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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
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UJI TOKSISITAS DENGAN METODE BSLT PADA NANOPARTIKEL KOMBINASI OBAT CISPLATIN, BOVINE SERUM ALBUMIN DAN ASAM FOLAT Ersalina Nidianti; Ary Andini
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.575 KB) | DOI: 10.36387/jiis.v6i1.609

Abstract

Cancer is a non-communicable disease that causes morbidity and mortality in all regions of the world. Cancer treatment is important in reducing the high number of deaths (mortality) due to cancer sufferers. One of the cancer treatments is using chemotherapy drug cisplatin. However, cisplatin drug has side effects, namely nephrotoxicity, ototoxicity, neurotoxicity, hemotoxicity, cardiotoxicity, and hepatotoxicity. Therefore, the combination of cisplatin in albumin nanoparticles and modification of the bond using folic acid as an alternative solution minimizes the resulting toxic effects. This study aimed to determine the toxicity effect of the cisplatin drug formulation with a combination of bovine serum albumin (BSA) nanoparticles and folic acid through the Brine Shrimp Lethality Test (BSLT) method. The research methods used were BSA nanoparticle synthesis (NP-BSA), NP-BSA Synthesis with Cisplatin Drug (CP-NP-BSA), Folic Acid Synthesis with CP-NP-BSA Combination (As-CP-NP-BSA). Then, a toxicity test was carried out using the BSLT method to determine the toxicity level of BSA nanoparticles and the effect of adding folic acid in the cisplatin drug in the nanoparticles. The results showed that the absorbance of the 358 nm As-CP-NP-BSA UV-Vis spectrophotometer was 0.86. The toxicity level of the NP-BSA with the LC50 value was 69.23 ppm while the As-CP-NP-BSA LC50 toxicity level was 56.56 ppm. Nanoparticles consisting of a combination of bovine serum albumin, cisplatin and folic acid can be used as candidates for anticancer drugs
PENGGUNAAN INSULIN PADA PASIEN DIABETES MELITUS TIPE 2 PESERTA JKN DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT ST. ELISABETH SEMARANG Fef Rukminingsih; Valentina Catur Nova
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (169.72 KB) | DOI: 10.36387/jiis.v6i1.611

Abstract

Diabetes mellitus (DM) type 2 is a chronic and progressive clinical syndrome, characterized by polyuria, polydipsi and polyphagy accompanied by increased blood glucose or hyperglycemia. Management of type 2 diabetes mellitus in patients with HbA1C values > 9% is by administering insulin or a combination of insulin with oral hypoglycemic agents. This study aims to determine the suitability of the type and dose of insulin in type 2 DM patients in the Outpatient Pharmacy Installation of St. Elisabeth Hospital Semarang. This research is a descriptive observational study using retrospective data. The data were obtained from the medical records of Universal Health Coverage participant patients with type 2 diabetes mellitus in the Outpatient Pharmacy Installation of St. Elisabeth Hospital Semarang, who only received insulin therapy in January 2020, is 26-65 years old, and has examination results for fasting blood glucose, post prandial blood glucose and HbA1C (examination results for the last 6 months). The results showed that 57 patients consisted of 29 (50.88%) male patients and 28 (49.12%) female patients. A total of 47 (82.46%) patients were more than 45 years old. A total of 38 patients (66.67%) received combination insulin and all patients had HbA1C values> 9%. The suitability of using insulin based on the type of insulin was 68.42% and most of the patients (80.70%) received inappropriate insulin doses.
AKTIVITAS REPELLENT FORMULASI SEDIAAN SPRAY KOMBINASI MINYAK ATSIRI SERAI (Cymbopogon winterianus), DAUN KEMANGI (Ocimum basilicum) DAN NILAM (Pogostemon Cablin) BESERTA UJI PREFERENSINYA Faikah Dyah Utami; Arif Budi Setianto
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.085 KB) | DOI: 10.36387/jiis.v6i1.631

