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Herb-Medicine Journal
Published by Universitas Muhammadiyah Purwokerto
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Herb-Medicine Journal (HMJ) merupakan Terbitan Berkala Ilmiah Herbal, Kedokteran, dan Kesehatan diterbitkan oleh Fakultas Kedokteran Universitas Muhammadiyah Purwokerto dengan frekuensi terbit 2 (dua) kali dalam setahun yaitu di bulan April dan Oktober. Jurnal ini merupakan media komunikasi ilmiah bagi siapapun yang tertarik menekuni bidang herbal baik dalam proses pendidikan, penelitian, maupun pengabdian kepada masyarakat yang dihubungkan dengan bidang kedokteran maupun kesehatan secara luas. Secara terbuka, redaksi menerima kontribusi artikel ilmiah tentang herbal, kedokteran, dan kesehatan dari pihak manapun yang ingin berpartisipasi dalam perkembangan dunia herbal, kedokteran, dan kesehatan.
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Articles 105 Documents
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Hubungan Antara Status Gizi Dan Kebiasaan Berolahraga Dengan Nilai Volume Oksigen Maksimal (VO2 Max) Pada Siswa Laki - Laki SMP Negeri Di Temanggung Selama Pandemi Covid-19 Irvan Dwi Cahyono; Tri Agustina; Sri Wahyu Basuki; Budi Hernawan
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 4 (2021): Herb-Medicine Journal Oktober 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i4.10218

Abstract

The negative impacts of the Covid-19 pandemic include anxiety, stress, reduced appetite, boredom, and physical fitnessproblems. These conditions certainly affect the nutritional status and also the cardiorespiratory fitness of a person. InIndonesia, at least 15 out of 1000 people, or around 2,784,064 individuals suffer from heart disease. In Central JavaProvince, 0.61% of them are children aged 5-14 years old (Riskesdas, 2018). The VO2 Max value is a method formeasuring cardio respiration that can be used to determine which children are at risk of suffering from cardiovasculardisease. The VO2 Max value is influenced by several factors, including nutritional status and exercise habits. Thisstudy aimed to find out the correlation between nutritional status and exercise habits and the value of maximum oxygenvolume (VO2 Max) in male students at SMP Negeri in Temanggung during the Covid-19 pandemic. This was adescriptive-analytic study with across-sectional design. The sampling was done using the purposive sampling methodon 57 samples at SMP Negeri 1 Kaloran. It used Chi-square test for nutritional status variable with p value = 0.000 andexercise habits with p value = 0.001. The logistic regression test was used for each p-value with the nutritional statusOR value of 6.640 and the exercise habit OR value of 4.807 and with R Square value of 0.38 or 38%. There was acorrelation between nutritional status and exercise habits and the value of maximum oxygen volume (VO2 Max) inmale students at SMP Negeri in Temanggung during the Covid-19 pandemic.
Formulasi dan Uji Stabilitas Sediaan Suspensi Ekstrak Rimpang Zingiber zerumbet Shafa Shavira; Angel Dineta Margaretta; Aprilia Dwi Sandra; Raya Uli Sitorus; Fatmaria Fatmaria
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 4 (2021): Herb-Medicine Journal Oktober 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i4.11628

Abstract

Zingiber zerumbet (L) Smith rhizome has been used traditionally as an herbal medicine in Indonesia. Isolated extracts and metabolites of Z. zerumbet have shown anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial, analgesic and antiviral activity. The form of suspension is carried out to facilitate the utilization of the main bioactive content, zerumbone, which is difficult to dissolve in water. The formulation of suspension is based on variations in the concentration of Z. zerumbet extract, which is 2.5% (formulation 1), 5% (formulation 2), and 10% (formulation 3). To determine the physical stability, the evaluation is carried out, namely: organoleptic test, density, viscosity, redispersibility and pH. The results showed all three formulations did not provide organoleptic changes for 30 days, >1 g/cm3 density, good redispersibility, and pH of 6. The viscosity of each formulation is quite varied i.e., 3.74 cp; 4,27 cp; and 11.8 cp. Formulation 3 is determined as the best formulation based on its viscosity which is closest to the standard range of good suspension viscosity according to the SNI.
Perbandingan Uji Aktivitas Antibakteri Filtrat Aquadest Umbi Bawang Suna (Allium schoenoprasum L.) Terhadap Pertumbuhan Streptococcus pneumoniae Dan Escherichia coli Dengan Metode Difusi Cakram Kirby-Bauer Bella Chrysthya Utamy; Ni Nyoman Sri Yuliani; Dewi Klarita Furtuna
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 4 (2021): Herb-Medicine Journal Oktober 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i4.8812

