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INDONESIA
Indonesian Journal of Obstetrics & Gynecology Science
Published by Universitas Padjadjaran
ISSN : 2615496X     EISSN : 2615496X     DOI : -
Core Subject : Health,
Health Professions Public Health
OBGYNIA (Indonesian Journal of Obstetrics & Gynecology Science ) adalah jurnal dalam bidang ilmu Obstetri & Ginekologi yang diterbitkan resmi oleh Departemen Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran. OBGYNIA menerbitkan artikel penelitian tentang kemajuan ilmiah, manajemen klinis pasien, teknik bedah, kemajuan pengobatan dan evaluasi pelayanan, manajemen serta pengobatan dalam bidang obstetri & ginekologi.
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Faktor-Faktor Risiko dan Status Kecemasan Ibu dengan Kehamilan Tidak Diinginkan Hairunnisa, Hairunnisa; Tahir, Andi Mardiah; Lisal, Lenny M.; Sunarno, Isharyah; Chalid, St. Maisuri T.; Leonardy, Rudy B.
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.540

Abstract

Tujuan: Untuk mengetahui hubungan faktor-faktor risiko dan status kecemasan pada ibu dengan kehamilan tidak diinginkan.Metode: Metode  kasus kontrol terhadap 62 sampel perempuan dengan kehamilan tidak diinginkan di RSUP Dr. Wahidin Sudirohusodo, RSKDIA Fatimah, RSIA Sitti Khadijah 1, RSKDIA Pertiwi, RS Syekh Yusuf dan RSUD Lapalaloi periode Januari 2022–Juni 2022. Data diperoleh menggunakan kuesioner dan status kecemasan dihitung berdasarkan Hamilton  Anxiety Rating Scale.Hasil: Kehamilan tidak diinginkan dihubungkan dengan paritas (16.500; CI 95%=3.675–74.081; p=0,001), penghasilan (OR 3.818; CI 95% = 1.398–10.429; p=0.012), unmet needs (OR 4.444; CI 95% = 2.087–9.464; p=0.001) dan penggunaan kontrasepsi (OR 2.722; CI 95%=1.309–5.659; p=0.011).Kesimpulan: Faktor risiko multiparitas, penghasilan, status unmet need, dan penggunaan kontrasepsi berhubungan dengan tingkat kecemasan pada ibu dengan kehamilan tidak diinginkan.Risk Factors and Anxiety Status in Women with Unwanted PregnancyAbstract Objective: To determine the relationship between risk factors and anxiety status in women with unwanted pregnancies.Method: Case control method of 62 samples of women with unwanted pregnancies at Dr. Wahidin Sudirohusodo, RSKDIA Fatimah, RSIA Sitti Khadijah 1, RSKDIA Pertiwi, Syekh Yusuf Hospital and Lapalaloi Hospital for the period January 2022 - June 2022. Data were obtained using a questionnaire and anxiety status was calculated based on the Hamilton Anxiety Rating Scale.Results: Unwanted pregnancy was associated with parity (16,500; 95% CI = 3,675–74,081; p=0.001), income (OR 3,818; 95% CI = 1,398–10,429; p=0,012), unmet needs (OR 4,444; 95% CI = 2.087–9.464; p=0.001) and contraceptive use (OR 2.722; 95% CI=1.309–5.659; p=0.011).Conclusion: Multiparity risk factors, income, unmet need status and contraceptive use are associated with the level of anxiety in mothers with unwanted pregnancies.Key words: Unwanted Pregnancy, Anxiety, Risk Factors, Hamilton Anxiety Rating Scale
Front Cover, Editorial Team, Table of Contents, and Back Cover Jurnal, Obgynia
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.601

Abstract

Pengaruh Faktor Risiko terhadap Kejadian Bayi Berat Lahir Rendah di Rumah Sakit Bhayangkara Sartika Asih Bandung Santoso, Herman Budi; Susiarno, Hadi; Hidayat, Dini
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.555

