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All Journal Biology, Medicine, & Natural Product Chemistry Pharmascience IDJP (Indonesian Journal of Pharmaceutics) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Pharmasipha Majalah Farmasetika Jurnal Farmasi Etam Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Journal of Innovation Research and Knowledge Pharmaceutical Sciences and Research (PSR) Sciences of Pharmacy Media Farmasi Camellia Jurnal Pengabdian Kesehatan Jurnal Sains dan Kesehatan
Maria Elvina Tresia Butar-Butar
Departemen Farmasetika Dan Teknologi Formulasi, Fakultas Farmasi, Universitas Padjadjaran, Jalan Raya Bandung Sumedang KM 21 Jatinangor, Jatinangor 45363, Jawa Barat, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Antidepressant Activity Study of Keruing (Dipterocarpus grandiflorus) Oleoresin Candle Aromatherapy on Male Mice (Mus musculus) Balb/C Strain Agus, Adhe Septa Ryant; Butar-Butar, Maria Elvina Tresia; Fernandes, Andrian; Maharani, Rizki; Awan, Kevin Imanuel; Luhat, Martin Gilbert
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 3 No 2 (2024): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v3i2.24665

Abstract

Depression represents a manifestation of prolonged stress, which, if left untreated, may lead to severe mental disorders. For depression treatment therapy, it can be carried out based on evidence-based treatment for depression and anxiety. Aromatherapy candles can be used as a non-pharmacological medium for depression therapy, where keruing has active compounds are phthalic acid di(3-methoxybenzyl) ester and phthalic acid, 5-ethyl-1,3-dioxan-5-yl octyl ester, causing keruing oleoresin to have a distinctive fragrance. This study aims to evaluate the pharmacological potential of keruing as an antidepressant for non-pharmacological therapy. Aromatherapy candles were formulated with keruing oleoresin at concentrations of 0%, 2.5%, 5%, 7.5%, and 10%, followed by testing their antidepressant activity using the Conditioned Place Preference (CPP) method. The results of the Paired T-test for groups F0, F2, and F4 or formulas containing 0%, 5%, and 10% of keruing oleoresin have a significant effect (sig. values <0.05) between pre and post-test being given aromatherapy and induction. In the One-way ANOVA test, between their groups, it can be seen there was no significant difference in test activity, namely for the pre-treatment test (sig. 0.445 > 0.05) and for the post-treatment test (sig. 0.065 > 0.05). Results indicated that while the candles met physical quality standards outlined by the Indonesian National Standard (SNI), no significant antidepressant effects were observed in mice. Further refinement in methodology, including the concentration of active compounds and delivery methods, is recommended to enhance the pharmacological potential of keruing oleoresin.
Co-Authors Agnes Elisa Agus, Adhe Septa Ryant Andrian Fernandes, Andrian Anis Yohana Chaerunisaa Awan, Kevin Imanuel Ayugistia, Falen Sindi Clara Ritawany Sinaga Dwi Retno Sari, Dwi Retno Fahrudin Gozali Fajar Hayatus Sa'adah Hestiary Ratih Hutagalung, Remita Ully Jenly Adinata Luhat, Martin Gilbert Morijan, Risky asrina Nainggolan, Angel Natalia Nasrul Wathoni Nurillahi Febria Leswana Pahlevi, Muhamad Reza Pijaryani, Indria Ping, Maria Floriana Pratama, Reza Prehatin, Chrisbaningrum Rizki Maharani Roni, Asep Ryan, Adhe Septa Sagita, Novaliana Devianti Selvina, Selvina Septa Ryant Agus, Adhe Simanjuntak, Servis Simanullang, Raymon Sister Sianturi Sriminarty Tambing Taufiqurrahman, Muh Tiara, Anastasia Tokan, Santa Eufrasia Carolin Yoga Windhu Wardhana Yoga Windu Wardhana Yulia Sukawaty Zaelani, Diki