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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

JIIS
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Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

ISSN : 2502647X EISSN : 25031902 DOI : https://doi.org/10.36387/jiis

Core Subject : Health,

Medicine & Pharmacology

Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 24 Documents

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Search results for , issue "Vol 6 No 2 (2021): JIIS" : 24 Documents clear

STUDI TINGKAT PENGETAHUAN DAN PERSEPSI TENAGA KESEHATAN MENGENAI PERANAN FARMAKOGENOMIK Muhammad Akib Yuswar; Robiyanto Robiyanto; Eka Kartika Untari; Shoma Rizkifani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Research on the extent to which health practitioners in West Kalimantan understand the important role of pharmacogenomics have not been reported to date. West Kalimantan (Kalbar) is known as a province characterized by three main ethnicities, namely Chinese, Malay and Dayak. Therefore, the potential application of pharmacogenomics for the treatment of patients in health facilities across the province is very possible. This study aimed to measure the level of knowledge and perceptions of health practitioners (participants) about the role of pharmacogenomics in patient treatment plans. This research is descriptive with a questionnaire-based survey method. The data analyzed is primary data from the answers of participants to the online questionnaire. Based on the responses of 106 participants (involving doctors, pharmacists, nurses, midwives, and others) from various cities and districts in West Kalimantan, it was found that the level of knowledge was very good (75.5%), good (17.0%), and not good. (7.5%). The level of participants' perceptions of the role of pharmacogenomics are those who have positive perceptions (97.2%) and negative perceptions (2.8%). It can be concluded that 75% of health practitioners in West Kalimantan have a very good level of knowledge and 97% of them own a positive perception of the importance of pharmacogenomics.

EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN BENALU KERSEN (Dendrophthoe pentandra (L.) Miq) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN Adiyatma Putra Mahardika; Sadakata Sinulingga; Medina Athiah; Subandrate Subandrate
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

This study aims to determine the effect of lowering blood glucose. The study was conducted in an experimental laboratory in vivo with one group randomized prepost-test design. The extract was made through the gradual maceration process of Benalu Kersen leaf simplicia with ethanol solvent. The extract was divided into three groups with doses of 65 mg / kg, 130 mg / kg, and 260 mg / kg of body weight. The sample used was 9 male white rats (Rattus norvegicus) which were randomly divided into three groups. Blood glucose levels were measured before induction, after induction, after 7 days, and after 14 days of giving the extract. Data analysis was performed in the form of homogeneity test, normality test, paired t-test using Excel and SPSS programs. There was significant decrease in blood glucose levels on day 0 to day 7 in dose II group. The largest percentage reduction in blood glucose levels was shown in dose II group, namely 32.6%, followed by dose I group at 18.89%. The ethanol extract of Benalu kersen leaves did have an effect of lowering blood glucose levels on alloxan-induced male white rats.

SKRINING SENYAWA INHIBITOR H2 DARI KAYU MANIS (Cinnamomum verum J.Presl) Samsul Hadi; Diah Aulia Rosanti; Desiya Ramayanti Azhara; Kunti Nastiti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Digestive tract disorders, especially gastric disorders, are often experienced by people. One drug to treat this disorder has a mechanism of blocking the H2 receptor. This research was conducted to find compounds from C.verum which have the stability of bind to H2 receptors. The method used is protein modeling with swiss-model, docking with PLANTS (CHEMPLP) and activity prediction. The test results obtained that the docking score was ?- amorphene (-65,79), ?-bergamotene (-65,48), ?-copaene (-66,62), ?-cubebene (-66,46), Cadinene (-64 , 79), Camphor (-52.15), Caryophyllene (-62.61), Cinnamaldehyde (-68.17), Epicatechin (-80.43), Ergosterol (-85.24), Eugenol (-67.35), Hydrocinnamaldehyde (-65,53), Quercetin (-74,38), Protocatechuic acid (-71,49), Stigmasterol (-88,88), 4- (2,3-dihydro-3- (hydroxymethyl) - 5- (3-hydroxypropyl) -7- (methoxy) benzofuranyl] -2-methoxyphenyl (-85,29). Combined with the probability activity of compounds that have the potential to be further developed are Epicatechin and urolignoside.