Abstract

Tujuan: Diperlukan identifikasi faktor risiko yang bisa menyebabkan BBLR. Tujuan dalam penelitian ini yaitu mengetahui faktor risiko yang bisa menyebabkan BBLR meliputi faktor sosiodemografi, maternal,  janin, dan lingkungan.Metode: Penelitian menggunakan metode case control. Sampel berjumlah 126 orang. Pengambilan data berupa data rekam medis dengan instrumen menggunakan lembar ceklist mengenai faktor risiko sosiodemografi, maternal janin, dan lingkungan. Data dianalisis menggunakan uji chi square.Hasil: Faktor yang berpengaruh terhadap BBLR di antaranya usia (p-value 0,000), paritas (p-value 0,000), penghasilan (p-value 0,028), perdarahan antepartum (p-value 0,042), ketuban pecah dini (p-value 0,009), hipertensi (p-value 0,000), Kekurangan energi kronis (p-value 0,031), anemia (p-value 0,015), ibu perokok (p-value 0,006), gemeli (p-value 0,0016), hidramnion (p-value 0,042), prematur (p-value 0,000), kelayakan air (p-value 0,016) dan kelayakan sanitas (p-value 0,006). Sementara itu faktor yang tidak berpengaruh terhadap BBLR di antaranya pendidikan (p-value 0, 934), pekerjaan (p-value 0,312), TB paru (p-value 0,257), dan ibu minum alkohol (p-value 0,257). Hasil analisis multivariat didapatkan faktor yang berpengaruh terhadap kejadian BBLR secara berurutan yaitu gemeli (OR 42,218), prematur (OR 17,639), kelayakan air (OR 14,769), perokok (OR 12,462), hipertensi (OR 7,228), anemia  (OR 4,407), paritas (OR 3,116),  ketuban pecah dini (OR 1,674), usia (OR 1,245), dan kelayakan sanitasi (OR 1,230).Kesimpulan:  Faktor risiko yang paling berpengaruh terhadap BBLR yaitu Gemeli.Risk Factors on Low Birth Weight Infants at Hospital Bhayangkara Sartika Asih BandungAbstractObjective: Required identification of risk factors that can cause LBW. So the aim of this research is to know the risk factors that can cause LBW including sociodemographic, maternal, fetal and environmental factors.Method: Research using methods case control. The sample is 126 people. Data collection was in the form of medical record data with instruments using checklist sheets regarding sociodemographic, maternal and environmental risk factors. Data were analyzed using test who squares.Results: Factors that influence LBW include age (p-value 0.000), parity (p-value 0.000), income (p-value 0.028), antepartum hemorrhage (p-value 0.042), premature rupture of membranes (PRM) (p-value 0.009), hypertension (p-value 0.000), Chronic energy deficiency (p-value 0,031), anemia (p-value 0.015), smoking mothers (p-value 0.006), twins (p-value 0.0016), hydramnios (p-value 0.042), premature (p-value 0,000), water qualification (p-value 0.016) and sanitary feasibility (p-value 0.006). While the factors that do not affect LBW include education (p-value 0.934), work (p-value 0.312), pulmonary TB (p-value 0.257), and the mother drinks alcohol (p-value 0.257). The results of the multivariate analysis showed that the factors influencing the incidence of LBW were sequential (OR 42.218), premature (OR 17.639), water adequacy (OR 14.769), smokers (OR 12.462), hypertension (OR 7.228), anemia (OR 4.407), parity (OR 3.116), premature rupture of membranes (OR 1.674), age (OR 1.245) and sanitation feasibility (OR 1.230).Conclusion: The most influential risk factor for LBW is Gemelli.Key words: Gemelli, Low Birth Weight Babies, Risk Factors,
Effects of Combined Laparoscopic Cystectomy and Leuprolide Acetate Therapy on Anti-Mullerian Hormone Level and Antral Follicle Count Profile in Endometriosis Usman, Fatimah; Hilmawan, Bagus; Yusuf, Kemas; Manan, Heriyadi; Theodorus, Theodorus; Andrina, Hana
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.519

