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INDONESIA
The Indonesian Biomedical Journal
Published by The Prodia Education and Research Institute
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Public Health
Arjuna Subject : -
Articles 601 Documents
 55   56   57   58   59 
HPV18 E6/E7 Mutation and Their Association with The Expression Level of Tumor Suppressor Proteins p53 and pRb among Indonesian Women with Cervical Cancer Mahendra, I Nyoman Bayu; Prayudi, Pande Kadek Aditya; Dwija, Ida Bagus Nyoman Putra
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3400

Abstract

BACKGROUND: The E6/E7 mutation contributes to the intra-typic variant of HPV18 which may differ in their oncogenic potential. E6 and E7 target the tumour suppressor protein p53 and pRb, respectively, and their degradation play a crucial role in cervical carcinogenesis. However, the prevalence of HPV18 E6/E7 variants among Indonesian women with cervical cancer has not been elucidated. Therefore, this study was conducted to characterize the HPV18 variants among Indonesian women with cervical cancer and their association with tumor suppressor protein p53 and pRb.METHODS: A hundred Indonesian women with pathologically proven cervical cancer were consecutively recruited into the study. Polymerase chain reaction (PCR) was performed to detect HPV18 DNA E6 and E7 oncogenes using specific primers and the variants was determined through nucleotide sequencing. Expressions of p53 and pRb were analyzed through immunohistochemistry by using specific antibodies targeting p53 and pRB.RESULTS: The rate of HPV18 positivity was 24%. The rate of E6 and E7 mutation was 45.4% and 59.1%, respectively. Those with E6 mutation had significantly higher expression of p53 and pRb as compared to those with wildtype E6 (p<0.05). Subjects with E7 mutation only had higher expression of pRb (p<0.05). Phylogenetic analysis revealed that 54.5% subjects had genetic sequences closely related to Asian lineages, particularly A1, A4, and A5 sublineage. Interestingly, 3 subjects had genetic sequences closely related to MK813921, a newly identified sequences. However, 45.5% subjects had distinct genetic sequences that did not related to the reference sequence used in this study.CONCLUSION: E6 and E7 mutation was common among Indonesian women with HPV18 cervical cancer and associated with the level of tissue p53 and pRb expression.KEYWORDS: HPV18 E6/E7, mutation, epidemiology, Indonesian women
Intermittent Exposure to Hypobaric Hypoxia Increases VEGF, HIF-1α, and Nrf-2 Expressions in Brain Tissue Wardaya, Wardaya; Sukmawati, Dewi; Ibrahim, Nurhadi; Ferdinal, Frans; Mudjihartini, Ninik; Sadikin, Mohamad; Jusman, Sri Widia A.; Satriotomo, Irawan; Mulyawan, Wawan
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3519

Abstract

BACKGROUND: Hypoxia inducible factor-1α (HIF-1α), nuclear factor erythroid 2-related factor 2 (Nrf-2), and vascular endothelial growth factor (VEGF), play a crucial role as neuroprotective factors. Currently, there is a lack of studies examining the biomolecular responses of the brain to intermittent hypoxia resulting from various pressures. This study was conducted to investigate the physiological responses, histopathological features, and cellular adaptive responses in the brains of rats that were intermittently exposed to hypobaric hypoxic conditions.METHODS: Thirty male Sprague Dawley rats were divided into six groups: a control group and five treatment groups exposed to hypobaric hypoxia. The treatment groups were placed in a hypobaric chamber simulating an altitude of 3,048 meters for 1 hour/day for 1, 7, 14, 21, and 28 days. After exposure, brain tissue was collected for histopathological analysis and protein quantification of HIF-1α, Nrf-2, cytoglobin (Cygb), neuroglobin (Ngb), VEGF, malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT).RESULTS: In the brain, intermittent hypobaric hypoxia significantly increased HIF-1α expression (p=0.000) and its downstream proteins Cygb (p=0.000), and VEGF (p=0.001), with a peak at 14x IHH exposure compared to control. This was followed by a significant increase in Nrf-2 expression (p=0.000), SOD (p=0.000), Gpx (p=0.000), and CAT activity (p=0.000), indicating an adaptive antioxidant response. Conversely, MDA levels was decreased with prolonged exposure, suggesting reduced oxidative damage.CONCLUSION: IHH elevates HIF-1α, Nrf-2, and oxidative stress markers, triggering an adaptive antioxidant response in the rat’s brains.KEYWORDS: HIF-1α, intermittent hypobaric hypoxia, Nrf-2, oxidative stress
Resveratrol: The Multifaceted Roles and Mechanisms of Polyphenol to Improve Longevity, Immunomodulation, and Age-related Diseases Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3486

