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Meditory : The Journal of Medical Laboratory
Published by Poltekkes Kemenkes Denpasar
ISSN : 23381159     EISSN : 25491520     DOI : https://doi.org/10.33992/meditory
Core Subject : Science, Social,
Biochemistry, Genetics & Molecular Biology Environmental Science
Meditory : The Journal of Medical Laboratory secara khusus berfokus pada masalah utama dalam pengembangan ilmu di bidang laboratorium medis yang mencakup patologi klinik, mikrobiologi, kimia kesehatan dan patologi anatomi.
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Articles 165 Documents
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THE DIFFERENCES OF HEMATOCRIT LEVEL IN IMMEDIATE AND DELAYED BLOOD SAMPLES ON MICROHEMATOCRIT METHOD Dwijastuti, Ni Made Sri; Damarta, I Ketut Ari; Widiantari, Ni Putu
Meditory : The Journal of Medical Laboratory Vol 11, No 2 (2023): Meditory Volume 11 No. 2 Tahun 2023
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v11i2.3012

Abstract

Background:Hematology specimen examination should be performed at room temperature in less than 2 hours. Recommended specimen storage temperatures are in the range of 2- 6C. However, examining laboratory samples with uncertain storage time and temperature is often delayed.Aims:To determine the difference between the hematocrit values of blood samples examined immediately and those that were delayed for more than 2 hours at room temperature.Methods:This study was conducted from April to June 2023 at the Clinical Chemistry Laboratory of Universitas Bali Internasional. A total of 24 venous blood samples were grouped into three treatment groups that were stored for 3 hours (P1), 6 hours (P2), and 12 hours (P3) at room temperature (18-220C), and one control group was examined immediately. Data were analyzed using the Mann-Whitney U test (?=0.05).The results:Statistical tests showed that the comparison of control with P1 was not significantly different (p=0.313), while the comparison of control with P2 (p=0.003) and the control with P3 (p=0.000) was significantly different.Conclusions:There was no significant difference in hematocrit values between blood samples examined immediately and blood samples delayed for 3 hours. Significant differences in hematocrit values were shown in comparing blood samples examined immediately with blood samples delayed for 6 hours and examined immediately with blood samples delayed for 12 hours.
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT OF GALOBA DURIAN FRUIT PEEL (Ammomum spp.) Salamena, Fuadiska; Manurung, Brian Saputra; Mose, Windi; Patty, Kristi Lenci; Nusaly, Windy Natalia; Putri Usman, Dwi Anggara
Meditory : The Journal of Medical Laboratory Vol 13, No 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i1.4021

Abstract

Background: Amomum spp. (red variant), An endemic plant widely found in Maluku, including Hatu Village, Ambon, is valued for its medicinal and economic roles.Objective: This study aimed to evaluate the phytochemical content and antioxidant activity of Ammomum peel extract using the DPPH assay.Methods: The fruit peel of Ammomum spp. (red variant) was extracted by maceration using ethanol as solvent and concentrated by evaporation at room temperature. The antioxidant activity was quantitatively and qualitatively assayed using the DPPH assay method and by observing the color change in the extract. Percent inhibition data were analyzed using linear regression.Results: The analytical findings confirmed the presence of flavonoids, saponins, tannins, steroids, and phenolics as secondary metabolite content in the galoba fruit peel extract. The free radical scavenging activity exhibited a strong value of 59.04 µg/mL. Therefore, this study suggests using the red variant of Ammomum spp. fruit peel extract in the treatment of free radical-induced disorders.Conclusions: Our study revealed that the peel extract of red Galoba durian contained secondary metabolites and strong antioxidant activity.
HEPATOPROTECTIVE EFFECT OF BLACK CUMIN (Nigella sativa) AGAINST THE LIVER Aspartame-induced Rattus norvegicus BASED ON HISTOPATHOLOGICAL FEATURES Mukharomah, Katrine Adiansyah Dwi; Sayekti, Fitria Diniah Janah
Meditory : The Journal of Medical Laboratory Vol 12, No 2 (2024): Meditory, Volume 12 No. 2 Tahun 2024
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v12i2.3596

