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HAYATI Journal of Biosciences
ISSN : 19783019     EISSN : 20864094     DOI : -
HAYATI Journal of Biosciences (HAYATI J Biosci) publishes articles and short communication in tropical bioscience fields such as development, biotechnology, biodiversity and environmental issues. HAYATI J Biosci covers wide range of all life forms topics including virus, microbes, fungi, plants, animal and human. HAYATI J Biosci has been also indexed/registered in Crossref, DOAJ, CABI, EBSCO, Agricola and ProQuest.
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Articles 1,091 Documents
Exploring the Anti-Photoaging Potential of Bacillus cereus Superoxide Dismutase in New Zealand Rabbit Skin Indrayati, Ana; Nurfitriyawatie; Rukmana, Rizal Maarif
HAYATI Journal of Biosciences Vol. 31 No. 2 (2024): March 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.2.357-366

Abstract

Bacillus cereus is a heat-resistant bacteria that produces the enzyme superoxide dismutase (SOD). SOD is a metalloenzyme that can eliminate free radicals as the primary cause of photoaging. The point of this study is to find out how well B. cereus works as an anti-photoaging agent on the skin of rabbits’ backs. The SOD enzyme was isolated from B. cereus using the colorimetric method and characterized for its activity. It was encapsulated by the liposome method, while the activity was measured on the rabbit’s back skin exposed to ultraviolet-A (UV-A) radiation with the parameters of moisture, elasticity, and collagen levels using a skin analyzer. At the end of the treatment, a histological test for the animal skin was performed. The particle size analysis (PSA) results on the SOD in liposomes showed nanoparticles with an adsorption efficiency of 85.0% and a zeta potential of 28.0±11.7 mV. SOD encapsulated in the liposomes also indicated anti-photoaging activity potential by increasing collagen, elasticity, and moisture levels. In addition, histological tests revealed that the collagen density in the SOD liposome treatment was higher than the negatively of control and normally of control but lower than the liposome collagen.
Variation and Distribution of the Sulawesi Giant Rat (Paruromys dominator) Based on Morphological Approaches Dwijayanti, Endah; Suryobroto, Bambang; Widayati, Kanthi Arum; Achmadi, Anang Setiawan
HAYATI Journal of Biosciences Vol. 31 No. 6 (2024): November 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.6.1037-1049

Abstract

Correlations between natural geographic boundaries and variations in organisms' morphology have been well-documented in Sulawesi Island, which has a unique geological history and hundreds of endemic species. One of the widely distributed species of small mammals is Sulawesi giant rat (Paruromys dominator). Considering the geographic condition of Sulawesi, this species is a suitable model for studying geographic influences on morphological change. Moreover, there are no comprehensive studies on this species. Previous studies cannot fully explain the variability due to the lack of representative samples. Here, we measure 19 skull characteristics for 131 adult complete-skull specimens from six distribution areas in Sulawesi. We investigate the variation in skull characteristics using agglomeration nesting (AGNES) for cluster analysis and the standardized major axis (SMA) for allometry analysis. Our results show that P. dominator can be categorized into two groups, but distribution areas, elevation, or sex do not influence those. P. dominator in group 1 had a larger skull size than group 2. The two groups can be distinguished from four characteristics: breadth of mesopterygoid fossa (BMF), breadth of first upper molar (BM1), length of the auditory bulla (LB), and breadth of incisive foramina (BIF). The BMF and BM1 are related to mastication, and the LB and BIF are related to communication. We propose that the skull variation of this species is not correlated with geographical barriers but more clearly correlated with their feeding habits, mating behavior, and ability to escape predation. These findings were useful for future studies on the taxonomic status of P. dominator.
Supplementation Impact of Spirulina platensis Ethanol Extract on Inflammatory Homeostasis Modulation of Rat Spleen at Different Ages Paramita, Reni; Purba, Hastuti Handayani S; Prijanti, Ani Retno; Iswanti, Febriana Catur
HAYATI Journal of Biosciences Vol. 31 No. 6 (2024): November 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.6.1231-1242

