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Berita Biologi
Published by Badan Riset dan Inovasi Nasional
ISSN : 23378751     EISSN : 23378751     DOI : https://doi.org/10.55981/berita_biologi
Core Subject : Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology
Berita Biologi is the journal features articles showcasing advancements in biological research and related sciences in Indonesia. Berita Biologi comprises original scientific papers presenting research findings, short communications, and reviews that are unpublished or not under consideration elsewhere. Covered topics are expected to introduce novel aspects or information.
Arjuna Subject : Ilmu Pertanian dan Biologi (Semua) - Ilmu Pertanian dan Biologi (Lain-Lain)
Articles 149 Documents
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EVALUATION OF HEATED CHICKEN EGGSHELL POWDER AS ANTIBACTERIAL AGAINST ESBL (EXTENDED SPECTRUM BETA LACTAMASE) PRODUCING Escherichia coli: IN-VITRO AND IN-SILICO STUDIES Nugraha, Fajar; IH, Hariyanto; Kurniawan, Hadi; Nurbaeti, Siti Nani; Fajriaty, Inarah; Priady, Aldi
Berita Biologi Vol 25 No 1 (2026): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2026.13653

Abstract

Antimicrobial resistance (AMR) has become a critical global health concern, particularly with the increasing prevalence of Extended-Spectrum β-Lactamase (ESBL)-producing Escherichia coli. This study aimed to evaluate the antibacterial activity of heated chicken eggshell powder (HCEP) against ESBL-producing E. coli through both in-vitro and in-silico approaches. The In-silico molecular docking studies revealed that calcium diglyceroxide exhibited the strongest binding affinity toward dihydrofolate reductase –5.9 kcal/mol, suggesting disruption of folate metabolism as a potential antibacterial mechanism. Meanwhile, in vitro results demonstrated measurable antibacterial activity, with inhibition zones ranging from 6.90 to 12.36 mm and minimum inhibitory concentration (MIC) values of 1.421 µg/ml for non-ESBL and 2.842 µg/ml for producing-ESBL E. coli. The antibacterial effect was attributed to calcium oxide content, which generates reactive oxygen species (ROS) and induces a highly alkaline microenvironment. The correlation analysis showed a strong positive relationship between sample concentration and inhibition zone as antibacterial against E. coli producing-ESBL (r = 0.987). These suggest that increasing the concentration of the HCEP sample results in a larger inhibition zone. Overall, these findings highlight HCEP as a potential alternative antibacterial agent, particularly in topical applications, while also offering a sustainable approach to eggshell waste utilization.
DIVERSITY OF ODONATA IN NATURAL AND ARTIFICIAL LAKE HABITATS IN SERANG, BANTEN Jasmi, Riski Andrian; Nurul Hikmah, Azeng; Oktadiansyah, Rifan; Miftah Farid, Ammar; Faizal Firdaus, Akhmad
Berita Biologi Vol 25 No 1 (2026): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia is recognized as one of the countries with high biodiversity, including insects from the order Odonata, which consists of dragonflies (Anisoptera) and damselflies (Zygoptera). However, information on Odonata biodiversity in freshwater habitats in the Serang region of Banten Province remains limited. This study aims to describe and analyze Odonata diversity and community structure in two lake habitat types, namely an artificial lake and a natural lake. Sampling was conducted over eight days using an exploratory survey and direct collection method with an insect net, with observations carried out in the morning (08:00-10:00 WIB) and afternoon (15:00-17:00 WIB). Environmental factors measured included temperature, humidity, wind speed, and surrounding vegetation. A total of 10 Odonata species comprising 189 individuals were recorded. The natural lake was strongly dominated by Orthetrum sabina (85.71%), whereas the artificial lake was dominated by Agriocnemis pygmaea (33.61%). The artificial lake showed biodiversity index values of D = 0.241, H′ = 1.644, E = 0.714, and Dmg = 1.883, while the natural lake showed D = 0.7449, H′ = 0.509, E = 0.463, and Dmg = 0.47. These results indicate that the artificial lake has moderate diversity with relatively even species distribution, whereas the natural lake shows strong species dominance and lower diversity. Overall, the artificial lake provides more suitable habitat conditions for supporting Odonata diversity, highlighting the importance of habitat heterogeneity in freshwater ecosystems.
FORMULASI OBAT HERBAL IKAN DARI EKSTRAK KAYU SECANG (Caesalpinia sappan, L.) SEBAGAI ANTIBAKTERI PATOGEN IKAN Sazali, Ahmad; Adriadi, Ade; Yusuf, Ashif Irvan; Maritsa, Hasna Ul; Aprisilia, Nur Dwi Kesya; Yerdi, Nisyaroza
Berita Biologi Vol 25 No 1 (2026): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2026.14275

