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Jurnal Pharmacopoeia
Published by Politeknik Kesehatan Kemenkes Bengkulu
ISSN : 28094573     EISSN : 28094573     DOI : https://doi.org/10.33088/jp.v1i2
Core Subject : Health,
Medicine & Pharmacology Public Health
Jurnal Pharmacopoeia (JPharmaco) O-ISSN: 2809-4573 is an official journal published by Pharmacy Program, Health Analyst Department, Health Polytechnic of Bengkulu which the articles can be accessed and downloaded online by the public (open access journal). This journal is a national peer-reviewed journal published twice a year on topics of excellence of research results in the fields of service and practice of pharmacy, community medicine, pharmaceutical technology, and health science disciplines that are closely related. This journal accepts English texts. The following are the research areas that this journal focuses on Clinical Pharmacy, Community Pharmacy, Pharmaceutics, Pharmaceutical Chemistry, Pharmacognosy, Phytochemistry. JPharmaco receives manuscripts from the results of research (research article), systematic reviews and meta-analysis that are closely related to the health sector, particularly the pharmaceutical field. Selected manuscripts for publication in JPharmaco will be sent to two reviewers experts in their field, who are not affiliated with the same institution as the author(s) and are chosen based on the consideration of the editorial team. The review process is conducted in a closed manner where the author(s) and reviewers do not know the identity and affiliation of each. Each manuscript delegated to editorial members is examined for the final decision of the review process. The author(s) are required to respond to the review given and send revised manuscripts within the allotted time after the comments and suggestions from the reviewers have been sent. Manuscripts accepted for publication are edited copies checked for grammar, punctuation, print style, and format. The entire process of submitting the manuscripts to the final decision for publishing is done online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 71 Documents
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Skrining Fitokimia Dan Uji Aktivitas Antioksidan Ekstrak Buah Kupa (Syzygium polycephalum) Dengan Metode 1,1-diphenyl-2-picrylhydrazil dharmayanti, Luky; Jannah, Syauqul; Oktamauri, Ariesa
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1065

Abstract

Kupa fruit has a high anthocyanin content and is useful as an antioxidant. Phytochemical screening shows flavonoid compounds in the skin and fruit. Free radical damage to skin cells can be repaired using antioxidants, because antioxidants can kill and neutralize radicals in the body so that oxidative stress and cell damage can be avoided. The purpose of this study was to determine the value of antioxidant activity and antioxidant content of kupa fruit extract (Syzygium polycephalum). This study used kupa fruit extract (Syzygium polycephalum) This will be examined using the 1,1-diphenyl-2-picrylhydrazyl technique to determine its antioxidant activity. A UV-Vis spectrophotometer was used to detect absorbance at λ 517 nm. The results are represented as IC50 (Inhibitory Concentration) values, which indicate the concentration of antioxidant substances that capture 50% of DPPH radicals. Kupa fruit extract has an extract yield of 40.11% and is positive for alkaloid, flavonoid, and tannin components, according to phytochemical screening results, the water content is 30.65% and the ash content is 1.13%. The results of the antioxidant activity test of kupa fruit extract show a relatively strong IC50 value of <100 µg/mL with an IC50 value of 99.74. Keywords: Kupa fruit (Syzygium polycephalum), antioxidant, DDPH, IC50
Pengaruh Variasi Konsentrasi Basis Beeswax Dan Paraffin Wax Pada Lip Balm Ekstrak Bunga Soka Merah (Ixora coccinea L.) Setiyawati, Bayu; Endriyatno, Nur Cholis
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1068

