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Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan Ibnu Sina Ajibarang
ISSN : 29872987     EISSN : 29874793     DOI : 10.59841
Core Subject : Health,
Dentistry Health Professions Nursing Public Health Veterinary
Farmasi Klinis; Farmasi Sosial;Farmasi Klinikal;Farmasi Industri;Farmasi Kesehatan Masyarakat;Farmasi Klinik;Farmasi Komunitas;Farmasi Klinikal dan Sosial;Ilmu Biomedis;Epidemiologi;Kesehatan Masyarakat;Kedokteran;Gizi;Psikologi Kesehatan;K3;Manajemen Farmasi;
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 320 Documents
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Penerapan Range of Motion Pasif terhadap Gangguan Mobilitas Fisik pada Pasien Miastenia Gravis di RSUD Dr. Moewardi Putri Widya Ariyani; Sri Puguh Kristiyawati
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3130

Abstract

Myasthenia Gravis (MG) is a rare chronic disease caused by a neuromuscular disorder resulting from an autoimmune condition. The primary cause of MG is a thymus gland abnormality that produces an excessive amount of abnormal antibodies. These autoantibodies block signal transmission at the postsynaptic membrane of the neuromuscular junction. As a result, the signal transmission required for muscle contraction through acetylcholine receptor binding on muscle fibers becomes impaired. In Indonesia, MG prevalence remains low. The typical clinical manifestations include muscle weakness, such as ptosis, diplopia, limb weakness, dysphagia, speech difficulties, and respiratory failure. One progressive muscle weakness. Non-pharmacological management, which includes passive Range of Motion (ROM) exercises, involves joint movements that promote muscle contraction and enhance mobility. ROM serves as a rehabilitation intervention that improves muscle strength, increases joint flexibility, and prevents joint stiffness. During a six-day consecutive intervention, passive ROM exercises improved both muscle strength and limb range of motion. Prior to ROM administration, muscle strength and range of motion scores were recorded at and , respectively. After the intervention, muscle strength and range of motion scores increased to and These results indicate that passive ROM therapy can serve as a rehabilitation strategy to reduce physical limitations and improve the quality of life in patients with myasthenia gravis.
Skrining Fitokimia dan Uji Antioksidan Fraksi Etil Asetat Dari Ekstrak Etanol Daun Kunyit (Curcuma longa L.) Dengan Metode DPPH Julia Megawati Djamal; Hana Rindi Sahea; Agust A Laya
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3131

Abstract

Turmeric leaves (Curcuma longa L.) is a traditional medicinal plant that contains secondary metabolites such as flavonoids, tannins, and alkaloids, which have potential as natural antioxidants. This study aims to identify the secondary metabolite content and evaluate the antioxidant activity of the ethyl acetate fraction of the ethanol extract of turmeric leaves using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Extraction was carried out using the maceration method with 96% ethanol as the solvent, followed by liquid-liquid fractionation using ethyl acetate. Qualitative phytochemical screening was performed to detect the presence of bioactive compounds such as alkaloids, flavonoids, tannins, saponins, and steroids, while antioxidant activity was assessed by observing the color change of the DPPH solution. The results showed that the ethyl acetate fraction contained these secondary metabolites and exhibited antioxidant activity, as indicated by a color change from purple to yellow. In conclusion, the ethyl acetate fraction of the ethanol extract of turmeric leaves contains bioactive compounds and has potential as a natural antioxidant source.
Tinjauan Penggunaan Teknik Kromatografi untuk Memisahkan dan Memurnikan Senyawa Aktif Secara Efisien Nur Rifa Ashya; Aida Savitri; Annisa Annisa; Difa Az-Zahra; Nurul Hasni Julianti; Shada Adila Abadi; Yumna Zaida
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3145

Abstract

Indonesia boasts an incredible wealth of biodiversity, positioning it as a promising source of natural compounds with significant biological activities. Its flora harbors a wide array of secondary metabolites including alkaloids, flavonoids, phenolic compounds, and terpenoids that hold immense potential for pharmaceutical and health applications. However, to utilize these bioactive molecules effectively, efficient methods for their extraction, separation, and purification are essential. Chromatography techniques such as thin-layer chromatography (TLC), column chromatography, and high-performance liquid chromatography (HPLC) are widely recognized as the most effective approaches for isolating and characterizing these valuable compounds. This article offers a comprehensive review of the existing literature on the chromatographic processes applied in isolating active constituents from medicinal plants. It systematically examines different methodologies adopted for extraction, separation, and identification, critically assessing their strengths and limitations. The review covers how plant materials are prepared, solvents and mobile phases optimized, stationary phases selected, and detection systems employed to achieve high-purity isolates. By comparing outcomes across studies, it illustrates the efficiency of TLC in preliminary screening, the flexibility of column chromatography in bulk separation, and the high resolution and reproducibility offered by HPLC. Results from multiple research efforts demonstrate that these chromatographic techniques can consistently yield pure compounds suitable for further pharmacological testing. The purified isolates not only exhibit potential therapeutic effects but also meet quality standards necessary for development into safe and effective natural medicines. The review highlights best practices in methodology selection, solvent systems, and instrument conditions tailored to specific metabolite classes. Ultimately, this synthesis emphasizes that chromatography plays a pivotal role in unlocking the pharmaceutical potential of Indonesia’s natural biodiversity.
Review Artikel: Tinjauan Aplikasi LC-MS/MS dalam Analisis Senyawa Alamiah dari Berbagai Sumber Daya Alam Muhammad Fadhli; M. Chaidir Hafidz; Hidayatur Rizky; Luthfia Raisah Ahyati; Nor Hilalliyah; Regina Nabila; Sri Muliany
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3147

