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INDONESIA
Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
Arjuna Subject : -
Articles 576 Documents
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The Effect of Dekokta Jamu Cekok on Short Term Memory of White Rats (Rattus norvegicus L.) Male Wistar Strain Jaliyanti, Nelli; Astuti, Puji; Kurniawan, Hadi; Hermawati, Ery; Alex, Alex
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.519-524

Abstract

The rising prevalence of dementia in Indonesia has resulted in a decline in memory and cognitive abilities. This condition is believed to be linked to oxidative stress caused by an imbalance between free radicals and antioxidants. Jamu cekok, a traditional herbal remedy composed of rhizomes such as Kaempferia galanga, Zingiber officinale, Curcuma longa L., and Curcuma xanthorrhiza, is known for its antioxidant properties. These antioxidants have the potential to neutralize free radicals, thereby helping to prevent degenerative diseases like dementia and Alzheimer’s, which are associated with short-term memory impairment. This study aimed to evaluate the effects of jamu cekok decoction on the short-term memory of male Wistar rats (Rattus norvegicus L.). A laboratory-based experimental study with a post-test-only control group design was conducted. Male Wistar rats were divided into three treatment groups receiving jamu cekok doses of 100, 200 and 400 mg/kg BW, and a negative control group was included. Short-term memory was assessed using the Y-maze test. The highest Y-maze alternation percentage of 65.12% was observed in the treatment group receiving a dose of 400 mg/kg BW. However, statistical analysis using the Kruskal-Wallis test showed no significant difference in Y-maze alternation percentages among the groups receiving jamu cekok (p = 0.626). The findings indicate that jamu cekok decoction did not have a significant effect on the short-term memory of male Wistar rats. Further studies with larger sample sizes and alternative assessment methods are recommended to explore its potential cognitive benefits.
Acceptability and Nutrient Profile of Cocoa Fruit Peel-Based Cookies: Exploring a Functional Food Potential Irma, Rita; Risma, Risma; Hasan, Fonnie E.; Rosnah, Rosnah
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.483-489

Abstract

Cocoa (Theobroma cacao L.) is a valuable agricultural commodity that can be developed into diverse products with high economic potential. This study aimed to evaluate the sensory acceptability and nutrient composition of cookies formulated with cocoa fruit peel (Theobroma cacao L.) as a functional ingredient. Cocoa peel flour and cookies were analyzed for macronutrients (protein, fat, carbohydrates, fiber) and micronutrients (minerals, vitamins, flavonoids). Sensory evaluation was conducted using a hedonic scale on color, aroma, texture, and taste among 40 semi-trained panelists. Results showed that all formulations were generally acceptable, with the 10% cocoa peel substitution achieving the highest preference. Statistical analysis indicated significant differences in color and taste (p < 0.05), while aroma and texture showed no significant variation. Nutritional analysis confirmed that cocoa peel flour and cookies contained essential nutrients, including protein (9.46-9.75%), fat (5.14-9.35%), carbohydrates (46.48-55.37%), vitamins C and E, minerals (Fe, Ca, Zn), and flavonoids, although antioxidant levels decreased after baking. These findings highlight cocoa peel’s potential as a functional food ingredient, supporting sustainable utilization of cocoa by-products.
The Effect of Moringa oleifera Fruits Extract in Lowering Triglycerides Levels in Obesity Arif, Abdul Halim; Susantiningsih, Tiwuk; Wahyuningsih, Sri; Kristanti, Melly; Zulfa, Fajriati
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.623-629

Abstract

Obesity is a global health problem that is often accompanied by hypertriglyceridemia as a manifestation of lipid metabolism disorders. Moringa fruit contains bioactive compounds that have the potential to be a natural hypolipidemic agent. Objective: This study aims to determine the effect of moringa fruit extract administration on triglyceride levels in obese model mice. An experimental study used 30 male Sprague Dawley mice divided into five groups: normal control, obesity negative control, positive control with vitamin C 15 mg/kgBB, moringa fruit extract treatment 500 mg/kgBB once daily, and moringa fruit extract treatment 500 mg/kgBB twice daily. Obesity was induced with a high-fat, high-protein feed for 49 days, followed by treatment for 14 days. Triglyceride levels were measured using the ELISA method and analyzed by the One-Way ANOVA test. The obese group showed the highest triglyceride levels (265.767 mg/dL) compared to the normal control (191.639 mg/dL). The administration of moringa fruit extract lowered the triglyceride level to 230,054 mg/dL for a once-daily dose and 212,463 mg/dL for a twice-daily dose. Statistical tests showed a significant difference (p<0.05) between the twice-daily treatment group and the obesity group. Moringa fruit extract was effective in lowering triglyceride levels in obese rats, with administration twice daily showing more optimal results.
Antioxidant Activity Comparison of Jamu Cekok and Its Individual Herbal Components Using the DPPH Method Lusi, Lusi; Astuti, Puji; Ropiqa, Meri; Novianry, Virhan
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.443-449