Abstract

Infectious diseases are one of the most frequent diseases of major health problems, caused by bacteria are still beinga health problem in developing countries as well as in developed countries. One of the mostly occurred respiratorytract infection is pneumonia, this caused by Gram-positive bacteria Streptococcus pneumoniae. Gastrointestinaldiseases that are often caused by gram-negative bacterial infections Escherichia coli. Local plant which can be foundin Central Kalimantan are Suna onion (Allium schoenoprasum L.). Suna onion (Allium schoenoprasum L.).Researchpurposes. Research was conducted to determine the influence of the Suna’s bulb (Allium schoenoprasum L.) filtratedby aquadest with a simple filtration technique on the growth of Streptococcus pneumoniae and Escherichia usingKirby-Bauer Disk Diffusion method. Method. This type of research is true experimental design research. The designused in this study was post test-only control group design. This research uses 7 treatment groups, with concentrationsof 100%, 75%, 50%, 25%, 12.5%. Aquadest as a negative control, Erytromycin and Cifrofloxacin as positivecontrols. The method used for testing the antibacterial activity are Kirby-BaueDisk Diffusionmethod.The resultsfound that the aquadest tuber extract of onion cannot inhibit the growth of Streptococcus pneumoniae andEscherichia coli. Conclusion. Aquadest filtrate of onion tubers (Allium schoenprasum L.) cannot inhibit the growthof Streptococcus pneumoniae and Escherichia coli
The Effect Of Family Support And Education On The Level Of Anxiety Of Pulmonary TB Patients In Community Lung Health Center (BKPM) Purwokerto Alifia Putri Karomah Budijarto; Mustika Ratnaningsih Purbowati; Refni Riyanto; Dyah Retnani Basuki
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 4 (2021): Herb-Medicine Journal Oktober 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i4.9579

Abstract

Pulmonary tuberculosis is a disease with a long duration of treatment and involves wide types of drugs which couldcause various adverse andharmful effects, then further could cause the risk of emotional changes such as anxiety. Therole of family support and education in reducing mortality, the escalating incidence rate of pulmonary TB in CentralJava Province, the unachieved target of successful TB treatment and also high rates of anxiety in TB patient, affirmthe necessity to conduct this research.To determine the effect of family support and education on the anxiety levelsamong pulmonary TB patients in BKPMPurwokerto.The type of this research is a quantitative study using a cross-sectional design. This research was conducted at the Purwokerto Community Lung Health Center with Spearman testas the hypothesis test used in the research.The analysis result shows the influence of family support on anxiety levelsobtained a p value <0.05 meanwhile  the influence of education on anxiety levels acquired a p value> 0.05.Familysupport could affect significantly while education could not significantly affect the anxiety levels in pulmonary TBpatients at BKPM Purwokerto
Identifikasi Telur Soil Transmitted Helminths Pada Caisim (Brassica chinensis) di Pasar Patikraja Kabupaten Banyumas Nurul Qomariyah; Dita Pratiwi Kusuma Wardani; Retno Sulistiyowati
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 4 (2021): Herb-Medicine Journal Oktober 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i4.10448

