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INDONESIA
Jurnal Farmasi Indonesia
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : https://doi.org/10.35617/jfionline
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 164 Documents
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Ciplukan (Physalis angulata L.): Review Tanaman Liar yang Berpotensi Sebagai Tanaman Obat Fadhli, Haiyul; Ruska, Shinta Liana; Furi, Mustika; Suhery, Wira Noviana; Susanti, Emma; Nasution, Musyirna Rahmah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.144

Abstract

Ciplukan (Physalis angulata L.) has been widely used as a traditional medicine in several countries and regions in Indonesia, such as to increase blood flow and relieve body aches, asthma, diabetes, chickenpox, cough medicine, fever, diarrhea, hypertension, and back pain. This article reviews the potential of ciplukan to overcome various health problems. The preparation of this review article uses references from research articles related to the results of phytochemical screening, the isolation of secondary metabolites, and biological activity tests (pharmacology) of Physalis angulata plants reported in the last 10 (ten) years. This plant contains many secondary metabolite compounds isolated from its roots, leaves, stems, and fruits, such as physalin, withanolide, and flavonoid glycoside compounds. Several studies have reported that this plant has biological and pharmacological activities such as antioxidants, toxicity, anticancer, anti-inflammatory, antidiabetic, antidiarrheal, antibacterial, antifibrotic, and anti-hypercholesterolemia.
Pengembangan Metode Analisis Sitrinin dan Upaya Penurunan Produksi Sitrinin dalam Fermentasi Cair Monascus purpureus Jatmika, Catur; Wibowo, Marlia Singgih; Miftah, Amir Musadad
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.146

Abstract

Citrinin, a fluorescent compound that contaminates a number of agricultural products, is a toxic compound especially to the kidneys and liver. This study aimed to develop analysis method for citrinin by HPLC and to reduce the level of citrinin in broth extract from Monascus purpureus fermentation microbiologically. The citrinin extraction method from fermentation broth was optimized by various pH and extracting solvents. The citrinin extract was incubated with Bacillus firmus bacteria at various growth phases. The levels of citrinin in the extract decreased significantly after incubating for 24 hours with the bacteria. Citrinin was analyzed HPLC by fluorescence detector at λexc 330 nm and λem 500 nm, mobile phase 0.033 M phosphoric acid: acetonitrile (1: 1), flow rate 1 mL/min with an average retention time of 6.1 minutes. The recovery was in the range of 78-83%. The precision method as shown by the coefficient of variance of 2.1%, with limit of detection and quantitation 0.03 µg/mL and 0.11 µg/mL respectively. Linearity was expressed by a correlation coefficient (r) of 0.9996 and a coefficient of variation of the regression function (Vx0) of 1.3%. The citrinin level in the extract was 0.69 µg/mL. The levels of citrinin after incubation with nutrient broth media contain bacterial culture aged 5 hours, 9 hours, and 14 hours were 0.56 ± 0.03, 0.27 ± 0.02, 0.26 ± 0.01, and 0.24 ± 0.01 µg/mL, respectively. Incubation of Bacillus firmus bacteria on citrinin extract significantly reduced the levels of citrinin in the extract.
GAMBARAN TINGKAT PENGETAHUAN PENGGUNAAN OBAT TRADISIONAL HIPERTENSI PADA PENDERITA HIPERTENSI DI KABUPATEN PELALAWAN PROVINSI RIAU Husnawati, Husnawati; Sastrawati, Atriwida; Pratiwi, Erniza; Laia, Cindy Oktaviana
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.149

