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MPI (Media Pharmaceutica Indonesiana)
Published by Universitas Surabaya
ISSN : 25276208     EISSN : 25279017     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Pharmaceutica Indonesiana (MPI) is a journal focusing on pharmaceutical aspects. MPI is dedicated to update and support the development of information and knowledge on pharmaceutical fields. This journal is published twice a year (June and December).
Arjuna Subject : -
Articles 162 Documents
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Kajian Efektivitas Lansoprazol dan Pantoprazol sebagai Profilaksis Stress Ulcers di Intensive Care Unit (ICU) Mega Octavia; Zullies Ikawati; Tri Murti Andayani
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 3 (2019): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (427.896 KB) | DOI: 10.24123/mpi.v2i3.1568

Abstract

Resiko kejadian perdarahan meningkat pada pasien dengan kondisi kritis di intensive care unit (ICU) sehingga kebutuhan penggunaan profilaksis cukup tepat untuk mengurangi kejadian perdarahan selama di ICU. Kajian penggunaan profilaksis yang efektif sangat diperlukan untuk mencegah komplikasi tersebut dengan harapan dapat meminimalkan kejadian perdarahan saluran cerna pada pasien di ICU. Penelitian ini bertujuan untuk mengetahui efektivitas dan biaya penggunaan lansoprazol dan pantoprazol sebagai profilaksis stress ulcers di ICU rumah sakit di Yogyakarta. Penelitian ini merupakan penelitian non eksperimental dengan rancangan penelitian kohort retrospektif. Subjek penelitian adalah seluruh pasien rawat inap di ICU dengan usia ≥ 18 tahun sampai 65 tahun yang mendapatkan terapi obat lansoprazol dan pantoprazol sebagai profilaksis stress ulcers selama bulan Januari 2014 – Desember 2016 yang memenuhi kriteria inklusi dan eksklusi. Penelitian dilakukan dengan membandingkan efektivitas terapi obat lansoprazol dan pantoprazol dengan melihat kejadian perdarahan minor dan mayor. Data penelitian dianalisis menggunakan Chi-Square untuk melihat perbedaan efektivitas antara 2 kelompok terapi. Dari total 119 pasien yang memenuhi kriteria inklusi, terdapat 48 pasien (77,4%) dari kelompok terapi lansoprazol yang tidak mengalami kejadian perdarahan, sedangkan pada kelompok pantoprazol pasien yang tidak mengalami kejadian perdarahan sebanyak 35 pasien (61,4%). Secara statistik efektivitas lansoprazol dan pantoprazol sebagai profilaksis untuk mengatasi kejadian perdarahan tidak berbeda signifikan (P = 0,057). Dari penelitian ini dapat disimpulkan bahwa tidak terdapat perbedaan efektivitas antara lansoprazol dan pantoprazol sebagai profilaksis stress ulcers pada pasien dengan resiko tinggi perdarahan saluran cerna di ICU.
Aktivitas Antibakteri Ekstrak Maserasi Bertingkat Bawang Dayak (Eleutherine palmifolia) terhadap Porphyromonas gingivalis dan Staphylococcus aureus Lusi Indriani; Prasetyorini Prasetyorini; Arfian Eka Saputri
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 3 (2019): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1913.485 KB) | DOI: 10.24123/mpi.v2i3.1316

