cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
chiefeditor.amj@gmail.com
Editorial Address
Gedung Rumah Sakit Pendidikan Unpad/Pamitran Unpad (Teaching Hospital Building) Faculty of Medicine Unpad, 3rd Floor Jl. Prof. Eyckman No. 38, Bandung, 40161, Indonesia
Location
Kota bandung,
Jawa barat
INDONESIA
Althea Medical Journal
Published by Universitas Padjadjaran
ISSN : -     EISSN : 23374330     DOI : 10.15850/amj
Core Subject : Health,
Medicine & Pharmacology
Althea Medical Journal (AMJ) is a peer reviewed electronic scientific publication journal which is published every 3 months (March, June, September, and December). Althea Medical Journal publishes articles related to research in biomedical sciences, clinical medicine, family-community medicine, and public health.
Arjuna Subject : -
Articles 1,078 Documents
 104   105   106   107   108 
Early Left Ventricular Structural Changes With Preserved Function in Overweight and Obese Adolescents: A Speckle-Tracking Echocardiography Study Nurfandi, Wendi; Hafsah, Tisnasari; Rahayuningsih, Sri Endah; Apandi, Putria Rayani; Hakim, Dzulfikar Djalil Lukmanul; Ghrahani, Reni; Kuswiyanto, Rahmat Budi; Gurnida, Dida Akhmad
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4343

Abstract

Background: Overweight and obesity in adolescents are associated with dyslipidemia and may contribute to early cardiovascular remodelling. Speckle-tracking echocardiography (STE) is a sensitive imaging technique capable of detecting early myocardial functional alterations before the onset of clinical symptoms. This study aimed to evaluate the correlation between cardiac chamber dimensions, left ventricular (LV) geometry and function, and lipid profiles in overweight and obese adolescents. Methods: A cross-sectional study was conducted from June to September 2023, involving 51 overweight and obese adolescents aged 15–18 years in Bandung, Indonesia. Anthropometric measurements, fasting lipid profiles (triglycerides, total cholesterol, LDL, HDL), and transthoracic echocardiography were obtained. LV dimensions, LV mass index (LVMI), ejection fraction (EF), fractional shortening (FS), and global longitudinal strain (GLS) were assessed. Associations were analyzed using Pearson correlation.Results: Participants were predominantly male (64.7%) with a mean age of 16.3±0.6 years. Overweight (47.1%) and obesity (52.9%) were almost equally distributed with a mean BMI of 29.6±4.1 kg/m². LVMI correlated negatively with total cholesterol (r=−0.356; p=0.005), HDL (r=−0.351; p=0.006), and LDL (r=−0.280; p=0.023). The LV posterior wall thickness and LV end-diastolic diameter were also inversely correlated with selected lipid parameters. Interventricular septal thickness in systole correlated positively with triglycerides (r=0.270; p=0.028). No significant correlations were found between lipid profiles and LV function parameters, including EF, FS, and GLS (p>0.05).Conclusions: In overweight and obese adolescents, lipid profiles are associated with early alterations in LV structural dimensions while LV systolic function remains preserved. These findings support the importance of early cardiovascular screening and lifestyle modification to reduce future cardiometabolic risk.
Clinical Outcomes of Hypertonic Dextrose Prolotherapy Injection in Obese Patients with Knee Osteoarthritis: A Quasi-Experimental Study Pane, Rita Vivera; Al Hajiri, Aufar Zimamuz Zaman
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n2.4307

Abstract

Background: Obesity is a major risk factor for knee osteoarthritis (KOA), contributing to pain, reduced joint function, and decreased quality of life. Hypertonic dextrose prolotherapy (HDP) has emerged as a potential treatment to lessen pain and improve function in KOA. This study aimed to observe the clinical outcomes of HDP injections in obese patients with KOA.Methods: A quasi-experimental study was conducted in 2023, involved obese patients diagnosed with KOA. Participants were divided into two groups: an intervention group receiving HDP injections and a control group receiving normal saline (NS) injections. Clinical outcomes were assessed using the Numeric Rating Scale (NRS) for pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) before intervention, and at two and six weeks after intervention. Intergroup and intragroup mean differences were analyzed, with a significance value of p<0.05.Results: A total of 38 participants were included, with 20 assigned to the HDP group and 18 to the control group. Intragroup analysis showed a significant reduction in NRS scores in both groups (p<0.001), whereas no significant intragroup change was observed in WOMAC scores. Intergroup analysis showed significantly greater improvement in both NRS and WOMAC scores in the HDP group compared with the control group at two and six weeks after intervention (p<0.001).Conclusions: HDP injections improve clinical outcomes in obese patients with KOA, particularly in reducing pain intensity and improving functional status. Pain reduction may support participation in exercise and weight management programs, although persistent obesity may increase the risk of KOA recurrence.
Association of Cognitive Function, Depression, and Social Engagement with Quality of Life among Community-Dwelling Elderly in West Jakarta, Indonesia Wijaya, Kenneth Noah; Suryakusuma, Linda; Handajani, Yvonne Suzy; Turana, Yuda
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4214