PHYSICAL STABILITY TEST AND ETHANOL CREAM IRRITATION TEST OF Moringa oleifera L. Nining Sugihartini; Zainab Zainab; Aji Pamungkas
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

The development of topical dosage forms of Moringa leaf extract cream has been carried out because of its properties that can moisturize the skin. A pharamceutical preparation must meet the requirements of stability and non toxic. The study aimed to determine the effect of variations un the concentration ethanol extract cream of Moringa leaf of physical stability and irritability. Ethanol extract of Moringa leaves was obtained by maceration method with 50% ethanol solvent. The extract was then formulated in the form of O/W base scarring with concentrations of 1% (F1), 3% (F2), and 5% (F3). Creams were evaluated for physical stability including mechanical tests (centrifugation) and physical stability at room temperature (25 Ã‚Â± 2oC) with parameters pH, viscosity on days 1, 7, 14, 21 and 28. In addition, creams were also evaluated for their irritability in vivo with using test animals (rabbits). The data obtained were analyzed using one-way ANOVA test. The results of the physical stability test showed that an increase in the concentration of Moringa leaf extract caused an increase in viscosity (P <0.5) and a decrease in pH (P <0.5) but did not affect physical stability (mechanical test) and its irritating effect. F2 (1%) has a pH of 7.61 while F4 (5%) is 7.01. Based on the results of the study, it is concluded that variations in the concentration of ethanol extract of Moringa leaves can affect the physical stability of the cream and do not affect its irritation properties. Moringa leaf ethanol extract cream with a concentration of 5% (F4) has physical stability and does not irritate the skin better than other formulas. Keywords: extract of moringa leaves, cream, physical properties test, irritation test, stability

KARAKTERISASI SIMPLISIA DAN EKSTRAK KULIT BATANG SEKILANG (Embelia borneensis Scheff.) Risa Supriningrum; Reksi Sundu; Triswanto Sentat; Rakhmadhan Niah; Eka Kumalasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

The Sekilang plant (Embelia borneensis Scheff.) Is one of the plants used by the Dayak community for fishing, leech repellent and as an ingredient for hair care. Empirical use of plants can be developed into products based on natural ingredients. This must be supported by research data. As a first step, the simplicia and ethanol extract of the stem bark were characterized. The research objective was to determine the specific and non-specific characteristics of the simplicia and the extracts of the bark of the sekilang. The research stage includes plant determination, collection of raw materials, manufacture of simplicia, extract preparation, organoleptic, microscopic testing, phytochemical screening, determination of water soluble extract content, determination of ethanol soluble extract content, determination of water content and determination of ash content. Microscopy test results of sekilang stem bark showed the presence of fiber fragments, stone cells, and oxalate crystals. The average water soluble content for simplicia and sekilang bark extract was 7.5% and 80%. The average ethanol soluble content for simplicia and extract was 6% and 30%. The average moisture content for the simplicia and extract was 9.5% and 12%. The mean total ash content for simplicia and extract was 5% and 8.5%. The mean acid insoluble ash content for simplicia and extract was 1% and 0.5%.

METODE INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS (IPA): PERSEPSI TENAGA KESEHATAN DAN PASIEN TERHADAP PENGOBATAN ASMA Marthy Meliana Ariyanti Jalmav; Amelia Lorensia; Ananta Yudiarso; Daniel Maranatha
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Pharmaceutical care by pharmacists in the management have an important role of treatment monitoring. Optimal asthma treatment for patients requires cooperation between patients, healthcares, involving doctors, nurses, and pharmacists. Therefore the purpose of this study is to know the perception of healthcares and patients about asthma treatment and pharmaceutical cares on asthma mangement. The method of this study is based on phenomenological perspective with interpretative phenomenological analysis (IPA) on pulmonologist, outpatient asthma, pharmacist and nurse who directly correlated with asthma treatment at a hospital in Surabaya conducted for two years using purposive sampling. The results of this study indicate that asthma patients know how to manage asthma and use asthma drugs well. In addition it is known that asthma patients feel the role of doctors in the treatment of asthma is very dominating; pulmonologists and nurses perceive that the role of pharmacists is limited to drug delivery; and pharmacists assume that their role has been well done although not all patients get the same asthma treatment education. It is therefore necessary to evaluate the role of pharmacist in performing its role in the treatment of this asthma in order for a more harmonious collaboration.

