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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
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A rare case of Salmonella sp septic arthritis in a patient with systematic lupus erythematosus (SLE) Steffanus, Mario; Yusuf, Cindy; Hadiyanto, Jessica Novia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202306

Abstract

Septic arthritis is considered as a medical emergency which can lead to significant morbidity and cause substantial mortality, especially if the diagnosis is delayed. Prolonged use of immunosuppressive and cytotoxic medications as therapy for systemic lupus erythematosus (SLE) causing patient susceptible to secondary infection. However, septic arthritis due to Salmonella sp. is very rare,  makes this is an important extraintestinal manifestation especially in immunosuppressed patients. We presented a case of 25 y.o. female diagnosed with SLE 3 m.o. earlier presented with fever and arthritis on her left genu for 1 wk duration. Genu ultrasonography showed synovitis genu sinistra with fluid volume of 1-2 cc on recessus lateral genu sinistra. The patient was further analysis on her synovial fluid was conducted, the gram stained smear of the fluid showed >25 leucocytes, low power field, and Salmonella sp. was isolated from her synovial fluid analysis. The patient was given intravenous ciprofloxacin and discharged home well. Septic arthritis should always be considered in any patients on long-term immunosuppression state who present with acutely swollen joints. It considered as an important medical emergency with high mortality and morbidity. Hence, prompt recognition, joint aspiration with administration of systemic antibiotics and appropriate surgical intervention plays a pivotal role to minimize morbidity and mortality.
Dermoscopy features on dermatomycosis Lubis, Flora Marlita
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202311

Abstract

Dermoscopy is a non-invasive tool mainly used to clarify pigmented and nonpigmented skin lesions. Based on its physical properties, dermoscopy is divided into non-polarized and polarized. Dermoscopy examination is a diagnostic technique that is often performed on skin disorders, including skin disorders due to fungal infections. Some of the fungal diseases that are examined bydermoscopy are tinea capitis, pityriasis versicolor and onychomycosis. The dermoscopy features found in tinea capitis are comma hair, corkscrew hair, black dots and short hair. Onychomycosis found dermoscopy chromonychia, white longitudinal stripes and opaque nails (cloudy). The dermoscopy in pityriasis versicolor shows hypopigmented and hyperpigmented patterns.
Gut dysbiosis and the role of probiotics in chronic kidney disease Cahyadi, Alius; Yuwono, Angelina; Subagio, Stephanie Widodo; Iryaningrum, Maria Riastuti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202309

Abstract

Chronic inflammatory condition in chronic kidney disease (CKD) patients is associated with increased risk of cardiovascular morbidity and mortality. Gut dysbiosis is assumed as one of leading factors to the chronic inflammatory condition. The relationship between the kidney and the gastrointestinal, knowns as the gut-kidney axis, has a role in production and accumulation of uremic toxins derived from gut microbial fermentation of protein, and translocation of endotoxins and microbial from gut lumen into bloodstream due to alterations of intestinal epithelial barrier in CKD patients. Probiotics supplementation is one of the optional theraphy to restore the gut dysbiosis in CKD patients. Recent studies found that probiotics supplementation in CKD patients decreased uremic toxins and pro-inflammatory cytokines production, and delayed CKD progression. The improvement of this chronic inflammatory condition is expected to decrease cardiovascular disease risk in CKD patients. This review aims to describe the importance of gut-kidney axis in CKD patients, particularly in gut dysbiosis, and the role of probiotics in progression of CKD.
Comorbidities of COVID-19 patients associated with mortality at the Baubau Regional Public Hospital, South East Sulawesi Mustiqawati, Evi; Yolandari, Sri; Nurwanti, Ratih; Sapril, Sapril
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202305

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that cause coronavirus disease 2019 (COVID-19) has become a global pandemic. Until November 30th, 2020, World Health Organization (WHO) confirmed 61,869,330 positive cases with 1,448,896 deaths (CFR 2.3%). Some comorbidities are associated with the COVID-19 mortality. This study aimed to investigate risk factors of the COVID-19 mortality at the Baubau Regional Public Hospital, Sout East Sulawesi. It was a cross-sectional study with a retrospective analysis involving 81 COVID-19 patients. Purposive sampling was applied in this study. Chi-square analysis was conducted to calculate odd ratio (OR). The result showed that in the period from January to September 2021, 30 COVID-19 patients died consisting of 20 male and 10 female. Most of the patients died were >45 yo and only 4 patients died were <45 yo. Among the patients died, 11 patients had hypertension, 12 patients had type 2 diabetes mellitus (DM), 4 patients had pulmonary TB and 3 patients had dyspepsia. Further analysis showed that hypertension (OR=6.803; 95%CI: 1.925-24.038; p=0.002) and dyspepsia (OR=0.222; 95%CI: 0.059-0.838; p=0.016) were significantly associated with the COVID-19 mortality, whereas type 2 DM (OR=1.123; 95%CI: 0.445-2.832; p=0.495) and pulmonary TB (OR=0.559; 95%CI: 0.059-0.838; p=0.270) were not. In conclusion, hypertension is risk factor, whereas dyspepsia is protective factor of COVID-19 mortality.
Moringa oleifera Lam. to accelerate wound healing: a review Jaya, Fidi Bhawana; Syamsunarno, Mas Rizky Anggun Adipurna; Sahiratmadja, Edhyana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202310