Abstract

Background: As Indonesia’s elderly population grows, quality of life (QoL) has become a critical indicator of healthy aging. Evidence regarding the influence of cognitive function, depression, and social engagement on QoL remains inconsistent and is often limited to institutionalized elderly. This study examined these associations among community-dwelling elderly in an urban setting.Methods: A cross-sectional study was conducted at PUSAKA Kebon Jeruk, West Jakarta, from March to November 2023. Ninety-eight participants aged ≥60 years were selected using simple random sampling. Cognitive function was assessed using the Montreal Cognitive Assessment–Indonesian version (MoCA-INA), depression using the Geriatric Depression Scale (GDS), social engagement using the Social Disengagement Index, and QoL using the WHO Quality of Life–Brief Version (WHOQOL-BREF). Data were analyzed using Chi-square, Fisher’s exact, and multivariate logistic regression.Results: Most respondents were female (71.4%), aged 60–74 years (74.5%). The majority demonstrated normal cognitive function (63.3%), good social engagement (90.8%), and no depression. Overall QoL satisfaction was high, particularly in the social relationship (71.4%) and environmental domains (90.8%). Bivariate analysis showed associations between education, cognitive function, social engagement, gender, depression and specific QoL domains (p<0.05). Multivariate analysis identified gender as the strongest predictor of the environmental QoL (OR=5.63, p=0.025), education for social relationship (OR=2.99, p=0.020), and depression for general health perception (OR=3.16, p=0.041).Conclusions: Cognitive function, depression, education, and social engagement are key determinants of QoL among community-dwelling elderly. Community-based interventions focusing on mental health, cognitive stimulation, and social participation may improve QoL and support healthy aging. 
PPAR-γ, but not KCNJ11, Is Associated with Type 2 Diabetes Mellitus Progression among First-Generation Offspring of Lembak Ethnicity in Bengkulu, Indonesia Dita, Diah Ayu Aguspa; Yunita, Elvira; Rizqoh, Debie; Ashan, Hesty Rhauda; Fahira, Dita
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4448

Abstract

Background: Genetic and environmental factors influence the onset and progression of type 2 diabetes mellitus (T2DM). Variants affecting peroxisome proliferator activated-receptor gamma (PPAR-γ) and potassium, inwardly rectifying channel subfamily J member 11 (KCNJ11) may alter insulin secretion and sensitivity. This study investigated the association between PPAR-γ and KCNJ11 gene expression and the risk of T2DM among first-generation (F1) offspring of T2DM patients of Lembak ethnicity in Bengkulu, Indonesia.Methods: A cross-sectional observational study was conducted from July to September 2024, recruiting 60 unrelated participants aged 18–40 years, all of whom were exposed to the neron tradition (high-sugar consumption). Gene expression of PPAR-γ and KCNJ11 was determined using real-time quantitative PCR (qRT-PCR).Results: F1 offspring of T2DM patients (n=30) had significantly (p<0.05) higher body weight (66.89±15.62 kg; p=0.008), body mass index (BMI) (23.55±3.46 kg/m2), HbA1C (6.55±1.25), random blood glucose levels (median 131 [75–371] mg/dl), and duration of neron consumption (median 3 [1–12] years) compared with controls (n=30). PPAR-γ expression differed significantly between group (1.60±2.91 vs 4.23±8.54; p=0.009), whereas KCNJ11 expression did not (0.79±0.76 vs 1.37±0.89; p=0.124). Multivariate analysis revealed no correlation between gene expression and the patients characteristic (p>0.05). Linear regression showed 30.4% of PPAR-γ and 45.8% of KCNJ11 variability.Conclusions: PPAR-γ expression is associated with T2DM onset among Lembak F1 offspring, whilst KCNJ11 expression is not. Multiple genetic and environmental factors likely contribute to disease progression. Screening for PPAR-γ expression may support interventions targeting insulin sensitivity and lipid metabolism.
Serum Lipid Profile and Inflammatory Severity in Acne Vulgaris: Implications for Metabolic Health Kapantow, Marlyn Grace; Kapantow, Nova Hellen; Kairupan, Tara Sefanya; Gaghana, Sthefanie Mariska; Christopher, Paulus Mario
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4392