Abstract

Traditional medicine is an ingredient or ingredient in the form of plant material, animal material, mineral material, sarian preparation, or a mixture of these materials which have been used. One of the traditional treatments carried out by the community is for the treatment of hypertension. Knowledge is the result of knowing and occurs after someone has sensed a certain object. This study aims to describe the level of knowledge of the use of traditional hypertension drugs in patients with hypertension. The benefits of this study are to know the level of knowledge of hypertension sufferers in using traditional hypertension drugs. The design in this study was an observational study with descriptive methods. The sample was selected using purposive sampling technique. Data collection wasdone by using a questionnaire. Based on the results of the study, it was found that the description of the level of knowledge of respondents in using traditional hypertension medicine was generally categorized as good, namely as many as 77 respondents, the level of knowledge of respondents in the sufficient category as many as 20 respondents and as many as 3 respondents had a low level of knowledge.
Gambaran Penggunaan Antipsikotik Terhadap Pasien Skizofrenia di Rumah Sakit Kota Indramayu Suzana, Dona; Febriyani, Ayu
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.151

Abstract

Schizophrenia is a psychiatric disorder characterized by disturbances in thinking processes, perceptions, emotional responses, and social interactions. The therapy commonly used in the treatment of schizophrenia is antipsychotic or psychotropic drugs. The use of psychotropic drugs is the first step in overcoming and following up on mental disorders. The object of this research is several hospitals that treat patients with psychiatric disorders, namely schizophrenia. Where the subjects used in this study were men/women with schizophrenia aged 18 to 60 years in the city of Indramayu who are undergoing treatment at the hospital for the 2020-2022 period. This study aims to describe the use of antipsychotic classes that are used as one of the pharmacological therapies in patients. This research method uses a descriptive quantitative method, while the sample fee used in this study is the slovin calculation formula, with a total population of 875 and a sample of 274 is obtained. The results obtained are based on the proportion of sex, mostly male patients (62.4%), the highest proportion of the age range was found in early adulthood (70.8%), the highest diagnosis was YTT schizophrenia (46%). Then patients with a history of not going to school (63.5%) and a history of not working (88.3%). Most of the data obtained were patients who experienced mild recurrence of 62%. As for the large number of patient histories with mild or insignificant recurrence, this can influence the factors supporting the success of treatment, namely the use of insurance. This opinion was obtained from patient payment status data, in which the most widely used payment status was the use of insurance by 82.1%. In data on the use of the single antipsychotic that is most widely used in each type of schizophrenia is the antipsychotic haloperidol and the combination that is most widely used is haloperidol-chlorpromazine
Analisis Kebutuhan Formulasi Kebijakan Program Pengembangan Karier Apoteker Non Aparatur Sipil Negara Pratita, Rasta Naya; Bachtiar, Adang; Ernawati, Desak Ketut
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.152

Abstract

The level of public health is determined by the quality of public health services, as stated by WHO, the quantity of health personnel contributing as much as 80% of the success in health services. According to Undang-Undang No 36/2014 regarding Health Worker article1, health works improvement is directed to improve the quality and career of health worker. One of the current problems for health worker is the career path / career improvement. There is still no regulation regarding health worker’s career development aside from health civil worker, especially for pharmacist, that also suffer from the lack of synchronization of the career development program between the one from the government and the one from the pharmacist organization. Qualitative method is used in the research of the process of formulating the related regulations and stakeholder analysis. Primary data is acquired by doing in-depth interview with chosen informant, and literature research is used as secondary data. The result shows that all the interviewed stakeholders are supporting and committing in the Pharmacist’s career development program. Pharmacist organization along with the government are of two of the most important actors regarding the implementation of this program. The competency certification and specialization education program are expected to be the right options for the pharmacist career development program. On the other side, the interaction, advocacy and communication process between the stakeholders in pharmacist organization and the government still need improvement, and there are many of the pharmacist itself that not aware of the career development program. Therefore improvement in stakeholder’s coordination and communication is a must.
HUBUNGAN TINGKAT PENGETAHUAN DENGAN PERILAKU PENGGUNAAN TABLET HISAP ANTIBIOTIK PADA MASYARAKAT KECAMATAN BEKASI SELATAN Arrang, Sherly Tandi; Widia Kimla Ningrum, Raymunda; Eko Adi Prasetyanto, Yohanes
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.153