Abstract

Kegagalan panen dalam budidaya ikan, khususnya di Provinsi Jambi, sering disebabkan oleh infeksi bakteri patogen seperti Aeromonas hydrophila, A. Sobria, Edwardsiella ictaluri, dan Streptococcus iniae. Penggunaan antibiotik sintetis secara berlebihan telah menimbulkan resistensi mikroba serta berdampak negatif terhadap lingkungan dan kesehatan manusia. Penelitian ini bertujuan untuk mengembangkan prototipe obat herbal ikan berbasis ekstrak kayu secang (Caesalpinia sappan L.) dalam bentuk larutan perendaman yang memiliki aktivitas antibakteri tinggi terhadap bakteri penyebab penyakit ikan. Metode penelitian meliputi ekstraksi kayu secang dengan pelarut etanol 96%, formulasi tiga jenis larutan perendaman menggunakan kombinasi bahan tambahan (Tween 80, PEG 400, dan gliserin), dan uji aktivitas antibakteri secara in vitro terhadap empat bakteri patogen ikan.. Hasil penelitian menunjukkan bahwa formula III (mengandung gliserin sebagai bahan tambahan) menghasilkan zona hambat terbesar terhadap keempat bakteri uji, menunjukkan aktivitas antibakteri paling tinggi dan stabilitas larutan yang baik. Formula III memiliki zona hambat rata-rata sebesar 16 cm untuk keempat bakteri A. hydrophila, A. Sobria, E. ictaluri, dan S. iniae dengan katergori kuat. Dengan demikian, Formula III ditetapkan sebagai formulasi terbaik untuk dikembangkan menjadi prototipe obat herbal ikan yang efektif dan aman digunakan dalam sistem budidaya perikanan.
SKRINING FITOKIMIA DAN POTENSI PROBIOTIK KOMBUCHA DAUN SIRSAK (Annona muricata) DAN KAYU SECANG (Caesalpinia sappan) SERTA AKTIVITAS ANTIMIKROBA PADA BAKTERI PATOGEN SALURAN CERNA Sintyadewi, Putu Rima; Rabani, I Gusti Agung Yogi; Widnyani, Ida Ayu Putu Ary; Wulansari, Nadya Treesna; Indrayoni, Putu
Berita Biologi Vol 25 No 1 (2026): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2026.14345