Abstract

Foods and beverages containing artificial sweeteners in the form of aspartame are widely consumed in various countries including Indonesia, and have increased every year. Excessive consumption of aspartame can increase the occurrence of hepatotoxicity in the liver such as changes in the histopathological picture of the liver characterized by degeneration and cell necrosis (cell death). Hepatoprotectors are compounds that have antioxidant benefits so that they can protect the liver by reducing oxidation reactions in liver damage. One compound that functions as a hepatoprotector is black cumin (Nigella sativa). Aims: This study aims to determine the effect of black cumin administration on macroscopic and microscopic observations of liver organs in male white rats induced by aspartame. Methods: This study was experimental with 5 treatment groups including 1 normal group, 1 negative group and 3 aspartame and black cumin treatment groups. Liver tissue is observed macroscopically based on color, texture and size, while microscopically it is done by assessing the presence of normal cells, degeneration and necrosis. The results. The results of microscopic observations showed that the negative control and treatment groups showed cell damage in the form of cell degeneration and necrosis. The results of the study based on the ANOVA test obtained a significance value of 0.05 which means there is an average difference between groups and continued with the Tukey test. Conclusions: Based on Tukey's test, the fourth group (K4) is a treatment group with the most effective dose of black cumin in preventing liver cell damage to white rats, which is 0.2 ml / 200 g body weight / day.
DESCRIPTION OF URIC ACID LEVELS BUS DRIVER PT ARSA BUANA MANUNGGAL KARANGASEM Yulia, Ni Putu Mentari; oka suyasa, ida bagus; sudarmanto, i gede; suyasa, i nyoman gede
Meditory : The Journal of Medical Laboratory Vol 12, No 1 (2024): Meditory, Volume 12 No. 1 Tahun 2024
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v12i1.3209

Abstract

Uric acid is the end result of breaking down a substance called purine. Purine substance is a natural substance which one of the chemical structure groups is the formation of DNA and RNA. Uric acid can be influenced by several factors such as age, long sitting while driving, consumption of alcoholic beverages, and consumption of foods high in purines. The aim of this study was to determine uric acid levels in PT.ABM drivers. The study sample consisted of 45 people selected by random sampling using the POCT method with the Autoclick Easy Touch GCU tool. The results showed normal uric acid levels in 32 people (71.1%) and high uric acid levels in 13 people (28.9%). High uric acid levels were more common at the age of 43-51 years in 5 people (45.5%), duration of sitting while driving was dominated by driving duration for ? 7 hours/day in 10 people (29.4%), while drivers 11 people (34.4%) consumed alcoholic beverages and 25 people (55.6%) consumed high-purine foods. The conclusion of this study is that high uric acid levels occur in respondents aged 43-51 years, driving for ? 7 hours/day, consuming alcoholic beverages and consuming foods high in purines.
BIOVIABILITY OF BIDURI LEAF EXTRACT (Calotropis Gigantea L.) ON FIBROBLAST CELL CULTURE Setyaningsih, Sari; Astuti, Pudji; Meilawaty, Zahara; Dharmayanti, Agustin Wulan Suci
Meditory : The Journal of Medical Laboratory Vol 13, No 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i1.4049

Abstract

Background: Biduri is recognized for its medicinal properties, particularly in wound healing. The active compounds influence the number of fibroblast cells, which play a role in wound healing. Research on the bioviability of biduri leaf extract has never been conducted, so in vitro testing is necessary to determine the ability of biduri leaf extract to influence fibroblast cells.Objective:  To assess the effect of Biduri leaf extract on the viability of BHK-21 fibroblast cells in vitro. Methods: This experiment used a posttest-only group Design with an MTT assay to assess the viability of BHK-21 fibroblast cells after exposure to different concentrations of Biduri leaf extract. The study employed four treatment groups with varying extract concentrations and used one-way ANOVA followed by an LSD test to analyze the proportion of living cells statistically.Results:  The viability percentages of fibroblast cells varied with the concentration of Biduri leaf extract. The highest viability was observed at 5% concentration (80.82%), while the lowest was at 20% concentration (60.25%). A one-way ANOVA test was used to analyze the data, and differences were considered statistically significant at p 0.05..Conclusions: The highest viability was observed at 5%, while the lowest was at 20% concentration. All treatment groups had cell viability above 60%, indicating that the Biduri extract is generally biocompatible with fibroblast cell culture.
PHOSPHATE BUFFER SALINE AS AN ALTERNATIVE DILUENT IN EXAMINATION OF ERYTHROCYTE SEDIMENTATION RATE WESTERGREEN METHOD Alfia, Shofa; Nugraha, Gilang; Anggraini, Rahayu; Lukiyono, Yauwan Tobing
Meditory : The Journal of Medical Laboratory Vol 11, No 2 (2023): Meditory Volume 11 No. 2 Tahun 2023
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v11i2.2817

