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MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Semarang
ISSN : 24070505     EISSN : -     DOI : https://doi.org/10.26714/magnamed
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Magna Medica is a medical journal of APKKM contains papers and scientific articles created as a form of realization Tridharma college. The journal is published every six months, April and October of three articles in the form of: - Research article - Case report - Literature review The scope of this journal is all the field of medicine such as: -Internal medicine (including Pulmonary medicine and cardiovascular medicine) -Surgery (including urology, orthopaedic and traumatologic, plastic surgery, neurosurgery) -Anesthesia and Emergency Medicine -Neurology -Dermatology -Obstetric and Gynecologic -Forensic and Medicolegal -Clinical Pathology -Anatomical Pathology -Psychiatric -Ophthalmology -Otolaryngology -Pediatric -Radiology -Microbiology and parasitology -Basic Science of Medicine (including biochemistry, physiology, anatomy and Histology) -Public health and Health Management
Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran
Articles 222 Documents
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The Effects of Heavy Metal Contamination on Liver Function in a Rat Model Yuliana, Ida; Triawanti, Triawanti; Prenggono, Muhammad Darwin; Oktaviyanti, Ika Kustiyah; Asnawati, Asnawati; Ulfah, Fahrina; Maulana, Irfan
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.145-153

Abstract

Background:  Mining activities in South Kalimantan have been widely associated with the emergence of various health issues through heavy metal contamination in the water. Previous studies have demonstrated that the presence of heavy metals has an impact on physiological alterations inside many organs, notably the liver.Objective: The study aimed to determined the impact of liver damaged from heavy metal of lead (Pb), cadmium (Cd), and mercury (Hg), and the combination of the three in rat model.Methods: Our research used the true experiment laboratory method with a post-test group design. Male white rats (Rattus norvegicus), aged 2–6 months and weighing 250–300 grams, were assigned to the control group and the treatment group. Treatment groups were administered orally with water contaminated with heavy metals of Pb, Cd, and Hg orally for 28 days. The serum markers of liver damaged were then measured.Results: The levels of transaminase enzymes (AST and ALT) in the heavy metal-exposed group were increased compared to the control group. However, the increase was not statistically significant (p = 0.247; p = 0.349, respectively). The group exposed to Hg exhibited the highest levels of AST and ALT in comparison to the other groups.Conclusion: Heavy metal exposure tend to raise transaminase enzyme levels, indicating liver damage. Hg exhibited the greatest transaminase value increase of all heavy metals, indicating its highest potential for liver toxicity.
Validity and Reliability of Indonesian Version of Diabetes Quality of Life Brief Clinical Inventory in Patients with Type 2 Diabetes at Primary Care Azmiardi, Akhmad; Febrinasari, Ratih Puspita
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 12, No 2 (2025): AUGUST
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.12.2.2025.124-132

Abstract

Background:  Type 2 diabetes (T2DM) has a significant impact on patients' quality of life (QoL), including physical, psychological, social, and economic aspects. However, a culturally and linguistically adapted Diabetes Quality of Life Brief Clinical Inventory (DQoL-BCI) for Indonesian patients remains limited. A validated Indonesian version of this instrument is necessary to ensure accurate assessment and effective interventions for diabetes management.Objective: This study aimed to assess the validity and reliability of the Indonesian version of the Diabetes Quality of Life Brief Clinical Inventory (DQoL-BCI) among patients with T2DM in primary care.Methods: A cross-sectional study was conducted among 30 T2DM patients at a primary health care center in Singkawang City, West Borneo, Indonesia. Data were collected through interviews. The DQoL-BCI, a 15-item questionnaire, was used to measure QoL, with responses rated on a 5-point Likert scale. Construct validity and internal consistency were assessed using Pearson’s r and Cronbach’s alpha.Results: All items showed Pearson’s r values greater than 0.361, indicating an adequate correlation with the overall scale and thus validating the items. The highest Pearson’s r values were for satisfaction with the time to determine sugar levels (0.688) and sex life (0.680). The Cronbach’s alpha coefficient for all items was 0.887, exceeding the minimum requirement of 0.70, demonstrating excellent internal consistency.Conclusion: The Indonesian version of the DQoL-BCI is a valid and reliable instrument for measuring the QoL in individuals with T2DM in primary care settings.
Acethylcholinesterase Levels of Aedes aegypti Larvae after Exposure to The Pandanus amaryllifolius Leaf Extracts Anin, Lidya; Adrianto, Hebert; Silitonga, Hanna Tabita Hasianna; Indrasari, Setyarina; Sari, Kartika Buana
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 12, No 1 (2025): FEBRUARY
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.12.1.2025.31-39