Abstract

Infection is a disease that can occur at any age, caused by microorganisms such as bacteria, fungi, viruses, or protozoa. Drugs used to treat infections caused by bacteria are known as antibiotics. A lack of public knowledge can encourage the irrational use of antibiotics and lead to bacterial antibiotic resistance. This study aims to describe the knowledge and behavior of using brand X antibiotics and the relationship between gender, age, education, income, and knowledge with the behavior of using brand X antibiotics in the people of the South Bekasi District. This research is an observational study with the cross-sectional method. This study's measuring tool was a questionnaire distributed to respondents using Google Forms. Analysis of the relationship between gender, education, income, and knowledge with behavior was carried out using the Chi-Square Test. In contrast, the analysis of the relationship between age and behavior used Way ANOVA. The research was conducted on 384 respondents. The majority of respondents in this study were female (62.5%), aged between 17-25 years (56.5%), had a senior high school/vocational school education (54.2%), and had income below Rp—2,500,000 every month (56%). The level of knowledge of respondents in the high category is 57.3%, and the behavior of respondents in the rational category is 50.5%. Factors influencing the behavior of using antibiotic lozenges were education (p=0.000), income (0.003), and knowledge (p=0.000), while gender (p=0.562) and age (p=0.280) had no relationship with use behavior brand X antibiotic lozenges.
Formulasi dan Evaluasi Granul Mukoadhesif Amoksisilin trihidrat dengan Polimer Kitosan Rosmawati; Hartianty, Eka Pebi; Ashfar Kurnia; Siti Mardiyanti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.157

Abstract

Infeksi saluran pernapasan akut (ISPA) merupakan infeksi saluran pernapasan yang mengakibatkan gangguan aktivitas pernapasan normal. Amoksisilin merupakan antibiotik pilihan pertama yang umumnya diberikan untuk pasien ISPA. Frekuensi penggunaan obat akan memengaruhi kepatuhan pasien dalam minum obat untuk mencapai keberhasilan terapi. Formulasi granul mukoadhesif Amoksisilin trihidrat dengan penambahan polimer kitosan diharapkan dapat mempertahankan sediaan obat agar tertahan berada lebih lama di lambung sehingga dapat memperkecil frekuensi harian penggunaan obat. Formulasi granul mukoadhesif Amoksisilin trihidrat dirancang dengan penambahan polimer kitosan yang diformulasikan dengan metode granulasi basah. Hasil evaluasi menunjukan peningkatan konsentrasi kitosan dalam formula menunjukan profil pelepasan obat yang semakin diperlama yaitu pada formula 6 dengan konsentrasi kitosan 40% dapat mempertahankan pelepasan obat sebesar 41% selama 6 jam pengujian. Kinetika pelepasan obat dari formula 1, 3, 4, dan 5 cenderung mengikuti kinetika pelepasan higuchi, sedangkan pada formula 2 cenderung mengikuti kinetika pelepasan orde nol dan formula 6 cenderung mengikuti kinetika pelepasan orde satu. Peningkatan konsentrasi kitosan pada tiap formula menunjukan daya mukoadhesif yang baik dan profil pelepasan obat yang semakin diperlama. Pelepasan yang paling baik diperoleh dari formula 5 yaitu mampu memperlambat pelepasan obat lebih dari 50% selama 6 jam pengujian dalam medium HCl 0,1N pH 1,2.
UJI AKTIVITAS ANTIOKSIDAN DAN TABIR SURYA EKSTRAK ETANOL DAN FRAKSI DAUN TERAP (Artocarpus odoratissimus Blanco) Furi, Mustika; Feriansyah, Robby; Fadhli, Haiyul; Utami, Rahayu; Lestari, Putri
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.159