Abstract

Soka flower extract (Ixora coccinea L.) is a very powerful source of natural antioxidants. Soka flower extract is formulated as a lip balm to utilize its potential as an antioxidant that can protect the lips. This study aims to determine the effect of variations in the concentration of beeswax and paraffin wax bases on the physical properties of soka flower extract lip balm preparations and to obtain the best component variations. Soka flowers were extracted using maceration extraction using 96% ethanol. The lip balm preparations were made in 3 formulas with variations in the concentration of beeswax and paraffin wax bases, namely FI (5%:15%), FII (7.5%:12.5%), and FIII (10%:10%). The lip balm was evaluated for physical properties such as organoleptic tests, homogeneity tests, pH tests, spreadability tests, smearability tests, adhesion tests, irritation tests, and moisture tests. Data analysis was carried out using the One Way ANOVA method. Based on the results of the study, it was shown that variations in the concentration of beeswax and paraffin wax bases affected the physical properties of the preparations, including pH, adhesiveness, spreadability, and viscosity. In this study, FII (7.5% beeswax and 12.5% paraffin wax) was determined as the best formula for the soka flower extract lip balm preparation, based on consideration of the requirements and statistical tests.
Hubungan Peran Pengawas Menelan Obat Dengan Kepatuhan Minum Obat Penderita Tuberkulosis Di Puskesmas Sukarahayu Miranda, Elfa Dhela; Adiutama, Novian Mahayu; Ningrum, Dwi Agustia
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1080

Abstract

Tuberculosis (TB) remains a health challenge in Indonesia. Its treatment is lengthy and requires discipline, making medication adherence crucial. One way to improve adherence is through the involvement of Medication Supervisors (PMO) during treatment. To examine the relationship between the role of PMO and the level of medication adherence among pulmonary TB patients at Puskesmas Sukarahayu. This study used a quantitative approach with a cross-sectional design and purposive sampling, involving 135 TB patients. Data were collected via questionnaires on the role of PMO and MMAS-8, then analyzed using Spearman's Rank test. The study showed that the majority of respondents had PMOs who played a supportive role (94.8%), and most respondents were adherent to their medication (63.7%). The statistical analysis indicated a significant relationship between the role of PMO and medication adherence (p = 0.000) with a correlation coefficient r = 0.638, indicating a strong and positive relationship. The better the PMO role, the higher the adherence of TB patients to treatment. Improving the quality and engagement of PMOs is an effective strategy to reduce dropout rates, prevent resistance (DR-TB), and accelerate recovery. This confirms the importance of training and support for PMOs in TB control programs.    
Correlation Between Probiotic Use And Blood Pressure In Hypertensive Adults: A Cross-Sectional Study Sultan, Dharma; Setyawan, Yuswanto
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1081

Abstract

Hypertension remains a significant global health burden and is closely linked to cardiovascular morbidity. Emerging evidence suggests that gut microbiota plays an essential role in modulating blood pressure, particularly through the use of probiotics and prebiotics. This study investigated the relationship between the frequency of probiotic consumption and blood pressure control in patients with essential hypertension. A total of 100 hypertensive adults participated in this cross-sectional study, and data were collected through structured interviews, food frequency questionnaires, and blood pressure assessments. Statistical analyses included Chi-square and Spearman correlation tests. The results demonstrated a significant association between higher frequency of probiotic intake and better blood pressure control (p = 0.008), with a moderate negative correlation (r = –0.45) observed between intake duration and systolic blood pressure. Additionally, individuals who consumed both probiotics and prebiotic-rich foods exhibited enhanced blood pressure improvement. These findings support the potential of probiotic-prebiotic synergy in modulating gut microbiota to regulate blood pressure. The incorporation of prebiotics is essential, as they serve as substrates that stimulate the growth and activity of beneficial bacteria, thereby optimizing the efficacy of probiotic supplementation. The study highlights the practical implications of dietary interventions targeting the gut environment as a complementary strategy in hypertension management. Keywords: Hypertension, Probiotics, Prebiotics, Gut microbiota, Blood pressure
Penetapan Kadar Hesperidin Pada Seduhan Kulit Jeruk Keprok (Citrus Nobilis L.) Dhirisma, Fitria; Pinasti, Rahayu
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1092

