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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 270 Documents
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Pengaruh Nitrogen Cair terhadap Morfologi dan Jumlah Fibroblas pada Tendon Patela Tikus Wistar Jantan Isma, Satria Pandu Persada; Norahmawati, Eviana; Irsan, Istan Irmansyah; Asmiragani, Syaifullah; Phatama, Krisna Yuarno; Adiwignyo, Dandy Drestanto; Pratama, Yudit Alfa`
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Introduction: Cryoablation with liquid nitrogen has shown promise in treating bone sarcomas, but its effect on fibroblast morphology and viability in ligament tissues remains unclear. This study aims to evaluate the impact of liquid nitrogen on fibroblasts in the patellar tendon ligament of male Wistar rats. Methods: This experimental study utilized 28 male Wistar rats (6 months old, 300-400 grams) that were randomly divided into four groups. The control group was not exposed to liquid nitrogen, while the experimental groups were exposed to liquid nitrogen for 1, 5, and 10 minutes. After a 7-day acclimatization, the rats were exposed to liquid nitrogen and euthanized. The patellar tendon ligaments were collected for histological analysis, stained with Hematoxylin-Eosin, and examined under a microscope. Statistical analysis was performed using One-Way ANOVA, followed by Tukey post hoc tests to determine the significant differences between the exposure times. Results: Significant changes were observed in fibroblast morphology and count with increasing exposure times. One-way ANOVA analysis revealed significant differences (p < 0.001) in fibroblast count and morphological alterations across exposure groups. Tukey post hoc tests revealed that 10-minute exposure resulted in substantial reductions in fibroblast count and viability, accompanied by progressive morphological changes as exposure time increased. Discussion: Liquid nitrogen exposure significantly impacts fibroblast cells, with longer exposure times causing more severe cellular damage. The exposure duration should be carefully controlled in cryotherapy to optimize therapeutic benefits. Conclusion: Exposure to liquid nitrogen adversely affects fibroblast cells in the patellar tendon ligament, with prolonged exposure resulting in decreased cesll viability and morphological changes.
OPTIMALISASI PERAN KADER POSYANDU DALAM UPAYA PENCEGAHAN STUNTING MELALUI PSIKOEDUKASI CILUKBA niken, niken merna; Mira
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Background, Stunting is a growth disorder that may indicate abnormalities in various organs, including the brain. The brain is a vital neural center that significantly influences a child’s ability to see, hear, think, and perform motor functions. Prolonged nutritional deficiencies can cause permanent brain function impairment. Furthermore, children who experience stunting are more susceptible to illness, decreased cognitive abilities, lower academic performance, and even disability in old age. Objective, To determine the effect of psychoeducation using the CILUKBA method on the role of Posyandu cadres in stunting prevention efforts. Method, This research employed a pre-experimental one-group pre-test and post-test design conducted in Dauh Puri Kaja Village, under the jurisdiction of Public Health Center (Puskesmas) III North Denpasar. The subjects were 36 Posyandu cadres in Wanasari Hamlet, Dauh Puri Kaja Village. Data were collected using a questionnaire and analyzed with the Wilcoxon test. Results, Before the intervention, 19 respondents (52.8%) had a moderate level of knowledge, 30 respondents (83.3%) showed a moderate attitude, and 27 respondents (75%) demonstrated moderate practices. After the intervention, 30 respondents (83.3%) had a good level of knowledge, 29 respondents (90%) demonstrated a good attitude, and 29 respondents (80.6%) had good practices. The Wilcoxon statistical test showed a p-value = 0.000 < α (0.05), thus Ho is rejected and Ha is accepted. This indicates that the psychoeducation using the CILUKBA method significantly influences the knowledge, attitude, and practices of Posyandu cadres in stunting prevention efforts. Conclusion, Psychoeducation using the CILUKBA method has a significant effect on improving the knowledge, attitude, and practices of Posyandu cadres in efforts to prevent stunting.
Anemia Berat pada Pembawa Sifat Thalassemia dengan Riwayat Tuberkulosis Peritoneal: Sebuah Laporan Kasus Fadilah, Tubagus Ferdi; Salsabila, Diva Azura; Farsyah, Muhammad Athar; Amelia, Ade
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Thalassemia is a genetic disorder that causes chronic anemia. While the thalassemia trait is typically mild, its severity can be amplified by coexisting conditions. This report discusses a unique case where thalassemia was complicated by peritoneal tuberculosis, leading to an unusually severe anemic state not typical for a carrier. A 15-year-old female undergoing treatment for peritoneal tuberculosis presented with severe anemia (Hemoglobin 7.43 g/dL). Physical examination revealed classic signs of thalassemia such as Cooley's facies and splenomegaly. Laboratory findings confirmed severe microcytic hypochromic anemia, and HPLC analysis showed elevated HbF and the presence of Hb Bart's, consistent with a thalassemia trait. The patient was managed with packed red cell (PRC) transfusions and folic acid, which successfully resolved the acute symptoms. The severe anemia in this patient was likely a result of multifactorial causes: an underlying thalassemia trait compounded by anemia of chronic disease (ACD) from tuberculosis. This case highlights the critical need to investigate for co-morbidities in thalassemia carriers with atypical presentations.