Abstract

Objective: This study examines the effectiveness of combined laparoscopic cystectomy and leuprolide acetate therapy on AMH level and AFC profile in endometriosis.Method: This study is a randomized controlled clinical trial with open label form. The subjects were divided into control and therapy groups, with the therapy group receiving leuprolide acetate injection following laparoscopic cystectomy. In both groups, the AMH levels and AFC were examined prior to the surgery and six weeks after before they were compared.Results: There were significant pre-post differences of AMH levels(p = 0.000) and AFC (p = 0.000) in the therapy group but not in the control group. In the therapy group, the mean increases of AMH level and AFC were 0.94 (95% CI: 0.63-1.25) and 9.53 (95% CI: 6.83-12.24), respectively. Linear regression model found that AFC level prior to intervention was a significant predictor of endometriosis ASRM grade (p = 0.001) with an R-value of 0.633, suggesting strong correlation.Conclusion: The combined therapy of laparoscopic cystectomy and leuprolide acetate injection for endometriosis provided better outcome concerning ovarian reserve, as opposed to the therapy with laparoscopic cystectomy alone. Peran Kombinasi Laparoskopi Kistektomi dan Terapi Leuprolide Asetat Terhadap Kadar Hormon Anti-Mullerian dan Profil Jumlah Folikel Antral pada Penderita EndometriosisAbstrakTujuan:Studi ini bertujuan menguji keefektifan kombinasi kistektomi laparoskopi dan terapi leuprolide acetate terhadap kadar AMH dan profil AFC pasien endometriosis.Metode: Penelitian ini merupakan uji klinis terkontrol acak dengan bentuk open label. Subjek dibagi menjadi kelompok kontrol dan terapi, dengan kelompok terapi menerima injeksi leuprolide acetate setelah kistektomi laparoskopi. Pada kedua kelompok, kadar AMH dan AFC diperiksa sebelum pembedahan dan enam minggu setelahnya sebelum kemudian dibandingkan.Hasil: Terdapat perbedaan bermakna kadar AMH (p = 0,000) dan AFC (p = 0,000) sebelum dan sesudah pada kelompok terapi tetapi tidak pada kelompok kontrol. Pada kelompok terapi, rata-rata peningkatan kadar AMH dan AFC adalah masing-masing 0,94 (95% CI: 0,63-1,25) dan 9,53 (95% CI: 6,83-12,24). Model regresi linier menemukan bahwa kadar AFC sebelum intervensi merupakan prediktor signifikan derajat endometriosis sesuai ASRM (p = 0,001) dengan nilai R sebesar 0,633 yang menunjukkan korelasi yang kuat.Kesimpulan: Terapi kombinasi kistektomi laparoskopi dan injeksi leuprolide acetate untuk endometriosis memberikan hasil yang lebih baik terhadap cadangan ovarium, dibandingkan dengan terapi dengan kistektomi laparoskopi saja.Kata kunci: endometriosis; leuprolide acetate; kistektomi; hormon anti-mullerian; jumlah folikel antral
Gambaran Faktor Risiko Kanker Endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022 Erfiandi, Febia; Balqis, Shalma Alaika Aurel; Salima, Siti; Mantilidewi, Kemala Isnainiasih; Kurniadi, Andi; Wibowo, Viko Duvadilan
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.578