Abstract

High in polyphenols diet has been known to protect human against chronic metabolic diseases including cancer, diabetes, neurological and cardiovascular disorders. Resveratrol (RSV) is a natural polyphenol that presents in fruits, vegetables, and nuts. The polyphenols content of RSV possesses anti-inflammatory, antioxidant, immunomodulatory, and anticancer properties by influencing the nuclear factor-kappaB (NF-κB), p53, adenosine monophosphate-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathways, enzymatic antioxidants expressions, and the levels of microRNAs. Therefore, this review article will focus on the potential of RSV in improving aging and metabolic diseases, which mostly induced by low-chronic inflammation and oxidative stress. RSV is also known as calorie restriction (CR)-mimetics to activate sirtuins family which improve mitochondrial function, repair DNA and genomic stability and reduce inflammation thus become a promising substance to extend health span and longevity. RSV can be useful as a supplement to prevent aging-related diseases, with a dose range between 250–1,000 mg depending on the intended health benefit and individual factors. More clinical data is needed to determine the impact of RSV metabolites and the relationship between dose, concentration, and effect, particularly in the context of chronic illness.KEYWORDS: mesenchymal stem cell, extracellular vesicle, exosome, cancer therapy, drug delivery
MCM6 rs4988235 Allele G, AGT rs699 Allele C, ACE rs4343 Allele A, FADS1 rs174547 Allele C, DCHR7 rs12785878 Allele G, and GC rs7041 Allele T: Candidate Genes for Preeclampsia Prevention Riu, Deviana Soraya; Sunarno, Isharyah; Lukas, Efendi
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3422

Abstract

BACKGROUND: Preeclampsia is the primary cause of maternal and neonatal morbidity and mortality; however, currently there is no definitive method exists to prevent preeclampsia. Recent findings indicate a possible genetic influence on preeclampsia. Therefore, this study was conducted to assess nutrigenomic patterns in preeclampsia as a potential mechanism for identifying appropriate preventive strategies through a nutrigenomic approach.METHODS: This descriptive study focused on 15 primiparous pregnant women diagnosed with preeclampsia. The nutrigenomic test was performed using DNA microarray method to examine variant genes associated with food response and nutrient metabolites. The genetic tendencies were categorized as "low," "average," and "high." The frequencies of alleles and probabilities were assessed for gene variants expressing "high" and "low" genotypic tendencies.RESULTS: The identified genetic variations were MCM6 rs4988235 allele G that indicated lactose intolerance (allele frequency 100%), AGT rs699 allele C and ACE rs4343 allele A that were associated with sodium metabolism (allele frequency 82% and 90%, respectively), as well as FADS1 rs174547 allele C that was pertained to omega metabolism (allele frequency 85%). Likewise, DCHR7 rs12785878 allele G and GC rs7041 allele T were relevant for vitamin D (allele frequencies 82% and 77%, respectively). However, MCM6 rs4988235 allele G, FADS1 rs174547 allele C, DCHR7 rs12785878 allele G, and GC rs7041 allele T had not been explicitly linked to preeclampsia.CONCLUSION: MCM6 rs4988235 allele G, AGT rs699 allele C, ACE rs4343 allele A, FADS1 rs174547 allele C, DCHR7 rs12785878 allele G, and GC rs7041 allele T are the dominant variant genes observed. The associations between preeclampsia and AGT rs699 allele C and ACE rs4343 allele A are consistent with other study.KEYWORDS: preeclampsia, nutrigenomics, nutrition metabolism
Insulin Resistance, Adiponectin, and Dyslipidemia as Key Determinants of Metabolic and Reproductive Dysregulation in Polycystic Ovary Syndrome Haddawi, Krarr Haider; Yaseen, Bushra Raouf; Abd Alredha, Redha Dawud; Handool, Kareem Obayes
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3530

Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with insulin resistance, dyslipidemia, and metabolic dysfunction. However, the predictive value of insulin resistance (HOMA-IR), dyslipidemia, and adiponectin in identifying PCOS and stratifying metabolic risk remains unclear, particularly in underrepresented populations, such as Iraqi women. This study evaluated these parameters to improve risk stratification and early intervention strategies in resource-limited settings.METHODS: This case-control study included 100 women (50 with PCOS diagnosed using the Rotterdam criteria and 50 age-matched healthy controls). Anthropometric and clinical assessments, including BMI and hirsutism scores, were performed. Fasting blood samples were analyzed for glucose and lipid profile using colorimetric assays, insulin via electrochemiluminescence immunoassay (ECLIA), and adiponectin via enzyme-linked immunosorbent assay (ELISA), and HOMA-IR was calculated to quantify insulin resistance.RESULTS: Women with PCOS exhibited significantly higher BMI, fasting glucose, insulin, and HOMA-IR values (p<0.001 for all) than controls. Dyslipidemia was evident, characterized by elevated total cholesterol, LDL-C, and triglyceride levels, as well as lower HDL-C levels (p<0.001). Adiponectin levels were markedly reduced in the PCOS group (p<0.001) and showed strong inverse correlations with HOMA-IR (r=–0.554, p<0.001) and fasting insulin (r=–0.453, p<0.001). Logistic regression indicated that HOMA-IR was the most significant predictor of PCOS (OR=28, 95% CI 4.86–161.44, p=0.0002), whereas higher adiponectin levels offered significant protective effects (OR=0.54, 95% CI 0.36–0.82, p=0.0039).CONCLUSION: Insulin resistance, dyslipidemia, and low adiponectin levels are strongly associated with PCOS and metabolic dysfunction in Iraqi women. HOMA-IR is a key predictor, whereas adiponectin may have protective effects. These findings highlight the potential of these biomarkers in risk stratification and early intervention in resource-limited settings.KEYWORDS: PCOS, adiponectin, HOMA-IR, dyslipidemia
Alpha-Actinin-3 (ACTN3) R577X Polymorphism on Brain-derived Neurotrophic Factor (BDNF) Levels of Pre- and Post-Eccentric Exercised Male Subjects Khadijah, Audira Syafana; Aryati, Aurel; Arpy, Aurel Diffa; Susetyo, Angela Excellcia Larasaty; Hartanti, Monica Dwi
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3465

Abstract

BACKGROUND: Eccentric exercise, characterized by muscle lengthening underload, elicits physiological responses, including alterations in brain-derived neurotrophic factor (BDNF) levels, crucial for neuroplasticity and exercise adaptations. The Alpha-Actinin-3 (ACTN3) gene encodes α-actinin-3, a protein in fast-twitch muscle fibers associated with explosive performance. The R577X polymorphism in ACTN3 is associated with athletic performance, particularly in power-based activities. However, its influence on the BDNF response to eccentric exercise remains unclear. This study investigated whether the ACTN3 R577X polymorphism modulates BDNF levels post-exercise.METHODS: Male subjects aged 18-30 years old, who were not involved in structured physical activity, and abstaining from alcohol and protein supplements within specified periods, were involved in this study. Subjects’ genotypes were identified using polymerase chain reaction (PCR) and classified into different ACTN3 genotypes (RR, RX, XX). All subjects underwent an eccentric exercise protocol. BDNF levels were measured pre-exercise, post-exercise, and 72 hours post-exercise using sandwich Enzyme-Linked Immunosorbent Assay (ELISA).RESULTS: Most of subjects had RX genotype (52.2%), followed by XX (39.1%) and RR genotypes (8.7%), respectively. BDNF levels decreased significantly across all time points. The RR genotype showed a decrease from approximately 270 pg/mL to 230 pg/mL, while RX and XX genotypes showed similar patterns of reduction. No significant differences in BDNF levels were observed between genotypes at any time point.CONCLUSION: Eccentric exercise leads to a consistent decrease in BDNF levels, with no significant modulation by ACTN3 genotype. These findings suggest a uniform response to exercise-induced stress across genotypes.KEYWORDS: ACTN3, BDNF, eccentric exercises, genotype, adaptation
miR-29 Family as Epigenetic Regulators of DNMTs in Prostate Cancer and Benign Prostatic Hyperplasia Foenna, Yudi Gebri; Calapoğlu, Nilüfer Şahin; Sancer, Okan; Tepebaşı, Muhammet Yusuf; Calapoğlu, Mustafa
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3456