Abstract

Pro- and anti-inflammatory mediators need to be released in a balanced way to maintain a healthy state as we age. One important regulatory element in the equilibrium of pro- and anti-inflammatory mediators is NF-κB. The purpose of this study was to examine how S. platensis affected the control of inflammatory mediators in young, healthy, emerging adults and adults in rats. In this investigation, 200 mg/kg BW of S. platensis extract was administered to six groups of male Wistar rats, ages 12, 18, and 24 weeks, along with a control group. In both the treatment and control groups, NF-κB p65 protein expression was lower at 24 weeks than it was at 12 and 18 weeks. TNF-α and COX-2 proteins were lower in the treatment group than in the control group. All age groups in the treatment group had higher levels of IL-10 protein than the control group. The quantity of NF-κB p65 was positively correlated with COX-2 and TNF-α. By raising the concentration of NF-κB p65, the ethanolic extract of S. platensis altered a mediator of cellular immunity. A decrease followed this in TNF-α and COX-2 and a rise in IL-10 in the rat spleen at different ages.
Pharmacognostic Evaluation and Antioxidant Activities of Tetracera indica (Christm. and Panz.) Merr Ladeska, Vera; Elya, Berna; Hanafi, Muhammad; Kusmardi; Rohmat, Siti Saudah
HAYATI Journal of Biosciences Vol. 31 No. 5 (2024): September 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.5.836-853

Abstract

The community uses Tetracera indica (Christm. and Panz.) Merr extensively as a traditional medicine. This plant was the main source of raw materials for herbal medicinal products, so identification was needed to ensure its authenticity through pharmacognosy evaluation. The present study evaluated macros- and microscopic characteristics, performed phytochemical analysis, and performed total phenolic (TPC) and flavonoid content (TFC) analysis. The organoleptic and macroscopic studies were carried out through sensory organs. The microscopic characteristics of leaf powder and twigs identification using chloral hydrate and distilled water. Numerous chemical reagents, TLC methods and LC-MS/MS analysis were employed in the phytochemical study. Research employed DPPH and FRAP tests to assess the antioxidant activity. Furthermore, quercetin was used as a marker of antioxidant activity. The morphological marker of the leaf T. indica showed the surface of the leaves is rough bristles, shape elliptic-oblong, margin serratus and phyllotaxy alternate. The stem is lignosus, and the rough stem surface is slightly peeling. The lower leaf surface had paracytic stomata and uniseriate trichomes with tapering ends. Raphide crystals and cork cells were detected in the powder analysis of the twigs. The ethyl acetate extract's twig had the highest TPC and TFC values. Ethyl acetate extract from Tetracera indica twigs has potent antioxidant activity with IC50 = 99.84±0.011 µg/ml (DPPH) and 4296.67±0.024 mol/g (FRAP). The study showed that Tetracera indica contains possible active components that could be developed as novel antioxidants. The result of this study might provide early verification and identification to obtain quality medicinal raw materials.
Biodiversity of Mangrove Brachyuran Crabs of Family Ocypodidae and Sesarmidae in Koto XI Tarusan District, West Sumatera, Indonesia Kamal, Eni; Yuspardianto; Wulandari, Dwieke Putri; Fitriyani; Lubis, Amelia Sriwahyuni
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.507-516

Abstract

The Mangrove ecosystem is an ecosystem that is around the edge of the coast and many organisms live in this ecosystem, one of them is crabs. The crabs that are often found are deposit crabs from the Ocypodidae and Sesarmidae families that act as balancers in the mangrove ecosystem. This study aimed to analyze species, diversity, evenness, and dominance in the mangrove vegetation area of Koto XI Tarusan District, West Sumatera, Indonesia. The method used is the descriptive method. The biodiversity of brachyuran crabs’ families, Ocypodidae and Sesarmidae, was analyzed with the Shannon-Wiener index (H’). Four indices were calculated for crabs Ocypodidae and Sesarmidae: species identification, Shannon-wiener (H’) diversity, evenness, and dominance indices. The results showed that there were six species of deposited crabs from the Ocypodidae and Sesarmidae families, namely Uca bellator, U. rosea, Perisesarma eumolpe, P. plicatum, Sarmatium germaimi, and Sesarma curoense. The most abundant species (Di) came from the family Sesarmidae. However, for all stations, diversity (H') has a value that is in the medium category, and evenness (E) is in the high category at each station. The dominance (D) obtained a value categorized as low at each observation station. The condition of environmental parameters in the mangrove vegetation area is included in the category of a good environment. It is still within normal limits for the crabs of the Ocypodidae and Sesarmidae families to live. Two substrate types are found in each observation path: muddy and sandy mud.
Topical Application of Paraboea leuserensis on Excision Wound with Angiogenesis and Vascular Endothelial Growth Factor Analysis Heryani, Dyah Wijiana; Maya Wardhani, Fiska; Yensuari; Nazimuddin Putri, Nadya; Nardi, Leo; Ikhtiari, Refi
HAYATI Journal of Biosciences Vol. 31 No. 2 (2024): March 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.2.300-316