ANALISIS KADAR VITAMIN C PADA KUBIS MERAH (Brassica oleracea L. var capitata) YANG DIBUAT JUS DENGAN VARIASI LAMA PENYIMPANAN Siska Nur Aini; Crescentiana Emy Dhurhania
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Vitamin C is an antioxidant that is contained in red cabbage (Brassica oleracea L. var capitata). Generally, people store juice ingredients in the refrigerator. This research was carried out to determine the effect of storage time on vitamin C levels in juiced red cabbage. The variation of storage time used was 1, 4, and 7 days with a storage temperature of 5 oC. Qualitative test using iodine, Fehling, and ammonium molybdate reagent gave positive results containing vitamin C. The quantitative test was carried out by UV-Vis spectrophotometry at a maximum wavelength of 570.5 nm with operating time at 20 minutes after the test solution was added with H2SO4 and ammonium molybdate. The quantitative test results showed that the level of vitamin C on the first day was 63.92 mg / 100 g, on the fourth day was 63.32 mg / 100 g, on the seventh day was 62.52 mg / 100 g red cabbage with coefficients of variation 0.26%. The Tukey test resulted in a p value of more than ??0.05, ie 0.831, so that the levels of vitamin C red cabbage juice made on the 1st, 4th, and 7th days were not significantly different.

AKTIVITAS INHIBISI ENZIM ALFA-GLUKOSIDASE DARI EKSTRAK KULIT BATANG BUNGA KUPU-KUPU (Bauhinia semibifida Roxb) SECARA IN VITRO Haiyul Fadhli; Nofri Hendri Sandi; Ainun Nurain Nurdin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Research on the activity of ?-glucosidase inhibition of Bunga Kupu-Kupu stem bark extract (Bauhinia semibifida Roxb) has been carried out in vitro. This study aims to determine the inhibitory activity of the extracts of B. semibifida Roxb. stem bark against the ?-glucosidase enzyme in vitro. Testing the inhibitory activity of the ?-glucosidase enzyme using extracts of n-hexane, ethyl acetate, and methanol from the stem bark of the Bunga Kupu-Kupu and the Akarbose as a positive control. In vitro testing was carried out using a microplate reader instrument with a wavelength of 410 nm. The results showed that the extract of n-hexane extract of the B. semibifida stem bark had an IC50 value 15,625 Ã‚Âµg/mL, ethyl acetate extract had an IC50 value 35,495 Ã‚Âµg/mL, and the methanol extract had an IC50 value 34,279 Ã‚Âµg/mL. By category, the three B. semibifida stem bark extracts have the active ability to inhibit the ?-glucosidase enzyme, while the Akarbose had an IC50 value 0,384 Ã‚Âµg/mL as a positive control has a very active ability as an antidiabetic through the inhibition of the ?-glucosidase enzyme. The results showed that extraction of ?-glucosidase inhibitor compound with n-hexane yielded extract with highest inhibitor activity.

