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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
Arjuna Subject : -
Articles 270 Documents
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Hubungan antara Tingkat Pemahaman Piktogram (Label Keamanan Kimia) dan Sikap terhadap Kepatuhan Kesehatan dan Keselamatan Kerja di Laboratorium Kimia Universitas Nusa Cendana Karolus Tokan, Yohanes; Roga, Anderias Umbu; Muntasir, Muntasir; Ratu, Jacob M; Riwu, Magdarita
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.282-292

Abstract

Background Students' knowledge of OHS is a basic knowledge that must be possessed by students before and during experiments in chemistry laboratories. Hazard pictograms warn us of the presence of hazardous chemicals. Student compliance with OHS and basic knowledge that students must have before and during experiments in chemistry laboratories. This research was to analyze the relationship between the level of knowledge, skills, and occupational health and safety (OHS) compliance in the Chemistry Laboratory at Nusa Cendana University to minimize risks and prevent occupational accidents in the Laboratory. Methods Observational analytical research with cross-sectional design. The population was students of Chemical Education (FKIP), Chemical Science Students (FST), and Pharmacy Students (FKKH) of Nusa Cendana University. A sample of 75 samples was taken. Data were collected using a questionnaire that was observed during February - March 2024. Measurement of the average value of compliance, attitude, and knowledge between the three study programs using statistical analysis conducted is univariate and bivariate using the chi-square test (p=0.05). Results The attitude variable has a significant effect on compliance. In the skill variable statistical results on SPSS version 25 with Chi-Square analysis, the results obtained a p-value of 0.330 (>0.05) which can be concluded that there is no relationship between OSH compliance in Nusa cendana university students.  The attitude variable has a significant effect on compliance. The positive coefficient value indicates that the influence exerted by attitude on compliance is positive. Statistical results on SPSS version 25 with Chi-Square analysis, the results obtained a p-value of 0.000 (>0.05) which can be concluded that there is a relationship between the level of attitude towards OHS compliance in students.     Conclusions The level of knowledge of students does not have a significant effect on compliance in OHS, while Attitude, has a significant effect on OHS Laboratory OHS.
Rambut Beruban Prematur pada Anak Usia Tujuh Tahun Wijaya, Edward; Winaya, Ketut Kwartantaya; Sadeli, Marrietta Sugiarti
Jurnal Biomedika dan Kesehatan Vol 7 No 3 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.345-350

Abstract

Premature graying of hair is defined as the occurrence of gray hair, depending on ethnicity, before the age of 30 in Africans, 25 in Asians, and 20 in Caucasians. Premature graying is an important cause of low self-esteem, which often interferes with sociocultural adjustment. Premature graying, known as premature canitis, the exact etiopathogenesis is still unknown, although it has been associated with disorders of premature aging, atopy, and autoimmune diseases. Many pathological conditions have been discussed in relation to premature canitis such as certain medications, deficiencies of Vitamin B12, vitiligo, hypothyroidism, and progeroid syndromes. Premature canitis may occur as an autosomal dominant condition only or associated with premature aging syndromes or various autoimmune. This condition needs to be differentiated from the various genetic hypomelanosis hair disorders. Patients with PGH should be evaluated for metabolic diseases and syndromes. Among the various pharmacotherapeutic management options, calcium pantothenate, PABA, and a combination of calcium pantothenate + PABA can be given. Some herbal agents such as Anu-tailam has been evaluated in a clinical research setting. Hair dye remains the primary treatment modality for cosmetic problems after nutritional supplementation. Lastly, addressing underlying pathological conditions often results in a reversal of the condition in many cases.