Abstract

Background: 0.9% NaCl is the standard method for examining ESR with EDTA blood, it was found that PBS has properties comparable to 0.9% NaCl because the osmolarity and ion concentration of this solution is isotonic with human body fluids.Aims: This study was to determine the difference in LED results using PBS pH 7.2 and pH 7.4 with the results of examining LEDs using 0.9% NaCl Westergren method.Methods: This study used an experimental method with a static group comparison research design. The difference in the results of the LED examination using 0.9% NaCl as the control group and PBS pH 7.2 and pH 7.4 as the test group.Results: statistical tests showed that the average value of LED using 0.9% NaCl was 13.10 mm/hour, PBS pH 7.2 was 12.40 mm/hour and PBS pH 7.4 was 10.30 mm/hour. Based on the results of the One Way Anova test, the p-value was 0.528 and the Post Hoc test results on PBS pH 7.2 obtained a p-value of 0.959 and PBS pH 7.4 p-value 0.523. Conclusion: the results of examining the LED using both PBS pH 7.2 and PBS pH 7.4 diluents showed no difference in results with 0.9% NaCl diluent as the standard method. So there is a suggestion from researchers to use abnormal samples diluted with PBS pH 7.2 to 7.4.
VARIATIONS IN LEUKOCYTE COUNTS OF TUBERCULOSIS PATIENTS DURING THE TREATMENT PERIOD mfh, aini aini
Meditory : The Journal of Medical Laboratory Vol 12, No 2 (2024): Meditory, Volume 12 No. 2 Tahun 2024
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v12i2.3543

Abstract

Background: Tuberculosis is one of the deadliest infectious diseases in the world. The disease is caused by Mycobacterium tuberculosis bacteria that spread in the air through the saliva of the patient. Infection from these bacteriacauses an increase in leukocytes in the blood as a form of body resistance in the process of phagocytosis. Administrationof anti-tuberculosis drugs during the first-line phase can kill bacteria and relieve symptoms arising from infection becausethese drugs have an effect on the work of the spinal cord in producing new blood cells. Research Objective: This study aims to determine the variation of leukocyte count of tuberculosis patients who are undergoing the first-line phase of treatment as an indication of cure rate. Research Methods: The research method used was analytic cross sectional, whichwas then analyzed by performing normality and homogeneity tests, then continued with the one way anova test. Results: The results of this study showed the average leukocyte value in the first month of treatment was 5,026 cells/mm3 blood, month two 9,415 cells/mm3 blood, month three 6,140 cells/mm3 , month four 6,566 cells/mm3 , month five 6,054 cells/mm3, and month six 6,667 cells/mm3 . With an average value of all 6,776 cells/mm3 . Conclusion: From these results, it can be concluded that there is a significant difference in the variation of leukocyte counts between the six treatment duration groups with an overall mean value of 6,776 cells/mm3 blood... The significant difference in leukocyte count variation between the six treatment duration groups indicates that leukocytes can be used as a benchmark to determine indications of the recovery rate of tuberculosis patients who are undergoing the first line of treatment.
CORRELATION BETWEEN BLOOD PRESSURE AND URINE PROTEIN PREGNANT WOMEN AT PUSKESMAS KEDIRI II Rastuti, Luh Putu Anik; Prihatiningsih, Diah; Yanti, Ni Luh Gede Puspita
Meditory : The Journal of Medical Laboratory Vol 12, No 1 (2024): Meditory, Volume 12 No. 1 Tahun 2024
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v12i1.3156

Abstract

AbstractBackground: Preeclampsia is a complication during pregnancy characterized by elevated blood pressure followed by proteinuria, the presence of protein in the urine of pregnant women who previously did not have hypertension. Aims: The aim of this study is to determine the relationship between blood pressure and urinary protein in pregnant women at the Puskesmas Kediri II.   Methods: This study is an observation alanalytical research with a cross-sectional design. The study subjects were 50 pregnant women selected through total sampling. Secondary data were used to determine the blood pressure and urinary protein levels of pregnant women.  The results The research findings indicate that dominant normal blood pressure occurred in 45 individuals (90%), while dominant negative proteinuria was found in 48 individuals (96%). Based on the Spearman Rank statistical test for both variables, a p-value of 0.639 was obtained, indicating that p-value 0.05, meaning there is no relationship between blood pressure and urinary protein in pregnant women at the Puskesmas Kediri II. The correlation coefficient result of -0.068 indicates a very weak relationship between the two variables. Conclusions: Statistical analysis yielded a p-value of 0.639 (0.05), indicating acceptance of the null hypothesis (Ho) and rejection of the alternative hypothesis (Ha). Thus, there is no significant relationship between blood pressure and urine protein levels in pregnant women at Puskesmas Kediri II. Meanwhile, the correlation coefficient of -0.068 indicates a very weak relationship between the two variables. Keywords: Blood pressure, Urinary protein, Pregnant women
INFLUENCE GIVING INFUSION OF LEMON WATER (Citrus limon) AND CUCUMBER (Cucumissativus L) ON SUFFERER HYPERTENSION IN REGION WORK PUBLIC HEALTH CENTER PUUWATU CITY KENDARI Rofiqoh, Rofiqoh; Van Gobel, Sri Yunanci
Meditory : The Journal of Medical Laboratory Vol 11, No 2 (2023): Meditory Volume 11 No. 2 Tahun 2023
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v11i2.2401