Abstract

Tujuan: Mengetahui faktor risiko pasien kanker endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022.Metode: Penelitian metode deskriptif dengan menggunakan data sekunder. Kriteria inklusi yaitu pasien dengan diagnosis utama kanker endometrium.Hasil: Mayoritas pasien kanker endometrium berusia 50 – 59 tahun (34,8%), multipara (40,9%), Indeks Masa Tubuh ≥25 kg/m2 (33,2%), usia menarche ≥12 tahun (68,8%), tidak memiliki riwayat infertilitas (49,0%), belum menopause (36,4%), tidak memiliki riwayat terapi hormon (74,1%), pasien tidak memiliki riwayat kanker/lynsch syndrome (71,7%), tidak memiliki riwayat keluarga dengan lynch syndrome (75,7%), tidak menggunakan kontrasepsi (42,5%), dan tidak memiliki riwayat hipertensi (72,9%).Kesimpulan: Pasien kanker endometrium di RSUP Dr. Hasan Sadikin Bandung periode tahun 2020 – 2022 ditemukan paling banyak pada rentang usia 50 – 59 tahun, status paritas yaitu multi para (≥2 kelahiran hidup), indeks massa tubuh ≥25 (obesitas), belum menopause, usia menarche ≥12 tahun, tidak memiliki riwayat terapi hormon, tidak terdapat riwayat infertilitas, pasien tanpa riwayat kanker, tidak memiliki riwayat keluarga dengan kanker, tidak menggunakan kontrasepsi, dan tidak memiliki riwayat hipertensi.Overview of Endometrial Cancer Risk Factors at RSUP Dr. Hasan Sadikin in 2020 - 2022AbstractObjective: Indentifying the risk factor of endometrial cancer patients at RSUP Dr. Hasan Sadikin in 2020 - 2022.Method: This research used descriptive method by collecting secondary data. The inclusion criteria was patients with primary diagnosis of endometrial cancerResults: In this research, the majority of endometrial cancer patients were aged 50 - 59 years (34,8%), multiparous (40,9%), with body mass index ≥25 kg/m² (33,2%), menarche age of ≥12 years (68,8%), no history of infertility (49,0%), not menopausal yet (36,4%), no history of hormone therapy (74,1%), no patient history of cancer/Lynch syndrome (71,7%), no family history of lynch syndrome (75,7%), no history of contraceptive use (42,55), and no history of hypertension (72,9%).Conclusion: In 2020 - 2022, endometrial cancer patient in Dr. Hasan Sadikin Central General Hospital Bandung were mostly foung in the aged range 50 - 59 years, multiparous, obesity, not menopausal yet, menarche age of ≥12 years, no history of hormone therapy, no patient and family history of cancer, no history of contraceptive use and hypertension.Key words: Endometrial cancer, risk factor, descriptive study
Pencegahan Abortus pada Awal Kehamilan Bernolian, Nuswil; Pangemanan, Wim T.; Syamsuri, Ahmad Kurdi; Ansyori, M. Hatta; Mirani, Putri; Lestari, Peby Maulina; Martadiansyah, Abarham; Kesty, Cindy
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.403

Abstract

Abortus merupakan suatu kejadian terminasi kehamilan dengan usia kehamilan <20 minggu dan berat janin <500 g. Angka kejadian abortus disebutkan sekitar 15% dari seluruh kehamilan. Terdapat beberapa faktor risiko abortus yaitu faktor risiko yang dapat dimodifikasi dan tidak dapat dimodifikasi. Beberapa faktor risiko yang dapat dimodifikasi yaitu faktor nutrisi, konsumsi kafein, alkohol, kebiasaan merokok, infeksi, paparan radiasi, beban kerja, dan pengaruh obat-obatan. Beberapa faktor risiko yang tidak dapat dimodifikasi, yaitu genetik, kelainan kongenital, dan lain-lain. Dengan mengetahui faktor risiko tersebut, dokter dapat melakukan pencegahan dan intervensi yang sesuai dengan kondisi masing-masing pasien yang mengalami abortus. Metode yang digunakan adalah tinjauan pustaka dengan menggunakan beberapa database seperti Pubmed, Wiley Online Library, dan ScienceDirect dari 10 tahun terakhir.Prevention of Miscarriage in Early PregnancyAbstractMiscarriage is an event of termination of pregnancy with < 20 weeks of gestation and fetal weight < 500 grams. The incidence of miscarriage is around 15% of all pregnancies. There are several risk factors for miscarriage, namely modifiable and non-modifiable risk factors. Some modifiable risk factors are nutritional factors, consumption of caffeine, alcohol, smoking habit, infection, radiation exposure, workload, and the influence of drugs. Several risk factors that can not be modified, namely genetics, congenital abnormalities, and others. By knowing these risk factors, doctors can carry out prevention and intervention according to the conditions of each patient who undergoes miscarriage. The method used is a literature review using several databases such as Pubmed, Wiley Online Library, and ScienceDirect from the last 10 years.Key words: miscarriage, prevention, risk factors, pregnancy.
Effect of Pregnancy towards Prognosisof Women and Babies with COVID-19 Sinaga, Luhut Parsaulian
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.563

