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Meditory : The Journal of Medical Laboratory
Published by Poltekkes Kemenkes Denpasar
ISSN : 23381159     EISSN : 25491520     DOI : https://doi.org/10.33992/meditory
Core Subject : Science, Social,
Biochemistry, Genetics & Molecular Biology Environmental Science
Meditory : The Journal of Medical Laboratory secara khusus berfokus pada masalah utama dalam pengembangan ilmu di bidang laboratorium medis yang mencakup patologi klinik, mikrobiologi, kimia kesehatan dan patologi anatomi.
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Articles 165 Documents
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EFEKTIVITAS EKSTRAK ETANOL DAUN KERSEN (Muntingia Calabura) TERHADAP PROFIL HISTOLOGI HEPAR TIKUS DIABETES Theosobia Grace Orno; Aswiro Hasan; Fonnie Esther Hasan
Meditory : The Journal of Medical Laboratory Vol 11, No 1 (2023): Meditory, Volume 11 No. 1 Tahun 2023
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v11i1.2403

Abstract

Background: Diabetes mellitus occurs due to insulin resistance or absolute insulin deficiency as a result of damage to pancreatic beta cells. Long-term conditions of gluconeogenesis lead to auto-oxidation of glucose, protein glycation and activation of the polyol pathway which result in increased production of free radicals which is characterized by the formation of reactive oxygen compounds. Antioxidant compounds contained in Muntingia calabura L. leaves are expected to be able to protect liver cells from damage caused by free radicals with flavonoids as the dominant active compound. Aims: This study aims to test the effectiveness of Muntingia calabura L. leaf ethanol extract on the histological profile of diabetic rats.Methode:This research method is a laboratory experimental research, tissue staining using the hematoxylin eosin staining method. The result : showed that the liver histology of diabetic ratsafter therapy with ethanol extract of Muntingia calabura L. leaves at dose I, dose II and dose III did not appear to be significantly different. Similar to the group of DM rats treated with glibenclamide, the hepatocyte cells appeared to be still expe riencing enlargement, widening of the sinusoids and changes in parenchymatous cells. In addition, the ethanol extract of Muntingia calabura L. leaves dose I, II and III were also unable to regenerate the central vein. Conclusion: ethanol extract of Muntingia calabura L. leaf dose groups I, II and III were not effective in repairing hepatocyte necrosis.
CORRELATION BETWEEN TOTAL CHOLESTEROL AND HYPERTENSION SEVERITY IN ELDERLY PATIENTS: A STUDY FROM SOUTH DENPASAR, INDONESIA Arjani, Ida Ayu Made Sri; Made Ratih, Gusti Ayu; Jirna, I Nyoman; Hana Sundari, Cok Dewi widhya; Mastra, Nyoman; Rahmawati, Lukiyani Putri
Meditory : The Journal of Medical Laboratory Vol 13, No 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i1.4023

Abstract

 Background. High cholesterol levels contribute to the formation of atherosclerotic plaques in blood vessels, which can lead to the narrowing of these vessels and increased vascular resistance. Aims This study aims to investigate the relationship between total cholesterol levels and the degree of hypertension among the elderly at UPTD Puskesmas 1 South Denpasar.This study investigates the relationship between total cholesterol levels and hypertension severity among the elderly at UPTD Puskesmas 1 South Denpasar.. Method This research employs an analytical observational design with 43 respondents selected using a consecutive sampling technique. Data were collected through interviews, total cholesterol levels were measured using a Point Of Care Testing (POCT) device, and hypertension was assessed with a sphygmomanomete. Results This research employs an analytical observational design with 43 respondents selected using a consecutive sampling technique. Data were collected through interviews, total cholesterol levels were measured using a Point Of Care Testing (POCT) device, and hypertension was assessed with a sphygmomanometer.  Conclusion The study concludes that there is a significant correlation between total cholesterol levels and the degree of hypertension in the elderly
THE EFFECT OF JICAMA (Pachyrhizus erosus) CONCENTRATION ON THE GROWTH OF Staphylococcus aureus BACTERIA IN SOLID MEDIA Mirawati, Mega; Prasetyorini, Tri; Irmadhani, Fania
Meditory : The Journal of Medical Laboratory Vol 11, No 2 (2023): Meditory Volume 11 No. 2 Tahun 2023
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v11i2.3093

