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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN PROSIDING SEMINAR NASIONAL JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Media Medika Muda Journal of Dedicators Community ISM (Intisari Sains Medis) : Jurnal Kedokteran Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Medica Arteriana (Med-Art) Diponegoro International Medical Journal (DIMJ) Acta Odontologica Indonesia
Retnoningrum, Dwi
Department Of Clinical Pathology, Faculty Of Medicine, Universitas Diponegoro
Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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POLA PEMBERIAN ANTIBIOTIK DI ERA PANDEMI COVID-19 (STUDI KASUS DI RUMAH SAKIT NASIONAL DIPONEGORO) Putra, Dominikus Evano; Pramudo, Setyo Gundi; Arkhaesi, Nahwa; Retnoningrum, Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (283.94 KB) | DOI: 10.36408/mhjcm.v8i2.578

Abstract

Background: Inappropriate use of antibiotics could increase the incidence of antibiotic resistance, hence increasing morbidity, mortality, and health cost. WHO has recommended to conduct a study of rational use of antibiotics in order to overcome this problem. Aim: To analyze the quality and quantity of antibiotic use in inpatient care facility at Diponegoro National Hospital (RSND). Methods: Quality and quantity assessment conducted by the use of DDD/100 patient–days and the Gyssens criteria. The study was conducted retrospectively at 86 patients’ medical records that were obtained by consecutive sampling method. Results: There were 141 antibiotics prescriptions from 86 medical records. Azithromycin, levofloxacin, and ceftriaxone were the most commonly used and had 48,12; 44,01; and 21,13 DDD/100 patient–days. By Gyssens crieteria, 35,4% of antibiotic usage was appropriate, 51,1% of antibiotic usage was inappropriate, and 13,5% no indication of the use of antibiotic. Based on the type of therapy, ADE 89,4% and ADET 10,6%. Conclusion: In terms of quantity, the most commonly used antibiotic was azithromycin. In terms of quality, 35,4% antibiotic were used appropriately according to Gyssens criteria. Keywords: Antibiotic usage; internal medicine; DDD/100 patient–days; Gyssens criteria
Penyuluhan Osteoporosis dalam Upaya Pencegahan Komplikasi Tulang pada Pasien Talasemia Mayor di Kabupaten Rembang dan Grobogan Widyastiti, Nyoman Suci; Retnoningrum, Dwi; Ariosta, Ariosta; Nency, Yetty Movieta; Ngestiningsih, Dwi; Partiwi, Rina; Muniroh, Muflihatul; Naviati, Elsa; Afriana, Rizky Dyas
Journal of Dedicators Community Vol 7, No 3 (2023)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v7i3.3577

Abstract

Background Osteoporosis is a complication that often occurs in thalassemia major patients. This complication is still not widely known. This community service program aims to increase the knowledge of families of major thalassemia patients in Rembang Regency and Grobogan Regency regarding the complications of osteoporosis in thalassemia patients. Methods Education about osteoporosis, risk of osteoporosis in thalassemia patients, and prevention of osteoporosis. Extension method with presentation and discussion. The activity was attended by 20 thalassemia families in the Rembang Regency and 21 families of thalassemia patients in the Grobogan Regency. Before and after counseling, pretest and posttest questionnaires were completed to measure the knowledge of families of thalassemia major patients regarding bone complications in thalassemia patients. Results and Discussion Nearly half (46.34%) of respondents did not know the risk of osteoporosis in thalassemia. After counseling, 82.93% of respondents knew the risk of osteoporosis in thalassemia, but there were still 17.07% of respondents who still did not know this risk. Conclusion There is a significant increase in family knowledge of thalassemia major patients about the risk of osteoporosis in thalassemia. Further efforts to increase knowledge are needed with written information media (leaflets) given to families of thalassemia major patients
The Difference between Salivary Viscosity and Salivary Flow Rate on Nicotine Electric Smokers and Non-Smokers Difaputra, Syavergio Avia; Kusuma, Ira Anggar; Dewi, Dian Puspita; Retnoningrum, Dwi
Acta Odontologica Indonesia Vol 1, No 2 (2025): December Edition
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/actodont.27232

Abstract

Background: Electric cigarette which contained nicotine affected bad impact to oral cavity, since the nicotine contained on e-liquid electric cigarette could reduce function of salivary gland. This condition decreases the salivary flow rate and increase salivary viscosity. could impact to less activity of self-cleansing and antimicrobial of saliva. Objectives: To prove the difference of salivary viscosity and salivary flow rate on nicotine electric smokers and non-smokers. Methods: This research was an analytic descriptive research which exerted cross sectional research design. As many as 60 people were selected to be the research subjects who were then divided into 30 electric smokers and 30 non-smokers. The saliva on each subject was collected in a beaker cup stimulated for 8 minutes, and continued to the viscosity measurement to be valued both visually and subjectively. The data was analyzed through Mann-Whitney test to identify the difference between viscosity and salivary flow rate on nicotine electric smokers and non-smokers. Results: The result of Mann-Whitney test showed a significant difference between salivary flow rate (p<0,05) and salivary viscosity of nicotine electric smokers and non-smokers (p<0,05). Conclusion: This research indicated the difference of viscosity and salivary flow rate between electric smokers and non-smokers. The electric smokers have thicker viscosity and lower flow rate compared to the non-smokers.
Lycopene Enhances the Beta Cell Capacity and Antihyperlipidemic Effects of Metformin on Type 2 Diabetic Rats Nugroho, Heri; Sianturi, Medina; Retnoningrum, Dwi; Susiloningsih, Neni
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.2989