Abstract

Objective: Analyzing the relationship of pregnancy with COVID-19 towards the prognostic profiles in mothers and babies.Method: Observational analytics with cross sectional study approach. Data collection through medical records of pregnant women infected with COVID-19 who were treated at Kebayoran Lama Hospital from October 2020 to September 2021.Results: Chi-square statistical test between among women with COVID-19 on prognostic profiles obtained probability value p-value = 0.001 (p-value < 0.05) and Chi-square statistical test among pregnant women with COVID-19 on prognostic profiles in infants obtained a probability value of 0.0001 (p-value < 0.05).Conclusion: Aspects of severity and duration of treatment in cases of pregnancy with COVID-19 are positively related to the prognostic profiles in pregnant women at Kebayoran Lama Hospital. Aspects of COVID-19 exposure in infants, length of treatment, and complication status in cases of pregnancy with COVID-19 are positively related to the prognostic profiles in infants at Kebayoran Lama Hospital.Pengaruh Kehamilan terhadap PrognosisWanita dan Bayi dengan Covid-19AbstrakTujuan: Menganalisis hubungan kehamilan dengan COVID-19 terhadap profil prognosis pada ibu dan bayi.Metode: Analitik observasional dengan pendekatan studi potong lintang. Pengambilan data melalui rekam medis ibu hamil yang terinfeksi COVID-19 yang dirawat di Rumah Sakit Kebayoran Lama sejak Oktober 2020 sampai dengan September 2021.Hasil: Uji statistik Chi-square antara ibu hamil dengan COVID-19 terhadap profil prognosis mendapatkan nilai probabilitas p-value = 0,001 (nilai p < 0,05) dan uji statistik Chi-square antara ibu hamil dengan COVID-19 terhadap profil prognosis pada bayi didapatkan nilai probabilitas sebesar 0,0001 (p value < 0,05).Kesimpulan: Aspek derajat keparahan dan lama perawatan dalam kasus kehamilan dengan COVID-19 berhubungan positif terhadap profil prognosis pada ibu hamil di Rumah Sakit Kebayoran Lama. Aspek paparan COVID-19 pada bayi, lama perawatan, dan status komplikasi pada kasus kehamilan dengan COVID-19 berhubungan positif terhadap profil prognosis pada bayi di Rumah Sakit Kebayoran Lama.Kata kunci: kehamilan, COVID-19, prognosis, ibu, bayi
A Case Report: MRI versus Ultrasonography in Abdominal Pregnancy, Which One is Better? Rahman, Luthfi; Reswari, Arnova; Pribadi, Adhi
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.485