Abstract

Gagatan harimau or Paraboea leuserensis B.L. Burtt is an endemic plant that grows in limestone areas, natively found in Leuser Mountain Area, North Sumatra Province, Indonesia. This study determines the wound healing potential of P. leuserensis gel-based ethanolic extract (PGEE) on full-thickness excision wounds based on the angiogenesis and VEGF expression. Here, we reported 67 compounds detected by LC-MS/MS from the ethanolic extract. The antibacterial activity regarding pathogenic wound infection was also investigated. The experimental study used 30 Rattus novergicus, randomly divided into five treatment groups: base gel as a negative control, Bioplacenton as a positive control, PGEE 2.5%, 5%, and 10%. Experimental data showed that PGEE indicated a significant effect on bacterial inhibition (p = 0.02), where the greatest inhibitory was found against S. epidermidis. Topical application of PGEE showed significant differences in the number of blood vessels of PGEE 2.5% and 10% (p = 0.007) and expression of VEGF (p<0.05). The correlation between the number of blood vessels and VEGF was also described with the number of macrophages, fibroblasts, collagen, and wound diameter. Overall, this study demonstrates the pharmacological potential of PGEE for wound healing applications regarding angiogenesis and VEGF expression.
Naringin Effect on SARS-CoV-2 Pseudovirus Entry and Spike Mediated Syncytia Formation in hACE2-overexpressing Cells Septisetyani, Endah Puji; Prasetyaningrum, Pekik Wiji; Paramitasari, Komang Alit; Suyoko, Ahmad; Himawan, Alayna Lillahida Indri; Azzahra, Salsabila; Wisnuwardhani, Popi Hadi; Anam, Khairul; Ramadani, Ratna Dwi; Santoso, Adi; Ningrum, Ratih Asmana; Herawati, Neng; Rubiyana, Yana
HAYATI Journal of Biosciences Vol. 31 No. 2 (2024): March 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.2.336-347

Abstract

A molecular docking study demonstrates the interaction between naringin, a citrus flavonoid, with SARS-CoV-2 spike RBD. Nevertheless, in vitro investigation of the inhibitory effect of naringin on SARS-CoV-2 entry and syncytia models has yet to be carried out. We synthesized VSV∆G-GFP/Spike* pseudovirus (PSV) as a SARS-CoV-2 model by pseudotyping VSV∆G-GFP/S* in BHK-21 cells overexpressing the SARS-CoV-2 spike glycoprotein. In the SARS-CoV-2 PSV entry assay, we utilized CHO-K1 cells transfected with hACE2 plasmid, which were then treated with naringin and SARS-CoV-2 PSV/naringin. After 16-18 h incubation, PSV internalization represented by the GFP signal was observed under a fluorescence microscope. Immunofluorescence staining was also performed to probe the SARS-CoV-2 spike and confirm the PSV entry. We performed a syncytia assay using 293T cells co-transfected with SARS-CoV-2 spike/hACE2. Six hours after transfection, the cells were treated with naringin and incubated for another 16-18 hours. Then, we observed syncytia using a phase contrast microscope. Based on fluorescence foci quantification, the results indicated that naringin might inhibit SARS-CoV-2 PSV entry at a concentration of 100 µM (P<0.05). However, naringin did not prevent syncytia formation compared to solvent control. These PSV entry and syncytia assay results suggested that naringin potentially inhibited SARS-CoV-2 viral infection but not cell-to-cell viral transmission.
The Potential of Weissella confusa K2 Isolated from Longan (Dimocarpus longan) Fruit as High Exopolysaccharide-Producing Strain Ma'unatin, Anik; Khoirumiyah, Afifatul Fitri
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.539-547

