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dr. Mitayani, M.Si. Med
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Fakultas Kedokteran Universitas Muhammadiyah Palembang Gedung F lantai 1 Jl. K.H. Balqhi, 13 Ulu, Seberang Ulu I, Palembang
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Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Palembang
ISSN : 2087233X     EISSN : 25806971     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Syifa MEDIKA published by Faculty of Medicine, University of Muhammadiyah Palembang is a peer-reviewed journal that published two times a year: September and March. Syifa MEDIKA is a national peer-reviewed and open access journal. We accept original article, case report, and literature review from all area of medicine, biomedicine, and publich health fields. Focus and Scope: All area of medicine, biomedicine, and publich health fields. Anatomy, Biomedicine, Pharmacology, Microbiology, Nutrition, Biochemistry, Physiology, Tropical Medicine, Public Health, Pediatric, Internal Medicine, Obstetry and Gynaecology, Dermatovenereology, Surgery, Neurology, Family Medicine, Medical Education.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 230 Documents
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Uji Efektivitas Ekstrak Kurma Ajwa, Povidone Iodine 10%, dan Bioplacenton pada Luka Bakar Mencit Putri A.R., Shafira Nur Afifa; Dwimartyono, Fendy; Lantara, Andi Millaty Halifah Dirgahayu; Syahril, Erlin; Khalid, Nur Fadhillah
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.9972

Abstract

Burns are tissue damage caused by contact with heat sources and require proper medical treatment. Povidone iodine 10% is often used, however, it can cause irritation and slow healing. This study aimed to evaluate the effectiveness of Ajwa Date Extract (Phoenix dactylifera), Povidone iodine 10%, and Bioplacenton in healing burns in mice (Mus musculus). The research method used a post-test controlled group design  with four treatment groups: control (NaCl 0.9%), Ajwa Date Extract, Povidone iodine 10%, and Bioplacenton. The number of samples used was 24 mice in each of 4 groups, so that 6 mice were obtained in each group. The statistical tests used were the Normality Test and  the Saphiro-Wilk Test  The parameters observed included the duration of healing, infection, and allergic reactions. The results showed that Ajwa Date and Bioplacenton extracts  accelerated wound healing by an average of 11.5 days, faster than Povidone iodine 10% (12 days) and control (13.6 days). All groups showed the same total healing score (8), with no infections or allergic reactions. The Kruskal-Wallis statistical test  showed a significant difference in the duration of healing (p = 0.003). In conclusion, Ajwa Date Extract and Bioplacenton are  effective in accelerating the healing of burns and can be a safe and effective treatment alternative.
PENINGKATAN INDEKS MASSA TUBUH PADA REMAJA BERKORELASI DENGAN PENINGKATAN TEKANAN SISTOLIK DAN TEKANAN NADI mayasari, Ni made elva; Oktariza, Rury Tiara; Abelfa, Nanda Kristania
Syifa'Medika Vol 13, No 2 (2023): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v13i2.10024

Abstract

Pemasalahan gizi yang sering dijumpai pada remaja adalah obesitas. Kejadian obesitas sering dikaitan dengan kejadian hipertensi. Penelitian observasional analitik dengan desain potong lintang dilakukan untuk meihat hubungan variabel independen berupa tekanan darah sistolik dan diastolik, frekuensi denyut nadi serta tekanan nadi dengan variabel dependen berupa Indeks Massa Tubuh (IMT). Analisis bivariat menggunakan One Way ANOVA dan analisis korelasi spearman. Sebanyak 92 responden dengan rata-rata usia 19 tahun terlibat dalam penelitian ini dan sebagian besar memiliki kategori IMT overweight dan obesitas. Rata-rata tekanan sistolik dan tekanan nadi didapatkan lebih tinggi pada kelompok overweight dan obesitas dibandingkan pada kelompok kelompok underweight dan normal. Peningkatan tekanan sistolik dan diastolik serta tekanan nadi juga mempunyai korelasi yang signifikan dengan peningkatan IMT.
Hubungan Kepatuhan Mengkonsumsi Obat Antidiabetik Oral dengan Kendali Gula Darah pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Mamajang Wibowo, Suchika Aisyah; Nurmadilla, Nesyana; Dahliah, Dahliah; Iskandar, Darariani; Hamzah, Pratiwi Natsir
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.9626