Abstract

Tangerine peel (Citrus nobilis L.) has a high content of flavonones, namely hesperidin, naringin and narirutin which can be used as antidiabetics by increasing insulin release through increasing serum insulin and C-peptide levels. The drying method can affect the total phenolic content of orange peel so that the air-dried drying method is reported to be able to produce high phenol levels. The purpose of this study was to determine the hesperidin levels in tangerine peel infusion (Citrus nobilis L.). This type of research is an experimental laboratory study in the form of a test to determine the hesperidin levels in tangerine peel infusion using Uv-Vis speccrophotometry. The sample was 2 grams of orange peel infusion, the hesperidin standard was made in a series of levels of 2, 4, 6, 8, 10 ppm. The wavelength is obtained from the absorbance of the hesperidin reference solution, then a standard curve is made and a linear equation is obtained. The maximum wavelength of hesperidin is 282.7 nm according to the literature. The standard curve of hesperidin is obtained y = 0.0448x + 0.0265 with a correlation coefficient (r) of 0.9994. Determination of hesperidin levels in tangerine peel infusion was carried out in 3 replications and obtained R1 8.559 ppm, R2 7.517 and R3 6.649 with an average of 7.588 ppm. The hesperidin levels in 2 grams of tangerine peel infusion using UV-Vis spectrophotometry were 151.77 ppm.
Studi Komparatif Efektivitas Antioksidan Umbi Bawang Dayak (Eleutherine americana) Dengan Teknik Ekstraksi Infusa dan Maserasi Nur Ihsan Kamilah; Hardiansyah, Sigit Cahyo; Saputra, Adi
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1102

Abstract

Perkembangan polusi dan gaya hidup modern dapat meningkatkan produksi radikal bebas dalam tubuh. Jika tidak dikendalikan, jumlah radikal bebas yang berlebihan dapat menurunkan kualitas hidup, memicu berbagai gangguan kesehatan, dan bahkan menyebabkan kematian. Oleh karena itu, diperlukan antioksidan alami untuk melindungi tubuh. Antioksidan alami cenderung lebih aman dibandingkan antioksidan sintetik. bawang dayak (Eleutherine americana) sebagai tanaman obat tradisional memiliki potensi sebagai sumber antioksidan. Pemanfaatan bawang dayak masih secara tradisional mengambil sari umbinya dengan cara merebus dan meminum air rebusannya. Tujuan penelitian ini adalah untuk membandingkan efektivitas antioksidan ekstrak umbi bawang dayak (Eleutherine americana) yang dihasilkan dari dua teknik ekstraksi yaitu infusa dan maserasi. Metode penelitian ini merupakan eksperimen yang menguji efektivitas antioksidan dari infusa dan maserasi umbi bawang dayak (Eleutherine americana). Pengujian dilakukan menggunakan metode DPPH dan Spektrofotometri UV-Vis. Hasil penelitian diperoleh ekstrak umbi bawang dayak (Eleutherine americana) dari maserasi memiliki efektivitas antioksidan yang sangat kuat (IC50 47.85 ppm). Angka ini jauh lebih baik daripada infusa (IC50 110.65 ppm) yang hanya memiliki kategori sedang. Meskipun masih di bawah vitamin C (IC50 7.49 ppm). Dapat disimpulkan bahwa maserasi umbi bawang Dayak (Eleutherine americana) terbukti memiliki efektivitas antioksidan yang lebih tinggi dibanding infusanya. Namun, daya antioksidan dari kedua sampel umbi bawang dayak (Eleutherine americana) tersebut masih lebih rendah jika dibandingkan dengan vitamin C.
Karakteristik Analisis Spektrofotometri IR Ekstrak Batang Kebiul (Caesalpinia bonduc (L.) Roxb) dengan Variasi Pelarut pada Maserasinya Desy Amalia; Karina Primtyas; Septi Wulandry; Delta Baharyati
Jurnal Pharmacopoeia Vol 5 No 1 (2026): Maret 2026
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v5i1.1229