AIR POLLUTION AND THE RISK OF ACUTE EAR, NOSE, AND THROAT INFECTIONS: A CROSS-SECTIONAL STUDY IN WEST JAKARTA Tjhin, Purnamawati
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Background: Air pollution, particularly in urban areas like West Jakarta, is a major public health concern. Long-term exposure to pollutants such as PM2.5 can lead to respiratory problems, including acute otolaryngologic infections. Outdoor workers, such as those involved in urban infrastructure maintenance, are more vulnerable to these conditions. This study aimed to assess the relationship between air pollution levels, mucociliary clearance function, and the prevalence of acute otolaryngologic infections among outdoor workers in West Jakarta. Methods: A cross-sectional study was conducted with 120 Public Infrastructure and Facility Maintenance (PPSU) workers from Cengkareng, Rawa Buaya, and Cengkareng Timur sub-districts. Air quality was measured using data from nearby monitoring stations, assessing PM2.5 levels and the Air Quality Index (AQI). Health assessments included mucociliary clearance testing, Eustachian tube patency evaluation, and the prevalence of acute otolaryngologic infections. Results: The average PM2.5 level was 57.58 μg/m³ (high risk for respiratory issues), and the AQI was 144.71 µg/m³ (unhealthy). Mucociliary clearance (Sakarin test) averaged 427.29 seconds, with a mean nasal cavity length of 63.76 mm. The prevalence of subjective acute rhinosinusitis was 24.2%, rhinopharyngitis 67.5%, and Eustachian tube dysfunction 71.7%. However, no significant correlation was found between air pollution exposure, mucociliary function, and acute otolaryngologic infections (p > 0.05). Conclusion: Despite high exposure to air pollution, no significant relationship was found between air pollution, mucociliary clearance, and acute otolaryngologic infections in PPSU workers. Further studies with larger sample sizes and longitudinal designs are needed. Keywords: Air pollution; acute otolaryngologic infections; mucociliary clearance, outdoor workers; PM2.5
Analisis Aterogenik Indeks Plasma Terhadap Obesitas dan Normal Weight Obesity Pada Dewasa Muda Anwar, Rofila Asjad; de Lima, Filda Vionita Irene; Latief, Rahmi Rifany; Mus, Rosdiana; Latuconsina, Vina Zakiah; Agustin, Rachmawati Dwi
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Background Obesity is characterized by the excessive accumulation of body fat, which heightens cardiovascular risk. Normal Weight Obesity (NWO) is a recently identified phenotype of obesity. It describes individuals who have a Body Mass Index (BMI) within the normal range but a high body fat percentage (>25% for male and >30% for female). Despite its outwardly healthy appearance, NWO poses significant hidden cardiovascular risks due to this internal fat accumulation. A major biomarker for determining cardiovascular risk is the Atherogenic Indeks of Plasma (AIP), which is calculated as the logarithmic value of the ratio of triglycerides to high-density lipoprotein (HDL) cholesterol. Methods This study utilized a total sample size of 52 subjects, which were divided into two equal groups 26 students comprised the Normal Weight Obesity (NWO) group and 26 students comprised the obesity group. The classification of participants into the NWO and obesity groups was determined through measurements obtained using a Bioelectrical Impedance Analyzer (BIA) and microtoise. Measurements of triglyceride and High-Density Lipoprotein (HDL) levels were conducted using the Glycerol Phosphate Oxidase/Peroxidase (GPOP) method and the Cholesterol HDL Direct method, respectively, at the Maluku Province Health Laboratory. The resulting data were subjected to statistical analysis using the Chi-square test. Results There were no significant difference in AIP value (p value = 0.578) between NWO group (Mean=0.19; SD=0.18) and obesity group (Mean=0.26; SD=0.23). Conclusions This study concluded that there was no difference in the AIP value of the NWO and obesity groups in medical students of the Faculty of Medicine, Pattimura University. Keywords: Atherogenic Index Plasma; Normal Weight Obesity; Obesity
PREOPERATIVE EMBOLIZATION FOR NASOPHARYNGEAL ANGIOFIBROMA Abdillah, Fauzan; Nugroho, Dwi Agustawan; Fadillah, Ibnu Harris; Mashabi, Yasmine; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Background: Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign vascular tumor that almost exclusively affects adolescent males. Despite its benign nature, JNA demonstrates locally aggressive behavior and is associated with significant intraoperative bleeding. Preoperative embolization has become an important modality to reduce tumor vascularization and minimize intraoperative blood loss. The Objective of this case report is to discuss the role of preoperative embolization in the management of JNA, including relevant vascular anatomy, embolic materials, benefits and limitations, as well as local case experiences in Indonesia. Methods: A literature review was conducted on the external carotid artery anatomy, etiology, epidemiology, histopathology, tumor spread and staging, and preoperative embolization techniques