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Jurnal Pharmacopoeia
Published by Politeknik Kesehatan Kemenkes Bengkulu
ISSN : 28094573     EISSN : 28094573     DOI : https://doi.org/10.33088/jp.v1i2
Core Subject : Health,
Medicine & Pharmacology Public Health
Jurnal Pharmacopoeia (JPharmaco) O-ISSN: 2809-4573 is an official journal published by Pharmacy Program, Health Analyst Department, Health Polytechnic of Bengkulu which the articles can be accessed and downloaded online by the public (open access journal). This journal is a national peer-reviewed journal published twice a year on topics of excellence of research results in the fields of service and practice of pharmacy, community medicine, pharmaceutical technology, and health science disciplines that are closely related. This journal accepts English texts. The following are the research areas that this journal focuses on Clinical Pharmacy, Community Pharmacy, Pharmaceutics, Pharmaceutical Chemistry, Pharmacognosy, Phytochemistry. JPharmaco receives manuscripts from the results of research (research article), systematic reviews and meta-analysis that are closely related to the health sector, particularly the pharmaceutical field. Selected manuscripts for publication in JPharmaco will be sent to two reviewers experts in their field, who are not affiliated with the same institution as the author(s) and are chosen based on the consideration of the editorial team. The review process is conducted in a closed manner where the author(s) and reviewers do not know the identity and affiliation of each. Each manuscript delegated to editorial members is examined for the final decision of the review process. The author(s) are required to respond to the review given and send revised manuscripts within the allotted time after the comments and suggestions from the reviewers have been sent. Manuscripts accepted for publication are edited copies checked for grammar, punctuation, print style, and format. The entire process of submitting the manuscripts to the final decision for publishing is done online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 62 Documents
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Formulasi Sediaan Gel Face Scrub Dari Ekstrak Etanol Bayam Merah (Amaranthus tricolor L) Rosi, Devahimer Harsep
Jurnal Pharmacopoeia Vol 3 No 2 (2024): September 2024
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v3i2.879

Abstract

Telah dilakukan penelitian “Formulasi Sediaan Gel Face Scrub Dari Ekstrak Etanol Bayam Merah (Amaranthus tricolor L).” Tujuan dari penelitian ini untuk mengetahui ekstrak etanol bayam merah dapat diformulasikan sebagai sediaan gel face scrub. Ekstraksi sampel dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Ekstrak yang didapatkan dibuat gel face scrub. Pada penelitian ini dibuat menjadi 3 formulasi sediaan gel face scrub dengan konsentrasi yang berbeda yaitu F1 0,5 g, F2 0,75 g, dan F3 1 g ekstrak. Dilakukan evaluasi sediaan gel face scrub yaitu meliputi uji organoleptis, uji homogenitas, uji pH, uji iritasi, uji daya sebar dan uji daya lekat. Bayam merah yang digunakan telah diidentifikasi sebagai Amaranthus tricolor L. Hasil skrining fitokimia terhadap ekstrak bayam merah menunjukkan ekstrak positif mengandung flavonoid, alkaloid, steroid, saponin, dan tanin. Kesimpulan yang didapat bahwa sediaan gel face scrub dari ekstrak etanol bayam merah dapat diformulasikan menjadi sediaan gel face scrub karena sediaan gel yang diperoleh telah memenuhi parameter uji fisik yaitu uji organoleptis, uji homogenitas, uji pH, uji iritasi kulit, uji daya lekat, namun belum memenuhi persyaratan terhadap uji daya sebar.
Cost Minimization Analysis Penggunaan Antihipertensi Candesartan Dibandingkan Amlodipin Pada Pasien JKN Rawat Jalan Di Rumah Sakit Roemani Muhammadiyah Semarang Islami, Bella Citra; Rahmaniar, Ranita
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1008