Abstract

Tren hidup sehat semakin mendorong masyarakat untuk mengkonsumsi pangan fungsional, khususnya minuman hasil fermentasi yang kaya senyawa bioaktif serta probiotik. Kombucha merupakan salah satu minuman yang banyak diminati karena mengandung asam organik, antioksidan, dan mikroorganisme bermanfaat bagi kesehatan. Indonesia sendiri memiliki beragam tanaman herbal, termasuk daun sirsak (Annona muricata) dan kayu secang (Caesalpinia sappan), yang dikenal memiliki aktivitas farmakologis yang kuat. Penggunaan dua bahan tersebut dalam pembuatan kombucha berpotensi menghasilkan efek bioaktif yang lebih optimal. Penelitian ini bertujuan untuk menganalisis profil fitokimia, total Bakteri Asam Laktat (BAL) dan yeast, aktivitas antimikroba, serta penentuan nilai Konsentrasi Hambat Minimum (KHM) pada minuman kombucha daun sirsak dan kayu secang. Penelitian menggunakan Rancangan Acak Lengkap (RAL) dua faktorial yaitu variasi konsentrasi daun sirsak dan kayu secang yaitu, P1 (90%:10%), P2 (80%:20%), P3 (70%:30%) dan waktu fermentasi D1 (0 hari), D2 (4 hari), D3 (8 hari), D4 (12 hari). Data dianalisis menggunakan ANOVA dan DMRT pada taraf signifikansi p < 0,05. Hasil penelitian menunjukkan bahwa variasi konsentrasi daun sirsak dan kayu secang pada kombucha memberikan pengaruh signifikan (p<0,05) terhadap aktivitas antibakteri E. coli dan S. aureus pada kombucha daun sirsak dan kayu secang. Formulasi P3D3 dengan komposisi 70% daun sirsak dan 30% kayu secang yang difermentasi selama 8 hari disimpulkan sebagai formulasi terbaik, yaitu berpotensi sebagai minuman probiotik dengan total BAL dan yeast masing-masing sebesar 2,0 × 10⁶ CFU/mL dan 3,2 × 10⁶ CFU/mL, aktivitas antimikroba tertinggi dengan zona hambat terhadap E. coli dan S. aureus masing-masing 12,7 mm dan 15,7 mm, dengan KHM terhadap E. coli dan S. aureus adalah 40% dan 20%.  Skrining fitokimia kombucha daun sirsak dan kayu secang menunjukkan adanya senyawa alkaloid, flavonoid, tanin, fenol, steroid dan saponin yang diduga kuat berkontribusi terhadap antivitas antibakteri.
UJI TOKSISITAS AKUT DELPHINOL® EKSTRAK MAQUI BERRY (Aristotelia chilensis) PADA TIKUS SPRAGUE-DAWLEY BETINA Sari, Windi Yunita; Sim, Kezia Jeconia; Yuliani, Tri; Dewi, Rizna Triana; Angelina, Marissa; Nursiswanto, Heri; Atifah, Yusni
Berita Biologi Vol 25 No 1 (2026): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2026.14648

Abstract

Delphinol® merupakan ekstrak terstandar dari buah maqui berry (Aristotelia chilensis) yang kaya antosianin. Evaluasi toksikologi digunakan untuk menilai keamanan senyawa aktif yang terkandung di ekstrak tanaman. Tujuan penelitian ini menentukan nilai toksisitas (LD50) dari Delphinol®, yaitu ekstrak terstandar buah maqui berry, guna memastikan keamanannya untuk digunakan. Penelitian dilakukan menggunakan 6 ekor tikus Sprague-Dawley betina, terbagi dua kelompok yaitu perlakuan Delphinol® dan normal. Dosis Delphinol® yang digunakan adalah 5000 mg/kg. Gejala klinis toksisitas diamati selama 24 jam pertama setelah pemberian bahan uji untuk memantau kemungkinan terjadinya kematian. Selanjutnya, dilakukan pengamatan klinis harian selama 14 hari, disertai pemantauan berat badan dua kali dalam seminggu guna mengevaluasi potensi efek toksik yang mungkin timbul. Setelah itu dilakukan pengamatan individu terhadap ada tidaknya gejala keracunan dengan cara tikus dikorbankan untuk ambil darah  dengan analisis hematologi dan ALT serta organ vital seperti  otak, jantung, hati, paru-paru, limfa, ginjal, uterus, ovarium diamati makropatologi dan ditimbang beratnya, serta organ hati dan uterus diamati histopatologinya. Hasil penelitian menunjukkan bahwa pemberian Delphinol® pada dosis 5000 mg/kg berat badan tidak menyebabkan kematian maupun gejala toksisitas akut. Dengan demikian, nilai LD50 Delphinol® lebih dari 5000 mg/kg berat badan sehingga masuk dalam kategori aman dan tergolong praktis tidak toksik.
EXPLORATION OF THE POTENTIAL OF ASTERACEAE FAMILI PLANTS ETHANOL EXTRACT AS BIOLARVICIDES AGAINST THIRD-INSTAR Aedes aegypti LARVAE Dwianto, Stefanus Agung; Kasmiyati, Sri; Kristiani, Elizabeth Betty Elok
Berita Biologi Vol 25 No 1 (2026): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2026.14933