using various materials such as gelfoam, polyvinyl alcohol, ethanol, and microspheres. Additionally, two cases of JNA at Cipto Mangunkusumo Hospital were reported, both treated with preoperative embolization using gelfoam prior to transpalatal tumor resection. Results: In both cases, embolization successfully reduced tumor vascularity. However, due to surgical delay beyond 48 hours after embolization, intraoperative bleeding remained significant (800–1000 mL). Both patients recovered uneventfully without postoperative complications, and histopathological findings confirmed JNA. Conclusion: Preoperative embolization is effective in reducing intraoperative blood loss during JNA surgery and should ideally be performed within 24–48 hours before resection. This approach facilitates safer tumor removal, although its optimal success depends on timing, embolization technique, and operator expertise.
Studi Kasus – Kelola: Paparan Asap Rokok dan Kunjungan Antenatal sebagai Faktor Risiko Kejadian Kelahiran Prematur Kurniasari, Kurniasari; Hasmah Zachrani, Aliviannisa
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Background: Premature birth is still one of the largest contributors to infant mortality in Indonesia. In addition, babies born prematurely tend to develop diseases more easily. Obstetric (obstetric) factors such as the number of parity and frequency of antenatal visits as well as environmental factors such as exposure to cigarette smoke can influence the incidence of preterm birth. In Indonesia, parity is still high and the frequency of antenatal visits still varies from region to region, as well as a lack of understanding of the dangers of second-hand smoking for fetuses. This study aims to analyze the relationship and risk of parity, frequency of antenatal visits, and second-hand smoking with the incidence of premature birth. Methods: This study is a case study of Managed using the subjects of pregnant women aged 20 – 35 years who gave birth to premature and preterm babies in the period of January 2022 – December 2023 in hospitals. Pregnant women with hypertension during pregnancy, experiencing complications of antepartum hemorrhage, multiple pregnancies, smoking, alcohol consumption, and giving birth to babies with postterm gestational age (>42 weeks) were not included in this study. The questionnaire was used to collect data on the amount of parity, second-hand smoking history and frequency of antenatal visits in the last pregnancy, as well as gestational age at childbirth. Medical records and Maternal – Child Health Books are used to confirm the data collected through questionnaires. The relationship and magnitude of the risk of parity, second-hand smoking, frequency of antenatal visits to preterm birth were analyzed using the Chi-Square Test. Results: Exposure to cigarette smoke (p=0.036;OR=2.727(CI: 1.058 - 7.031)) and antenatal visits (p=0.033;OR=4.167(CI: 1.046 - 16.605)) were associated with the incidence of preterm birth, while the amount of parity was not associated (p=0.251;OR=1.699(CI: 0.685 - 4.209) with the incidence of preterm birth. Conclusions: Mothers who were exposed to cigarette smoke ≥ 5 sticks/day and had non-routine antenatal visits had a 2,727 times greater and 4,167 times greater risk of premature birth.
The Effect of Health Education on Leprosy-Related Stigma Among Patients and Family Contacts at Prof. Dr. I.G.N.G. Ngoerah General Hospital: A Pre- and Post-Study Sari, Luh Putu Sustiana Kartika; N. L. P Ratih Vibriyanti Karna; Luh Made Mas Rusyati
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Background Stigma against leprosy patients remains a challenge in efforts to control this disease. Educational interventions are needed to increase public knowledge and reduce prejudice against patients. This study aims to evaluate the effect of education on leprosy stigma among patients and their family contacts at Prof. Dr. I.G.N.G. Ngoerah General Hospital. Methods This study used a quasi-experimental design with a one-group pretest-posttest approach. The study was conducted at the Dermatology and Venereology Polyclinic of Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Bali, from February to July 2025. Data analysis was performed using SPSS software version 26.0 with a significance level of α = 0.05. Results A total of 50 respondents were involved, consisting of 37 leprosy patients and 13 family members. A significant relationship was found between stigma before and after health education (p = 0.031). Educational level (p = 0.001), clinical presentation (p = 0.002), and economic level (p = 0.029) were also significantly associated with the level of stigma after health education. Respondents with higher education showed a significant decrease in stigma (OR = 11.245; 95% CI: 2.044–61.862; p = 0.005). Similarly, respondents with non-neurological disorders showed lower levels of stigma (OR = 12.415; 95% CI: 2.208–69.808; p = 0.004). Conclusions The findings of this study indicate that health education significantly contributed to reducing leprosy-related stigma, with educational level and clinical presentation identified as key determining factors.