Abstract

Caisim (Brassica chinensis) is one of the vegetables that has many benefits such as protein, carbohydrates, fat and plays an important role in meeting food needs, and is good for health. Caisim is well adapted to high temperatures and the price is relatively stable and easy to cultivate. The purpose of this study was to determine the presence of Soil-Transmitted Helminths eggs in caisim (B. chinensis). The research was conducted in a descriptive observational. The research was conducted in July-August 2020 at Parasitology and Microbiology Laboratory, Faculty of Medicine, Universitas Muhammadiyah Purwokerto. Identification of Soil-Transmitted Helminths eggs from 20 caisim as the samples used NaCl flotation method and were analyzed by using a univariate test with tabulated frequency distribution. The results showed that no Soil-Transmitted Helminths eggs were found in caisim (B. chinensis).   Caisim (Brassica chinensis) merupakan sayuran yang mempunyai banyak kandungan manfaat seperti protein,karbohidrat, lemak dan berperan penting untuk memenuhi kebutuhan pangan serta baik untuk kesehatan. Caisimmampu beradaptasi dengan baik terhadap suhu tinggi serta harga relatif stabil dan mudah diusahakan. Tujuanpenelitian ini untuk mengetahui adanya telur Soil Transmitted Helminths terdapat pada caisim (B. chinensis).Penelitian dilakukan secara observasional deskriptif. Penelitian dilakukan pada bulan Juli-Agustus 2020 diLaboratorium Parasitologi Fakultas Kedokteran Universitas Muhammadiyah Purwokwerto. Identifikasi telur SoilTransmitted Helminthsdari 20 sampel caisim dengan metode Flotasi NaCl. dianalisis dengan uji univariat dengandistribusi tabulasi frekuensi. Hasil penelitian menunjukan tidak ditemukan telur Soil Transmitted Helminths padacaisim (B. chinensis)
Pengaruh Pemberian Suplemen Vitamin B12 Sebagai Neuroregenerasi Pada Pasien Tinnitus: Literature Review Mohammad Ihza Satriatama; Sulistyani Sulistyani; Nining Lestari; Yan Wirayudha
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 5, No 1 (2022): Herb-Medicine Journal Januari 2022
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v5i2.12994