Abstract

This study provides a comprehensive review of the application of Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) in the analysis of various natural product sources. LC-MS/MS has emerged as one of the most reliable and sensitive instrumental techniques for the identification, characterization, and quantification of bioactive compounds. Its strength lies in the ability to detect minute quantities of analytes, even in complex matrices such as plant extracts, microorganisms, and marine organisms. Numerous studies reviewed in this research demonstrate the effectiveness of LC-MS/MS in profiling chemical constituents from natural sources. Plants such as Allium ascalonicum L., Zingiber officinale, Uncaria sclerophylla, Momordica charantia L., Artocarpus integer, Garcinia xanthochymus, Piper nigrum Linn., Pometia pinnata, and Synsepalum dulcificum have been successfully analyzed using this method. Additionally, microorganisms like Aspergillus flavus and marine organisms such as Callyspongia aerizusa have also been studied with the same approach. The identified compounds belong to several major classes of secondary metabolites, including alkaloids, flavonoids, terpenoids, and saponins. These compounds have been reported to exhibit significant biological activities such as antioxidant, antidiabetic, anticancer, antimalarial, and enzyme-inhibiting properties. The successful identification and profiling of these bioactives provide a strong scientific foundation for the development of natural product-based innovations, including herbal medicines, health supplements, natural cosmetics, and functional foods. LC-MS/MS also plays a critical role in pharmacokinetic studies, method validation, and quality control of natural products. The advancement of data analysis software and improvements in instrument resolution have further strengthened the capability of LC-MS/MS to support multidisciplinary research based on biodiversity. In conclusion, LC-MS/MS is a key analytical tool that facilitates efficient and systematic exploration of bioactive compounds from nature. This review highlights the importance of integrating advanced technology in the sustainable utilization of natural resources to drive innovation in the health, industrial, and scientific research sectors.
Tinjauan Aplikasi Teknik Spektroskopi dalam Identifikasi dan Karakterisasi Senyawa Kimia Bahan Alam secara Efisien Nabila Sativa; Nailia Nur Isma Sumarno; Rusnia Apriliana; Laohannia Challiztha; Gabriyuvella Gabriyuvella; Syifa Askila Rahmadani; Yenni Hafizah
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3156

Abstract

This review discusses the application of various spectroscopic methods such as UV-Vis, FTIR, NMR, and GC-MS in the isolation and identification of secondary metabolites from natural products. The use of these spectroscopic techniques is crucial in the field of natural product chemistry as they provide accurate information about the structure, composition, and presence of bioactive compounds without destroying the sample. UV-Vis spectrophotometry is widely used for quantifying compounds such as flavonoids, saponins, tannins, and alkaloids in various plant species, including chili, okra, ridge gourd, and Averrhoa bilimbi leaves. This method is known for being fast, simple, and sufficiently sensitive for both qualitative and quantitative determination of phenolic and antioxidant compounds. FTIR spectroscopy is utilized to identify functional groups in plant extracts such as rose apple, noni fruit, red ginger, bay leaves, and red spinach. The results indicate the presence of phenolic compounds, flavonoids, and alkaloids through the identification of characteristic absorption bands from hydroxyl, carbonyl, methyl, and amine groups. FTIR is also useful for evaluating the purity and consistency of extracts. Mass spectrometry (MS), particularly GC-MS, is applied to determine the chemical profiles of essential oils and plant extracts such as citronella, Urena lobata, and Libo plants. Major compounds identified include zingiberene, citronellal, citronellol, digitoxigenin, and various terpenoids. This technique is highly effective in detecting volatile and semi-volatile compounds with high sensitivity. Meanwhile, NMR spectroscopy is employed to elucidate the structure of complex compounds such as xanthones and their derivatives, either from natural sources like endophytic fungi or from synthetic processes. NMR is essential for determining the three-dimensional structure and stereochemistry of molecules. This review highlights that a combinative approach involving multiple spectroscopic techniques is highly effective in rapidly and accurately identifying the structure and composition of active compounds in natural product research. The integration of these techniques represents a strategic approach to support the discovery and development of natural product-based drugs in the future.
Review: Perbedaan Penggunaan Pelarut Terhadap Nilai Rendemen yang Dihasilkan dengan Berbagai Metode Ekstraksi dalam Proses Ekstraksi Nur Latipah Sulistiawanti; Hairunnisa Hairunnisa; Niken Widya Ningrum3; Salma Fitriyanti
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3169