Abstract

Hypertension was a global health problem that required long-term therapy and caused economic burden. The cost efficiency of therapy needs to be analyzed using the Cost Minimization Analysis (CMA) approach, especially when treatment outcomes were assumed to be equivalent. This study aimed to analyze direct medical costs and the factors influencing cost differences in single antihypertensive therapy between candesartan and amlodipine among outpatient hypertensive patients covered by the National Health Insurance (JKN) at Roemani Muhammadiyah Hospital Semarang. A descriptive quantitative method with a retrospective approach was used. Samples were selected using purposive sampling from medical records of outpatient with hypertension from January 1 to December 31, 2024. The data included components of direct medical costs: doctor, administrative, laboratory, antihypertensive drug costs, and concomitant drugs costs. CMA and statistical tests were used to examine the effect of age, gender, and number of comorbidities on total direct medical costs. Of the 168 patients, 87 patients (51%) were in the candesartan groups and 81 patients (49%) were in the amlodipine group. The majority of patients were female, with 93 patients (55%) compared to 75 male patients (45%), and aged 45-64 years in both groups. Most had 1-2 types of comorbidities. The result showed that the average total direct medical cost in the candesartan group was lower (IDR213.427,00) than in amlodipine group (IDR231.305,00). Age, gender, and number of comorbidities had no significant effect on the total cost. Considering the assumed equal effectiveness and cost efficiency, candesartan was the more economical choice compared to amlodipine.
Hubungan Tingkat Pendidikan Dengan Perilaku Penyimpanan Dan Pembuangan Obat Di Kelurahan Sungai Lulut Nabilla, Yasmin; Melviani; Kusumawati, Linda
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1038

Abstract

Obat-obatan sangat penting untuk mengobati masalah kesehatan. Namun, tingginya penggunaan telah menyebabkan sisa obat-obatan di rumah tangga, yang menimbulkan berbagai risiko kesehatan. Jika obat tidak disimpan dengan benar maka akan mempengaruhi stabilitas obat. Pembuangan obat yang salah juga dapat menimbulkan dampak buruk terhadap lingkungan sekitarnya. Tujuan penelitian ini untuk mengetahui hubungan antara tingkat pendidikan dengan perilaku penyimpanan dan pembuangan obat di Kelurahan Sungai Lulut. Metode yang digunakan yaitu observasional deskripstif dengan pendekatan Cross Sectional dan menggunakan instrumen berupa kuisioner dengan teknik purposive sampling. Hasil penelitian menunjukkan sebagian besar responden di Kelurahan Sungai Lulut RT. 08 bertingkat pendidikan SMA (35,7%), responden yang berkategori baik dalam perilaku penyimpanan obat yaitu (47,9%), responden yang berkategori kurang baik dalam perilaku pembuangan obat yaitu (38,7%). Hasil uji spearman rank menunjukkan nilai koefisien korelasi perilaku penyimpan (0,297) dan nilai koefisien korelasi perilaku pembuangan obat (0, 402). Kesimpulannya tingkat pendidikan yang lebih tinggi memiliki perilaku baik dalam hal penyimpanan dan pembuangan obat. Terdapat hubungan yang signifikan antara tingkat pendidikan dengan perilaku penyimpanan dan pembuangan obat di Kelurahan Sungai Lulut dengan tingkat kekuatan hubungan cukup kuat dan arah korelasi positif.
Identifikasi Kasus Anemia Pada Ibu Hamil Pre Dan Post Pemberian Suplemen Zat Besi Di Puskesmas Kota Bengkulu Azzahra, Istiqoma; Putri, Yona Harianti; Banon, Charles; Oktarini, Rizki
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1047