Abstract

The improper use of synthetic larvicides results in detrimental environmental impacts. To mitigate these effects, biolarvicides serve as a viable alternative. Plants within the Asteraceae family contain bioactive compounds with potential biolarvicidal properties. This research aimed to explore the potential of Asteraceae species as biolarvicides. This research utilizes Artemisia vulgaris, Cosmos caudatus, Eclipta prostrata, and Tagetes erecta. Extraction was conducted by the maceration method using 96% ethanol. The resulting extracts were analyzed for secondary metabolite content. Data were analyzed using SAS 9.0 software Two-way ANOVA, followed by Tukey’s post-hoc test. Larvicidal bioassays were performed on third-instar Aedes aegypti larvae at concentrations of 1,000-10,000 ppm. The parameters measured included mortality percentage, LC50, and LC90. Morphological changes in dead larvae were observed and compared against a control group. The results indicated that secondary metabolite in the leaf ethanolic extracts were higher than those in the stems and roots. The leaf ethanolic extract of C. caudatus exhibited the highest content of flavonoids (928.3±368.7 mg/g), phenolics (310.2±84.9 mg/g), tannins (187.1± 55.5 mg/g), and saponins (314±95.4 mg/g extract). Conversely, the highest alkaloid content was recorded in the leaf extract of T. erecta (27.8±7.1 mg/g). The highest mortality rate was observed in larvae exposed to A. vulgaris leaf extract, reaching 100% mortality across all concentrations within 24 hours. Consequently, LC50 and LC90 values for A. vulgaris could not be determined. For C. caudatus, the LC50 values were 7204.7 ppm (24 h) and 6839.7 ppm (48 h), while LC90 values were 9077.3 ppm (24 h) 8226.4 ppm (48 h), respectively. E. prostrata yielded an LC50 of 10255.6 ppm and an LC90 of 18048.9 ppm at 24 hours; however, these values were not detectable at 48 hours. T. erecta showed an LC50 of 6569.6 ppm (24 h) and 6397.1 ppm (48 h), with LC50 values of 9682.1 ppm and 9343.3 ppm, respectively. Morphological observations of dead larvae exposed the extracts alterations, including pigmentation, elongation, and shrinkage. While the leaf ethanolic extract of C. caudatus contained the highest concentration of secondary metabolites. The leaf ethanolic extract of A. vulgaris demonstrated the greatest potential as a biolarvicide.
EFEK PEMBERIAN EKSTRAK ETANOL DAUN DURIAN (Durio zibethinus Murr.) TERHADAP KUALITAS SPERMATOZOA MENCIT (Mus musculus L.) Maharani, Desita Aulia; Harlita
Berita Biologi Vol 25 No 1 (2026): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2026.14941

Abstract

Daun durian (Durio zibethinus Murr.) mengandung senyawa bioaktif yang berpotensi mempengaruhi sistem reproduksi jantan, tetapi pengaruhnya terhadap kualitas spermatozoa belum banyak diteliti. Penelitian ini bertujuan untuk mengetahui efek pemberian ekstrak etanol daun durian terhadap berat badan mencit dan kualitas spermatozoa mencit (Mus musculus L.) meliputi parameter morfologi dan motilitas. Penelitian ini merupakan penelitian eksperimental dengan RAL. Hewan uji mencit jantan galur Balb-c berumur 3-4 bulan dengan rata-rata berat badan 33 ± 4 gram yang dibagi menjadi tiga kelompok dengan masing-masing kelompok terdiri dari 3 ekor mencit, yaitu kontrol negatif (K) serta kelompok perlakuan yang diberikan ekstrak etanol daun durian dengan dosis 250 mg/kg BB (P1) dan dosis 500 mg/kg BB (P2). Perlakuan diberikan selama 14 hari melalui pemberian oral menggunakan sonde satu kali per hari. Parameter yang diamati meliputi berat badan, kualitas spermatozoa berupa morfologi dan motilitas. Data dianalisis menggunakan Anova dan uji lanjut LSD (Least Significant Difference) dan Games-Howell. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol daun durian tidak berpengaruh signifikan terhadap berat badan mencit, namun berpengaruh signifikan terhadap kualitas spermatozoa. Pemberian ekstrak etanol daun durian menyebabkan penurunan persentase morfologi dan motilitas normal spermatozoa serta peningkatan abnormalitas. Pada dosis tertinggi (500 mg/kg BB), persentase morfologi normal menurun dari 81.33% (kontrol) menjadi 16.00%. Persentase motilitas normal juga menurun dari 69.33% (kontrol) menjadi 5.33% (p < 0,05). Kesimpulannya, ekstrak etanol daun durian berpotensi menurunkan kualitas spermatozoa mencit meliputi parameter morfologi dan motilitas dan memiliki aktivitas antifertilitas.
IN SILICO STUDY OF Bacillus velezensis-DERIVED VOLATILE COMPOUNDS AS POTENTIAL INHIBITORS OF THE CUTINASE ENZYME FROM Colletotrichum gloeosporioides CAUSING ANTHRACNOSE DISEASE Putra, Anton Meilus; Khairunnisa, Amalia; Dewi, Rifani Rusiana
Berita Biologi Vol 25 No 1 (2026): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2026.15006