Abstract

Bawang Dayak (Eleutherine palmifolia) dengan kandungan alkaloid, glikosida, flavonoid, fenolik, steroid, dan tanin, telah digunakan secara turun-temurun oleh suku Dayak sebagai obat tradisional. Secara empiris bawang Dayak berkhasiat sebagai diuretik, astringent, pencahar, analgesik, obat luka, batuk, sakit perut, disentri, kanker kolon, payudara, dan obat bisul. Porphyromonas gingivalis (bakteri gram negatif anaerob) dan Staphylococcus aureus (bakteri gram positif aerob) masing-masing merupakan bakteri yang menjadi penyebab periodontal dan infeksi kulit. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak bawang Dayak hasil maserasi bertingkat terhadap P. gingivalis dan S. aureus. Bawang Dayak diekstraksi menggunakan metode maserasi bertingkat dengan pelarut n-heksan, etil asetat, dan etanol 70%. Masing-masing ekstrak ditentukan aktivitasnya dengan metode dilusi sehingga diperoleh nilai Konsentrasi Hambat Minimum (KHM). Ekstrak dengan nilai KHM terkecil kemudian ditentukan daya hambatnya terhadap kedua bakteri dengan metode difusi kertas cakram sehingga diperoleh nilai Lebar Daerah Hambat (LDH). Hasil penelitian menunjukkan bahwa ekstrak etil asetat memberikan daya hambat paling baik terhadap bakteri P. gingivalis yaitu dengan KHM 1,25%, sedangkan ekstrak etanol 70% dan ekstrak n-heksan masing-masing sebesar 2,5% dan 20%. Ekstrak etil asetat dan etanol 70% memberikan daya hambat yang sama terhadap bakteri S. aureus yaitu dengan KHM sebesar 5%. Daya hambat ekstrak etil asetat terhadap bakteri P. gingivalis dengan metode difusi tidak dapat ditentukan karena bakteri sulit ditumbuhkan. Daya hambat ekstrak etil asetat terhadap bakteri S. aureus lebih baik dibanding esktrak etanol 70%. Hal ini ditunjukkan dengan nilai LDH ekstrak etil asetat pada konsentrasi 20% adalah 9,21 mm, sedangkan ekstrak etanol 70% pada konsentrasi yang sama adalah 6,48 mm.
Isolasi dan Karakterisasi Senyawa Non Fenolik dari Daun Gowok (Syzygium polycephalum Miq.) Nur Amalia Choironi; Kaefiyah Nurul Insani; Dina Parika; Sunarto Sunarto; Ade Martinus; Muhamad Salman Fareza
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 3 (2019): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.931 KB) | DOI: 10.24123/mpi.v2i3.1574

Abstract

Syzygium polychepalum (gowok) merupakan salah satu tanaman yang sering digunakan sebagai obat tradisional di Indonesia. Penelitian ini bertujuan untuk melakukan kajian fitokimia terhadap daun gowok yang berasal dari Purwokerto. Ekstraksi dilakukan dengan cara maserasi, sedangkan fraksinasi dan pemurnian dilakukan dengan metode kromatografi vakum cair dan gravitasi. Karakterisasi senyawa hasil isolasi dilakukan dengan menggunakan metode spektroskopi 1H-NMR dan GC-MS. Hasil karakterisasi menunjukkan bahwa isolat merupakan senyawa asam lemak jenuh yaitu asam heksadekanoat dan 3-etilpropanoat.
Ameliorative Effect of Carica papaya Seed Extract on Diabetic Rat Model with Muscle Atrophy Devyani Diah Wulansari; Devyana Dyah Wulandari; Reine Risa Risthanti; Aguslina Kirtishanti
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.2184

Abstract

This study aims to prove that papaya seed extract has the potential to improve muscle cell atrophy in diabetic conditions. Type 2 diabetes mellitus (DM) animal model were made with conditions similar to type 2 DM in humans i.e. with long-term (56 days) high sugar (fructose) consumption. Then, the next 14 days were treated with papaya seed extract at the dose of 100, 200, and 300 mg/kg BW orally. Body weight and blood glucose levels were monitored throughout the study period. At the end of the study, histopathological examination of gastrocnemius skeletal muscle tissue was carried out using hematoxylin-eosin staining and measuring myocyte cell area. Results showed that there is a correlation between blood glucose levels with the area of muscle cells which explains that the decrease in blood glucose levels is in line with the increase in the area of muscle fiber cells. In the diabetic group and the treatment group the dose of 100 mg/kg BW has a smaller area, whereas in the treatment group the dose of 200 and 300 mg/kg BW has an area close to the area of the muscle cell in the normal group. This is supported by the results of measurements of the area of muscle fiber cells observed through cross sections and measured at the end of this study. The treatment group at the dose of 200 and 300 mg/kg BW did not have significant difference (P>0.05) compared to the normal group. It can be concluded that papaya seed extract therapy at the dose of 200 and 300 mg/kg BW on diabetic rats can reduce the fasting blood glucose levels so that it can ameliorate cell atrophy in the diabetic conditions.
Pengembangan Formula Nanoemulsi Air dalam Minyak Biji Anggur (Vitis vinifera L.) sebagai Basis Lipstik Siti Zahliyatul Munawiroh; Agenilia Permatasari; Lutfi Chabib
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.1780