Abstract

Background: Tinnitus is one of the most common complaints in family medicine practice, with the incidence of tinnitus being highly variable and dominated by subjective tinnitus rather than objective tinnitus, about 30-40% of the adult population has experienced tinnitus in their lifetime, and 0.5-2.5% of the population has impaired quality of life. Because the research conducted is still controversial, this study is a study to look specifically at the effect of giving vitamin B12 on the treatment of tinnitus and so it is important to do further research to prove the administration of vitamin B12 supplements as neuroregeneration in tinnitus patients. In the discussion later, the researcher divides the research subjects into two parts, namely humans and animals. Human subjects to see the effect of vitamin B12 in the healing process of tinnitus and animal subjects to see the effect of vitamin B12 in neuroregeneration. This is expected to provide a reference in the treatment of tinnitus in Indonesia. Objective: :To see specifically the effect of giving vitamin B12 in the neuroregeneration process in tinnitus patients. Methods: This research method is a literature review study. Data collection techniques through Pubmed and Science direct have been limited for the last 10 years. The article review was carried out on 292 scientific articles and obtained 7 articles that met the restriction criteria and the PICO. Results: The results of a review of 7 articles found that Vitamin B12 can regenerate the myelin sheath (3 articles) and Vitamin B12 can reduce noise or improve tinnitus (4 articles). Conclusion: There is potential of Vitamin B12 on the healing process through neuroregeneration of cells in tinnitus patients. Vitamin B12 has the potential to prevent disease or reduce severity in tinnitus patients.  Latar Belakang: Tinnitus merupakan salah satu keluhan yang banyak ditemukan dalam  praktik kedokteran keluarga dengan angka kejadian tinnitus sangat bervariasi dan didominasi oleh tinnitus subjektif daripada tinnitus objektif, sekitar 30-40% pada populasi dewasa dan sebesar 0,5-2,5% terganggu kualitas hidupnya. Penelitian tentang pengaruh dari pemberian vitamin B12 terhadap pengobatan tinnitus masih cukup beragam hasilnya, sehingga penting dilakukan penelitian lebih lanjut untuk membuktikan pemberian suplemen vitamin B12 sebagai neuroregenerasi pada pasien tinnitus. Pembahasan dalam penelitian ini peneliti perlu membedakan subjek penelitian menjadi dua bagian yaitu pada manusia dan hewan. Subjek manusia untuk melihat efek vitamin B12 dalam proses penyembuhan tinnitus dan subjek hewan untuk melihat efek vitamin B12 dalam neuroregenerasi. Hal ini diharapkan dapat memberikan referensi dalam pengobatan tinnitus di Indonesia. Tujuan: untuk mengetahui pengaruh pemberian vitamin B12 dalam proses neuroregenerasi pada pasien tinnitus. Metode penelitian ini adalah studi literatur review. Teknik pengambilan data melalui Pubmed dan Science direct limitasi 10 tahun terakhir. Telaah artikel dilakukan pada 292 artikel ilmiah dan didapatkan 7 artikel yangsesuai kriteria restriksi dan PICO. Hasil telaah didapatkan 7 artikel dengan hasil bahwa Vitamin B12 dapat meregenerasi selubung myelin (3 artikel) dan Vitamin B12 dapat menurunkan kebisingan atau mangalami perbaikan tinnitusnya (4 artikel). Kesimpulan: Terdapat pengaruh Vitamin B12 terhadap proses penyembuhan melalui neuroregenerasi sel pada pasien tinnitus. Literatur juga menyebutkan bahwa Vitamin B12 berpotensi mencegah penyakit atau menurunkankeparahan pada pasien tinnitus.
Status Sel Inflamasi dan Stadium Kanker Nasofaring di RS PKU Muhammadiyah Gombong Oke Kadarullah; M. Nurrizki Haitamy; Andi Muh. Maulana
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 5, No 1 (2022): Herb-Medicine Journal Januari 2022
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v5i2.11156

Abstract

Background: Nasopharyngeal cancer (NPC) is still a global health problem as well as in Indonesia. Patients come with an advanced stage which has a high impact on patient morbidity and mortality. The patient's prognosis is highly dependent on the supporting modalities to determine the stage. Supporting examinations with guiding standards are still limited, especially for hospitals in non-educational centers or not big cities. It is known that there is a close relationship between inflammation and a malignancy, especially NPC with risk factors for chronic viral infection. Objective: To see the role of easy and inexpensive routine blood tests to help assess the prognosis of NPC patients. Methods: Searching for secondary medical record data including histopathological data, CT Scan or physical examination or nasoendoscopy as well as routine blood laboratory data for NPC patients at PKU Muhammadiyah Gombong Hospital. Results: NPC patients were found with 100% non-keratinizing carcinoma-undifferentiated type,gender was male by 63% and in the most age range 46-65 years with advanced clinical stages reaching 66.7%. Inflammatory cell status includes a high neutrophil-lymphocyte cell ratio (NLR) of 70.4% and a high plateletlymphocyte cell ratio (PLR) of 62.8%. Conclusion: The most inflammatory cell status in NPC patients at PKUMuhammadiyah Gombong Hospital are high NLR and high PLR which are in line with the findings of high T stage and positive N (advanced clinical cancer stage).Latar belakang : Kanker nasofaring (KNF) masih menjadi permasalahan kesehatan dunia juga Indonesia. Pasien datang dengan stadium lanjut yang berdampak tingginya morbiditas dan mortalitas pasien. Prognosis pasien sangat tergantung modalitas penunjang guna menentukan stadium. Pemeriksaan pendukung dengan standar panduan masih bersifat terbatas terutama bagi rumah sakit di non sentra pendidikan atau bukan kota besar. Diketahui terdapat hubungan yang erat antara inflamasi dan suatu keganasan terutama KNF dengan faktor risiko infeksi virus kronik Tujuan : Untuk melihat peran pemeriksaan darah rutin yang mudah dan murah untuk membantu penilaian prognosis pasien KNF. Metode: Pencarian data skunder rekam medik meliputi data hasil histopatologi, CT Scan atau pemeriksaan fisik atau nasoendoskopi serta data laboratium darah rutin pasien KNF di RS PKU Muhammadiyah Gombong Hasil : Didapatkan pasien KNF dengan 100% tipe non keratinizing carcinoma-undifferentiated, jenis kelamin laki-laki sebesar 63% dan pada rentang usia terbanyak 46-65 tahun dengan stadium klinik lanjut mencapai 66,7%. Status sel inflamasi meliputi rasio sel netrofil-limfosit (NLR) tinggi sebesar 70,4% dan rasio sel trombosit-limfosit (PLR) tinggi mencapai 62,8%. Kesimpulan : Status sel inflamasi terbanyak pada pasien KNF di RS PKU Muhammadiyah Gombong adalah NLR tinggi dan PLR tinggi yang selaras dengan  temuan stadium T tinggi serta N positif (stadium kanker klinis yang lanjut).
Hubungan Faktor Internal Dan Eksternal Akseptor Terhadap Kepatuhan Akseptor Kontrasepsi Suntik Khofifah Dwi Oktaviana; Muhammad Anas; Ninuk Dwi Ariningtyas; Uning Marlina
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 5, No 1 (2022): Herb-Medicine Journal Januari 2022
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v5i2.9953