Abstract

Plants that are played as mosquito repellents, one of which is plants that contain essential oils, such as lemongrass, basil and patchouli. As an effort to make it easier to use, this research will make a spray repellent preparation with a combination of active ingredients from essential oils of lemongrass, basil and patchouli. The research methods included making a spray repellent using essential oils of lemongrass, basil, patchouli every 0.1 ml (5 concentrations %), 0.2 ml (10% concentration), 0.3 ml (15% concentration) and the additives 1ml Propylene glycol and 5 ml 96% Ethanol which functions as a solvent. The experiment used five treatments, namely: Negative control (Kn), Formula A (0.1ml), Formula B (0.2ml), Formula C (0.3ml), and Positive Control (Kp). The parameters tested included pH test, patch test, organoleptic, specific gravity, emulsion stability, preference and percentage of protective power. The protective power test was carried out 10 times from each treatment for 6 hours of observation (0-1 hours, 1-2 hours, 2-3 hours, 3-4 hours, 4-5 hours and 5-6 hours). The results showed that the best spray expulsion treatment was formula B with a concentration of 10% (0.2 ml)
PENAMBATAN MOLEKULER SENYAWA CENDAWAN ENDOFIT Trichoderma sp. SEBAGAI INHIBITOR PROTEIN LOW DENSITY LIPOPROTEIN, ENZIM LANASTEROL 14 DEMETILASE DAN LIPASE YANG BERTANGGUNG JAWAB DALAM DERMATITIS SEBOROIK Eka Sukmawaty; Susi Susanti; Masriany Masriany Masriany
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.054 KB) | DOI: 10.36387/jiis.v6i1.636

Abstract

Seborrheic dermatitis (SD) occurs due to excessive sebum production resulting in the growth of the fungus Mellasezia sp. on the skin becomes uncontrollable. Some of the receptors that play a role in SD regulation are Low Density Lipoprotein (LDL) protein, Lanasterol 14-α Demetylase enzyme, and Lipase enzyme. This study aims to determine the potential compounds of the endophytic fungi Trichoderma sp. as an antiseborrheic and knowing the interaction between ligands as inhibitors in SD regulation. The research was conducted with computer-based molecular docking. The results showed that there were two inhibitor candidate compounds based on the selection by binding affinity value, namely Chloromycetin and Benzyl benzoate. Based on the results of docking with VINA autodock, the potential compounds were Benzyl benzoate on LDL protein with binding affinity values of -7.3 kcal/mol, compounds were Chloromycethin on Lipase enzyme with binding affinity values of -7.3 kcal/mol and Lanasterol 14-α demethylase enzyme with a binding affinity value of -7.6 kcal/mol. These compounds form hydrogen bonds and hydrophobic bonds. Based on the prediction of Lipinski's rule of five, the two compounds are effective orally used as anti seborrheic dermatitis drugs
STUDI TINGKAT PENGETAHUAN DAN PERSEPSI TENAGA KESEHATAN MENGENAI PERANAN FARMAKOGENOMIK Muhammad Akib Yuswar; Robiyanto Robiyanto; Eka Kartika Untari; Shoma Rizkifani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.255 KB) | DOI: 10.36387/jiis.v6i2.640

Abstract

Research on the extent to which health practitioners in West Kalimantan understand the important role of pharmacogenomics have not been reported to date. West Kalimantan (Kalbar) is known as a province characterized by three main ethnicities, namely Chinese, Malay and Dayak. Therefore, the potential application of pharmacogenomics for the treatment of patients in health facilities across the province is very possible. This study aimed to measure the level of knowledge and perceptions of health practitioners (participants) about the role of pharmacogenomics in patient treatment plans. This research is descriptive with a questionnaire-based survey method. The data analyzed is primary data from the answers of participants to the online questionnaire. Based on the responses of 106 participants (involving doctors, pharmacists, nurses, midwives, and others) from various cities and districts in West Kalimantan, it was found that the level of knowledge was very good (75.5%), good (17.0%), and not good. (7.5%). The level of participants' perceptions of the role of pharmacogenomics are those who have positive perceptions (97.2%) and negative perceptions (2.8%). It can be concluded that 75% of health practitioners in West Kalimantan have a very good level of knowledge and 97% of them own a positive perception of the importance of pharmacogenomics.
STUDI PENGGUNAAN ANTIBIOTIK PASIEN PNEUMONIA ANAK DENGAN METODE DDD DAN DU 90% Farah Bidara; Mumfasiroh Saputri; Dyah Aryani Perwitasari; Intan Fatah Kumara; Muhammad Ardhani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (398.318 KB) | DOI: 10.36387/jiis.v6i1.644