Abstract

Abdominal pregnancy is a rare potentially life-threatening form of ectopic pregnancy. First trimester sonography is very useful to identify an abdominal pregnancy earlier. However, cases of undiagnosed abdominal pregnancy at second and third trimesters are still reported in obstetric practice. Abdominal pregnancy is often missed during routine ultrasound examination that has classical findings such as the absence of myometrial tissue between the maternal bladder and the pregnancy, an empty uterus, poor visualization of the placenta, oligohydramnios, and abnormality of fetal lie. Magnetic Resonance Imaging (MRI) has been reported as the best abdominal pregnancy detection modality in a later gestational age due to its ability in detailing vascular and placental organ invasion.The reporting of a case of a patient with an abdominal pregnancy involves a diagnosis using abdominal ultrasound in the second trimester.  A 38-year-old woman was admitted to RSUP Dr. Hasan Sadikin Bandung with suspected abdominal pregnancy at gestational age of 28 weeks. Due to unclear clinical manifestation, the diagnosis of abdominal pregnancy was not detected and there was a plan for vaginal termination of pregnancy by misoprostol induction in the hospital before. The patient complained about progressive abdominal pain and difficult of defecation for 2 months before and this condition worsened in the last 4 days. Ultrasound examination in RSHS revealed that there were one living fetus, extra-uterine pregnancy with estimated fetal weight of 664 grams, fetal heart rate (+), and transverse breech presentation. Congenital abnormality was difficult to assess due to oligohydramnios. MRI was performed and showed intra-abdomen pregnancy with one living fetus, breech presentation, and intact amniotic membrane with oligohydramnios which was superior to the uterus and attached along the anterior aspect of uterus. The placenta had the size os 11.52 x 7.02 x 13.07 cm, was diffusely heterogenous in shape, on the right superoanterolateral wall of the gestational sac, and seemed to be attached to the right anterior abdominal wall and part of the intestine in the superior part while no placental adherence was seen. The patient was successfully treated with exploratory laparotomy with complete removal of the fetus and placenta. This case was reported to compare the advantage of MRI and ultrasound examination in detecting abdominal pregnancy, especially in late gestational age.Laporan Kasus: MRI dan Ultrasonografi pada Kehamilan Abdomen, Manakah yang Lebih Baik?AbstrakKehamilan abdomen adalah bentuk kehamilan ektopik yang jarang terjadi dan memiliki potensi mengancam jiwa. Pemeriksaan ultrasonografi (USG) pada trimester pertama berguna untuk mengidentifikasi kehamilan abdominal lebih awal. Namun, kehamilan abdomen yang tidak terdiagnosis masih sering dijumpai pada trimester kedua dan ketiga. Tanda klasik kehamilan abdomen sering terlewatkan oleh operator pada saat pemeriksaan USG rutin. Magnetic Resonance Imaging (MRI) merupakan modalitas terbaik untuk mendeteksi kehamilan abdomen pada usia kehamilan yang lebih tua karena mampu melihat invasi pembuluh darah dan organ plasenta secara lebih detail.Kami melaporkan sebuah kasus mengenai seorang wanita 38 tahun yang terdeteksi memiliki kehamilan abdominal pada usia kehamilan 28 minggu pada pemeriksaan USG saat perawatan di RSHS. Manifestasi klinis pada pasien tidak spesifik sehingga diagnosis kehamilan abdominal terlewati dan sempat diberikan rencana terminasi kehamilan pervaginam di rumah sakit sebelumnya. Pemeriksaan USG menunjukkan terdapat satu janin hidup dan terletak luar rahim. Kemudian pasien diputuskan menjalani pemeriksaan MRI, ditemukan adanya kehamilan intra abdomen dengan satu janin hidup, presentasi bokong, dan plasenta berbentuk heterogen difus, di dinding superoanterolateral kanan kantung kehamilan, melekat pada dinding abdomen anterior kanan dan bagian usus di bagian superior, dan tanpa adanya perlengketan plasenta. Pasien ditangani dengan laparotomi eksplorasi dengan pengangkatan janin dan plasenta secara lengkap. Kasus ini bertujuan membandingkan keunggulan pemeriksaan MRI dan USG dalam mendeteksi kehamilan abdominal, terutama pada usia kehamilan lanjut.Kata kunci: ultrasonografi, MRI, kehamilan abdominal
Effects of Calcium on Calmodulin and bFGF/FGF-2 Expression: In Vitro Study on the Sacrouterine Ligament Rahajeng, Rahajeng; Indriani, Anin; Ninik, Suheni; Nooryanto, M; Agung, I Wayan; Palapa, Heny
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.579

Abstract

Objective: To evaluate the effects of calcium on the Sacrouterine Ligament by evaluating the expression of calmodulin and bFGF/FGF-2.Method: A true experimental study was carried out by assessing the cell cultures of sacrouterine ligament from female patients who underwent hysterectomy. The cell cultures were divided into groups that were exposed to calcium at different concentrations of 100 nM, 300 nM, 500 nM, 700 nM, and control group without any exposure. The expression of calmodulin and bFGF/FGF-2 was subsequently analyzed using immunofluorescence and ELISA method.Results: This study showed that exposure to calcium significantly affected calmodulin expression (p-value <0.05). The concentration found to be the most effective to induce calmodulin expression was at 500 nM. Calsium also significantly affected the bFGF/FGF-2 expression (p-value <0.05) with the concentration found to be the most effective to induce bFGF/FGF-2 expression at 500 nM.Conclusion: This study suggested that calcium had a significant positive effect of increasing extracellular matrix expression. A further in vivo study needs to be conducted in order to enhance the evidence of the potential effects to become a preventive agent for pelvic organ prolapse. Calcium is widely available in tropical countries like Indonesia, so this preparation is considered very easy for Indonesian women to apply.Key words: Calcium, calmodulin, bFGF/FGF-2, Extracellular MatrixPengaruh Kalsium pada Ekspresi Calmodulin dan bFGF/FGF-2: Studi In Vitro pada Ligamentum SakrouterinaAbstrakTujuan: Mengevaluasi efek kalsium pada Ligamen Sakrouterina dengan evaluasi ekspresi calmodulin dan bFGF/FGF-2,Metode: Sebuah penelitian true eksperimental dilakukan dengan menilai kultur sel ligamentum sakrouterurina dari pasien wanita yang menjalani histerektomi. Kultur sel dibagi menjadi beberapa kelompok yang diberi paparan kalsium pada konsentrasi yang berbeda yaitu 100 nM, 300 nM, 500 nM, 700 nM, dan kontrol tanpa paparan. Ekspresi calmodulin dan bFGF/FGF-2 selanjutnya dianalisis menggunakan metode ELISA dan imunofluoresensi.Hasil: Penelitian ini menunjukkan bahwa paparan kalsium berpengaruh nyata terhadap ekspresi calmodulin (p-value <0,05). Konsentrasi yang paling efektif untuk menginduksi ekspresi calmodulin adalah pada 500 nM. Kalsium juga berpengaruh nyata terhadap ekspresi bFGF/FGF-2 (p-value <0,05), dengan konsentrasi yang paling efektif untuk menginduksi ekspresi bFGF/FGF-2 adalah pada 500 nM.Kesimpulan: Penelitian ini menunjukkan bahwa kalsium memiliki efek positif yang signifikan terhadap peningkatan ekspresi matriks ekstraseluler. Penelitian in vivo lebih lanjut perlu dilakukan untuk meningkatkan bukti potensi efek sebagai agen pencegahan prolaps organ panggul. Kalsium banyak tersedia di negara tropis seperti Indonesia, sehingga olahan ini dinilai sangat mudah diterapkan untuk wanita Indonesia.Kata kunci: Kalsium, Calmodulin, bFGF/FGF-2, Matriks Ekstraseluler
Current Evidence of Platelet-Rich Blood Plasma for Pelvic Organ Prolapse: A Review Fakhrizal, Edy; Simanjuntak, Arya Marganda; Hutapea, Anastasya
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.530