EFEKTIVITAS KOMBINASI PLASMA JET NON -THERMAL DAN SPRAY Aloe vera (L). Burm. f . PADA PENYEMBUHAN LUKA DIABETES Ratih Arum Astuti; Laela Hayu Nurani; Eka Wahyuning Tyas; Iis Wahyuningsih; Devi Kumala Dewi; Isabella Meliawati Sikumbang; Nasruddin Nasruddin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Plasma jet non thermal has benefit in wound healing, but less control can to accumulation of reactive oxygen species. This study aims to determine the effectiveness of the combination of plasma jet and A. vera spray 1% for wound healing in diabetic wounds mice model with parameters of malondialdehyde levels, the skin wound ratio, and blood profile. This study used male Balb/C were induced by a streptozotocin (STZ) and divided into 4 groups, namely groups of untreated diabetic mice wounds (N), groups of diabetic mice wound with A. vera spray 1% (Av), groups of diabetic mice wound with plasma jet non thermal at distance of 20 mm for 3 minutes (P), and groups of diabetic mice wound with plasma jet non thermal at distance of 20 mm for 3 minutes and A. vera spray 1% (PAv). The solution of A. vera spray 1% preparation consists of A. vera, DMSO, and aquabidest extracts. The wounds of all groups treated for 14 days then the malondialdehyde, skin wound ratio and blood profile were calculated by SPSS Statistic. The results of blood glucose before treatment were 241.74 dL Ã‚Â± 51.99. The combination of plasma jet and A. vera spray 1% groups were significant (p <0.05) in reduce malondialdehyde levels, reduced the the skin wound ratio but not different significantly (p> 0.05), and not effect on blood profile data (p> 0.05). In conclusion, A. vera spray 1% can reduce the side effects of plasma jet in diabetic wounds by reducing malondialdehyde levels.

SOSIOEKONOMI, PENGETAHUAN PENYAKIT DIARE DAN PENGETAHUAN SWAMEDIKASI DIARE PADA IBU BALITA DI YOGYAKARTA Faridah Baroroh; Ana Hidayati; Siti Nurbayanti; Intan Tin Sari; Atikah Zain; Redy Redy; Siwi Retnaning Dyahayu
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

In Indonesia, the prevalence of diarrhea is highest among children under five. Economic factors and maternal knowledge are, in this case, significantly related to diarrhea incidence, and the latter substantially defines self-medication measures taken for acute diarrhea treatment. The research was intended to determine the extent to which socioeconomic conditions and diarrheal knowledge formed comprehension of such treatment. For this purpose, it employed a cross-sectional study with 504 research subjects, namely, mothers of children under five in the Special Region of Yogyakarta, Indonesia. Data were collected using a validated questionnaire consisting of items on socioeconomic details (education, employment, income), diarrheal knowledge, and relevant self-medication knowledge. Afterward, education and post-test were conducted using the same list of questions. Analytical techniques were carried out to identify how significant socioeconomic characteristics determined knowledge of diarrheal disease and self-medication.Results showed that, socioeconomically, a large proportion of research subjects attained secondary to tertiary education (76%), were unemployed (71%), and earned low income (62%). Educational attainment was found to be significantly related to levels of knowledge of diarrheal disease and self-medication (p < 0.005), but employment status and income were not (p > 0.005). Analysis results also indicate a significant relationship (p = 0.000) between the level of knowledge of diarrheal disease and that of diarrheal self-medication. Overall, socioeconomic status (i.e., level of education) and diarrheal knowledge is significantly related to diarrheal self-medication knowledge.

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Siska Musiam

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Home Page

OAI Link

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Contact Name Siska Musiam

Contact Email siska@stikes-isfi.ac.id

Phone +62511-3301610

Journal Mail Official jiis@stikes-isfi.ac.id

Editorial Address Jl. Flamboyan III/7c Kayu Tangi 70123 Banjarmasin Kalimantan Selatan

Location Kota banjarmasin, Kalimantan selatan INDONESIA

Abstract

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Contact Name
Siska Musiam

Contact Email
siska@stikes-isfi.ac.id

Phone
+62511-3301610

Journal Mail Official
jiis@stikes-isfi.ac.id

Editorial Address
Jl. Flamboyan III/7c Kayu Tangi 70123 Banjarmasin Kalimantan Selatan

Location
Kota banjarmasin,

Kalimantan selatan

INDONESIA