Abstract

Anthracnose disease caused by Colletotrichum gloeosporioides remains a major constraint in horticultural production, particularly in tropical regions. The cutinase enzyme plays an essential role in fungal pathogenicity by facilitating penetration of the host cuticle during the early stages of infection. Volatile organic compounds (VOCs) produced by Bacillus velezensis have been reported to exhibit antifungal activity. Inhibiting the cutinase enzyme disrupts the biochemical mechanism used by C. gloeosporioides to breach the plant’s waxy cuticle. By blocking cutin degradation, this anti-virulence strategy prevents initial infection and tissue invasion. However, information regarding their molecular interactions with cutinase is still limited. This study aimed to evaluate the potential of B. velezensis-derived VOCs as inhibitors of the cutinase enzyme from C. gloeosporioides using an in-silico approach. Antifungal bioactivity was predicted using PASS Server analysis, while binding affinity and inhibition constant (Ki) values were determined through molecular docking simulations with AutoDock Vina. Molecular interactions between VOC ligands and the target enzyme were analyzed based on their involvement with key active-site residues. The Pa–Pi analysis indicated that most VOCs, particularly terpenoids and medium-chain alcohols, exhibited higher predicted antifungal activity than inactivity. Molecular docking results showed that several VOCs interacted stably with the active site of cutinase, involving key residues Ser57, Ser136, and Gln137. Among the evaluated compounds, β-ionone exhibited the strongest binding affinity, as indicated by the lowest binding energy and inhibition constant. These results suggested that VOCs produced by B. velezensis, especially terpenoid compounds, had potential as biocontrol-based antifungal agents through inhibition of cutinase activity and required further validation through in vitro and in vivo studies.
MIKROMORFOLOGI POLEN DAN ANALISIS NUMERIK Plagiostachys Ridl. (ZINGIBERACEAE) DARI SUMATRA DAN IMPLIKASI SISTEMATISNYA Nurhasna; Nurainas; Mildawati, Mildawati; Fauzan, Atthoriq; Taufiq, Ahmad; Syamsuardi
Berita Biologi Vol 25 No 1 (2026): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2026.15465

Abstract

Studi mikromorfologi polen dan analisis numerik karakter morfologi telah dilakukan terhadap lima taksa Plagiostachys yang terdistribusi di Sumatra. Observasi mikromorfologi polen dilakukan menggunakan mikroskop cahaya (Light Microscope/LM) dan mikroskop elektron pemindai (Scanning Electron Microscope/SEM). Pengelompokan taksa dilakukan secara numerik menggunakan analisis UPGMA berdasarkan 16 karakter makromorfologi dan mikromorfologi. Butir polen yang diamati tergolong tipe monad, berbentuk prolate-sphaeroidal, tidak memiliki apertur (inaperturate), berukuran sedang (medium), dengan tipe ornamentasi dinding polen micro-rugulate, psilate, dan echinate-reticulate. Ornamentasi berduri (echinate) ditemukan pada sebagian besar spesies Plagiostachys, dan pada tingkat spesies, karakter ini memberikan evidensi tambahan yang signifikan untuk membedakan P. roseiflora dan P. crocydocalyx. Analisis numerik menghasilkan dua kelompok utama, dengan P. crocydocalyx dan P. roseiflora pada kelompok A, dan kelompok B terbagi menjadi 2 subkelompok: subkelompok I terdiri dari seluruh individu P. mucida dan Plagiostachys sp. sedangkan subkelompok II terdiri dari seluruh individu P. sumatrensis. Sebagai kesimpulan, karakter mikromorfologi polen memberikan kontribusi secara sistematis untuk memperkuat klasifikasi genus Plagiostachys.

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