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Journal of General Procedural Dermatology and Venereology Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 24607991     DOI : https://doi.org/10.19100/jdvi.v1i1.8
Core Subject : Health,
Medicine & Pharmacology
Journal of General-Procedural Dermatology & Venereology Indonesia is an open access and peer-reviewed journal that focuses on dermatology and venereology. This journal publishes original articles, reviews, case reports, and brief communications which contain short features of medicine, current developments in diagnostic procedures, treatments, or other health issues that are relevant and important.
Arjuna Subject : Kedokteran - Dematologi
Articles 11 Documents
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Search results for , issue "Vol. 8, No. 1" : 11 Documents clear
Administration of vitamin D3 topical in increasing serum vitamin D level: A literature review Nafaisa, He Yeon Asva; Waskito, Fajar; Martien, Ronny; Danarti, Retno
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
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Background: Vitamin D is an essential fat-soluble vitamin that is required daily by the body. Deficiency in vitamin D is experienced by most of the world's population. Vitamin D plays a role in maintaining the skin barrier by regulating keratinocyte proliferation and differentiation, promoting filaggrin formation, and intraepidermal lipids. Discussion: The vital role of vitamin D, non-compliance with supplement consumption, and poor nutritional status of adult patients and the elderly with deficiency and insufficiency of vitamin D encourage studies regarding vitamin D delivery via the transdermal route. The lipophilicity of vitamin D allows it to penetrate through the skin barrier. Conclusion: Research indicates that topical application of vitamin D3 is not only safe but also effective in increasing serum vitamin D levels. Thus, topical delivery is a promising alternative method for providing vitamin D supplementation or as a therapeutic option for specific conditions that leads to improved skin hydration and serum vitamin D levels.
Empowering nonmedical personnel to detect scabies in endemic area using DeSkab instrument: A diagnostic study Widaty, Sandra; Kekalih, Aria; Friska, Dewi; Bramono, Kusmarinah; Sari, Siti Maulidya; Darmawan, Irene; Sujudi, Yufanti; Hartanto, David Dwiadiputra; Kartika, Emiliana; Oktavia, Nikken Rima
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
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Background: Scabies has been added to World Health Organization (WHO) list of neglected tropical disease in 2017. Various methods have been developed to control scabies in highly prevalent communities. In this study we conducted a diagnostic study to evaluate the performance of scabies detection by trained nonmedical personnel (NMP) using Deteksi Skabies (Deskab) instrument which has been validated for NMP. Methods: Eight NMPs in a boarding school were trained to detect scabies using DeSkab instrument. The NMPs diagnosis were compared to diagnosis of 10 medical doctors. The study was conducted in a religion-affiliated boarding school in West Java, Indonesia. Both examiners consecutively assessed boarding school students using DeSkab instrument and were blinded to each other findings. Results: Among 140 participants included in this study, scabies was confirmed by medical doctors in 60 participants. Diagnostic accuracy of NMPs examination is 72.14% [95% confidence interval (CI) 64.2-78.9], with sensitivity and specificity 67.42% (95% CI 57.13-76.26), and 80.32% (95% CI 67.54-88.98) respectively. The inter-rater agreement (Cohen’s kappa) for diagnosing scabies is 0.44. Conclusion: NMPs can be trained to detect scabies in their community with acceptable accuracy. Improving training are recommended to further improve the diagnosis skills and maintaining sustainable detection program.
Chronic cutaneous chromoblastomycosis: A rare case Earlia, Nanda; Maulida, Mimi; Handriani, Risna; Kamarlis, Reno Keumalazia; Pradistha, Aldilla
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
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Background: Chromoblastomycosis (CBM) is a rare, chronic granulomatous and suppurative skin infection classified as a subcutaneous mycosis. CBM has a poor prognosis with a low cure rate and a high recurrence rate. The lack of scientific data regarding the diagnosis and treatment of CBM also presents a challenge for clinicians in treating this disease. Appropriate therapy can increase the cure rate and prevent disease recurrence. Case Illustration: A 66-year-old woman presented with swelling in her left arm since the last 18 years due to wood-related injuries. There were multiple well-defined hyperkeratotic verrucous plaques, papules, and nodules, measuring 6-10 cm in diameter on the left antebrachial and hand regions. Some lesions were covered with erosion and crusts. The patient also had bone malformation. Histopathological examination showed typical characteristics of CBM. The patient was treated with 100 mg Itraconazole b.i.d. for 8 months. Discussion: Clinical manifestations and histopathological examination showed typical characteristics of CBM. Bone malformation occurred due to complications in chronic cases. Facility limitations led to the inability to perform direct microscopic examination using potassium hydroxide (KOH) and fungal culture on Sabouraud's dextrose agar. After 8 weeks of treatment, the patient's lesions were improved. The patient will be evaluated every month until treatment is complete to monitor the side effects of therapy. Conclusion: CBM lesions were improved after 8 weeks of treatment. Bone malformation could occur in chronic cases. It is important to diagnose CBM correctly and provide adequate therapy for a good outcome.