Abstract

Secara global prevalensi anemia pada ibu hamil mencapai 41,8%, dengan prevalensi tertinggi di Afrika dan Asia. Di Indonesia, angka anemia ibu hamil mencapai 48,9% dan di Bengkulu 12,6%. Penyebab utama anemia adalah kekurangan zat besi dan mikronutrien, serta faktor usia. Kepatuhan yang rendah dalam konsumsi suplemen zat besi sering memperburuk kondisi anemia pada ibu hamil. Maka dari itu, dalam penelitian ini akan diteliti pengaruh pemberian suplemen zat besi dalam peningkatan kadar Hemoglobin (Hb) pada ibu hamil anemia. Penelitian ini menggunakan desain pre experimental dengan tipe one group pretest posttest yang dilakukan dengan mengukur kadar hb sebelum dan sesudah pemberian suplemen zat besi. Sampel yang digunakan adalah ibu hamil anemia di puskesmas kota Bengkulu. Data hasil penelitian di analisis menggunakan uji t-test pada aplikasi spss untuk melihat perbedaan yang signifikan kadar Hb pre dan post pemberian suplemen zat besi. Hasil analisis data menunjukkan p-vlue 0,001 (<0,05) yang berarti adanya perbedaan yang signifikan. Hal tersebut menunjukkan bahwa pemberian suplemen zat besi dapat meningkatkan kadar Hb pada ibu hamil yang mengalami anemia. Hasil penelitian menunjukkan bahwa dari 56 ibu hamil, 35 di antaranya mengalami anemia. Kadar Hb sebelum dan sesudah pemberian suplemen zat besi tercatat masing-masing sebesar 10,03 g/dl dan 12,85 g/dl. Kadar Hemoglobin (Hb) pada ibu hamil yang mengalami anemia sebelum pemberian suplemen zat besi menunjukkan angka yang lebih rendah, dengan rata-rata 10,03g/dl. Setelah pemberian suplemen zat besi, kadar Hb pada ibu hamil dengan anemia mengalami peningkatan, dengan rata rata 12,85 g/dl.
Skrining Fitokimia Dan Uji Aktivitas Antioksidan Ekstrak Buah Kupa (Syzygium polycephalum) Dengan Metode 1,1-diphenyl-2-picrylhydrazil dharmayanti, Luky; Jannah, Syauqul; Oktamauri, Ariesa
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1065

Abstract

Kupa fruit has a high anthocyanin content and is useful as an antioxidant. Phytochemical screening shows flavonoid compounds in the skin and fruit. Free radical damage to skin cells can be repaired using antioxidants, because antioxidants can kill and neutralize radicals in the body so that oxidative stress and cell damage can be avoided. The purpose of this study was to determine the value of antioxidant activity and antioxidant content of kupa fruit extract (Syzygium polycephalum). This study used kupa fruit extract (Syzygium polycephalum) This will be examined using the 1,1-diphenyl-2-picrylhydrazyl technique to determine its antioxidant activity. A UV-Vis spectrophotometer was used to detect absorbance at λ 517 nm. The results are represented as IC50 (Inhibitory Concentration) values, which indicate the concentration of antioxidant substances that capture 50% of DPPH radicals. Kupa fruit extract has an extract yield of 40.11% and is positive for alkaloid, flavonoid, and tannin components, according to phytochemical screening results, the water content is 30.65% and the ash content is 1.13%. The results of the antioxidant activity test of kupa fruit extract show a relatively strong IC50 value of <100 µg/mL with an IC50 value of 99.74. Keywords: Kupa fruit (Syzygium polycephalum), antioxidant, DDPH, IC50
Pengaruh Variasi Konsentrasi Basis Beeswax Dan Paraffin Wax Pada Lip Balm Ekstrak Bunga Soka Merah (Ixora coccinea L.) Setiyawati, Bayu; Endriyatno, Nur Cholis
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1068