Abstract

Hypertension is one of the silent killer diseases that causes the iceberg phenomenon. The prevalence of hypertension increases with age. If this pathological condition does not get treatment quickly and early, it will exacerbate the risk. Based on the results of Riskesdas (2018) in Indonesia the prevalence of hypertension was 31.7%. The prevalence of Hypertension for Southeast Sulawesi Province based on the results of Riskesdas in 2007 was 31.7%, Riskesdas in 2013 decreased to 25% and in Riskesdas in 2018 it rose to 31%. Data on the health profile of Puuwatu Public Health Center, Kendari City, hypertension in adults (20-44 years) in the last 3 years showed that in 2014 there were 284 cases, in 2015 there were 222 cases, in 2016 increased to 419 cases and in 2017 to 498 cases. Infused water is water that is mixed with fruit and then allowed to stand for a few hours until the juices come out . To determine the effect of Infusion of Fruit and Vegetable Water (cucumber and lemon) on Hypertension Patients in the Work Area of Puuwatu Health Center, Kendari City. This type of research is Quasi experimental using a two group pre-post test design with control with a survey approach. This research was conducted on November 5, 2020 to January 29, 2021. The design of this study was to provide Infused Water of fruits and vegetables (cucumber and lemon) to hypertension patients who were previously checked for blood pressure and then given an intervention in the form of giving Infused Water of fruits and vegetables (cucumber 100 g) and 50 grams of lemon plus 250 ml of mineral water) 1 time a day for 8 consecutive days. Blood pressure was checked 4 times after giving Infused Water fruit and vegetable. The sample is all adults who suffer from hypertension totaling 64 people. The sampling technique Purposive sampling. Blood pressure before and after the intervention by giving Cucumber and Lemon Infused Water for 8 days and measuring blood pressure 4 times (every 2 days) that the mean systolic blood pressure before and after the intervention for the case group was 144.4575 mgHg and the control group was 152.155 mgHg and diastolic blood pressure before and after the intervention, the mean for the case group was 90.9375 mgHg and the control group was 96.335 mgHg. The results of independent t-test in cases and controls systolic blood pressure p value = 0.339 ( 0.05) while diastolic p value = 0.374 ( 0.05), that there is no significant difference in systolic and diastolic blood pressure in the two sample groups .then averaged were . the diastolic variable obtained p value = 0.17 (0.05) so it can be said that for systolic and diastolic blood pressure there is an effect.
BACILLUS SP RM3 ISOLATED FROM MANGROVE FOREST HAS POTENTIAL AS ANTIBACTERIAL ACTIVITY AND CYTOTOXICITY Maheswari, Ida Ayu Kartika; Indraningrat, Anak Agung Gede; Paramasatiari, Anak Agung Ayu Lila; Choe, Daegeun
Meditory : The Journal of Medical Laboratory Vol 13, No 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i1.4073

Abstract

Background: Antibacterial resistance is a critical health concern, driving the search for new compounds from natural sources such as mangrove-associated bacteria, which produce diverse secondary metabolites.Objective:  This research focused on studying the bioactivity of the extract of Bacillus sp. RM3, previously isolated from mangrove forests through an extraction method using ethyl acetate solvent.Methods: The Bacillus sp. RM3 isolate was fermented in ISP-2 media and extracted with ethyl acetate. The resulting crude extract was tested for antibacterial activity using the Kirby-Bauer method against Staphylococcus aureus ATCC 25923, Streptococcus mutans FNCC 0405 (Gram-positive), Escherichia coli ATCC 25922, and Klebsiella pneumoniae ATCC 700603 (Gram-negative). Cytotoxic effects were assessed via the Brine Shrimp Lethality Assay (BSLT).Results: The ethyl acetate extract displayed moderate antibacterial activity, evidenced by inhibition zone diameters between 5 to 10 mm. Triplicate measurements revealed the following average inhibition zone diameters: E. coli (9.65±1.62 mm), K. pneumoniae (7.88±1.92 mm), S. aureus (7.77±1.26 mm), and S. mutans (7.03±0.99 mm). Furthermore, the BSLT assay revealed an LC50 value of 504.586 ppm, which indicates the extract was toxic (LC50 1000 ppm).Conclusions: Overall, these results indicate the potential of Bacillus sp. RM3 isolate as a producer of antibacterial and cytotoxic compounds 

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