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease that requires good management, including blood sugar control through adherence to oral antidiabetic drugs. This study aimed to analyze the relationship between medication adherence and blood sugar control in T2DM patients at Mamajang Community Health Center, February 2025. The method used was observational analytics with a cross-sectional approach. The research subjects were 57 T2DM patients who met the inclusion and exclusion criteria. Data were analyzed using univariate and bivariate analysis to test the relationship between medication adherence and blood sugar control. The results showed that adherence to treatment was significantly associated with HbA1c values (p = 0.042), but there was no significant relationship with fasting blood glucose levels (p = 0.360). This study concluded that although medication adherence affects HbA1c control, other factors such as diet, physical activity, and stress also play a role in blood sugar control. A more holistic approach to type 2 diabetes mellitus management is needed to improve optimal blood sugar management.
Analisis Rasio Neutrofil Limfosit pada Pasien Carcinoma Mammae dengan Risiko Kejadian Efusi Pleura Lolongan, Gerald Randy; Tangkilisan, Adrian; Sukanto, Wega; Langi, Fima Lanra Fredrik G.
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.9839

Abstract

Breast cancer is one of the most common cancers, with complications such as pleural effusion potentially worsening patient prognosis. This study aims to analyze the relationship between the neutrophil-lymphocyte ratio (NLR) and pleural effusion occurrence in breast cancer patients at RSUP Prof Dr. R.D. Kandou Manado. The study used a cross-sectional retrospective design, involving 196 breast cancer patients divided into two groups: those with and without pleural effusion. The results showed that while there is a tendency for higher NLR in patients with pleural effusion, other factors like cancer stage and supraclavicular lymph node enlargement play a more dominant role in predicting pleural effusion. NLR was not found to be a strong biomarker for independently predicting pleural effusion. This study provides insights into the potential of NLR for predicting complications in breast cancer patients, but further research is needed to identify more sensitive biomarkers for pleural effusion prediction.
Hubungan Faktor Risiko dengan Keberhasilan Asi Eksklusif dalam Pendekatan Biopsikososial badri, Putri rizki; Kesuma, Putri Zalika Laila Mardiah; Alfarizi, Ahmad Bayu; Asmalia, Resy; Urfi, Aiverda
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.9994

Abstract

Exclusive breastfeeding is breast milk (EBF) given to babies from 0-6 months of age without any additional food, including water. The goal is for babies to achieve optimal growth, development and health because breast milk contains complete nutrition for babies. Several factors that can influence breastfeeding are biological, psychological and social factors for breastfeeding mothers. This study aimed to determine the relationship between the biopsychosocial model and exclusive breastfeeding in Posyandu, Kelurahan 16 Ulu. This type of research was descriptive analytic with a cross sectional design, used primary data with a sample size of 64 people taken by purposive sampling. The results obtained were obtained from three factors, namely biopsychosocial, only educational variables from social factors related to exclusive breastfeeding. The statistical test results obtained a p value > 0.05 for all variables except education. So it can be concluded that there is a relationship between education and exclusive breastfeeding at Posyandu, Kelurahan 16 Ulu.
Efek Inhibisi Senyawa Aktif Spoge Haliclona sp. terhadap Pertumbuhan Plasmodium falciparum Berdasarkan Studi In Slico Wulandari, Ni Made Diah; Utami, Prawesty Diah; Sukmana, Judya
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.9077

Abstract

Malaria is still a problem in many places, caused by a parasite Plasmodium falciparum spreaded by mosquitoes. Haliclona sp. is a sea sponge that contains active compounds, some of which are Manzamine and Haliclonacyclamine A, and have antimalarial activity. This study aimed to find the potential effects of different active compounds on the sponge Haliclona sp. on the growth of Plasmodium falciparum based on in silico. This was an experimental study using in silico method. The materials were prepared and taken from the PubChem web, predicted the potential of compounds, predicted pathways using Discovery Studio version 21.1.1, molecular docking using Molegro virtual Docker 5.0, predicted ADME using SWISS ADME, and predicted toxicity via Protox web. The results showed that Haliclona sp. contained several active compounds, namely Manzamine and Haliclonacyclamine A. The study of the active compounds in Haliclona sp. showed that there was a link between the Plasmodium falciparum enzymes. The PfTK and PfDHODH enzymes are responsible for breaking down malaria parasites. In the ADME prediction analysis of the active compounds contained in Haliclona sp., Haliclonacyclamine A can meet Lipinski's criteria. The last test performed was a toxicity test where it was found that Haliclonacyclamine.
Hubungan Kejadian Melasma terhadap Paparan Sinar Ultraviolet (UV) pada Pekerja Luar Ruangan di Pasar Induk Minasa Maupa Fadhilah, Andi Sausan; Vitayani, Sri; Namirah, Hanna Aulia; Yuniati, Lisa; Rasfayanah, Rasfayanah
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.9727