Abstract

Soka flower extract (Ixora coccinea L.) is a very powerful source of natural antioxidants. Soka flower extract is formulated as a lip balm to utilize its potential as an antioxidant that can protect the lips. This study aims to determine the effect of variations in the concentration of beeswax and paraffin wax bases on the physical properties of soka flower extract lip balm preparations and to obtain the best component variations. Soka flowers were extracted using maceration extraction using 96% ethanol. The lip balm preparations were made in 3 formulas with variations in the concentration of beeswax and paraffin wax bases, namely FI (5%:15%), FII (7.5%:12.5%), and FIII (10%:10%). The lip balm was evaluated for physical properties such as organoleptic tests, homogeneity tests, pH tests, spreadability tests, smearability tests, adhesion tests, irritation tests, and moisture tests. Data analysis was carried out using the One Way ANOVA method. Based on the results of the study, it was shown that variations in the concentration of beeswax and paraffin wax bases affected the physical properties of the preparations, including pH, adhesiveness, spreadability, and viscosity. In this study, FII (7.5% beeswax and 12.5% paraffin wax) was determined as the best formula for the soka flower extract lip balm preparation, based on consideration of the requirements and statistical tests.
Hubungan Peran Pengawas Menelan Obat Dengan Kepatuhan Minum Obat Penderita Tuberkulosis Di Puskesmas Sukarahayu Miranda, Elfa Dhela; Adiutama, Novian Mahayu; Ningrum, Dwi Agustia
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1080

Abstract

Tuberculosis (TB) remains a health challenge in Indonesia. Its treatment is lengthy and requires discipline, making medication adherence crucial. One way to improve adherence is through the involvement of Medication Supervisors (PMO) during treatment. To examine the relationship between the role of PMO and the level of medication adherence among pulmonary TB patients at Puskesmas Sukarahayu. This study used a quantitative approach with a cross-sectional design and purposive sampling, involving 135 TB patients. Data were collected via questionnaires on the role of PMO and MMAS-8, then analyzed using Spearman's Rank test. The study showed that the majority of respondents had PMOs who played a supportive role (94.8%), and most respondents were adherent to their medication (63.7%). The statistical analysis indicated a significant relationship between the role of PMO and medication adherence (p = 0.000) with a correlation coefficient r = 0.638, indicating a strong and positive relationship. The better the PMO role, the higher the adherence of TB patients to treatment. Improving the quality and engagement of PMOs is an effective strategy to reduce dropout rates, prevent resistance (DR-TB), and accelerate recovery. This confirms the importance of training and support for PMOs in TB control programs.    
Correlation Between Probiotic Use And Blood Pressure In Hypertensive Adults: A Cross-Sectional Study Sultan, Dharma; Setyawan, Yuswanto
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1081

Abstract

Hypertension remains a significant global health burden and is closely linked to cardiovascular morbidity. Emerging evidence suggests that gut microbiota plays an essential role in modulating blood pressure, particularly through the use of probiotics and prebiotics. This study investigated the relationship between the frequency of probiotic consumption and blood pressure control in patients with essential hypertension. A total of 100 hypertensive adults participated in this cross-sectional study, and data were collected through structured interviews, food frequency questionnaires, and blood pressure assessments. Statistical analyses included Chi-square and Spearman correlation tests. The results demonstrated a significant association between higher frequency of probiotic intake and better blood pressure control (p = 0.008), with a moderate negative correlation (r = –0.45) observed between intake duration and systolic blood pressure. Additionally, individuals who consumed both probiotics and prebiotic-rich foods exhibited enhanced blood pressure improvement. These findings support the potential of probiotic-prebiotic synergy in modulating gut microbiota to regulate blood pressure. The incorporation of prebiotics is essential, as they serve as substrates that stimulate the growth and activity of beneficial bacteria, thereby optimizing the efficacy of probiotic supplementation. The study highlights the practical implications of dietary interventions targeting the gut environment as a complementary strategy in hypertension management. Keywords: Hypertension, Probiotics, Prebiotics, Gut microbiota, Blood pressure
Analisis Perbedaan Tarif Rumah Sakit dan Tarif INA-CBG’s Pelayanan Rawat Inap Salah Satu Rumah Sakit Pemerintah Tipe C Tahun 2021 Melviani; Yulianto, Rivai Endra Dwi; Ruslan, Riswati
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1086