Abstract

BACKGROUND: Hyperglycemia causes dyslipidemia in type 2 diabetes mellitus (T2DM). Metformin monotherapy is known to be less effective at improving glycemic status, insulin function, and lipid profiles. Lycopene is a potential antioxidant and has been shown to be hypoglycemic and hypocholesterolemic. However, the effects lycopene and metformin combination are still up for debate. This study was conducted to determine the potential of lycopene in enhancing the ability of metformin to improve glycemic status, insulin resistance, beta cell capacity, and lipid profile of T2DM rats.METHODS: Thirty male Wistar rats were randomly divided into six groups: control (N), T2DM-untreated (D), T2DM + metformin (DM), T2DM + metformin + 10 mg/kgBW lycopene (DMLy-10), T2DM + metformin + 20 mg/kgBW lycopene (DMLy-20), and T2DM + metformin + 40 mg/kgBW lycopene (DMLy-40). The treatment was administered once daily through oral route and lasted for 28 days, before blood samples were collected. Fasting blood glucose (FBG) was assessed by oxidase-peroxidase method, fasting serum insulin and HbA1c were measured using enzyme-linked immunosorbent assay (ELISA), while lipid profile was determined using enzymatic methods. The homeostatic model assessment for insulin resistance (Homa-IR) as well as the homeostatic model evaluation of β-cell function (Homa-B) were then calculated.RESULTS: Fasting serum insulin levels increased significantly (p<10.05) in the DMLy-20 and DMLy-40 groups, but Homa-B or high-density lipoprotein (HDL) did not significantly increase. Additionally, the FBG, HbA1c, Homa-IR, total cholesterol, triglyceride, and low-density lipoprotein levels were not significantly decreased than in the group treated with metformin alone.CONCLUSION: Lycopene can enhance the ability of metformin to improve the glycemic status, insulin resistance, beta-cell capacity, and lipid profile of T2DM rats.KEYWORDS: dyslipidemia, Homa-B, insulin resistance, lycopene, metformin, type 2 diabetes mellitus
Effects of the BPAL Regimen On Hematological Parameters In Patients With Multidrug-Resistant Tuberculosis Dwi Retnoningrum; Sustika Novianita Assan; Villa Sekar Cita; Ardhea Jaludamascena
Diponegoro International Medical Journal Vol 7, No 1 (2026): July 2026
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v7i1.30994

Abstract

Background: BPaL is a new oral drug combination consisting of Bedaquiline (B), Pretomanid (Pa) and Linezolid (L) for multi-drug resistance tuberculosis. In Indonesia BPaL has been officially launched by the government as a therapeutic regimen for multidrug resistant tuberculosis patients since August 2023. One of the drugs in this regimen has the side effect of anemia. Until now, there are still no references explaining the effect of BPaL on the hematological profile.Objective: To determine the differences in the hematological profile of multidrug resistance tuberculosis patients before receiving the multi drug resistance regimen BPaL anti-tuberculosis drug regimen and while receiving the multi drug resistance regimen BPaL anti-tuberculosis drug regimen.Methods: This research was a retrospective observational analytical study with a retrospective cohort design involving patients with multidrug-resistant tuberculosis in Kariadi Hospital based on medical records. The difference test used the paired T-test and the Wilcoxon test.Results: 40 subjects were recruited, there were significant differences in hemoglobin level (p=0.003), hematocrit (p=0.002), red blood cells count (p=<0.001), white blood cells count (p=0.004), platelet count (p=<0.001) and RDW (p=<0.001) before therapy with the BPaL regimen and during therapy with the BPaL regimen.Conclusion: There are significant differences in the hematological profile of multidrug resistant patients, before treatment with the BPaL regimen and while receiving the BPaL regimen.
Analisis Faktor Risiko Mortalitas pada Pasien COVID-19 dengan Keganasan Non-Hematologi Nyoman Suci Widyastiti; Dyah Mustika Nugraheni; Dwi Retnoningrum; Ariosta Ariosta; Fathur Nur Kholis; Nur Farhanah; Selamat Budijitno; Endy Cahyono Kristiawan
Medica Arteriana (Med-Art) Vol 7, No 2 (2025): Desember 2025
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.7.2.2025.74-81