Abstract

Background:  Dengue fever is a disease transmitted by Ae. aegypti. Controlling mosquitoes can use temephos. Temephos larvicides act primarily on the enzyme acetylcholinesterase (AChE) by inhibiting this enzyme. Temephos has drawbacks due to its high risk of resistance, so larvicides from natural ingredients such as pandan leaf extract (P. amaryllifolius) can be an alternative. The mechanism of action of P. amaryllifolius larvicide is still unclear.Objective: This study aims to ascertain how LC85 pandan leaf methanol extract affects AChE levels in Ae. aegypti.Methods: This is an actual experiment design with only a post-test control group research design. Tests were conducted by treating mosquito larvae with P. amaryllifolius LC85 extract, aquades, and temephos for 24 hours and measuring AChE levels with an ELISA Reader.Results: The results showed that the AChE enzyme levels of P. amaryllifolius LC85 extract had an average AChE enzyme level of 147.19 + 70.87 units/l. The AChE enzyme levels of larvae exposed to P. amaryllifolius LC85, aquades, and temephos significantly differed (p <0.05).Conclusion: P. amaryllifolius has potential as a larvicidal, with a mechanism of action as a neurotoxin.
Raphanus Sativus Leaves Ethanol Extract's Effect on Heart Muscle's Nuclear Factor Kappa B (NFkB) in Diabetic Rats Hendrawati, Asri; Djunet, Nur Aini
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.198-204

Abstract

Background:  Type 2 diabetes mellitus is characterized by hyperglycemia. Hyperglycemia increases free radicals and oxidative stress that damage heart muscle cells. Nuclear factor kappa B (NFkB) plays an important role in inflammation and cell damage. Radish leaves (Raphanus sativus) are known to have compounds that can control NFkB expression.Objective: To measure the effect of radish leaves on the expression of NFkB in heart muscle.Methods: The study design was experimental laboratory post test control group design. The subjects were diabetic male Wistar rats, weight 150-300 grams, 3-4 months old. Rats were divided into four groups and given treatment orally for 28 days. The 1st group received placebo. The 2nd group received glibenclamide 5 mg/kg BW/day. The 3rd and 4th groups received 50% and 100% ethanol extract of radish leaves. Heart NFkB was measured using immunohistochemistry.  Results: Radish leaves ethanol extract 50% and 100% reduced NFkB  in the heart muscle better than placebo and glibenclamide 5 mg/kg BW ((p=0.000). There was no difference between radish leaf extract 50% and 100% in reducing heart NFkB expression (p=0.876).Conclusion: Radish leaf extract 50% and 100% reduce NFkB expression better than placebo and glibenclamide 5 mg/kg BW.
E-Prescription: Opportunities and Challenges Jamil, Ahmad Mochtar; Fahrudda, Ansarul; Mundakir, Mundakir; Hartamto, Offia Melda Permata; Absor, Sholihul; Suswojo, Heru; Anas, Muhammad; Rahmah, Laila
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 12, No 2 (2025): AUGUST
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.12.2.2025.182-195

Abstract

Background: The research explores the advancements and implications of e-prescribing systems within modern healthcare.Objective: The primary objective is to assess the growing body of literature, examining global trends, effectiveness, and challenges associated with e-prescribing implementation.Methods: Using a comprehensive literature review methodology, data were sourced from the Scopus database, revealing many publications from 1980 to 2024.Results: A notable increase in scholarly interest was observed, particularly from 2015 to 2024, highlighting e-prescribing as a mature research subject. The results indicate a high concentration of research activity in advanced healthcare systems, contrasting with the limited contribution from developing contexts such as Indonesia.Conclusion: The study identifies that while e-prescribing improves medication safety and efficiency, gaps in understanding its long-term impacts on patient outcomes persist. Additionally, disparities in technology adoption among demographic groups emerge as significant barriers. This research contributes to existing knowledge by underscoring the need for localized studies and international collaboration to enhance e-prescribing practices. Future research directions should focus on evaluating long-term outcomes, improving digital literacy, and assessing training impacts on healthcare professionals.
Germ Cell Tumors in the Mediastinum Sulthansyah, Muhammad Harris Sis; Lestari, Lilik
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 12, No 1 (2025): FEBRUARY
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.12.1.2025.79-86