Abstract

Caesalpinia bonduc (L.) Roxb is known to contain various secondary metabolites with antioxidant, anti-inflammatory, and antimicrobial properties. Differences in solvent polarity influence the types of compounds extracted; therefore, functional group profiling is essential to identify active constituents. This study aimed to compare the FTIR-ATR spectral profiles of C. bonduc stem extracts obtained using three solvents of different polarities: ethanol, ethyl acetate, and n-hexane. Extraction was carried out by maceration, and characterization was performed using a Bruker Alpha II FTIR spectrophotometer within the 4000–400 cm⁻¹ range. The ethanol extract exhibited strong absorption at 3430 cm⁻¹ (–OH) and 1635 cm⁻¹ (C=O), indicating polar compounds such as flavonoids and phenolics. The ethyl acetate extract showed distinctive bands at 1740 cm⁻¹ (C=O ester), while the n-hexane extract displayed peaks at 2922–2858 cm⁻¹ (C–H), associated with non-polar compounds such as fatty acids and terpenoids. Variations in absorption bands among the three extracts confirm that solvent polarity significantly affects the extracted chemical composition. The FTIR-ATR technique proved effective for rapid and non-destructive characterization of bioactive compounds in medicinal plant extracts.
Hubungan Pengetahuan tentang Tablet Tambah Darah dengan Sikap dan Tindakan Konsumsi Pada Mahasiswi Farmasi Poltekkes Kemenkes Aceh Burdah Burdah; Alfia Amlisa; Ernita Silviana; Amelia Sari; Rima Hayati
Jurnal Pharmacopoeia Vol 5 No 1 (2026): Maret 2026
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v5i1.1230

Abstract

Anemia merupakan masalah gizi yang umum terjadi pada remaja putri dan disebabkan oleh kurangnya asupan zat gizi penting, terutama zat besi. Di Indonesia, prevalensi anemia pada perempuan masih tergolong tinggi dan menjadi masalah kesehatan masyarakat, khususnya pada remaja dan dewasa muda. Tablet tambah darah merupakan salah satu upaya pemerintah dalam mencegah anemia, namun kepatuhan dalam mengonsumsinya masih rendah. Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan tentang tablet tambah darah dengan sikap dan tindakan konsumsi pada mahasiswi Jurusan Farmasi Poltekkes Kemenkes Aceh. Penelitian ini merupakan jenis penelitian observasional dengan desain penelitian cross-sectional. Populasi penelitian adalah mahasiswi Jurusan Farmasi Poltekkes Kemenkes Aceh. Sampel penelitian berjumlah 78 responden yang dipilih menggunakan teknik simple random sampling. Data dikumpulkan menggunakan kuesioner terstruktur dan dianalisis menggunakan uji Fisher’s Exact Test. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara pengetahuan tentang tablet tambah darah dengan sikap terhadap konsumsi (p = 0,001; p < 0,05). Namun, tidak terdapat hubungan yang signifikan antara pengetahuan dengan tindakan konsumsi (p = 0,366; p > 0,05). Hasil ini menunjukkan bahwa meskipun pengetahuan memengaruhi sikap, tindakan konsumsi yang sebenarnya dipengaruhi oleh faktor lain di luar pengetahuan. Kesimpulannya, pengetahuan tentang tablet tambah darah berhubungan dengan sikap, tetapi tidak berhubungan dengan tindakan konsumsi pada mahasiswi Jurusan Farmasi Poltekkes Kemenkes Aceh. Diperlukan penguatan faktor pendukung untuk meningkatkan kepatuhan dalam mengonsumsi tablet tambah darah.
Penentuan Kandungan Vitamin D2 Pada Ekstrak Etil Asetat Jamur Sawit (Volvariella volvacea) Dengan Metode Spektrofotometeri UV-Vis Oky Hermansyah; Apriyanti Apriyanti; Suci Rahmawati; Rose Intan Perma Sari; Dwi Dominica
Jurnal Pharmacopoeia Vol 5 No 1 (2026): Maret 2026
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v5i1.1245