Abstract

Jamu cekok is a traditional Indonesian herbal drink commonly consumed by children to increase appetite. It is made from a combination of several plants, including Curcuma zanthorrhiza (C. zanthorrhiza), Curcuma longa (C. longa), Zingiber officinale (Z. officinalle), and Kaemferia galanga (K. galanga). The combination of these plants potentially enhanced the antioxidant effects due to the synergism or antagonism interaction among the constituent herbs. This research aimed to determine the antioxidant activity of jamu cekok and compare it with the antioxidant activity of its individual herbal components. Methods were started with the extraction of jamu cekok using ethanol as the solvent, prepared from a 1:1:1:1 ratio of C. zanthorrhiza, C. longa, Z. officinale, and K. galanga extract. The resulting extracts were tested using a 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay and phytochemical screening. Analysis revealed that jamu cekok extract contains alkaloids, flavonoids, and saponins. Turmeric, ginger, and galangal exhibited strong antioxidant activity with IC50 values of 96.158 ppm, 87.040 ppm, and 83.855 ppm, respectively. Curcuma showed moderate antioxidant activity with an IC50 value of 112.227 ppm. Jamu cekok exhibits very strong antioxidant activity (IC50 = 46.904 ppm), surpassing the activity of its individual herbal components. The synergistic interaction among bioactive compounds, particularly alkaloids, flavonoids, and saponins, is presumed to contribute to the enhanced antioxidant potential of jamu cekok. These results support its role as a natural antioxidant source and provide a scientific basis for its traditional use in health promotion.
Phytochemical Analysis and Bioactivity Evaluation of Ethanolic Exctract of Ironwood (Fagraea fragrans Roxb.) Leaves Anggraini, Mutiara; Harmida, Harmida; Juswardi, Juswardi; Tanzerina, Nina
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.575-584

Abstract

Ironwood (Fagraea fragrans Roxb.) has been widely used by the community as a medicinal plant, as well as a cosmetic ingredient. Various parts of the ironwood plant are used for health due to the content of metabolite compounds such as alkaloids, steroids, saponins, quinones, and tannins. In an effort to determine the bioactive metabolite compounds, an analysis was carried out on the ethanol extract of Ironwood leaves using GC-MS. The analysis revealed 131 peaks, with 79 corresponding to identified compounds. Five principal dominant compounds were identified: cis-13-Octadecenoic acid, 5-Hydroxymethylfurfural, n-Hexadecanoic acid, Erythocentaurin, and 5-Benzofuranacetic acid. Most of the metabolite compounds in Ironwood leaves exhibit bioactivity as antioxidants, antimicrobials (antibacterial, antifungal), antivirals, anti-inflammatory, anticancer, antiandrogens, antidiabetics, and other bioactivities. Based on the metabolite compounds and bioactivity, ironwood leaves have great potential to be developed as a source of medicinal and cosmetic ingredients.
Ascorbic Acid and Carotenoid Contents in Tomato Callus: Effects of Explant Source and Subculture Purwanto, Imam; Nurchayati, Yulita; Prihastanti, Erma
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.525-533

Abstract

The production of natural compounds in tomato can be achieved through callus culture by selecting the most suitable explant. The objectives of this study were to examine the effects of explant source and culture maintenance on the growth, ascorbic acid content, and carotenoid content of tomato callus. Callus induction was carried out on MS medium supplemented with 2,4-D. The resulting calli were divided into two groups: one subcultured into fresh medium and the other maintained without subculture. The study design used a completely randomized design of two factors, they were explants source (cotyledons, hypocotyls and root sprouts) and subculture treatment. The observed parameters were growth of callus, carotenoid and ascorbic acid content analized by spectrophotometer. The results showed that the highest callus weight (0.29 g) was obtained from hypocotyl explants. Subculture treatment significantly affected ascorbic acid content but did not influence carotenoid content. Callus from cotyledon explants produced the highest ascorbic acid content (15.2 g/100 g). Subculture treatment increased callus fresh weight, carotenoid content, and ascorbic acid content compared to the non-subculture treatment. In conclusion, hypocotyls were the best explant source for increasing biomass, while cotyledons were the most effective for enhancing ascorbic acid production.
The Effect of Cep-Cepan (Castanopsis costata) Leaf Extract Ointment on Post-Incision Wound Healing in Wistar Rats Theresia, Yohani; Chiuman, Linda; Ginting, Chrismis Novalinda; Suhartomi, Suhartomi
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.491-497

Abstract

Wound healing remains a challenge in medical practice, as available topical medications are often expensive, less effective, or associated with side effects. This study aimed to evaluate the effect of cep-cepan (Castanopsis costata) leaf extract ointment on post-incision wound healing in Wistar rats using a post-test only control group experimental design. Cep-cepan leaf extract was obtained through maceration method using 96% ethanol, with 22% yield. This extract was then formulated into ointments with concentrations of 15%, 30%, and 45%, subsequently tested for physical stability, phytochemical content, and wound healing effectiveness. The results showed that cep-cepan leaf extract contained alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. In vivo tests on rats showed that ointments containing 30% and 45% extract significantly increased skin tensile strength and collagen density compared to the control group. The effectiveness of the 45% extract ointment was almost equivalent to gentamicin ointment as the standard group. This study indicates the potential of cep-cepan leaves as an alternative agent in wound care, providing clinical benefits at a more affordable cost and minimal side effects.
Drying's Impact on Antioxidant Compound Levels in Curcuma heyneana Valeton & Zijp. (Temu Giring) Yumita, Agustin; Hikmawanti, Ni Putu Ermi; Mu’adah, Heksa; Hanani, Endang
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.631-637