Abstract

Background:  Germ mediastinum tumors grow in the mediastinum and consist of teratoma, seminoma, and nonseminomatous. Cases of germ mediastinum tumors are rare. During the last decade, only two cases have been found at Dr. Ario Wirawan Lung Hospital, Salatiga, Indonesia.Objective: Germ mediastinum tumor is a rare case. This paper aims to present a case report that would benefit the radiology database.Case Presentation: Two male patients aged 18 and 19 were referred to radiology complaining of continuous shortness of breath and coughing. The shortness of breath does not decrease daily, so the patient uses a breathing apparatus to help reduce shortness of breath. The patient underwent chest X-rays, ultrasonography (USG), and computerized tomography (CT). Pleural effusion is seen, the COR of the right heart border is good, the heart border is covered with a homogeneous covering, and the location of the heart is pushed to the right. The USG results showed a lot of pericardial effusion, a hyperechoic lesion with clear boundaries, a round, oval shape, lobulated with enormous size, vertical, right vertical, left atrium, and right atrium, aortic pressing lesion. The CT scan showed isohypodense lesions in the form of lobulated, partially indistinct boundaries, forced injection of contrast appeared inhomogeneous enhancement, the right lung had an increased bronchovascular pattern, and patches appeared on the dextra lung.Conclusion: The radiological imaging with x-ray, USG, and CT scan revealed that the patient found a mass in the mediastinum with firm boundaries, a round oval, homogeneous structure, fluid in the pericardial effusion, flat edges, and a homogeneous structure. Based on the findings, it can be concluded that radiological imaging can play a role in detecting germ mediastinum tumors.
Exploring COVID-19 Vaccine’s Adverse Event Following Immunization on educational staff at the Faculty of Medicine Muthmainah, Noor; Skripsiana, Nika Sterina; Aprilia, Gita Rizky; Rahmiati, Rahmiati; Yuniarti, Rina
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 12, No 2 (2025): AUGUST
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.12.2.2025.104-123

Abstract

Background: COVID-19 was declared a global pandemic on March 11, 2020. Vaccination is one of the efforts to prevent and treat COVID-19. One thing that needs to be considered in the COVID-19 vaccination is the emergence of Adverse Event Following Immunization (AEFI). The reactions after vaccination can be local, systemic, or other.Objective: This study aimed to depict the AEFI of the COVID-19 vaccine on educational staff, Faculty of Medicine, ULMMethods: This study was a retrospective descriptive study with a cross-sectional approach using primary data in the form of a questionnaire given directly to the respondents. This research was conducted in October-November 2022 at the Faculty of Medicine, ULM.Results: The results showed that 84.4% of the respondents experienced AEFI in the first vaccination dose.  The AEFIs were most experienced by groups of 41-50 years (36.84%), females (65.79%), S1 (55.26%), and the Sinovac vaccine type (84.21%). Besides, for the second dose, 77.8% respondents experienced AEFI. Most AEFIs were experienced by the group of 20-30, 31-40, and 41-50 years (31.43%), female (71.43%), S1 (57.14%), and the Sinovac vaccine type (80%). The most common symptom was pain at the injection area (48.89%). The onset was most often on the first day (48.89%), and it took 1-2 days, with 35.5% as the response to the first dose and 26.6% for the second dose.Conclusion: Most of the AEFIs in the first vaccination dose were experienced by the 41-50-year-old group. Meanwhile, the second vaccination dose was administered to groups of 20-30, 31-40, and 41-50. The AEFI occurred most often in females, S1, and the Sinovac vaccine type. The most common AEFI symptom was pain at the injection site, followed by drowsiness and fatigue. The most AEFI cases were on the first day, and the duration was 1-2 days.
Histologic comparison of the uterine pathologic effects of erythropoietin and U-74389G Tsompos, Constantinos; Panoulis, Constantinos; Zografos, Constantinos; Zografos, GeorgeC; Papalois, Apostolos
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 13, No 1 (2026): FEBRUARY
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.13.1.2026.%p