Abstract

An injury to the skin that disrupts the soft tissue may form a wound. The healing process in response to injury is a dynamic and well-regulated process of cellular, humoral, and molecular mechanisms that consists of four partly overlapping phases: hemostasis, inflammation, proliferation, and remodeling. An impaired wound-healing process may cause a formation of an abnormal scar and chronic wounds, leading to a reduced life quality. Therefore, it needs an optimal prevention strategy. Many modalities have been claimed to accelerate wound healing. The trend of using natural products is increasing in most Southeast Asian countries due to their biodiversity. Nowadays, studies on natural compounds are increasing to accelerate wound healing. Moringa oleifera Lam. is a high-value plant that each part of it has a high nutritional value as well as a great range of medicinal uses, including anti-inflammatory, antimicrobial, antioxidant, and wound healing properties. In this review, we have explored the M. oleifera that are very rich in vitamins, minerals, fatty acids, and phytochemical compounds like quercetin, kaempferol, and vicenin-2, that play a role in the wound healing process. Moreover, these compounds may enhance the healing of wounds with pathological conditions such as diabetes, immunocompromised and persistent infection.
Coronavirus disease 2019 (COVID-19) related stroke incidence: a case series Prabaningtyas, Hanindia Riani; Hapsari, Maria Yosita Ayu; Putra, Stefanus Erdana; Hafizhan, Muhammad; Mirawati, Diah Kurnia; Budianto, Pepi; Subandi, Subandi; Danuaji, Rivan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202307

Abstract

Coronavirus disease 2019 (COVID-19) can cause systemic and respiratory symptoms. Acute respiratory distress syndrome (ARDS), anemia, acute heart injury, secondary infection, and stroke are the complications of COVID-19. Age, oxidative stress, endothelial dysfunction, inflammatory status, vascular risk factors, and hypoxemia are risk factors for stroke associated with COVID-19. In this case report, two cases of COVID-19 complicated by stroke and other thromboembolic diseases were discussed. Case 1: a 46-year-old man presented with right extremities weakness, dysarthria, cough, colds, chest pain radiating to left upper extremity. He was diagnosed with moderate COVID-19, with complication of embolic stroke and myocardial infarction. After administration of IV furosemid and recombinant tissue plasminogen activator (rTPA), his condition improved, and he was discharged from our facility. Case 2: a 54-year-old woman presented with a decreased level of consciousness, skin discoloration, tenderness on her left calf, cough, fever, and shortness of breath. She was diagnosed with moderate COVID-19 with a complication of thrombotic stoke and deep vein thrombosis (DVT). She was treated with rTPA, IV citicoline, and fondaparinux for 5 days. In conclusion, COVID-19 carries a risk of thromboembolic complication. COVID-19 patients have a higher risk of bleeding, therefore, medications, particularly anticoagulant, should be administered with more caution.
Protective effect of corncob extract cream on guinea pig (Cavia porcellus sp) skin pigmentation exposed to ultraviolet B (UVB) rays Harlisa, Pasid; Puspitasari, Indah Wahyu; Yuliyanti, Suryani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202302

Abstract

Ultraviolet B (UVB) rays exposure causes skin inflammation and pigmentation lead to decrease skin lightness. Corncobs (Zea mays) contain flavonoids which can act as antioxidant to prevent free radicals and protect the skin pigmentation. This study aimed to evaluate the protective effect of corncob extract cream on skin pigmentation exposed to UVB rays. This pre-posttest control group study was applied to 25 guinea pigs (Cavia porcellus sp) randomly divided into five groups. Corncob extract cream was given every day 20 min before and 4 h after UVB exposure. The UVB exposure total dose was 780 mJ/cm2. Mexameter examination was carried out on the 1st day and 28th day after treatment. There were significantly differences in the lightness level and the mean melanin index (MI) difference of guinea pigs before and after intervention on various groups (p<0.05). No significantly different of the MI between pre- and post-treatment was observed on normal control group (0.22) and negative control group (-1.06) (p>0.05). However, significantly different of the MI was observed on positive control group (-4.01), corncob 40% group (-2.72), and corncob 30% group (-2.03) (p<0.05). In conclusion, corncob extract cream can inhibit the skin pigmentation due UVB rays exposure.
Complete recovery of severe coronavirus disease 2019 (COVID-19) infection in an obese patient Susanti, Vina Yanti; Anggraeni, Vita Yanti; Akbar, Adrianus; Leo, Benedreky
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202308