Abstract

Isolation of Lactic Acid Bacteria (LAB) from various sources has previously been carried out to obtain strains that produce high of exopolysaccharide (EPS). Isolate K2, which was LAB isolated from longan (Dimocarpus longan) fruit, can produce EPS. This study aimed to identify isolate K2, and evaluated the effect of supplementation carbon sources (glucose, fructose, sucrose, and lactose) and pH of media (4, 5, 6, 7, and 8) on EPS production. Isolate K2 was identified as Weissella confusa molecularly based on 16S rDNA, the type of carbon source, and the pH of media had significant effects (P<0.05) on EPS production. W. confusa K2 produced EPS that was highest on media with the supplementation of sucrose as a carbon source and produced the lowest EPS on lactose. The amount of EPS produced by W. confusa K2 under alkaline was higher than under acidic, the highest EPS of 47.703 g/L at pH 8 and the lowest EPS at pH 4 of 1.858 g/L. The physical properties showed EPS has good solubility in water with the solubility and Water Holding Capacity (WHC) at 40.533% and 354% respectively. Based on Surface morphology of EPS with Scanning Electron Microscope (SEM) analysis, the surface structure of EPS was a porous polymer matrix. Fourier Transform Infrared Spectrophotometer (FTIR) results of EPS showed the presence of absorption bands as characteristic of carbohydrates, such as the presence of O-H, C-H, C=O, C=C, C-O-C groups, and glycosidic bonds.
Salt and Heat Stress Trigger Morpho-Physiological Changes, Antioxidant Enzyme and Secondary Metabolites Gene Expression in Rice (Oryza sativa L.) Ubaidillah, Mohammad; Rozzita, Noor; Mufadilah, Mitha Aprilia; Thamrin , Nurhaliza; Puspito, Agung Nugroho; Kim, Kyung Min
HAYATI Journal of Biosciences Vol. 31 No. 2 (2024): March 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.2.256-270

Abstract

Climate change significantly increases salt and heat stress in rice plants. This condition causes plants to activate antioxidant enzymes and produce secondary metabolites. This study aimed to determine the morpho-physiological changes and gene expression profiles of antioxidant enzymes and secondary metabolites. This study used a completely randomized design factorial. The first factor was local rice varieties (IR64, Silaun, and Cigeulis), and the second factor was stress treatments (control, NaCl 150 mM, 40°C, and NaCl 150 mM + 40°C). The results showed that multiple stress significantly affected the plant height, stem length, stem diameter, leaf area, root length, total main root, plant biomass, necrotic length, chlorophyll content, relative water content, and plant ROS production. Multiple stress could up-regulate the gene expression of antioxidant enzymes (Mn-SOD, Cu/Zn SOD, Cytosolic APX, OsAPX1, CAT, OsCATA, and GPOD) in rice after stress combination treatments and increase the secondary metabolites gene expression (P5CS and GABA-T) in all rice varieties. Still, the OsNOMT gene was only active in the Cigeulis variety.
Effects of Surfactants on Biological, Physiological, and Histological Performance of Mahseer Seeds, Neolissochilus soro Rizkiya, Iffi; Juliandi, Berry; Nirmala, Kukuh; Puspaningsih, Dewi; Taufik, Imam
HAYATI Journal of Biosciences Vol. 31 No. 2 (2024): March 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.2.367-373

Abstract

Mahseer (Neolissochilus soro) grows and develops in Indonesian lakes and rivers. However, in line with the increase in population, the pollution load that enters water bodies is increasing due to anthropogenic activities along the river. One of the chemicals that can potentially be a source of water pollution is Linear Alkylbenzene Sulfonate (LAS). This study aims to determine the lethal toxicity of LAS surfactant to mahseer and to analyze the sub-lethal effect of this surfactant on the biological, physiological, and histological conditions of mahseer seeds. Parameters studied included lethal toxicity (LC50), sub-lethal toxicity, and biological, histological, and hematological conditions. The results showed that the LAS surfactant had an LC50-96 hour value of 6.14 mg/L in mahseer and was classified as highly toxic. Fish exposed to LAS for 40 days experienced a decrease in specific growth rate and feed efficiency as the surfactant concentration increased. Exposure to LAS also decreases the number of erythrocytes, hemoglobin, hematocrit, and blood sugar levels while increasing the number of leukocytes. There was also damage to the gills of fish exposed to LAS. In general, the sub-lethal concentration of LAS negatively affected mahseer seeds.

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