Abstract

Background: This manuscript compared the effects at uterine pathology (UP), after processing with either the drug erythropoietin hormone (Epo), or the lazaroid antioxidant agent (L) one U-74389G. This comparison was provided by outcomes of 2 preceding branches.Objective: Both studies estimated the effect, after each drug use in a planned uterine ischemia -  reperfusion (UIR) mice experimental setting.Methods: Both principal experiment timepoints, the uterine histology was evaluated were the min 60th after reperfusion (A, C, E groups) and also the min 120th after reperfusion (B, D, F groups). Along, A & B groups were placebo, C & D groups were processed by Epo and E & F groups after the L process.Results: The one study-branch of Epo has presented a hardly significant recessing potency for the total UP within the “lesion-free” grade alteration by -0.0916667 [-0.1907629 - 0.0074296] (p-values = 0.0583). However, the other study-branch of U-74389G presented a respective non-significant accentuation of the total UP within the “lesion-free” grade alteration by 0.2229748 [-0.1376592 - 0.5836089] (p-value = 0.4940). Both branch studies got co-evaluated as they belong to a common experiment. Their outcome was that Epo seems to ameliorate the UP status, whereas L seems to deteriorate it; however, their discrepancy seems to be non-significant (p-value = 0.0677).Conclusion: There is a slight non-significant superiority of Epo than L in UIR pathology restoration (p-value = 0.0677), possibly useful in several clinical situations. 
Diagnostic and Management Challenges of Congenital Dia-phragmatic Hernia in Preterm Newborn: A Case Report in Remote Area, Asmat, South Papua Maluenseng, Priska Priyanka; Toman, Kevin Pieter; Syafina, Adinda Bunga
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 13, No 1 (2026): FEBRUARY
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.13.1.2026.%p

Abstract

Background: Congenital diaphragmatic hernia (CDH) is a rare condition associated with pulmonary complications, as the herniation of abdominal viscera into the chest can impact lung development. The majority of CDH newborns have respiratory issues at delivery or shortly after and require mechanical ventilation, which puts them at risk when they are transferred to a tertiary hospital for more extensive treatment.Objective:This article presents a case of a preterm infant with low birth weight with CDH managed in the General Hospital, Asmat Regency.Case Presentation:A male, born preterm at the gestational age of 31 weeks by spontaneous vaginal delivery, with a birth weight of 1505 grams. The patient had respiratory distress and required invasive ventilation shortly after delivery. When the patient showed improved oxygenation with a nasal cannula, we did a chest X-ray and detected bowel loops in the left hemithorax and mediastinal shift to the right. CDH treatment must be administered in tertiary hospitals to receive standard protocols and multidisciplinary treatment. Transferring the patient to a tertiary hospital requires continuous ventilation on full-day transportation, but the patient was not transportable; thus, we decided to operate. Significant progress was observed three months following the operation.Conclusion: CDH requires a CT scan for definitive diagnosis, an operative procedure, and intensive treatment in a tertiary hospital. Despite the limited resources and no referral options, the patient showed clinical improvements.
Exploring Determinants of Electronic Medical Record (EMR) Ac-ceptance Using the Technology Acceptance Model (TAM): A Sys-tematic Literature Review Mulki, Thariq Malikul; Mundakir, Mundakir; Wiliyanarti, Pipit Festi; Fahrudda, Ansarul
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 13, No 1 (2026): FEBRUARY
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.13.1.2026.%p

Abstract

Background: Digital transformation in the healthcare sector has accelerated the implementation of Electronic Medical Records (EMR) to improve service quality and operational efficiency. However, the level of EMR acceptance among healthcare professionals still varies, indicating that technological readiness alone is not sufficient to ensure successful adoption.Objective: This study aims to analyze the determinants of EMR adoption based on a synthesis of empirical evidence using the Technology Acceptance Model (TAM) frameworkMethods: A systematic literature review was conducted following the PRISMA guidelines. A total of 20 empirical studies published between 2020 and 2025 were selected through systematic identification, screening, eligibility assessment, and quality assessment. The reviewed studies examined key TAM variables, including perceived usefulness (PU) and perceived ease of use (PEOU), as well as external factors such as management support, training, information technology infrastructure readiness, social influence, and digital literacy.Results: The synthesis reveals that PU and PEOU are the most consistent and significant determinants of both the intention to use and actual use of EMR systems. PEOU (Perceived Examination of Use/System Usefulness) often emerges as an initial determinant that influences PU (Perceived Use/User Usefulness), thereby indirectly reinforcing behavioral intent. Organizational factors generally do not have a direct influence on intention, but play an important role in shaping users' perceptions of the usefulness and ease of use of the system. Social factors and digital literacy were found to be increasingly relevant in collaborative and technology-based healthcare environments. Conclusion: Findings indicate that successful EMR implementation depends not only on technical readiness but also on organizational strategies and user capacity-building interventions. During the digital adoption transition phase, prioritizing system usability and ongoing training is essential to increase acceptance. Further research is recommended to integrate TAM (Technology Acceptance Model) with other behavioral theories, such as UTAUT (Uniform Teaching and Understanding/Information Technology), to better understand the dynamics of EMR acceptance in the context of mandatory policies, particularly in Indonesia following the implementation of PMK No. 24 of 2022.

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