Low plasma melatonin levels negatively correlate with melasma severity Praharsini, I Gusti Ayu Agung; Khathreen, Corry; Suryawati, Nyoman; Indira, I Gusti Ayu Agung Elis; Pramita, I Gusti Ayu Sattwika
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
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Background: Chronic exposure to ultraviolet light plays a role in the pathogenesis of melasma. Exposure to excessive sunlight leads to the formation of free radicals. As a result, the body responds by forming antioxidants such as melatonin, which is activated through the melatoninergic antioxidative system to fight oxidative stress. The relationship between melatonin and melasma is yet to be elucidated. This study aims to determine the correlation between melatonin and the severity of melasma. Methods: This analytical cross-sectional study involved 50 melasma subjects and 10 non-melasma subjects who met the inclusion criteria and were aged between 21-50 years at Prof. I.G.N.G. Ngoerah National General Hospital, Denpasar. The severity of melasma was measured by calculating the melasma area severity index (MASI) score and plasma melatonin levels were assessed using the ELISA method. Results: The median plasma melatonin level in the melasma subjects was lower (92.48 ng/ml) than in non-melasma subjects (436.35 ng/ml), with a p-value of Conclusion: Low plasma melatonin levels negatively-correlate with the severity of melasma.
Contribution to hair and skin science in Indonesia through a research grant program Verschoore, Michele; setiawan, rhadeya; Listiawan, Muhammad Yulianto; Nurtami, Nurtami; Moreau de Montcheuil, Eloïse
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
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To foster scientific advances in basic and clinical research projects, a philanthropic "hair & skin research grant" program was launched in 2021 through a partnership between University of Indonesia, Perdoski, and L’Oreal Research and Innovation. The aim of the program is to empower Indonesian scientists to generate research data on general skin and hair issues that affect the Indonesian population. We have grouped the eight grant projects awarded between 2021 and 2022 into five main themes: skin type characterization; skin microbiota; botanical extracts; photoaging therapies; and hair loss. The various studies are evaluating potential therapies for acne, skin aging, photoaging and male androgenetic hair loss (alopecia). The data will be useful for the development of guidelines for hair and skin care practices to raise awareness and educate the general public of Indonesia on the importance of skin and hair health.
The effects of vitamin D on chronic wounds Priyanto, Mufqi Handaru; Miranda, Eliza; Yusharyahya, Shannaz Nadia; Legiawati, Lili; Novianto, Endi; Bramono, Kusmarinah; Krisanti, Roro Inge Ade
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
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Abstract

Background: Wounds that fail to proceed through the normal healing process are referred to as chronic wounds, also known as ulcers. Chronic wounds have immeasurable biological, psychological, social, and economic effects, bringing tremendous challenges for patients, doctors, healthcare providers, and healthcare systems. Discussion: This condition is associated with a variety of comorbidities and complex etiologies. The global incidence of chronic wounds is expected to increase with longer life expectancy. Thus, a holistic approach is necessary, such as proper wound management, proper control of comorbidities, and provision of adequate nutrition, including vitamin D supplementation. Vitamin D is an essential pro-hormone for cell differentiation, proliferation, and growth. It affects the skin’s immune response, and is therefore thought to promote wound healing and tissue repair. Many studies have been published on the association between low vitamin D levels and chronic wounds. However, whether or not vitamin D supplementation directly contributes to wound healing still needs to be elucidated. Conclusion: Despite the many reports on vitamin D as an adjuvant treatment for chronic wounds, further large-scale clinical studies are needed to cement the role of vitamin D as an effective standard therapy for chronic wound healing.