Abstract

The objective of this research is to develop water in grape seed oil nanoemulsions which prepared by low energy method to be used in lipstick base formulation. Water in grape seed oil nanoemulsions were prepared by low energy methods which was employed a Phase Inversion Composition (PIC) technique in elevated temperature at 80°C using mixed-surfactants (tween 20/span 80). In ternary phase diagram (oil:water:mixed-surfactants), the largest area of nanoemulsions was occurred in equal ratio tween 20:span 80 (1:1). The maximum water content of water in grape seed oil nanoemulsions was reached at 20% water with 60% mixed-surfactants (1:1). An unimodal size distribution of water in grape seed oil nanoemulsions with varied water content at 6, 10, and 14% were found with droplet size at 29.33 ± 5.30, 30.23 ± 7.33, and 29.83 ± 11.47 nm. Water content of water in grape seed oil nanoemulsions insignificantly affected to melting profile and hardness properties of lipstick. Water in grape seed oil nanoemulsions which was prepared by low energy can be developed as lipstick base formulation.
Studi Penggunaan Flukonazol pada Pasien HIV/AIDS dengan Infeksi Oportunistik Jamur: Penelitian di RSUD Dr. Saiful Anwar Irsan Fahmi Almuhtarihan; Didik Hasmono; Hidajah Rachmawati; Agus Sunarko
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.1882

Abstract

AIDS is characterized by a transition of opportunistic infections. The most common opportunistic infection is candidiasis with prevalence among HIV patients between 80% to 95%. Fluconazole is the main treatment for candidiasis, but combination with nystatin is often done. This study aims to determine the pattern of fluconazole dosages, dosage forms, and combinations given to HIV/AIDS patient with opportunistic fungal infection. This observational retrospective study was conducted on HIV/AIDS patients who were hospitalized with opportunistic fungal infections in the period of January 1st, 2015 to December 31st, 2015 who received fluconazole. Thirty-five patients were included in this study. Fluconazole monotherapy was used by 21 patients (43%), while combination therapy with nystatin was used by 28 patients (57%). Fluconazole monotherapy was generally preceded by the loading dose (1×400 mg) IV drip followed by maintenance doses (1x200 mg) IV drip in 6 patients (24%), whereas the combination of fluconazole and nystatin was generally used as fluconazole (1×200 mg) IV drip and nystatin (3×300,000 IU) PO in 7 patients (14%). Oral fluconazole was mostly (86%) given less than five days, whereas fluconazole IV drip was mostly (43%) given for 6-10 days. The patterns of fluconazole dosages, dosage forms, and combinations given to HIV/AIDS patient with opportunistic fungal infection was appropriate.
Efek Antikalkuli Ekstrak Etanol Herba Seledri (Apium graveolens L.) terhadap Tikus yang Diinduksi Hidroksiprolin Taofik Rusdiana; Lutfi Sulaiman; Eli Halimah; Ami Tjitraresmi; Sri Adi Sumiwi; Yanni D. Mardhiani; Anas Subarnas
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.2052

Abstract

The investigation efforts of an alternative treatment of the kidney stone disease by utilizing Indonesian native plants have still continued both for treatment and prevention. This study aims to strengthen the scientific evidence of the activity of celery as an anticalculi by in vivo assessment using hydroxyprolineinduced rat method. The white male wistar rats used in this study were intraperitoneally induced by hydroxyproline in order to form kidney stones, the celery extract preparations were then given at a dose of 50, 100, and 200 mg/kg of body weight orally for 5 days and observed following parameters: concentration of filtrate urinary calcium, concentration of urinary sediment calcium, as well as kidney to body weight ratio. The results showed that the concentration of filtrate urinary calcium in the test group at a dose of 200 mg/ kg body weight was significantly higher than those of negative control group, whereas the other test groups were not significantly different with the negative control group. The similar result was also shown on the parameter of calcium concentration in the urine sediment, while the ratio of kidney to body weight showed significant differences between all test groups and the negative control group. It can be concluded that the ethanol extract of the herb celery has an anticalculi activity in rats at a dose of 200 mg/kg of body weight.
Profil Terapi dan Efek Samping Anti Tuberkulosis pada Pasien AIDS Rawat Inap Claudia Tiffany; Didik Hasmono; Agus Sunarko
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.1922