Abstract

The extraction process plays a crucial role in isolating bioactive compounds from natural materials. The success of the extraction process is heavily influenced by the type of solvent used and the extraction method applied. This review aims to evaluate the impact of solvents with varying polarities—both polar and non-polar—and compare the efficiency of various extraction techniques, such as Soxhlet extraction, reflux, and Ultrasonic Assisted Extraction (UAE) in obtaining extracts from various medicinal plants. Based on a review of previous studies, polar solvents generally yield higher rendemen compared to non-polar solvents, although non-polar solvents are more effective in selectively extracting non-polar compounds. Therefore, the selection of solvents should be tailored to the type of compound to be extracted to achieve optimal results. The UAE method has been proven to be more efficient than conventional extraction techniques, such as Soxhlet and reflux. The use of ultrasonic waves in UAE enhances solvent penetration into plant cells, resulting in higher yields in a shorter time. Several factors also significantly affect the extraction results, such as the solvent-to-material ratio, extraction time, and temperature. Variations in these three factors can lead to significant differences in both the quantity and quality of the extract obtained. Overall, choosing the right solvent and extraction method is essential for achieving optimal extraction results. By using solvents suited to the properties of the target compounds and selecting the most efficient method, the resulting extracts can be of higher quality and quantity. Therefore, further laboratory research is necessary to apply these findings in developing extraction methods that are not only effective but also environmentally friendly, particularly on an industrial scale. Future research could also focus on developing extraction methods that reduce the use of harmful solvents and enhance the sustainability of the extraction process at an industrial scale.
Formulasi Sediaan Serum Antioksidan dari Ekstrak Sari Tomat (Solanum Lycopersicum L.) sebagai Perawatan Kulit Hanita Christiandari; Intan Kumalawati; Jarot Yogi Hernawan
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3185

Abstract

Skin damage occurs because free radicals lose one electron in their outer orbit so that they are highly reactive which can cause oxidative stress. The impact is damage to body cells, such as large pores, acne, wrinkles and dark spots. Free radicals can come from the metebolism process in the body and from outside the body. One preparation that can prevent skin damage is a serum that contains antioxidants. To determine the physical properties, namely organoleptics, homogeneity, pH, spreadability, and adhesiveness of tomato juice extract (Solanum lycopersicum L.) serum preparations. The type of research used is experimental. The sample used was tomato juice extract. The research was conducted at the Pharmacy Laboratory of Politeknik Permata Indonesia Yogyakarta in May-June 2024. The independent variables of this study were 2%, 4%, 6% tomato juice extract. The dependent variable in this study is the test of physical properties of serum preparations including organoleptical tests, homogeneity, pH, spreadability, and adhesiveness. Data analysis in this method uses One way ANOVA. Organoleptical results are viscous, clear, clear yellow, light brown to dark brown in color and smells rose. The homogeneity results of the three formulations are homogeneous. The pH value in F0 was 5.08; F1 was 5.20; F2 was 5.35; F3 was 5.51. The value of spreadability in F0 was 5.2cm; F1 was 5.78cm; F2 was 5.91cm; F3 was 6.23cm. The stickiness value in F0 was 8.82; F1 was 15.94; F2 was 23.11; F3 was 30.75. All formulas have organoleptical arrangement, homogeneity, pH, spreadability, and adhesiveness that meet the requirements. Serum preparation of tomato juice extract (Solanum lycopersicum L.) has eligible physical properties.
Pengaruh Pendampingan Orang Tua terhadap Tingkat Stress Hospitality Pasien Pediatric di Rumah Sakit Muhammadiyah Lamongan Septiliana Dwi Handanyani; Raden Sugeng Riyadi; Nia Handayani
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3178