Abstract

Objective: To review the current evidence of the potential use of Platelet-Rich Plasma (PRP) in the field of urogynecology, especially in POP cases.Method: This review used several databases (Google Scholar, Pubmed, and Science Direct) and searched for English and Indonesian articles in the last ten years. Articles were received in the form of case reports, observational studies and clinical trials that discussed the use of Platelet-Rich Plasma in cases of Pelvic Organ Prolapse (POP).Results: A total of three articles were included in this review.Discussion: There were two patient studies and one in vitro study. The POP patient study showed favorable results with low recurrence rates in patients who received Platelet Rich-Plasma compared to those who did not and another study that conducted a one-year evaluation found no recurrences after the patients received Platelet Rich Plasma at the surgical site. The in vitro study showed good cell attachment and proliferation in vaginal tissue biopsies with Platelet-Rich Plasma applied to the tissue.Conclusion: Platelet-Rich Plasma may promote tissue regeneration, hence potentially reduce recurrency after reconstruction.Bukti Terkini Plasma Darah Kaya Trombosit untuk Prolaps Organ Panggul: Sebuah KajianTujuan: Untuk meninjau bukti terkini mengenai potensi penggunaan Platelet-Rich    Plasma di bidang uroginekologi, khususnya pada kasus POP.Metode:Tinjauan ini menggunakan beberapa database Google Scholar, Pubmed, dan Science Direct) dan mencari artikel berbahasa Inggris dan Indonesia dalam sepuluh tahun terakhir. Artikel yang diterima berupa laporan kasus, studi observasional, dan uji klinis yang membahas penggunaan Platelet-Rich Plasma pada kasus Prolaps Organ Panggul (POP).Hasil: Sebanyak tiga artikel termasuk dalam tinjauan ini.Diskusi: Terdapat dua studi pasien dan satu studi in vitro. Studi pasien POP menunjukkan hasil yang baik dengan tingkat kekambuhan yang rendah pada pasien yang menerima PRP dibandingkan dengan mereka yang tidak menerima Platelet-Rich Plasma dan studi lain yang melakukan evaluasi satu tahun tidak menemukan adanya kekambuhan setelah pasien menerima Platelet-Rich Plasma di tempat pembedahan. Studi in vitro menunjukkan perlekatan dan proliferasi sel yang baik pada biopsi jaringan vagina dengan Platelet-Rich Plasma yang diaplikasikan pada jaringan tersebut.Kesimpulan: Platelet-Rich Plasma dapat meningkatkan regenerasi jaringan, sehingga berpotensi mengurangi kekambuhan setelah rekonstruksi.Kata kunci: Platelet-Rich Blood Plasma, Prolaps Organ Panggul, Uroginekologi

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