Mengungkap Potensi Platelet-Rich Plasma untuk Meningkatkan Kualitas Hidup Pasien dengan Nyeri Punggung Bawah: Sebuah Tinjauan Literatur Sasongko, Muhammad Gagas; Ramadhan, Dwiky Ananda; Luwito, Jeffry; Latumahina, Jonathan; Widyatmiko, Himawan; Witarto, Andro Pramana
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Low back pain (LBP) is a widespread issue that affects many people globally, causing significant limitations in daily activities and work. LBP imposes a considerable economic burden due to healthcare costs and lost productivity. This review explores platelet-rich plasma (PRP) therapy, a promising treatment because of its ability to regenerate tissues. PRP contains growth factors that stimulate cell activity and collagen production, which can significantly reduce pain and enhance mobility and quality of life for LBP sufferers. PRP's capacity to aid in tissue repair and decrease inflammation suggests it could be beneficial for these various causes. Compelling clinical studies have demonstrated that PRP can dramatically reduce pain and disability, offering patients renewed hope and improved outcomes. Additionally, PRP therapy is minimally invasive with rare and mild side effects, underscoring its safety and efficacy. This review underscores the urgent need for further research to refine PRP treatment protocols and confirm long-term benefits. Large-scale randomized controlled trials are essential to develop standardized guidelines and ensure consistent, positive results across diverse patient populations. PRP therapy represents a revolutionary approach to managing LBP, promising to address the root causes and deliver lasting relief rather than merely masking symptoms. The future of LBP treatment could be significantly improved through the widespread adoption of PRP therapy.
Pengaruh Memory Training terhadap Memori Jangka Pendek pada Lansia Sidarta, Nuryani
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

BACKGROUND Decreased short-term memory capacity is a normal part of the aging process. According to the head of the Indonesian Psychogeriatric Association, 30% of the elderly experience memory impairment at the age of 50-59 years, and the percentage increases until the prevalence reaches 85% in the elderly aged up to 85 years. Memory training can be done with mnemonic techniques. This study aims to see the effect of memory training on the elderly, especially short-term memory. METHODS This study used a quasi-experiment method with a one group pre test-post test design. The population in this study were elderly subjects (> 60 years) at Panti Werdha Wisma Mulia with a sample size of 40 people taken with total sampling technique. The research data were analyzed using the Wilcoxon test. RESULTS The results of this study showed that most of the elderly (67.5%) had low short-term memory and more (62.9%) were found in the elderly female group. After being given memory training, there was a significant increase in short-term memory capacity with a p value of 0.000 (p ≤ 0.05). CONCLUSIONS Memory training has a significant effect on improving short-term memory capacity. Keywords: memory training, short-term memory, elderly, gender
The Potential of Mesenchymal Stem Cells in Wound Healing using Nanofiber Scaffold: A Mini Review Rambe Purba, Priskila Natasya; Rofaani, Elrade; Astirin, Okid Parama
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Currently, the use of mesenchymal stem cells (MSCs) in cell therapy is growing as a means to repair damaged cells. MSCs are multipotent stem cells that can differentiate into a variety of specialized cell types in various tissues. Adipose tissue, bone marrow, umbilical cord, and placenta are possible sources of MSCs. MSCs produce various bioactive molecules, called secretome that have effects on skin cells by mediating growth factors and cytokines. MSCs can actively contribute to wound healing through several phases, including promoting fibroblast migration, neovascularization, secreting anti-inflammatory cytokines, and re-epithelialization. To improve therapeutic effectiveness, appropriate biomaterials on nanofiber scaffolds were created to mimic the natural extracellular matrix and attract fibroblasts into the skin layer. The purpose of this review is to evaluate the research on the utilization of MSCs with various nanofiber scaffolds in the wound healing process in vitro. The result of this review is that there are several natural and synthetic polymers used as scaffold materials that are biocompatible, thus increasing the healing potential of wound tissue. MSCs when co-cultured in nanofiber scaffolds activate several mechanism pathways, such as expressing genes or growth factors related to wound healing. It is concluded that the utilization of biopolymers in MSC-seeded scaffold designs can contribute to the enhancement of wound healing and tissue regeneration.