Abstract

BACKGROUND: The miR-29 family (miR-29a/b/c) is recognized as a tumor suppressor, directly targeting DNA methyltransferases (DNMTs), key regulators of epigenetic gene silencing. Even though miR-29 has been implicated in tumor progression, its regulatory interaction with DNMT3A/3B, particularly in prostate cancer (PCa), has not been elucidated well. This study was conducted to explore the potential of miR-29a/b/c in targeting DNMT3A/3B in PCa and benign prostatic hyperplasia (BPH), addressing a critical gap in understanding their epigenetic role.METHODS: This study used tissue samples that were taken surgically from 30 subjects that consisted of 15 diagnosed PCa and 15 BPH patients (as the control group), aged between 18-75 years, with urinary system disorders and had a prostate specific antigen (PSA) value between 1.18 and 56.15 ng/dL. The miR-29a/b/c and DNMT3A/3B expressions were measured using quantitative real-time PCR (qRT-PCR). The variations in mean values across groups, the associations between miR-29a/b/c and DNMT3A/3B expression levels parameters, as well as the correlation between miR-29 levels and DNMT3A/3B variables were then statistically analyzed.RESULTS: The expression levels of miR-29a/b/c were significantly downregulated in the PCa subjects compared to the BPH subjects (p<0.05), and negative correlations were observed between miR-29a/b/c and DNMT3A/3B in the PCa subjects (p<0.001). In addition, a significant inverse correlation was detected only between miR-29a and DNMT3B in BPH subjects (p<0.05).CONCLUSION: The results of this study indicated that miR-29a/b/c in PCa may act as a negative regulator directly targeting DNMT3A/3B. These findings support the role of miR-29s in developing miRNA-based strategies for treating PCa.KEYWORDS: prostate cancer, benign prostatic hyperplasia, epigenetic, DNA methyltransferases-3A/3B, miR-29a/b/c
Elevation of miR-210 Expression and Mean Arterial Pressure as Early-onset Pre-eclampsia Biomarkers, while Elevation of Matrix Metalloproteinase-2 as Late-onset Pre-eclampsia Biomarker Nelson, Nelvianti; Yusrawati, Yusrawati; Serudji, Joserizal; Jamsari, Jamsari; Amir, Arni; Afriwardi, Afriwardi; Gumilar, Erry
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3490

Abstract

BACKGROUND: Pre-eclampsia has varying onset patterns, which are challenging to determine due to their association with diverse clinical parameters, including blood pressure regulation, vascular remodeling, and placental hypoxia. These parameters influence the expression of key biomarkers such as microRNAs, metalloproteinases, and arterial pressure indices. Therefore, understanding the associations is crucial for improving early diagnosis and management. This study was conducted to compare miR-210 expression, mean arterial pressure (MAP), and matrix metalloproteinase (MMP)-2 levels between early-onset pre-eclampsia (EOPE) and late-onset pre-eclampsia (LOPE).METHODS: Pregnant women with EOPE (20–34 weeks) and LOPE (35 weeks to term) were included in this cross-sectional comparative study, and their blood samples were collected. miR-210 expression was quantified with reverse transcription polymerase chain reaction (RT-PCR), MAP was measured using sphygmomanometer, while MMP-2 levels were measured using enzyme-linked immunosorbent assay (ELISA).RESULTS: miR-210 expression was more frequently observed in the EOPE group (87.5%) compared to the LOPE group (77.5%), with a significant difference identified between the two groups. The odds ratio for miR-210 expression in EOPE compared to LOPE was 2.03 (95% CI: 1.06–6.72). The MAP was notably higher in the EOPE group (121.15 mmHg) than in the LOPE group (116.15 mmHg), with a significant difference observed. Conversely, MMP-2 levels were significantly higher in the LOPE group (390.99 ng/mL) compared to the EOPE group (271.35 ng/mL).CONCLUSION: There are significant differences in miR-210 expression, MAP and MMP-2 between EOPE and LOPE. These findings suggest that miR-210, MAP, and MMP-2 could be useful biomarkers for distinguishing between EOPE and LOPE, potentially guiding more effective management and intervention strategies.KEYWORDS: miR-210, MAP, MMP-2, EOPE, LOPE, pre-eclampsia
N-Acetylcysteine Prevents Sleep Deprivation-induced Memory Deficit in Juvenile Rats Through the Suppression of BDNF, Cortisol, Acetylcholine Levels, and Inflammatory Cytokines Expressions Rosyidah, Citra; Arozal, Wawaimuli; Lee, Hee Jae; Tjandrawinata, Raymond Rubianto; Septiana, Wahyunia Likhayati
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3445