Abstract

Melasma is a common hyperpigmentation disorder that typically appears on sun-exposed areas of the face and is often associated with Ultraviolet (UV) exposure and hormonal factors. This study aimed to examine the relationship between UV exposure and melasma incidence among outdoor workers at Minasa Maupa Central Market, considering hormonal contraceptive use as a confounding factor. A cross-sectional design was used, involving 32 female respondents selected through purposive sampling. Data were collected via observation and validated questionnaires, then analyzed using univariate and bivariate Chi-Square tests. Results indicated a significant relationship between prolonged UV exposure (?4 hours) and melasma occurrence (p=0.022), as well as between hormonal contraceptive use and melasma (p=0.028). However, no significant interaction was found between UV exposure duration and contraceptive use (p=0.849). These findings highlight that UV exposure and hormonal contraceptive use independently contribute to melasma risk. Skin protection education and medical monitoring for contraceptive users are recommended preventive strategies. Future research using longitudinal design and direct UV intensity measurement is suggested to enhance understanding and accuracy.
Zebrafish Sebagai Model Hewan Coba Untuk Riset Diabetes Lim, Anthony Camilo; Rochmanti, Maftuchah; Khotimah, Husnul
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.10394

Abstract

Diabetes mellitus (DM) is a major global health problem, affecting over 500 million people worldwide. Understanding its pathophysiology and complications requires suitable animal models. Zebrafish (Danio rerio) has emerged as a promising model for diabetes research. This review aims to synthesize current research on the use of zebrafish as an experimental model for DM and its microvascular complications, focusing on induction methods, research applications, and observed outcomes. A literature review was conducted to investigate those variables. Zebrafish hyperglycemia can be induced through glucose immersion, overfeeding, chemical agents, and genetic modification. These models have been successfully used to study drug testing, molecular profiling, and diabetic complications. Observed variables included glucose levels, enzyme activity, gene expression, histopathological changes, and behavioral responses. Results demonstrated strong parallels with human diabetic pathology, including vascular alterations, proteinuria, renal apoptosis, and neuropathic dysfunction. Zebrafish provides a strong, cost-effective, and relevant model for diabetes research. Despite limitations such as physiological differences and methodological variability, they offer valuable insights into metabolic dysregulation and complications, while serving as an efficient platform for drug discovery.
Compliance with Antihypertension Medication In the Community Of Rambutan District South Sumatera Fitriani, Nyayu; Mayasari, Ni Made Elva; Rosita, Yanti; Indriyani, Indriyani; Handayani, Susi; Erlyn, Putri
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.7973

Abstract

Adherence to treatment is very important for hypertensive patients to control and prevent complications. This study aims to describe the level of adherence to antihypertensive drugs in hypertensive patients in Sungai Pinang Village, Rambutan District, Banyuasin Regency, South Sumatra, Indonesia. This research is a quantitative research with a descriptive type of research with a cross sectional research design. The sample size was 80 respondents with inclusion criteria aged ?40 years, using antihypertensive medication for at least two months before the study. Data was obtained using interviews using the Indonesian version of the Medication Adherence Report Scale Questionnaire and has been validated. The research results showed that 80 patients with hypertension had a prevalence of adherence to treatment of 8.75%. Most of the patients who adhere to treatment are aged 70-72 years, female, not working, college education level, long suffering from hypertension ?5 years, comorbidities with heart disease, no health insurance, no family support, number of medications ?1 type antihypertensive drugs. In conclusion, the level of compliance with taking antihypertensive medication in the Rambutan District Community of South Sumatra is not good. 
KORELASI KONTROL GULA DARAH SEWAKTU DENGAN FUNGSI KOGNITIF PADA PASIEN LANSIA DENGAN DIABETES MELITUS TIPE 2 DI RUMAH SAKIT MUHAMMADIYAH PALEMBANG khairani, lilis; Permana, Adhi; Fadillah, Yudi
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.10412

Abstract

Type 2 diabetes mellitus (DM) is a chronic disease that commonly affects the elderly. Hyperglycemia can accelerate cerebral vascular damage and increase the risk of cognitive impairment. Random blood glucose (RBG) testing is frequently used to monitor glycemic control in daily clinical practice. The purpose of this study was to determine the correlation between random blood glucose levels and cognitive function in elderly patients with type 2 DM. This was an observational analytical study with a cross-sectional design. Subjects were elderly patients with type 2 DM. Random blood glucose levels were measured using an enzymatic method, while cognitive function was measured using the Mini-Cog questionnaire. Statistical analysis used the spearman/pearson corerelation test. Results: The majority of patients with BG levels ?200 mg/dL had lower cognitive impairment scores than those with BG levels <200 mg/dL. There was a significant positive correlation between random blood glucose levels and cognitive scores (r=0.445;p<0.001). So it can be concluded that high random blood sugar levels are associated with decreased cognitive function in elderly people with type 2 diabetes. GDS examintaion can be an early indicator for detecting the risk of cognitive impairment in elderly type 2 diabetes patients.

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