Immunomodulators in leprosy: A narrative review Kimberly, Kesya; Ferina, Siti Aisha Nabila; Esti, Prima Kartika
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
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Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Current therapeutic regimen, like the multidrug therapy (MDT), are effective in treating most cases, but new cases continue to emerge in Indonesia every year. While multidrug therapy alone is adequate for treating leprosy, there is a need for adjuvant treatment options to boost the host’s immune system to prevent the worsening of leprosy and reduce the activation of M. leprae, such as immunomodulators. Discussion: Immunomodulators are drugs that can stimulate the body’s natural and adaptive defense mechanisms, acting as either immunosuppressants or immunostimulants. To understand how immunomodulatory drugs (IMiDs) work, it is important to understand the role of immunity. This article reviews the role of immunity in leprosy and discusses various immunomodulators that have been developed or investigated to enhance the host’s immune system. Substances like levamisole, thalidomide, zinc, selenium, as well as vitamins A, D, E, and C have been clinically tried in various combinations and durations, showing promise as immunomodulating agents. Conclusion: Studies have suggested that immunomodulating agents may be considered as adjuncts to MDT to enhance the elimination and clearance of bacteria, making them potential recommendations for leprosy treatment.
Facial skin rejuvenation with poly-l-lactic acid (PLLA): Four case studies Setiawan, Stanley; Handayani, Theressia; Luziani, Stefani
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
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Background: Facial aging is characterized by the decline and loss of skin structure. Poly-l-lactic acid (PLLA) is a biopolymer and biodegradable injection material that functions as a collagen stimulator. This active ingredient works by stimulating the formation of skin collagen after interacting with the PLLA crystal component. The expected final result is an increase in the skin volume with the thickening and increased density of the skin layers due to collagen remodeling. At present, data on the application of PLLA for facial photorejuvenation remains limited. Case Illustration: Four patients aged 22-49 years old, with different severity of aging, underwent PLLA injection procedures. The active component was administered through injection with a dilution ratio of 1:1 to 1:2 for the cheeks and temporal area and without dilution for the forehead, smile lines, and chin area. After the injection, a gentle massage was performed, and the patient was instructed to self-massage every day. Each patient was evaluated on the twentieth day and underwent additional injection sessions up to two times. Discussion: All patients showed improvement as assessed using photography and the Global Aesthetic Improvement Scale (GAIS) 20 days after the procedure. All patients were satisfied with the final result. There was no significant pain during the procedure. Conclusion: PLLA injection is a safe and effective procedure that stimulates the formation of new collagen adequately. Patient satisfaction with the treatment was excellent, and no complications were observed in all patients.
Agapanthus allergic contact dermatitis: A case report Horiuchi, Yasuhiro
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
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Background: Agapanthus (Lily of the Nile) is a genus in the flowering plant family Amaryllidaceae. Contact dermatitis caused by flowering plants is common, but there are no reports of contact dermatitis caused by this plant, Agapanthus. Case Illustration: An 82-year-old Japanese man had cultivated Agapanthus in his home garden. After breaking the stem of the leaf while wearing shorts, he noticed erythematous rashes on the thighs. The patch test of the leaf stem sap “as is” showed mildly positive, with erythematous papules. Discussion: The patch test confirmed the allergic contact dermatitis of Agapanthus with leaf stem sap. There are many well-known flowering plants, like lilies, daisies, jasmine, orchids so on, that can cause contact dermatitis. To date, many people fold Agapanthus flowers and decorate them at home, so far, this plant should also be added to the causative plant for contact dermatitis. Conclusion: To the best of our knowledge, there are no reports of contact dermatitis caused by this plant. Agapanthus contact dermatitis will need to be brought to people’s attention.
Dermoscopic and histopathologic findings in diagnosing postpartum pemphigoid gestationis Chandra, Rudi; Roesyanto-Mahadi, Irma Damayanti
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
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Background: Pemphigoid gestationis (PG) is an uncommon autoimmune vesiculobullous skin disorder associated with pregnancy, that occurs during mid-to-late pregnancy and immediate postpartum period. The diagnosis of PG is based on histopathology and direct immunofluorescence. Dermoscopy is a non-invasive diagnostic tool that provides a connection between macroscopic clinical dermatology and microscopic dermatopathology. Case Illustration: We reported a case of a 22-year-old primigravida woman with postpartum PG. This PG case was diagnosed clinically, dermoscopically, and histopathologically. Discussion: Since PG is thought to be a variation of the bullous pemphigoid (BP), the two resemble each other clinically and immunologically. The well-defined structures with brown-black dots in the central, yellowish translucent areas, follicular openings, peri-eccrine and perifollicular pigmentations, and a distorted pigment network were the dermoscopic findings of PG. To date, there is no literature about the dermoscopic features of PG. Conclusion: Dermoscopy is a simple non-invasive tool that can assist in making a rapid diagnosis, as well as in evaluating the prognosis, observing the response to treatment, and helping to determine the appropriate lesion and location for histopathological examination. We recommend that the dermoscopic features of PG in our case as a dermoscopic picture of PG.

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