Abstract

Background:Synthetic media for microbial growth are expensive, thus opening the way for making bacterial growth media using local raw materials at low prices. Jicama is one of the local raw materials that can be used as natural media for the growth of microorganisms. It contains a source of carbohydrates needed for the development of microorganisms. Aims: This study aims to determine the effect of variations in the concentration of Jicama, which has the potential to grow Staphylococcus aureus bacteria. Methods: This study used experimental research with the Static Group Comparison method. In this study, the experimental group Staphylococcus aureus was instilled in Jicama solid media with various concentrations (2%, 3%, 4%, 5%, 6%) with five repetitions. The results: The results showed that the average number of Staphylococcus aureus bacteria colonies in jicama flour with a concentration of 2% was 0, a concentration of 3% was 0, a concentration of 4% was 0.8, a concentration of 5% was 1.4, and at a concentration of 6% was 2.2. The results of the Kruskal-Wallis test with a degree of confidence of 0.05 obtained a p-value = 0.000 where the p-value 0.05 so that it can be concluded that there is a significant effect of variations in the concentration of jicama flour on the growth of Staphylococcus aureus bacteria. Conclusions:For future researchers, it is necessary to conduct further research using higher concentrations of jicama flour and by adding other nutrients, such as animal protein, so that the growth of Staphylococcus aureus bacteria is more optimal.
STINGLESS BEE-DERIVED NATURAL COMPOUNDS AS ANTI-INFECTIVE AGENTS: COMPARATIVE GC-MS PROFILING OF Itama sp. AND Tetragonula laeviceps Sintya, Erly
Meditory : The Journal of Medical Laboratory Vol 13, No 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i1.3977

Abstract

Background: Stingless bee honey is recognized for its therapeutic value, which is attributed to a diverse array of bioactive compounds.Objective:  This study aimed to compare the chemical profiles of honey from Tetragonula laeviceps and Itama sp. using gas chromatography-mass spectrometry (GC-MS), focusing on antimicrobial constituents. Methods: Honey samples were collected from Bali, Indonesia, and analyzed using GC-MS. Compounds were identified through spectral matching with established libraries, and primary constituents were compared based on relative abundance.Results:  T. laeviceps honey showed a high concentration of the rare sugar allose (7.6%), azulene (1.02%), and octadecanoic acid (2.07%), whereas Itama honey exhibited elevated levels of levoglucosan (5.35%), aromatic esters, and 3-methyl-2-furylacetone (2.58%). Notably, 5-hydroxymethylfurfural (HMF), known for its antimicrobial properties, was present in both samples at comparable levels (1–2%).Conclusions: The metabolite variations between the two species reflect differences in foraging and resin collection behavior, influencing honey bioactivity. The unique profiles suggest that both types of honey possess valuable antimicrobial potential and could serve as sources for developing novel anti-infective agents.
ANALYSIS OF PEMANGKU AND PENGAYAH BLOOD GLUCOSE LEVELS AT BESAKIH TEMPLE Dwijastuti, Ni Made Sri; Septiasari, Ni Putu Senshi; Dewi, I Gusti Agung Ayu Satwikha; Widiantari, Ni Putu; Putri, Ni Putu Puniari Eka
Meditory : The Journal of Medical Laboratory Vol 12, No 2 (2024): Meditory, Volume 12 No. 2 Tahun 2024
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v12i2.3568

Abstract

Background: Every year on Sasih Kedasa, Besakih Temple holds a series of ceremonies called Ida Bhatara Turun Kabeh. The ceremony is held annually for approximately one and a half months. The workload of Pemangku and Pengayah during the ceremony, with a long duration and repetitiveness, is considered to cause physical fatigue, which leads to increased stress and an increased tendency to eat poorly. Pemangku and Pengayah are also vulnerable to sunburn, coffee, sleep loss, and dehydration while on duty. These factors trigger diabetes and spikes in blood glucose levels (BGL). Aims: To analyze the BGL of Pemangku and Pengayah in Besakih temple. Methods: It is observational research with a cross-sectional approach. Data collection was carried out by Point of Care Testing (POCT), supported by interviews with 66 respondents to determine individual conditions. The results: One of the adult female respondents shows low BGL (48 mg/dl). High BGL (335,2 mg/dl on average) was obtained from five respondents: adult women, older women, and three elderly men. The rest of the respondents show normal BGL, which is 125,6 mg/dl on average. Conclusions: As many as 1,5% had low, 7,6% had high, and 90,9 % had normal BGL of 66 Pemangku and Pengayah at Besakih Temple.
Metabolism of Xenobiotic Compounds Increases Free Radical Production and Reduces Endogenous Antioxidant Mechanisms Saputra, I Putu Bayu Agus
Meditory : The Journal of Medical Laboratory Vol 11, No 2 (2023): Meditory Volume 11 No. 2 Tahun 2023
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v11i2.3069