Abstract

Pneumonia is one of the most common respiratory infections. The treatment of pneumonia mostly uses broad-spectrum empirical antibiotics that are susceptible to resistance. One of the efforts to reduce antibiotic resistance is to use antibiotics wisely which can be done by regularly evaluating the quantitative and qualitative use of antibiotics. The purpose of this study was to determine the quantity of consumption and the type of antibiotic used in patients pneumonia child inpatient ward at Hospital Mitra Paramedika Yogyakarta (MPY) and Yadika Pondok Bambu Jakarta (YPBJ) by DDD (Defined Daily Dose) and DU (Drug utility) 90%. This is a descriptive study period June 2017 - April 2020 in pediatric patients aged 1 - 18 years with a diagnosis of pneumonia. Sampling was performed at the Medical Record Installation. The Data taken were antibiotic type, dosage regimen, medication route, antibiotic duration (day), and hospital stay (day) as well as patient demographic data (age, type sex) .There are differences in the pattern of antibiotic use between YPBJ and MPY. Comparison of DDD and DU 90% may be due to differences in standard of therapy used by physicians, antibiotic resistance, differences in germ maps and hospital formularies. Keywords: Pneumonia, Children, Antibiotic, Defined Daily Dose, DU 90%
METODE SPEKTROSKOPI ATR-FTIR TANDEM PCA UNTUK MENDETEKSI KOPI ROBUSTA SEBAGAI ADULTERAN DALAM SEDIAAN KOPI ARABIKA TORAJA KOMERSIAL Aiyi Asnawi; Erli Berlianti; Ellin Febrina; Nursamsiar Nursamsiar; Sitti Rahmi; Ivan Andriansyah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.485 KB) | DOI: 10.36387/jiis.v6i1.646

Abstract

Toraja arabica coffee is well known for its higher price and quality compared to robusta coffee, but its commercial is often added with other ingredients, including robusta coffee which has low economic value. Visual inspection is unreliable in roasted ground coffee due to the resemblance of its chemical content. The ATR-FTIR method tandem PCA was able to provide an overview of the typical chemical content of the coffee preparation. The purpose of this study was to evaluate the robusta coffee as adulterant in Toraja arabica coffee preparation by using ATR-FTIR. Toraja arabica coffee beans were obtained from three smallholder plantations around Toraja and Robusta coffee beans were obtained from Toraja, Lampung, and West Java coffee plantations. The coffee beans were roasted and then macerated using 96% ethanol for 3×24 hours and concentrated using a rotary evaporator until being thick. The IR spectrum of each extract was measured using the ATR-FTIR spectroscopy at a range of 4000-650 cm-1. The results show there is a similarity in the IR spectrum patterns and there is only a small difference in the transmittance of Toraja arabica coffee and robusta coffee. Furthermore, the IR spectrum is clustered by using PCA in R program. The projection of three commercial samples shows that samples 1 and 2 do not contain robusta coffee while sample 3 shows the presence of robusta coffee. In conclusion, the ATR-FTIR spectroscopic method tandem PCA was able to clustered the presence or absence of robusta coffee content in the Toraja arabica coffee.
PENENTUAN AKTIVITAS TABIR SURYA DAN ANTIOKSIDAN EKSTRAK ETANOL BENALU (Henslowia frutescens) INANG JERUK BALI SECARA IN VITRO Henny Nurhasnawati; Rusdiati Helmidanora; Yullia Sukawaty; Andri Priyoherianto; Elly Purwati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.661 KB) | DOI: 10.36387/jiis.v6i1.647

