepar Piogenik Mukti, Ilham Ramadhana; Vidananda, I Wayan Bagoes; Rahmaningtyas, Ihzani; Hasanovic, Ilyas; Tsany, Imtiyaz; Suryajana, I Wayan; Napitupulu, Rudi Pandapotan; Fahimi, Mukti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.21290

Abstract

Pyogenic liver abscess is a dangerous, life-threatening disease with a high mortality rate that requires accurate diagnosis and treatment. The most common symptoms are upper abdominal pain, hepatomegaly, high fever, nausea, and vomiting. Pyogenic liver abscess occurs due to infection from anaerobic bacteria or aerobic bacteria. in the United States the reported annual incidence is 3.6 cases per 100,000 people. But in Taiwan it is 17.6 per 100,000 people. Pyogenic liver abscess sufferers are dominated by men but currently it affects older people more, with the most cases aged 50 to 60 years. The purpose of this study was to know the choice of antibiotics in patients with pyogenic liver abscess. Empiric antibiotics should be initiated immediately upon suspicion of a pyogenic liver abscess tailored to kill all possible bacteria: Gram-negative cocci, gram-positive cocci, and anaerobes. Antibiotic regimens include amoxicillin-clavulanic acid, third-generation cephalosporins combined with aminoglycosides, or piperacillin/tazobactam. In cases of penicillin allergy or antibiotic resistance, fluoroquinolones or carbapenems may be used.

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