Abstract

Xenobiotic compounds are foreign substances that enter the body. These substances include drugs, insecticides, toluene, chloroform, formalin, and others that can enter by inhalation, through skin exposure or swallowed together with food. The use of xenobiotic compounds is increasing every year along with the development of the industrial sector, which impacts greater exposure for workers. Xenobiotic compounds that enter the body will cause harm to the body, and they will be detoxified in the liver. Xenobiotic compounds can bind to cytochrome p450 isoform 2E1, which will cause the formation of free radicals. A body exposed to xenobiotic compounds can respond by reducing free radicals using endogenous antioxidants. They are Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPX). If the amount of free radicals exposure is too large, oxidative stress will occur. It triggers liver cell damage and release of alanine aminotransferase (ALT) and Aspartate Aminotransferase (AST) into the blood vessels, which causes an increase in these enzymes in the blood.
THE EFFECT OF VITAMIN A TREATMENT ON RENAL GLOMERULAR AREA OF RATS MODEL DIABETES MELLITUS TYPE 2 Pratiwi, Made Dinda; Adi, Prasetyo; Anita, Kenty Wantri
Meditory : The Journal of Medical Laboratory Vol 13, No 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i1.3955

Abstract

Background:  Diabetes mellitus (DM) type 2 is a metabolic disorder due to defects in insulin secretion. A microangiopathy complication of DM in the kidney can lead to renal enlargement. This augmentation in renal size can be attributed to several factors, including glomerular hypertrophy, tubular hypertrophy, and interstitial expansion. Retinoic acid, a vitamin A derivative, serves numerous cellular roles, including the induction of cell differentiation, the regulation of apoptosis, and exhibiting anti-inflammatory and antifibrotic properties.Objective: This study aims to evaluate the effect of vitamin A administration on the renal glomerular area in a rat model of type 2 diabetes mellitus. Methods: This study was experimental with five groups, including a negative control group, a positive diabetes mellitus group, and three groups of vitamin A treatment. The primary variable assessed was the glomerulus area across the different groups.Results: No significant decrease in glomerular area was observed in the vitamin A treatment group within the positive diabetes (ANOVA, p = 0.052).Conclusions: The findings of this study suggest that the administration of vitamin A does not significantly affect the reduction of renal glomerular area in rats with diabetes mellitus.
THE ETHANOL EXTRACT OF JUKUT PENDUL (KYLLINGA NEMORALIS) EXHIBITS INHIBITORY ACTIVITY AGAINST THE GROWTH OF STAPHYLOCOCCUS AUREUS Niluwih, Komang Deatriasa Pakerti; Swastini, I Gusti Agung Ayu Putu; Habibah, Nur; Suyasa, Ida Bagus Oka
Meditory : The Journal of Medical Laboratory Vol 11, No 2 (2023): Meditory Volume 11 No. 2 Tahun 2023
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v11i2.3060