Abstract

There is strong evidence indicating that excess adiposity in obesity impacts immune function and host defence. However, almost no known mechanism of how the immune and host defence are affected by the low-grade inflammatory response of the obese has been established. The significance of altered immune response in obesity was presumed to be an independent risk factor for increased morbidity and mortality following the influenza pandemic back in 2009. Similarly, obesity is linked with a higher risk of severity and a worse clinical outcome of severe acute respiratory coronavirus 2 (SARS-COV-2) infection.This case reports a complete recovery of a severe coronavirus disease 2019 (COVID-19) infection despite having morbid obesity aggravated by metabolic syndrome.
Diagnosis approach, treatment, evaluation and fertility preservation in patient with Herlyn-Werner-Wunderlich syndrome: a case report Indraswari, Lathifa Nadhya; Pangastuti, Nuring; Dwi Saputra, Akbar Novan; Widyasari, Anis
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202308

Abstract

Herlyn-Werner-Wunderlich (HWW) syndrome is a very rare female congenital anomaly of urogenital tract. The definite etiology of HWW syndrome is still unknown. It may be caused by the abnormal development of Mullerian and Wolffian ducts. The characteristic triad of this syndrome includes didelphys uterus, obstructed hemivagina, and ipsilateral renal agenesis, recently known as Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA) syndrome.  A 17 y.o. presented with intermittent lower abdominal pain. Physical examination revealed in normal limit. From the ultrasonography examination, it was found uterus didelphys with left hemiuterus hematomethra, hematocolpos, with normal anatomy and function of the right kidney, but there was no left kidney. From pelvic magnetic resonance imaging (MRI) and laparoscopy showing a complete duplication of the uterus from the horn to the cervix with no connection between the two uterine cavities. Both ovaries were normal. The right fallopian tube was normal. The left tube was enlarged, attached to the uterus and the left ovary. No left kidney was found.  From the previous surgery, there was a misdiagnosed with brown cyst. Physical examination such as rectal toucher often missed, regardless it can be used to determine some differential diagnosis. MRI is most accurate for providing details regarding the altered anatomy and for identifying associated hematocolpos, hematosalping or hematometra for HWW syndrome cases. The laparoscopy guiding diagnostic and operative management of the vaginal septectomy procedure was performed. In conclusion,  misdiagnosis of HWW syndrome can be occurred on ultrasound examination. MRI is an examination that is considered appropriate to help confirm the diagnosis. Laparoscopy can be used with the aim of establishing a diagnosis or in surgical management, in this case, a septectomy is performed.
Association between blood glucose levels at admission and severity of COVID-19 patients Asysyifa, Nurul; Sari, Shinta Dewi Permata; Martalena, Dewi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202301

Abstract

Hyperglycemia can be experienced by corona virus disease (COVID-19) patients due to the invasion of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) into pancreatic cells or other mechanisms such as insulin resistance, counter-regulatory, stress induction, and glucocorticoid therapy. Hyperglycemia can stimulate the production of reactive oxygen species (ROS) and pro-inflammatory cytokines leading to an increase in the disease severity.  Based on the clinical and laboratory criteria, the severity of COVID-19 patients is classified into asymptomatic, mild, moderate, severe, and critical. This study aimed to investigate the association between blood glucose levels at admission and the severity of COVID-19 patients with and without diabetes mellitus (DM). It was a cross-sectional study using secondary data from COVID-19 patients in Pondok Kopi Jakarta Islamic Hospital from April to June 2021. This study involved 340 patients with comorbid DM (n=78) and without comorbid DM (n=262). The Mann-Whitney and Spearman correlation test were used. A significant difference between random blood glucose levels in comorbid DM patients and patients without comorbid DM (p<0.05). However, there is a weak correlation between random blood glucose levels and severity with comorbid DM (r=0.112) and without comorbid DM (r=0.129). In conclusion, a positive and weak correlation between blood glucose levels at admission and the severity of COVID-19. The severity increases as the blood sugar level increases. Further study needs to be performed considering other comorbid conditions.

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