Effect of Deferiprone and Phaleria macrocarpa Fruit Extract on Renal Iron Accumulation in Rat Wahyudy, Silvy
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Iron overload can induce oxidative stress and kidney injury by increasing reactive oxygen species (ROS) production and reducing antioxidant capacity, including total glutathione (T-GSH). Chelation therapy using deferiprone (DFP) as a standard agent and ethanolic Phaleria macrocarpa (PM) fruit extract as a natural candidate is expected to reduce renal iron accumulation and restore redox balance. This study aimed to evaluate the effects of DFP, PM, and their combination on renal iron and T-GSH levels in an iron-overloaded rat model. A parallel in vivo experiment was conducted using 30 male Sprague-Dawley rats (29 analyzed) with iron overload induced by intraperitoneal iron-dextran injection (0.3 mL, ±15 mg Fe) twice weekly for three weeks, followed by daily oral treatments for five weeks. The rats were divided into six groups: normal (N), iron overload (IO), DFP 462.5 mg/kg BW (D), PM 100 mg/kg BW (PM), DFP 462.5 mg/kg BW + PM (DPM-1), and DFP 231.25 mg/kg BW + PM (DPM-2). Kidney iron levels were determined using atomic absorption spectrophotometry (AAS, λ 248.3 nm), and T-GSH was measured colorimetrically (λ 412 nm). Statistical analysis employed one-way ANOVA with post-hoc LSD for iron data and the Mann-Whitney U test for T-GSH (p < 0.05). The IO group showed a 1.44-fold increase in kidney iron compared with the normal group, while DFP, PM, and their combinations had no significant effect (p = 0.490). Mann-Whitney analysis revealed a significant difference in T-GSH between PM and DPM-1 (p = 0.034). In conclusion, the DFP-PM combination (DPM-1) demonstrated a potential synergistic effect in enhancing renal T-GSH levels, although it did not significantly reduce iron accumulation. Further studies with longer treatment durations and additional antioxidant parameters are recommended to confirm the protective potential of DFP-PM combination therapy against oxidative stress and ferroptosis in iron-overloaded kidneys.
Polycystic Ovarian Syndrome (PCOS) in Adolescent Girls in Indonesia: A New Burden in Women Reproductive Health Murthi, Aditya Krishna
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Adolescence is a crucial phase in individual growth and development, especially for young women, who experience significant physical and hormonal changes. These changes impact reproductive health, including the regularity of the menstrual cycle. Menstrual cycle irregularities can be an early manifestation of Polycystic Ovarian Syndrome (PCOS), one of the most common endocrine disorders in women of reproductive age. Hyperandrogenism, ovulatory disorders, and polycystic ovarian morphology characterize PCOS. Its prevalence in adolescents ranges from 6–10% and tends to increase with lifestyle changes such as a high-calorie diet, lack of physical activity, and psychological stress. Pathophysiologically, PCOS involves complex interactions among genetic, epigenetic, and environmental factors that disrupt the balance of hormones LH, FSH, and AMH and cause insulin resistance. This condition triggers hyperandrogenism, inhibits follicular maturation, and leads to chronic anovulation. The diagnosis of PCOS in adolescents requires caution based on the Rotterdam Consensus (2003) and the 2018 International Guidelines, taking into account similarities to the physiological symptoms of puberty. PCOS is strongly linked to obesity, metabolic syndrome, and family history, with insulin resistance playing a significant role in its development. Elevated Anti-Müllerian Hormone (AMH) levels indicate the severity of PCOS and are associated with metabolic disorders. Therefore, a preventive, holistic approach that promotes a healthy lifestyle is essential for adolescents, including education on balanced nutrition, increased physical activity, and stress management. These measures are expected to decrease the occurrence of PCOS and long-term complications such as infertility and metabolic syndrome in young women in Indonesia.

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