Determinants of National Health Insurance Utilization for Catastrophic Disease Management in Indonesia Widayati, Hesti Prawita; Intiasari, Arih Diyaning; Rejeki, Dwi Sarwani Sri
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Latar Belakang: Penyakit katastrofik merupakan penyakit yang membutuhkan biaya yang besar sehingga diperlukan Jaminan Kesehatan Nasional untuk menjaminnya. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor pendukung pemanfaatan Jaminan Kesehatan Nasional (JKN) untuk penanganan penyakit katastrofik. Subjek dan Metode: Penelitian dilakukan secara sistematis dengan pendekatan PRISMA. Pencarian dilakukan dengan menggunakan basis data elektronik yang terdiri dari PubMed, PubMed central, semantic scholar, google scholar dengan kata kunci pemanfaatan Jaminan Kesehatan Nasional dan penyakit katastrofik, menghasilkan 678 artikel yang dipersempit menjadi 6 artikel yang relevan selama kurun waktu 10 tahun. Hasil: Faktor-faktor pendukung pemanfaatan JKN untuk penanganan penyakit katastrofik di Indonesia adalah pendapatan keluarga, jumlah anggota keluarga, status perkawinan, jenis kelamin, usia, biaya pengobatan dan penyakit kronis, Kesimpulan: Kajian penelitian ini dapat menemukan faktor-faktor pendukung pemanfaatan Jaminan Kesehatan Nasional dalam penanganan penyakit katastrofik di Indonesia. Temuan dari berbagai negara menunjukkan bahwa pendapatan, jumlah anggota keluarga, status perkawinan, jenis kelamin, usia, biaya pengobatan dan penyakit kronis berperan penting dalam pemanfaatan JKN dalam penanganan penyakit katastrofik.
Shielding the Skin: A Comprehensive Review of Inorganic Sunscreens and Their Role in Photoprotection Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Sunscreens are topical agents designed to protect the skin from the damaging effects of ultraviolet (UV) radiation, a major contributor to premature aging and skin cancer. These products are typically categorized into two main types: physical (inorganic or mineral) and chemical (organic) sunscreens. Physical sunscreens primarily consist of zinc oxide (ZnO) and titanium dioxide (TiO₂), which act by reflecting and scattering UV rays, thereby providing broad-spectrum protection. Compared to chemical sunscreens, which absorb UV radiation and transform it into heat, inorganic agents are associated with a lower risk of systemic absorption and skin irritation, making them particularly suitable for sensitive skin and pediatric use. This review explores the fundamental mechanisms of action, formulation challenges, and comparative effectiveness of inorganic sunscreens. Special attention is given to their photostability, which contributes to longer-lasting protection, and their safety profiles in both acute and chronic use. Additionally, recent innovations in nanoparticle technology have enhanced the aesthetic appeal of these agents by reducing visible residue. However, this has also raised new concerns regarding nanoparticle penetration and environmental impact. Finally, the review addresses public health considerations, including regulatory updates, consumer preferences, and the role of education in promoting informed use of sunscreen.
Hubungan Usia Menarche dengan Kejadian Kanker Payudara pada Wanita Dewasa Balgahoom, Najwa; Surjadi, Lily Marliany; Kurniawan, Febriyanto
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Background: Breast cancer is a non-communicable disease that is a health problem worldwide. Based on breast cancer prevalence data according to the World Health Organization (WHO) in 2020, 2.3 million women have been diagnosed, and 685,000 of them have died from breast cancer. There are several factors that can increase the risk of possible breast cancer incidence, some of which are age of menarche, nulliparity (never giving birth), and obesity. The purpose of this study was to determine the relationship between age at menarche, body mass index (BMI), and nulliparity with the incidence of breast cancer in adult women. Methods: This cross-sectional study was conducted at Dharmais Cancer Hospital, Jakarta, with 104 respondents aged 19-59 years with breast complaints in the period March-May 2024. By excluding respondents with consecutive non-random sampling techniques. Data analysis using the Mann-Whitney test with a probability level (p < 0.05). Results: The results showed that 98 respondents had breast cancer, and >80% of them had the no special type (NST) breast cancer. While 6 other respondents were not diagnosed with breast cancer. There were 62 respondents with normal menarche age (>12 years), with a p-value = 0.979. There were 91 respondents with multiparity, with a p-value = 0.891. In addition, 74 respondents had excessive body mass index (BMI), with a p-value = 0.336. Conclusions Based on statistical analysis, it can be concluded that there is no significant relationship between menarche age, body mass index (BMI), and parity with breast cancer in adult women. Keywords: Breast cancer, menarche age, body mass index (BMI), nulliparity.