Abstract

Indonesian Case Base Groups (INA-CBG) become a reference for the Social Security Administering Body (BPJS) in payment of claims at advanced health facilities. From the article search, 20 articles were found that compare the real rates with the INA CBGs rates. Five articles yield higher INA CBG rates than hospital rates and another 15 articles provide higher real rates than INA CBG rates. RS. X is one of the hospitals located outside Java. This study aims to obtain an overview of the comparison between real rates and INA CBGs rates in hospitals. X, diseases with catastrophic or non-catastrophic categories that are widely used in hospitals. X and the comparison of costs and the effect of length of stay on real costs. This study is a cross-sectional study using secondary data, namely BPJS claim data for inpatients at the hospital. X in Southeast Sulawesi in 2021. The distribution normality test uses the Kolmogorov Smirnov normality test. Data with normal distribution were tested for significance using an independent t-test. Data that were not normally distributed were tested for significance with Mann Whitney. There are 2,534 data claimed by RS. X to BPJS in 2021. Claims consist of 209 types of disease descriptions where claims for non-catastrophic diseases are more than claims for catastrophic diseases. The biggest claim was cesarean section (mild) which was 209 claims (8.2%) which was included in the non-catastrophic category. RS. X must spend IDR 1,411,298,920,- to cover the difference between the INA CBGs tariff and the real rate for the non-catastrophic category and IDR 6,878,400 for catastrophic diseases. A stronger correlation between length of stay and real rates indicates that length of stay is one of the factors that cause real rates to be higher than INA CBG rates. The results of the t-test on non-catastrophic diseases showed that nine out of 10 disease descriptions had significant differences for real rates and INA CBG rates, while for catastrophic diseases there were no significant differences. There is only one disease description that has no significant difference, namely a disease with a description of Antepartum Disorder (Mild). The non-catastrophic disease is the most common in hospitalized patients. X in Southeast Sulawesi. The cost of hospital claims is greater than the cost of claims for INA CBGs in non-catastrophic and catastrophic diseases. Length of hospitalization has a significant correlation in hospitalized patients with catastrophic and non-catastrophic diseases. The correlation between length of stay was greater in patients with the catastrophic disease.
Penetapan Kadar Hesperidin Pada Seduhan Kulit Jeruk Keprok (Citrus Nobilis L.) Dhirisma, Fitria; Pinasti, Rahayu
Jurnal Pharmacopoeia Vol 4 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v4i2.1092

Abstract

Tangerine peel (Citrus nobilis L.) has a high content of flavonones, namely hesperidin, naringin and narirutin which can be used as antidiabetics by increasing insulin release through increasing serum insulin and C-peptide levels. The drying method can affect the total phenolic content of orange peel so that the air-dried drying method is reported to be able to produce high phenol levels. The purpose of this study was to determine the hesperidin levels in tangerine peel infusion (Citrus nobilis L.). This type of research is an experimental laboratory study in the form of a test to determine the hesperidin levels in tangerine peel infusion using Uv-Vis speccrophotometry. The sample was 2 grams of orange peel infusion, the hesperidin standard was made in a series of levels of 2, 4, 6, 8, 10 ppm. The wavelength is obtained from the absorbance of the hesperidin reference solution, then a standard curve is made and a linear equation is obtained. The maximum wavelength of hesperidin is 282.7 nm according to the literature. The standard curve of hesperidin is obtained y = 0.0448x + 0.0265 with a correlation coefficient (r) of 0.9994. Determination of hesperidin levels in tangerine peel infusion was carried out in 3 replications and obtained R1 8.559 ppm, R2 7.517 and R3 6.649 with an average of 7.588 ppm. The hesperidin levels in 2 grams of tangerine peel infusion using UV-Vis spectrophotometry were 151.77 ppm.

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