Abstract

Background: Acne vulgaris (AV) is a chronic inflammatory disorder of the pilosebaceous unit with varying degrees of severity. Increasing evidence suggests that metabolic disturbances, including dsylipidemia, may contribute to its inflammatory progression. This study aimed to investigate the association between serum lipid profiles and AV severity. Methods: A cross-sectional study was conducted among 30 patients with AV aged 25–40 years at a tertiary hospital in Manado, Indonesia. Serum triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol levels were measured. Association between lipid parameters and AV severity were assessed using Spearman’s rank correlation. Group differences were analyzed using one-way ANOVA or the Kruskal-Wallis test with post-hoc analysis.Results: Participants were predominantly Minahasa (66.7%) and female (60.0%). Total cholesterol and LDL levels demonstrated strong positive correlations with AV severity (r=0.696 and 0.654, respectively; p<0.001). Patients with severe AV had significantly higher total cholesterol and LDL levels compared to those with mild and moderate AV (F= 13.275; p<0.001 for total cholesterol; H= 12.496; p=0.002 for LDL). Triglycerides levels showed a weak correlation with AV severity (r= 0.375; p=0.041) but no significant intergroup difference (p= 0.112). HDL levels were not significantly associated with AV severity (p= 0.198).Conclusions: Dyslipidemia, specifically elevated total cholesterol and LDL, is strongly associated with severe AV. These findings underscore the importance of metabolic evaluation and lifestyle-based interventions as part of comprehensive management to reduce inflammation and promote long-term metabolic health.
Cognitive Function and Nutritional Status in Pre-Elderly Individuals with Human Immunodeficiency Virus Putri, Felicia Cahyadi; Vetinly, Vetinly; Ayu, Astri Parawita; Hardi, Nicholas; Kristian, Kevin
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4179

Abstract

Background: Human immunodeficiency virus (HIV) infection remains a global health issue, particularly in Africa and Asia. Cognitive impairment may early develop in individuals living with HIV and can therefore potentially impact nutritional status. This study aimed to assess the correlation between cognitive function and nutritional status in pre-elderly individuals with HIV.Methods: A cross-sectional study was conducted from March 2023 to October 2024 among individuals living with HIV aged 45–59 years in Jakarta, Indonesia. Cognitive function was measured using the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina) and nutritional status was evaluated using body mass index (BMI). Data were analyzed using the Chi-square test with Jeffrey’s Amazing Statistics Program (JASP).Results: Of the 157 respondents, most were male (75.2%) with a mean age of 49±4.17 years. The majority were unmarried (44.6%), employed (70.1%), had incomes below the Jakarta minimum wage (74.5%), and had completed senior high school education (56.0%). Mild cognitive impairment was found in 70.7% of participants, whereas normal nutritional status was the most common (45.9%). However, no significant relationship was found between cognitive function and nutritional status (p=0.161).  Conclusion: Mild cognitive impairment is prevalent among pre-elderly individuals with HIV, most of whom have normal nutritional status. Although no significant relationship is observed between cognitive function and nutritional status, these findings highlight the importance of incorporating early cognitive screening into routine HIV care to support healthy aging and timely identification and management of cognitive decline.
Effect of Asana Pranayama Yoga on Sleep Quality: Implications for Stress Management and Healthy Lifestyle in Young Adults Adella, Abigail Sherolyn; Lilis, Lilis; Sudiyono, Nelson; Cahyadi, Alius; Gracia, Isadora
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.3799

Abstract

Background: Sleep is a fundamental human need. Young adults, such as medical students, are particularly vulnerable to poor sleep quality due to the academic pressures.  Yoga has a relaxing effect that may help improve sleep quality. This study aimed to evaluate the effects of Asana Pranayama yoga on sleep quality among female medical students.Methods: This quasi-experimental and case-control study was conducted in September 2023, including preclinical female medical students from the Atma Jaya Catholic University of Indonesia. Sleep quality was assessed using the Indonesian version of the Pittsburgh Sleep Quality Index (PSQI-I). The intervention group (n=24) had performed yoga Asana Pranayama six times per week for four weeks, with each session lasting 45 minutes, whereasthe control group had received no intervention. Data were analyzed using the Wilcoxon signed-rank test to compare pre- and post-intervention PSQI scores, and Spearman’s correlation to examine the relationship between yoga frequency and PSQI scores (p<0.05).Results: The intervention group showed a significant improvement in sleep quality (p=0.002). A significant negative correlation was found between yoga practice frequency and post-test PSQI scores (r=-0.607), indicating that higher consistency in yoga practice was associated with better sleep quality.Conclusion: Regular practice of asana pranayama yoga can improve sleep quality among female medical students. Incorporating yoga into daily routines may serve as a practical, non-pharmacological approach to promote wellness in young adults.
Correlation Between Lactate Dehydrogenase Levels and National Institutes of Health Stroke Scale Scores at the Onset of Acute Ischemic Stroke Fikriyah, Lathifatul; Ardhi, Mohammad Saiful; Setyowatie, Sita
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4391