Abstract

Staphylococcus aureus is a pathogenic bacteria that is often found to have resistance to antibiotics. Jukut pendul (Kyllinga nemoralis) extract is known to have antibacterial compounds such as flavonoids, tannins, saponins, and steroids. The purpose of this study was to determine the inhibitory ability of jukut pendul ethanol extract against Staphylococcus aureus bacteria. This research used the Kirby-Bauer disc diffusion method with five treatments within five repetitions. Data analysis was carried out using One Way Anova variance analysis. The variation in extract concentration tested was 5, 10, 20, and 40% with 96% ethanol as the control group and Ciprofloxacin as the work control. The results showed that extract concentrations of 5, 10, 20, and 40% were able to inhibit Staphylococcus aureus bacteria with an average inhibitory zone of 9,36; 10,85; 11,64; and 12.15 mm, respectively. The inhibitory zone formed indicates that jukut pendul ethanol extract has moderate to strong inhibitory ability in inhibiting the growth of Staphylococcus aureus bacteria.
THE EFFECT OF STORAGE TIME AND TYPE OF ANTIKOAGULANT IN PLATELET RICH PLASMA (PRP) ON PLATELET COUNTS Lestari, Felia; Noviar, Ganjar; Nurhayati, Betty; Hayati, Eem
Meditory : The Journal of Medical Laboratory Vol 12, No 2 (2024): Meditory, Volume 12 No. 2 Tahun 2024
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v12i2.3397

Abstract

Background: Platelet Rich Plasma is a biological product in the form of autologous plasma produced from the centrifugation process of blood specimens and has a platelet concentration above normal values. Things that can affect the results of PRP are blood collection, centrifugation speed, centrifugation time and temperature and the use of anticoagulants. Aims: The purpose of this study was to determine the average and see the effect of sodium citrate anticoagulant and ACD-A anticoagulant by using a shelf life of 0 hours, 4 hours and 8 hours in PRP on platelet count. Methods: This type of research is a pseudo-experiment with a Statistica Group Comparison research design. The number of samples in this study were 6 people. PRP research data on platelet count was processed statistically with the General Linear Model (GLM) method. The Results: The average data of PRP on platelet count using sodium citrate anticoagulant with a shelf life of 0 hours 533.333 cell/µL; 4 hours 527.167 cell/µL; 8 hours 190.167 cell/µL. Average data of PRP on platelet count using ACD-A anticoagulant with a shelf life of 0 hours 986.333 cell/µL; 4 hours 976.500 cell/µL; 8 hours 634.833 cell/µL. The data results for 0 hour and 4 hour shelf life on anticoagulants Sodium Citrate and ACD-A have a Sig value of 0.646 0.05 while 8 hour shelf life has a Sig value of 0.000 0.05. Conclusion: No effect of 0 hour and 4 hour shelf life while there is an effect of 8 hour shelf life and there is an effect of anticoagulants Sodium Citrate and ACD-A in PRP on platelet count.
ALTERNATIVE MEDIA FOR BACTERIAL GROWTH STAPHYLOCOCCUS AUREUS: SWEET POTATO INFUSA (IPOMOEA BATATAS), SOYBEANS (GLYCINE MAX (L) MERRILL) AND YEAST EXTRACT Martsiningsih, Marta Atik; Astuti, Fardhiasih Dwi; Sistiyono, Sistiyono; Suyana, Suyana; Rahmawati, Ullya; Rahayu, Muji; Musyafaah, Novita Siti
Meditory : The Journal of Medical Laboratory Vol 12, No 1 (2024): Meditory, Volume 12 No. 1 Tahun 2024
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v12i1.3081

Abstract

Background: Staphylococcus aureus needs nourishment for its growth. The needed nutrients of carbohydrates, proteins, nitrogen, vitamins, and minerals from the media. The media commonly used for bacterial growth is the nutrient medium for high prices. Alternative media from natural local foodstuffs are obtained easily and cheaply instead of instant media. This study aims to identify alternative media mixed with infuse sweet potato (ipomoea batatas), soybeans (glycine Max (l) Merrill), and yeast extract that can be used to grow the staphylococcus aureus bacteria.  Methode: this type of research is pure experimental research, and the design used is the posttest-only control design group. Staphylococcus aureus suspension was grown on alternative media and nutrient agar media as a comparison. measurements of colony diameter and number of colonies were compared between alternative media and nutrient agar. Result The results Research has provided an average number of staphylococcus aureus bacteria that grow on alternative media 78.00 x 104 CFU /ml and nutrient media for 94.19 x 104 CFU /ml. Whereas the colony's diameter of alternative media 2.56 mm, and the media nutrient increased by 2.66 mm. Conclusion: Alternative media from a blend of yam, soy infuse, and yeast extract can be used for the growth of the staphylococcus aureus bacteriaKeywords: Staphylococcus aureus; Alternative Media; Potato Infusa; soy infuse; soy infuse

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