Abstract

Plants from genus Artocarpus are known containing phenolic and flavonoid compounds that have potential as antioxidant and sunscreen agent. Terap is one of species plant of Artocarpus genus, which has latin name Artocarpus odorratissimus Blanco. This present study aims to determine the antioxidant and sunscreen activity of ethanol extract and fractions of terap’s leaves. The evaluation was conducted by in vitro assay, which were the antioxidant activity was tested using the DPPH method by Microplate Reader and the sunscreen activity was analyzed using UV-Vis spectrophotometer. The results indicated that ethanol extract, ethylacetate and butanol fractions afforded very strong category of antioxidant activity with IC50 values ​​of 44.04; 42.9 and 36.49 µg/mL, respectively, while moderate activity gave by n-hexane fraction with IC50 value of 168.31 µg/mL. As for the sunscreen activity test, the most potential activity exhibited by the ethylacetate fraction at tested concentrations of 500; 250; 200; and 150 µg/mL demonstrated SPF values of 39.45; 37.36; 33.27 and 26.14, respectively; with ultra protection category as well as showed %Te and %Tp values of <1% which categorized as sunblock.
Resistensi Antimikroba: Pengetahuan, Sikap, dan Kewaspadaan pada Komunitas Lokal Bali: - Dewi, Ni Luh Putu Sastrani; Widowati, I Gusti Ayu Rai; Wirajaya, Made Karma Maha; Maharianingsih, Ni Made
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 1 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i1.161

Abstract

Antimicrobial resistance (AMR) concerns may arise as a result of improper antibiotic use. Bacterial resistance to antibiotics, which has been identified by the WHO as one of the most serious threats to public health, can be worsened by a lack of public understanding of proper antibiotic use. The objective of this research was to find out the level of community knowledge, attitudes, and awareness about AMR. A validated questionnaire was adopted to conduct purposeful interviews with locals of Kerobokan Kaja Village during February and March 2023 to conduct the cross[1]sectional survey. There were 110 total responses (100% response rate). Most respondents (37 [33.3%]) are between the ages of 18 and 27; 56 [50.9%] are women; and 78 [70.9%] have completed secondary school.; (41 [37.3%]) work as private employees; and received minimum wages (41 [37.3%]). The findings indicated that more than half of the population (70 [63.3%]) had adequate knowledge regarding the use of antibiotics, adequate attitudes (64 [58.2%]), and fair awareness of AMR (63 [57.3%]). The results of the Spearman's Rank test reveal a moderately strong correlation between knowledge and AMR awareness (Sig.2-tailed=0.000; p-value
Reaksi Merugikan Obat Kanker Berbasis Antrasiklin pada Pasien Kanker Payudara di RS Kanker Dharmais Chairunnisa, Dian Fitri; Harahap, Yahdiana; Syafhan, Nadia Farhanah; Purwanto, Denni Joko
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 1 (2024): Jurnal Farmasi Indonesia
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i1.164

Abstract

Breast cancer is the type of cancer that most often affects women worldwide. Doxorubicin is an anthracycline class, a first-line anticancer therapy with clinical activity in breast cancer. Doxorubicin can cause cardiotoxic effects due to the formation of doxorubicinol as its primary metabolite. Adverse drug reactions also vary depending on the chemotherapy regimen. This study aimed to determine the adverse reactions to anthracycline-based drugs that breast cancer patients often experience. This observational descriptive study was conducted from April to July 2022 at the Dharmais Cancer Hospital, Jakarta. The sample in this study was breast cancer patients undergoing chemotherapy with anthracycline-based regimens. Data were collected through interviews and observation of medical records, which were analyzed by univariate analysis. The results showed that the most frequent drug reaction was alopecia, with a percentage of 97.1%. They were followed by nausea at 85.7%, vomiting at 71.4% and pain at 65.7%. The fastest time for nausea to appear is within 18-24 hours (peak days 2 to 3) after chemotherapy. Did not experience a decrease in left ventricular ejection fraction by 34.3%, and 65.7% experienced a reduction in left ventricular ejection fraction after doxorubicin chemotherapy. Patients who underwent a reduction in left ventricular ejection fraction after doxorubicin chemotherapy had a decrease in ejection fraction <10%, and no patients experienced a decline in left ventricular ejection fraction >10%. Breast cancer patients who receive anthracycline-based treatment can experience adverse drug reactions, including nausea, vomiting, alopecia, pain and decreased left ventricular ejection fraction.

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