Abstract

Hospitalization in children can trigger stress and anxiety due to unfamiliar environments, medical procedures, and separation from parents. School-age children (6–12 years old) are particularly susceptible to preoperative stress, which if left untreated can interfere with the anesthesia process and surgical procedures. Parental assistance during the pre-operative phase has the potential to reduce stress levels in pediatric patients. This study aims to determine the effect of parental assistance on the level of hospitalization stress in pediatric patients in the pre-operative room at Muhammadiyah Lamongan Hospital. This study uses a quantitative method with a quasi experiment pre-test and post-test two group design. The sample consisted of 24 children aged 6–12 years, who were divided into two groups: experimental (supervised by parents) and controlled (unsupervised). Sampling was carried out by accidental sampling. The measuring tool used is the Face Anxiety Scale. Data analysis used Wilcoxon and Mann-Whitney tests. The results of the Mann-Whitney test showed a p-value = 0.000 which means that there was a significant difference between the experimental and control groups in the level of hospitalization stress after treatment. This shows that parental mentoring has a significant effect on reducing stress in children before surgery. Parental assistance is effective in reducing hospitalization stress levels in pediatric patients in the preoperative room. Hospitals are advised to create policies that support parental counseling during the pre-operative process, and follow-up research can add control variables for more in-depth outcomes as well as consider psychosocial factors, previous experiences, the type of medical procedures performed, as well as parents' anxiety levels before and during counseling.
Pemeriksaan Kesehatan Dasar sebagai Upaya Deteksi Dini Masalah Kesehatan pada Santri SMK Islam Anharul Ulum Yayasan KH Dawami, Kademangan, Blitar Wening Pangesthi Maharani; Recavery Dwi Wulandari; Nevy Norma Renityas; Dyah Mubarokah Ahadiyati; Aurel Putri Iklima; Silvia Lailatus Sa’adah; Bayu Buwana; Chairumin Alvin; Galih Syifa'ul Ummah
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3199

Abstract

Adolescents are an age group vulnerable to various health problems, especially in Islamic boarding schools (pesantren) environments, which present their own unique challenges. Unbalanced lifestyles, busy schedules, limited access to health facilities, and a lack of knowledge about healthy lifestyles are factors that can be detrimental to the health of adolescents in these environments. Therefore, early detection through basic health checks is a strategic step in preventive and promotive efforts. This activity aims to conduct basic health checks and education as an effort to detect health problems early in students. A total of 64 students from Anharul Ulum Islamic Vocational School underwent vital signs checks, including blood pressure, body temperature, and pulse rate, as well as a short consultation session aimed at addressing subjective complaints such as dizziness, fatigue, sleep disturbances, or other often overlooked symptoms. In addition, brief interviews were conducted to determine their dietary habits, physical activity, and rest duration. The results showed that 23.4% of students experienced hypotension, 10.9% showed symptoms suggestive of anemia, 17.2% complained of dizziness, and 10.9% experienced sleep disturbances. A total of 48.4% had no significant complaints, but were still provided with health education to raise awareness about the importance of maintaining physical and mental health. This finding underscores the importance of regular check-ups in Islamic boarding schools as part of the adolescent health support system. These check-ups not only serve as a means of identifying problems but also serve as educational opportunities that strengthen students' understanding of the importance of a healthy lifestyle. The education provided covered nutritious food selection, the importance of regular exercise, stress management, and good sleep patterns. Students responded positively to the education, with high enthusiasm and active participation during discussion sessions.
Hubungan Status Gizi dengan Pola Makan Siswa Kelas IIIC SDN 064981 Cempaka Raya Sudana Fatahillah Pasaribu; Tuty Hertati Purba; Diana Reminiscere Telaumbanua; Hizkia Aribona Sianturi; Uski Sasja Rahmadani; Ludhovika Renata
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3208

Abstract

The nutritional status of elementary school-aged children is an important indicator in assessing health conditions, quality of life, and supporting optimal growth and development. School-aged children are in an active growth phase and therefore require a balanced nutritional intake to support learning activities, physical development, and cognitive abilities. This study aims to determine the relationship between nutritional status and dietary patterns in grade III C students of SD Negeri 064981 Cempaka Raya in 2025. This study used a quantitative approach with a cross-sectional design that allows researchers to assess the relationship between variables at a specific time. The study population consisted of all grade III C students, with a sample size of 30 students determined using a total sampling technique. Data on nutritional status were obtained through anthropometric measurements using the Body Mass Index for Age (BMI/U) referring to WHO standards. Meanwhile, dietary data were collected through a food frequency questionnaire that included the type, frequency, and daily food consumption habits of students. Data analysis was carried out using the Chi-Square test to examine the relationship between dietary patterns and nutritional status. The results showed a significant relationship between dietary patterns and students' nutritional status (p < 0.05). This indicates that a regular, balanced diet that meets energy needs plays a crucial role in establishing good nutritional status in elementary school children. These findings underscore the importance of schools in providing nutrition education, as well as the role of parents in fostering healthy eating habits within the family. Therefore, collaborative efforts to foster appropriate eating behaviors are essential to support children's physical growth, cognitive development, and ongoing academic achievement.  

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