Abstract

The population of Indonesian continues to increase, while the total fertility rate is not yet on target. So that an effective family planning program is needed to reduce Indonesia's population growth. Injection contraceptive acceptor adherence is needed to maximize family planning programs for a better future. Objective: to analyze the relationship between age, education, knowledge, work status, and support from husbands of injection contraceptive acceptors in women of childbearing age to compliance with re-injection visits. The study was using an analytical observational, cross-sectional study design. The sampling technique was non-random sampling purposive sampling, a sample size of 96 people, a questionnaire was used to collect data and data analysis using the chi-square test. Results: The number of adherent injecting contraceptive acceptors was 57.3%. The results showed that the variables associated with injection visit compliance were age (p = 0.022), knowledge (p = 0.005), and work status (p = 0.017). Meanwhile, the variables not related to compliance with injection visits were education (p = 0.172), husband's support (p = 0.833) and the number of children (p=0.167). Conclusion: There is a relationship between age, knowledge, and work status on the compliance of injection contraceptive acceptor visits.  Jumlah penduduk indonesia terus mengalami peningkatan, sedangkan total fertility rate belum sesuai target. Sehingga diperlukan program keluarga berencana yang efektif untuk menurunkan pertumbuhan penduduk indonesia. kepatuhan akseptor kontrasepsi suntik sangat diperlukan untuk memaksimalkan program keluarga berencana demi masa depan yang lebih baik. Tujuan : menganalisis hubungan usia, pendidikan, pengetahuan, status bekerja, dan dukungan suami akseptor kontrasepsi suntik pada wanita usia subur terhadap kepatuhan melakukan kunjungan suntik ulang. Jenis penelitian yang digunakan dalam penelitian ini yaitu analitik observasional desain Cross-sectional study. Teknik samplingnya menggunakan  non random sampling - purposive sampling, besar sampel 96 orang, kuesioner digunakan untuk mengumpulkan data dan analisis data menggunakan uji chii square. Hasil: Jumlah akseptor kontrasepsi suntik yang patuh yaitu sebesar 57,3%. Hasil penelitian diperoleh bahwa variabel yang berhubungan dengan kepatuhan kunjungan suntik yaitu usia (p=0,022), pengetahuan (p=0,005), dan status bekerja (p=0,017). Sedangkan variabel yang tidak berhubungan dengan kepatuhan kunjungan suntik yaitu pendidikan (p=0,172), dukungan suami (p=0,833), dan jumlah anak (p=0,167). Kesimpulan: Terdapat hubungan antara usia, pengetahuan, dan status bekerja terhadap kepatuhan kunjungan akseptor kontrasepsi suntik.
Terapi Kombinasi Poli Peptida Topikal Dan Gel Astaxantin Pada Ulkus Fenomena Lucio Putri Oktriana Rachman; Indah Julianto Kampono; Nurrachmat Mulianto
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 5, No 1 (2022): Herb-Medicine Journal Januari 2022
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v5i2.12348