Abstract

One plant in the genus Curcuma that exhibits potential as a natural antioxidant is Curcuma heyneana Valeton & Zijp., commonly known as temu giring. This species contains phenolic and flavonoid compounds. The objective of this research was to quantify the phenolic and flavonoid content, as well as assess the antioxidant activity of fresh and dried rhizomes. The extraction methods employed were infusion and decoction. Phenolic content was measured using the colorimetric method with the Folin-Ciocalteu reagent, while flavonoid content was determined using the AlCl3 reagent. Antioxidant activity was evaluated using the FRAP method. The highest phenolic content was observed in the oven-dried decoction extract (EDOD) at 6.258 mg GAE/g, and the highest total flavonoid content was also found in this EDOD at 2.899 mg QE/g. The most potent antioxidant activity among the test samples was exhibited by this EDOD, with a value of 12.064 mol FeEAC/g. The results indicate that higher drying temperatures correlate with increased phenolic and flavonoid levels in the temu giring rhizome, consequently influencing the antioxidant activity in the sample.
Computational Evaluation of Antibacterial Activity of Acalypha indica L. Phytochemicals Against Staphylococcus aureus DNA Gyrase Savitri, Lisa; Ihsan, Kharisul; Kasimo, Elfred Rinaldo; Krissanjaya, Rochmad
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.451-455

Abstract

This study investigated the antibacterial potential of phytochemical compounds derived from Acalypha indica L. against the DNA gyrase of Staphylococcus aureus using an in silico computational approach. Phytochemical structures were collected from established compound databases and subjected to geometry optimization to ensure conformational stability before molecular docking analysis. Docking simulations were carried out using AutoDock Vina to evaluate the binding affinity and interaction profiles of each ligand with the ATP-binding domain of DNA gyrase, a critical enzyme involved in bacterial DNA replication. The three-dimensional structure of S. aureus DNA gyrase was obtained from the Protein Data Bank and prepared through removal of water molecules, addition of polar hydrogens, and refinement of active-site residues. Among the screened ligands, five compounds exhibited strong predicted affinities, with binding energies ranging from -6.8 to -9.1 kcal/mol. Compound C demonstrated the most favorable interaction, forming stable hydrogen bonds and extensive hydrophobic contacts within the catalytic pocket, suggesting a strong inhibitory potential. Compound E also showed a high affinity, although its orientation within the binding site was slightly less optimal. ADMET predictions indicated that all top candidates satisfied drug-likeness criteria, showed good absorption potential, and presented low toxicity risks. Overall, the findings highlight that Acalypha indica L. contains bioactive constituents with promising inhibitory activity against bacterial DNA gyrase. These results support the traditional use of the plant in antimicrobial applications and provide a foundation for further experimental validation through in vitro enzyme inhibition assays and in vivo studies to confirm their therapeutic relevance.
Fermentation-Mediated Modulation of Nutraceutically Relevant Polyphenolic Compounds and Antioxidant Capacity of Red Spinach (Amaranthus tricolor L.) Leaf Extract Amelia, Nur; Pranata, Yovi; Setiawansyah, Arif; Marpaung, Mauritz Pandapotan; Wathan, Fika Minata
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.585-596

Abstract

Fermentation has emerged as a promising biotechnological approach to enhance the nutraceutical quality of plant-based materials through targeted modulation of bioactive compounds. This study investigated the effects of aerobic and anaerobic fermentation on total phenolic content (TPC), total flavonoid content (TFC), and antioxidant capacity of red spinach (Amaranthus tricolor L.) leaf extracts. Aerobic fermentation markedly enhanced the phytochemical profile, yielding a 1.87-fold increase in TPC (121.28 mg GAE/g extract) and a 1.66-fold increase in TFC (897.82 mg QE/g extract) compared with fresh leaves. These compositional improvements translated into superior functional activity, as evidenced by the lowest IC50 value (56.07 mg/L) and the highest antioxidant activity index (AAI = 0.713). In contrast, anaerobic fermentation provided limited phenolic enrichment and resulted in substantial flavonoid degradation, leading to inferior antioxidant performance. Strong correlations between polyphenolic contents and antioxidant parameters confirmed that phenolics and flavonoids are key contributors to radical scavenging activity. Overall, the findings demonstrate that aerobic fermentation is an effective, low-cost strategy to improve the nutraceutical value and antioxidant capacity of red spinach leaf extracts, highlighting its potential application in the development of functional foods and nutraceutical ingredients.

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