Abstract

AIDS is a global problem, including in Indonesia. AIDS patients are easy to get pulmonary tuberculosis. These patients will receive polypharmacy which require special attention to ensure patient safety. The objective of this study is to examine the usage patterns of anti-tuberculosis therapy in AIDS patients related to types, route, dose, and see whether there are any side effects during anti-tuberculosis use. This was observational and retrospective study using patient medical record, conducted at dr. Saiful Anwar hospital, Malang in the period of April-Mei 2016. Based on medical record of 36 AIDS patients with pulmonary TB, 22 patients (61%) were in the intensive phase of treatment anti-tuberculosis cate–gory I, 8 patients (22%) in the treatment of the intensive phase of category II, 2 patients (6%) in the continuation phase category I, 1 patient (3%) was in the intensive phase of category I then get a special conditions regimen of anti-tuberculosis therapy, 1 patient (3%) was in the intensive phase category II but underwent a change to the intensive phase of MDR-TB, and other 1 patient (3%) was get the intensive phase of special conditions. Drug related problems that identified were rash (6%), Steven Johnson syndrome (3%), drug induced hepatitis due to anti-tuberculosis (22%), and jaundice without other cause (3%).
Pengaruh Pemberian Edukasi Gizi dan Kapsul Serbuk Daun Kelor (Moringa oleifera L.) terhadap Kenaikan Kadar Hemoglobin Remaja Putri di Universitas Pakuan Lusi Indriani; Cantika Zaddana; Naufal Muharam Nurdin; Juniarti Sri Maryati Sitinjak
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.2109

Abstract

Anemia is a condition where the hemoglobin (Hb) level is lower than 12 g/dL. Teenagers are the most susceptible group experiencing a decrease in hemoglobin, especially teenage girls because they get menstruate so that they lose a lot of iron every month. It causes them become easily tired, drowsiness, dizziness, rapid concentration loss, then clearly inhibits the learning process and achievement. Natural ingredients as an alternative to increase Hb which is easily obtained and cultivated are Moringa oleifera L. leaves since they contain protein, vitamin C, and iron. This study aims to evaluate an increase of hemoglobin levels and the knowledge of anemia after giving education and capsules of moringa leaves powder. This is true experimental study with pre and posttest design. The respondents were female students with anemia which were divided to the intervention groups (getting education and kelor) and control groups (getting education and placebo). It was carried out for 30 days. The results showed that education and Moringa leaf powder capsules significantly increased hemoglobin levels by 1.76 ±0.80 g/dL, while the increase in the education group was 0.72 ± 0.97 g/dL. It can be concluded that the education and Moringa leaf powder capsules can significantly increase the knowledge of anemia and Hb levels.
Pengaruh Variasi Konsentrasi Zeolit sebagai Builder Agent terhadap Karakteristik Deterjen Cair Evi Sulastri; Ni Ketut Sumarni; Vitasari Vitasari
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.1572

Abstract

This study aimed to determine the effect of various concentrations of zeolite as a buider agent in liquid detergent. Zeolite was synthesized from rice husk ash using solution to gel (sol-gel) method, followed by hydrothermal and then characterized by X-Ray Diffraction (XRD). The synthesized zeolite was then formulated into liquid detergent with sodium lauryl sulfate, glycerin, citric acid, colouring agent, parfume, and three concentrations of zeolite, i.e.: 15% (F1), 20% (F2), and 25% (F3). Liquid detergent was prepared by mixing process using stirrer. The characterizations of liquid detergents were including pH, viscosity, specific gravity, foaming power, foam stability, and detergency power. The XRD showed that the zeolite was type-A zeolite. Moreover, the characterization showed that zeolite with varying concentrations tend to influence in pH, viscosity, and detergency power but relatively similar in specific gravity, foaming power, and foam stability. The result indicated that the detergents with zeolite have better cleaning ability than the control (without builder) and the comparator detergents (with STPP builder). The higher the concentration of zeolite, the higher the detergency power. Therefore, F3 was recommended as formula of detergent with the best detergency power.

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