Abstract

Lucio’s leprosy, also known as diffuse lepromatous leprosy, is a non-nodular and diffuse form of LL type leprosy caused by chronic infection with Mycobacterium lepromatous. Lucio’s phenomenon (LP) or type III leprosy reaction is a vasculitis-like leprosy reaction that can occur in untreated leprosy (Lucio’s leprosy). Multidrug therapy (MTD) for multibacillary leprosy (MB) was used in conjunction with corticosteroids to treat LP. Antibiotics and wound care are critical in preventing sepsis complications. Topical polypeptide and astaxanthin gel are both effective in the treatment of ulcers. We report the case of a 53-year-old man who presented to the Emergency Department of Dr. Moewardi Hospital Surakarta with red spots on his fingers and toes that developed into blisters and sores. Histopathological examination revealed a picture consistent with LP. Aeromonas hydrophyla bacteria were identified in pus cultures that are susceptible to gentamycin antibiotics. As recommended, the patient received systemic corticosteroids, specifically methylprednisolone IV 62.5 mg/24 hours as LP therapy and MDT treatment for MB leprosy. Additionally, the patient received systemic antibiotic gentamycin 80 mg/24 hours intravenously, and ulcer treatment with a topical polypeptide and astaxanthin gel applied to the skin. After three months of MDT therapy and treatment, patients’ ulcers improved. LP management and wound care help to reduce LP patients’ mortality and morbidity. Adjuvant therapy with topical polypeptide and astaxanthin may be used to repair ulcers in LP.  Kusta Lucio atau kusta lepromatosa difus, merupakan variasi kusta tipe LL yang bersifat non nodular dan difus yang dihubungkan dengan infeksi kronis bakteri M.Lepromatosa. Fenomena Lucio (FL) atau reaksi kusta tipe III adalah  suatu reaksi kusta dengan gambaran vaskulitis dapat terjadi pada (kusta Lucio) tidak diobati. Terapi multi drug terapy (MDT) kusta tipe multibasiler (MB) dan kortikosteroid diberikan untuk mengatasi FL. Perawatan luka dan antibiotik penting diberikan untuk mencegah komplikasi sepsis. Polipeptida dan astaxantin gel topikal memiliki efektivitas yang baik dalam penyembuhan ulkus. Kami melaporkan kasus seorang laki-laki berusia 53 tahun yang datang ke Instalasi Gawat Darurat Rumah Sakit Dr.Moewardi Surakarta dengan keluhan muncul bercak kemerahan yang kemudian menjadi lepuh dan luka pada jari-jari tangan dan kedua kaki. Pemeriksaan histopatologi didapatkan gambaran yang sesuai dengan FL. Pada pemeriksaan kultur pus didapatkan bakteri Aeromonas hydrophyla yang sensitif terhadap antibiotik gentamisin. Pasien diberikan kortikosteroid sistemik yaitu metilprednisolon IV 62.5mg/24 jam sebagai terapi FL dan pengobatan MDT kusta tipe MB sesuai yang direkomendasikan, pasien diberi antibiotik sistemik gentamisin 80 mg/24 jam intravena serta perawatan ulkus dengan polipeptida topikal dan astaxantin gel yang diaplikasikan pada ulkus pasien. Ulkus pada pasien mengalami perbaikan setelah 3 bulan menjalani terapi dan pengobatan MDT. Penatalaksanaan FL dan perawatan luka akan mengurangi mortalitas dan morbiditas pasien FL. Polipeptida topikal dan astaxantin dapat dijadikan terapi ajuvan untuk perbaikan ulkus pada FL.
Analisis In Silico Senyawa Aktif Batang Kayu Bajakah (Spatholobus littoralis Hassk) Sebagai Terapi Psoriasis Budi Eko Prasetyorini; Arie Kusumawardani; Fatimah Fitriani; Putri Ooktriana Rachman; Nathania Amelinda; Anggia Ramadhani
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 5, No 1 (2022): Herb-Medicine Journal Januari 2022
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v5i2.12744