Abstract

BACKGROUND: Sleep deprivation (SD) affects 20–30% of children and is known to impair cognitive functions, particularly memory. Despite its impact, there is currently no standardized treatment. Evidence from both adult animal and human suggests that N-acetylcysteine (NAC) possesses neuroprotective properties. This study was conducted to evaluate the effects of NAC on memory deficits induced by SD in juvenile rats.METHODS: Juvenile Sprague-Dawley rats were subjected to SD using the modified multiple platform method. NAC was administered intraperitoneally at doses of 100 mg/kgBW or 500 mg/kgBW. Y-maze and novel object recognition (NOR) tests were used for neurobehavioral assessment. Biochemical analyses were conducted to measure cortisol, brain-derived neurotrophic factor (BDNF), and acetylcholine (ACh) levels, using enzyme-linked immunosorbent assay (ELISA). Acetylcholine esterase (AChE) activity was measured by colorimetric method. Western blot analysis was performed to examine cAMP response element-binding protein (CREB) and phosphorylated CREB (p-CREB). Additionally, cytokine mRNA expressions were evaluated using polymerase chain reaction (PCR).RESULTS: Spontaneous alteration and discrimination ratio were decreased in SD group without treatment compared to the normal group (p<0.05). Similarly, BDNF was also decreased compared with normal group (p<0.05). Cortisol level and mRNA expression of TNF-α were increased significantly compared with normal group (p<0.05) along with a slight increase of ACh activity. Interestingly, NAC treatment mainly at the dose of 500 mg/kgBW prevented those pathological features significantly.CONCLUSION: NAC might prevent the SD-induced memory deficits by suppressing the inflammatory markers, activity of AChE, cortisol, and enhancing the level of BDNF.KEYWORDS: SD, NAC, memory, AChE, cortisol, inflammatory markers, BDNF
FGFR2 as A Prognostic and Predictive Marker in Colorectal Adenocarcinoma Based on TILs Grade Rianti, Andi Marcha; Cangara, Muhammad Husni; Yamin, Amalia; Dahlan, Haslindah; Ilyasa, Muhammad Riza; Miskad, Upik Anderiani
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3523

Abstract

BACKGROUND: Colorectal cancer remains a serious health problem due to its high incidence and mortality rate each year. Histopathological grades and tumor-infiltrating lymphocytes (TILs) are associated with patient’s outcome. Fibroblast growth factor receptor 2 (FGFR2) overexpression is correlated with a worse prognosis in colorectal adenocarcinoma patients. Unfortunately, there are not many studies investigating the relationship between FGFR2 with histopathological grade and TILs in Indonesia. This study was conducted to analyze the correlation between FGFR2 expression with histopathological grade and TILs grade in colorectal adenocarcinoma.METHODS: Immunohistochemistry examination using FGFR2 rabbit polyclonal antibody was performed on 94 paraffin-embedded colorectal adenocarcinoma blocks and its expression was examined using a light microscope. The relationship between FGFR2 expression with histopathological grade and TILs grade in colorectal adenocarcinoma was statistically analyzed.RESULTS: Of the 94 samples examined, low grade adenocarcinoma was more common (n=76), of which 60.5% showed high FGFR2 expression. While in high grade adenocarcinoma, 83.3% of the samples showed high FGFR2 expression. In low grade TILs (n=30), 80% showed strong FGFR2 expression. While in high grade TILs (n=17), 64.7% showed weak FGFR2 expression. Based on statistical analysis, there was a significant correlation between FGFR2 expression and TILs grade (p=0.008). However, there was no significant association with histopathological grade (p=0.127).CONCLUSION: The significant correlation between FGFR2 expression and TILs grade suggests that FGFR2 may be used as a prognostic and predictive marker in colorectal adenocarcinoma.KEYWORDS: FGFR2, Colorectal adenocarcinoma, TILs, Histopathological grade

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