Abstract

Dari hasil berbagai penelitian vitamin D memiliki peran yang signifikan tidak hanya penting dalam kesehatan tulang, namun juga imunitas, membantu pemulihan pada penyakit infeksi pernafasan, penyakit diabetes dan kolesterol. Salah satu sumber alami vitamin D adalah jamur, banyak penelitian yang mengungkapkan kandungan vitamin D pada jamur, seperti jamur tiram atau jamur merang padi, namun belum ada yang melaporkan kandungan vitamin D pada jamur sawit (Volvariella volvaceae). Jamur sawit ini banyak dihasilkan di daerah penghasil kelapa sawit seperti di Provinsi Bengkulu, khususnya di Kecamatan Pino. Tujuan penelitian ini adalah untuk menentukan kandungan vitamin D (ergokalsiferol) dalam esktrak etil asetat jamur sawit yang dihasilkan disekitar perkebunan kelapa sawit di Kecamatan Pino. Jamur sawit diolah menjadi simplisia dan diekstraksi menggunakan pelarut etil asetat melalui proses maserasi, kemudian diuapkan untuk mendapatkan ekstrak kental. Dari hasil proses ekstraksi didapatkan rendemen sebesar 1,076%. Ekstrak kental ini kemudian ditentukan kadar vitamin D-nya menggunakan Spektrofotometer UV-Vis dengan vitamiin D2 (ergokalsiferol BPFI) sebagai standar. Dari hasil pengujian, diperoleh kurva larutan standar vitamin D dengan koefisien regresi (r) sebesar 0,997 dan persamaan garis y=0,0337x+0,011. Absorbansi sampel yang diperoleh kemudian diplot ke dalam persamaan garis dan kadarnya dihitung, hasilnya didapatkan kadar vitamin D2 (ergokalsiferol) pada sampel. Dari hasil studi ini, dapat disimpulkan bahwa jamur sawit yang diperoleh di sekitar perkebunan kelapa sawit Kecamatan Pino di Provinsi Bengkulu mengandung vitamin D2 (ergokalsiferol) dengan kadar 0,1363% atau sekitar 54,52 IU/gram.
Verifikasi Metode Analisis Penetapan Kadar Kaptopril Sediaan Tablet Menggunakan KCKT–PDA dalam Mendukung Regionalisasi Laboratorium BPOM Laily Fauziah; Tuti Amalia As
Jurnal Pharmacopoeia Vol 5 No 1 (2026): Maret 2026
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v5i1.1254

Abstract

Captopril is a drug in the Angiotensin-Converting Enzyme Inhibitor (ACE Inhibitor) class that is widely used in the treatment of hypertension and heart failure. Given its widespread use, the availability of reliable and validated analytical methods is crucial to ensure the quality, safety, and efficacy of pharmaceutical preparations containing captopril. Captopril analytical methods have been reported using various techniques, such as high-performance liquid chromatography (HPLC) and UV-Vis spectrophotometry. However, before these methods are routinely used in the BPOM laboratory in Bengkulu, a method verification process is required to ensure that the adopted method meets analytical performance requirements under the conditions and equipment used.. The aim of this study was to verify the analysis method of Captopril in tablet preparations using HPLC with a PDA detector at the BPOM Bengkulu Laboratory. Verification was carried out using HPLC with a PDA detector at a wavelength of 220 nm, a 25 cm x 4.6 mm L1 column with a particle size of 5 um, using a mobile phase mixture of methanol; water; phosphoric acid (550; 450; 0.4) and a flow rate of 1 ml / minute in accordance with the Indonesian Pharmacopoeia edition VI. Verification results showed that the standard solution was detected at a retention time of approximately 4 minutes. In the specificity test, the Captopril standard and the tested sample produced peaks at identical retention times and spectra. The precision test provided a relative standard deviation (RSD) of 1.10%, the linearity test provided a correlation coefficient value of r = 0.9991, the accuracy test (recovery) at levels of 80%, 100% and 120% produced an average recovery of 97.55% with an acceptance range of 95% - 105%. In general, it can be concluded that the results of the verification of the analytical method for determining the levels of Captopril in tablet preparations meet the requirements and can be used in routine sample testing in the Laboratory.

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