Abstract

Background :  Innovative topical psoriasis therapy continues to be developed, Spatholobus littoralis Hassk or Bajakah has antipsoriatic activity so can be used as a topical herbal medicine in reducing the severity of psoriasis. In silico is a computational experiment which is analogous to biological experiments in vivo and in vitro. Objective : To evaluate content of Spatholobus littoralis Hassk using in silico analysis in the treatment of psoriasis. Methods : The active compound Spatholobus littoralis Hassk extracted from the knapsack database. The simplified molecular input line entry system (SMILE) format was taken from the pubchem database. Prediction in antioxidants, antiinflammatory, antipruritic and immunosuppressive was done using a pass server. The molecular mechanism of active compounds in human body was taken from search tool for interacting chemicals (STITCH) which was predicted experimentally, then analyzed computationally. Further pathway analysis using cytoscape software. Results : There are 14 active compounds in Spatholobus littoralis Hassk have potential as antioxidants, anti-inflammatory, antipruritic and immunosuppressive are predicted to have ability test computationally tested activity but laboratory tests have not been proven or have little potential. The highest bioactivity potential of Spatholobus littoralis Hassk is antioxidants where the most important role is dihydrokaemferol with an average probable to be active (Pa) value of 0.691, the compound has ability to computationally test but in laboratory tests it has not been proven or has a small potential. Conclusions : Spatholobus littoralis Hassk is a good choice for the treatment of psoriasis.  Latar belakang : Terapi psoriasis topikal inovatif terus dikembangkangkan, Spatholobus littoralis Hassk atau bajakah memiliki aktivitas antipsoriatik sehingga dapat digunakan sebagai obat herbal topikal dalam mengurangi keparahan psoriasis. In silico merupakan percobaan komputasi yang analog dengan percobaan biologis secara in vivo dan in vitro. Tujuan : Untuk mengevaluasi kandungan Spatholobus littoralis Hassk menggunakan analisis in silico pada pengobatan psoriasis. Metode : Senyawa aktif Spatholobus littoralis Hassk yang diekstraksi dari database knapsack. Format simplified molecular input line entry system (SMILE) diambil dari basis data pubchem. Prediksi dalam antioksidan, antiinflamasi, antipruritus dan immunosupresor dilakukan menggunakan pass server. Mekanisme molekuler senyawa aktif dalam tubuh manusia diambil dari search tool for interacting chemicals (STITCH) yang diprediksi secara eksperimental, kemudian dianalisis secara komputasional. Analisis pathway lebih lanjut menggunakan perangkat lunak cytoscape. Hasil : Terdapat 14 senyawa aktif pada Spatholobus littoralis Hassk yang memilik potensi sebagai antioksidan, antiinflamasi, antipruritus dan immunosupresor diprediksi memiliki kemampuan pada aktivitas yang diuji secara komputasional, namun secara uji laboratorium belum terbukti atau memiliki potensi kecil. Potensi bioaktivitas Spatholobus littoralis Hassk tertinggi adalah antioksidan dimana yang paling berperan adalah dihydrokaemferol dengan ata-rata nilai probable to be active (Pa) 0,691 dimana senyawa tersebut secara komputasional memiliki kemampuan pada aktivitas yang diuji namun secara uji laboratorium belum terbukti atau memiliki potensi kecil. Kesimpulan : Spatholobus littoralis Hassk merupakan pilihan yang baik untuk terapi psoriasis karena memiliki efek antioksidan, antiinflamasi, antipruritus dan immunosupresor serta menguntungkan dari segi ketersediaan serta keamanan.

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