Abstract

Background: In acute ischemic stroke, reduced oxygen supply may trigger metabolic acidosis and cellular injury. Lactate dehydrogenase (LDH), as an intracellular enzyme, helps generate energy by converting pyruvate to lactate in glycolysis. This study aimed to examine the correlation between serum LDH levels and the National Institutes of Health Stroke Scale (NIHSS) score at the onset of treatment among patients with acute ischemic stroke.Methods: This analytical observational study used cross-sectional design, involving patients with acute ischemic stroke hospitalized at Dr. Soetomo Surabaya Hospital, Indonesia, between February and May 2023. Participants were selected using consecutive sampling. Serum LDH levels and NIHSS score were measured upon admission. The correlation between LDH levels and NIHSS score was analyzed using the Spearman test, with statistical significance set at p<0.05. Results: A total of 30 patients were included, of whom 16 (53.3%) were male. A significant correlation was found between LDH levels and NIHSS scores (p=0.001). The correlation coefficient (r=0.785) indicated a strong positive correlation between serum LDH levels and stroke severity.Conclusions: This study demonstrates a strong positive correlation between LDH levels and NIHSS scores at the onset of acute ischemic stroke treatment. These findings suggest that LDH may serve as a practical early biomarker for assessing stroke severity. Integrating LDH measurement into initial evaluation may facilitate faster risk stratification and support timely clinical decision-making. Further studies with larger sample sizes are needed to validate its prognostic role in routine practice.

Page 108 of 108 | Total Record : 1078

 104   105   106   107   108 

Filter by Year

2014 2025


Reset
Filter By Issues
All Issue Vol 12, No 4 (2025) Vol 12, No 3 (2025) Vol 12, No 2 (2025) Vol 12, No 1 (2025) Vol 11, No 4 (2024) Vol 11, No 3 (2024) Vol 11, No 2 (2024) Vol 11, No 1 (2024) Vol 10, No 4 (2023) Vol 10, No 3 (2023) Vol 10, No 2 (2023) Vol 10, No 1 (2023) Vol 9, No 4 (2022) Vol 9, No 3 (2022) Vol 9, No 2 (2022) Vol 9, No 1 (2022) Vol 8, No 4 (2021) Vol 8, No 3 (2021) Vol 8, No 2 (2021) Vol 8, No 1 (2021) Vol 7, No 4 (2020) Vol 7, No 3 (2020) Vol 7, No 2 (2020) Vol 7, No 1 (2020) Vol 6, No 4 (2019) Vol 6, No 3 (2019) Vol 6, No 2 (2019) Vol 6, No 1 (2019) Vol 5, No 4 (2018) Vol 5, No 3 (2018) Vol 5, No 3 (2018) Vol 5, No 2 (2018) Vol 5, No 2 (2018) Vol 5, No 1 (2018) Vol 5, No 1 (2018) Vol 4, No 4 (2017) Vol 4, No 4 (2017) Vol 4, No 3 (2017) Vol 4, No 3 (2017) Vol 4, No 2 (2017) Vol 4, No 2 (2017) Vol 4, No 1 (2017) Vol 4, No 1 (2017) Vol 3, No 4 (2016) Vol 3, No 4 (2016) Vol 3, No 3 (2016) Vol 3, No 3 (2016) Vol 3, No 2 (2016) Vol 3, No 2 (2016) Vol 3, No 1 (2016) Vol 3, No 1 (2016) Vol 2, No 4 (2015) Vol 2, No 4 (2015) Vol 2, No 3 (2015) Vol 2, No 3 (2015) Vol 2, No 2 (2015) Vol 2, No 2 (2015) Vol 2, No 1 (2015) Vol 2, No 1 (2015) Vol 1, No 2 (2014) Vol 1, No 2 (2014) Vol 1, No 1 (2014) Vol 1, No 1 (2014) More Issue