CAESAREAN SCAR ENDOMETRIOSIS: REPORT AND LITERATURE REVIEW Yastani, Deasyka
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Background: Caesarean scar endometriosis is a rare form of extra pelvic endometriosis that often presents with nonspecific symptoms, leading to diagnostic challenges. Case Presentation: We report the case of a 41-year-old woman who presented with a painful subcutaneous mass at the site of a previous caesarean section, noted eight months post-surgery. MRI imaging revealed a mass suggestive of cutaneous endometriosis, and wide excision was performed. Histopathological analysis confirmed the diagnosis with identification of endometrial glands and stroma within the cutaneous tissue. Discussion: Caesarean scar endometriosis is often associated with Pfannenstiel incisions, with a latency period of symptom onset averaging over two years. While imaging such as MRI is useful for preoperative assessment, surgical excision remains the definitive treatment. Recurrence is uncommon but can occur. Iatrogenic seeding of endometrial cells during surgery is a likely etiological factor, highlighting the importance of proper surgical technique and wound cleaning. Conclusion: Although rare, cutaneous endometriosis should be considered in women presenting with cyclical pain and masses at surgical scars post-caesarean. Early recognition and surgical intervention are key to effective management and prevention of recurrence.Keywords: Cutaneus Endometriosis; Caesarean Scar; Abdominal wall mass.
Perbandingan Kualitas Hidup Berdasarkan Hasil Nilai SNOT-22 pada Penderita Rinosinusitis Kronik Sebelum dan Sesudah Terapi Irigasi Nasal dengan Larutan NaCl 0,9% Teuku Husni , Teuku Husni TR; Zakiaturrahmi, Zakiaturrahmi; Syakirah, Raihan
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Chronic Rhinosinusitis (CRS) is an inflammatory condition affecting the nasal mucosa and paranasal sinuses that persists for 12 weeks or longer. This condition frequently leads to physical, emotional, and social impairments in patients. CRS can significantly impact quality of life, characterized by symptoms such as nasal congestion, facial pain or pressure, and impaired sense of smell. Proactive management is essential for CRS, and nasal irrigation with a 0.9% NaCl solution is considered a supportive therapy that may help alleviate the condition. This study aims to evaluate changes in quality of life based on scores from the Sinonasal Outcome Test-22 (SNOT-22), a questionnaire comprising 22 items, in CRS patients before and 10 days after undergoing nasal irrigation therapy with a 0.9% NaCl solution. The research was conducted as an analytical observational study using a cross-sectional approach, involving 36 adult patients (aged 18–60 years) diagnosed with CRS at Zainoel Abidin Regional General Hospital, Banda Aceh. Data were collected using the SNOT-22 questionnaire, administered both before and 10 days after nasal irrigation therapy. The study identified a higher prevalence of CRS in female patients compared to male patients and in the young adult age group (20–40 years), likely associated with hormonal factors and environmental exposure. Normality testing yielded a p-value > 0.05, indicating that the data were normally distributed. For normally distributed data, a paired t-test was applied to compare pre- and post-treatment scores. Statistical analysis revealed a significant difference between SNOT-22 scores before and 10 days after nasal irrigation therapy using a 0.9% NaCl solution (p-value < 0.05). The reduction in SNOT-22 scores reflects improvements in physical symptoms, such as nasal congestion and facial pain, as well as in the emotional and social well-being of patients.

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