Abstract

Henslowia frutescens is a semi-parasitic plant, although considered harmful, it has medicinal and cosmetic potential. This plant has secondary metabolite compounds, namely phenolic compounds, flavonoids, saponins, tannins, and steroids which have high antioxidant activity. The purpose of this study was to determine the sunscreen activity of the ethanol extract of Henslowia frutescens based on the in vitro SPF (Sun Protecting Factor) value and to determine its antioxidant activity. The research stages included sampling, sampling, maceration extraction with 95% ethanol, yield calculation, phytochemical screening, sunscreen activity test based on SPF value, and antioxidant activity test. Data analysis was carried out descriptively based on the measurement results processed according to the calculation formula. The results showed that the sunscreen activity of the ethanol extract of Henslowia frutescens based on the in vitro SPF value was 14.57 - 25.20 with moderate protection category. The antioxidant activity of the ethanol extract of Henslowia frutescens showed a very strong category with an IC value of 22.82 ± 1.33.
EFEKTIVITAS PERENCANAAN KEBUTUHAN OBAT DENGAN METODE MORBIDITAS TERHADAP KETERSEDIAAN OBAT KEMOTERAPI Nina Puspitawati; Liza Pristianty; Abdul Rahem; Widawaty Hartono
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.562 KB) | DOI: 10.36387/jiis.v6i1.650

Abstract

One cycle of chemotherapy does not eliminate all cancer cells, therefore it takes a repeated cycle (Williams, et al, 2016), so the guarantee the availability of chemotherapy drugs is needed. An effective drug requirement planning is required to ensure the availability of chemotherapy drug. This study was intended to determine the effectiveness of planning the need for chemotherapy drugs using the morbidity method on the availability of chemotherapy drugs in Dr. Ramelan Navy Hospital. This study was an observational study with a cross sectional study design. The instrument used in this study was the data collection sheet with data sources prescription sheets and sheets of chemotherapy drug reconstitution during 2015-2017. Descriptive data analysis and to determine effective planning methods using indicators of drug availability. The results showed that the planning of drug needs with the morbidity method can better guarantee the availability of chemotherapy drugs and can minimize drug shortages compared to the consumption method that has been done so far in Dr. Ramelan Navy Hosptal. So it can be concluded that in this study, the morbidity method is effective in meeting the needs of chemotherapy drugs.
Keterlibatan Sistem MonoamineINVOLVEMENT OF MONOAMINERGIC SYSTEM IN THE ANTIDEPRESSANT-LIKE EFFECT OF Ocimum sanctum (LINN.) LEAVES EXTRACT IN TArgik pada Efek Antidepresan dari Ekstrak Daun Ocimum Sanctum (Linn.) terhadap Model Hewan Tail Suspention Test Ridho Islamie; Havid Ro’is; Intan Tristianti; Muhammad Helmi; Devyani Diah Wulansari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.157 KB) | DOI: 10.36387/jiis.v6i1.653

Abstract

Depression is a psychiatric disorder characterized by decreased mood and affects daily activities.The development of herbal ingredients as complementary therapy becomes increasing in line with the number of patients who avoid side effects in conventional treatment.The purpose of this study is to investigate the potential effects of ethanolic extract of Ocimum sanctumL. as an antidepressant as well as evaluate the potential mechanism of action in the monoaminergic system in invivo study.For evaluation of mechanisms of action, mice were treated serotonin synthesis inhibitors (pCPA), non-selective dopamine antagonists (Haloperidol) and selective antagonists D2 dopamine (Sulpiride) as pre-treatment.The Tail Suspension Test(TST)method is used as a standardized test that has generally been used to evaluate the antidepressant effects of a drug compound. The results showed that the ethanolic extract of OcimumsanctumL. has antidepressant effect at the dose of 150 mg/kg.Ethanol extract of OcimumsanctumL. was able to decrease the immobility time in TST mice model significantly when given pre-treatmentwith pCPA (p<0.05) and haloperidol (p<0.05), while sulpiride (p<0.05) inhibits the antidepressant effects of ethanolic extract of OcimumsanctumL. significantly.These results showed that the monoaminergic system especially serotonergic and dopaminergic were involved in the antidepressant-like effects of ethanolic extract of OcimumsanctumL. by involving dopamine receptors and has a role in serotonin synthesis.

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