Abstract

Latar Belakang: Corona Virus Disease-19 (COVID-19) merupakan masalah kesehatan dunia yang sangat serius. Gejala yang berat dapat berujung kematian terutama pada individu yang memiliki komorbid seperti penyakit jantung koroner, diabetes melitus, hipertensi dan pada kondisi imunosupresi seperti pada pasien dengan keganasan. Studi terdahulu menunjukkan peningkatan risiko mortalitas pada pasien keganasan yang terinfeksi COVID-19. Penelitian ini bertujuan untuk menganalisis hubungan antara jenis kelamin, jenis keganasan, hipertensi, diabetes melitus, derajat keparahan penyakit, nilai lymphocyte-to-CRP ratio (LCR), dan kadar kreatinin serum dengan tingkat mortalitas pada pasien COVID-19 dengan keganasan non-hematologi.Metode: Penelitian ini merupakan penelitian cross-sectional retrospektif yang dilaksanakan pada bulan Mei 2023 hingga Juni 2023 dengan mengambil data pasien COVID-19 dengan keganasan non-hematologi di RSUP Dr. Kariadi Semarang pada periode bulan Maret 2020 hingga Desember 2022. Semua data diambil melalui rekam medis elektronik (RME) RSUP Dr. Kariadi Sema-rang. Nilai cut-off untuk LCR dan kadar kreatinin serum masing-masing adalah 100 dan 1,3 mg/dL. Data kategorik dianalisis menggunakan uji Chi-square untuk mendapatkan nilai p dan Prevalence Ratio (PR). Uji regresi logistik digu-nakan untuk mengetahui hubungan independen antara derajat keparahan penya-kit dan kadar kreatinin serum terhadap tingkat mortalitas.Hasil: Seratus satu pasien diikutkan dalam penelitian dengan 48 kasus mortalitas. Hubungan antara jenis kelamin, jenis keganasan, hipertensi, diabetes melitus, dan nilai LCR dengan tingkat mortalitas didapatkan masing-masing nilai p = 0,924; p = 0,847; p = 0,101; p = 0,916; p = 0,143. Hubungan antara derajat keparahan penyakit dan kadar kreatinin serum dengan tingkat mortalitas didapatkan masing-masing nilai p < 0,001 (PR = 22,148) dan p = 0,009 (PR = 3,604). Hasil analisis mutivariat menunjukkan bahwa nilai PR dari hubungan antara derajat keparahan penyakit dan kadar kreatinin serum dengan tingkat mortalitas pasien masing-masing adalah 27,547 dan 7,090.Kesimpulan: Jenis kelamin, jenis keganasan, hipertensi, diabetes melitus, dan nilai LCR tidak berhubungan dengan tingkat mortalitas. Derajat keparahan penyakit dan peningkatan kadar kreatinin serum berhubungan dengan tingkat mortalitas.
Co-Authors Adhika Bastian Bagas Prananta Aditya Devi Ratnasari Afriana, Rizky Dyas Agung, Albert Ainun Rahmasari Gumay, Ainun Rahmasari Amalia, Lutfia Zein Ardhea Jaludamascena Ardhea Jaludamascena Ardhea Jaludamascena Ardhea Jaludamascena Arief Wildan, Arief Ariosta Ariosta Ariosta Ariosta Ariosta Ariosta Ariosta Ariosta Aryu Candra Astika Widy Utomo Astika Widy Utomo, Astika Widy Attila Yulaicha Banundari Rachmawati Darmawati Ayu Indraswari Dewi, Dian Puspita Diah Ajeng Purbaningrum Diah Ajeng Purbaningrum Dian Widyaningrum Dian Widyaningrum Difaputra, Syavergio Avia Djuara P Lubis Dwi Fajaryani Dyah Mustika Nugraheni Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi Elnitiarta, Jasmine Elsa Naviati Emelia Wijayanti Emi Setianingsih Endy Cahyono Kristiawan Erna Setiawati Excelinda, Tifanni Fathur Nur Kholis Fifin Luthfia Rahmi Findya Mutiara Bangsa Fitrianita Reghita Syari Hadian Widyatmojo Hanny Tiara A Sinaga Heri Nugroho Hermawan Istiadi Hermawan Istiadi Herniah Asti Wulanjani I. Edward KSL, I. Edward KSL Indah Saraswati Indranila Indranila Indranila Kustarini Samsuria Indranilla K. Samsuria Iraisa rosaria Jessica Christanti Josevaldo Bagus P Kusuma, Ira Anggar Lisyani B Suromo Luthfi Fathin Faishal Luthfinnisa, Fryta Ameilia MARIA BINTANG Medina Sianturi Meiliawati, Nur Aini Ayu Meita Hendrianingtyas Meita Hendrianingtyas Meita Hendrianintyas Mila Niqi Itami Mochamad Ali Sobirin Muchlis Achsan Udji Sofro Mulyono Mulyono Muniroh, Muflihatul Muyassar, Abyan Mursyid Nahwa Arkhaesi Neni Susilaningsih Nina Dorothea Budiamal Novianti Anggie Lestari Novita Fajar Sari Nur Farhanah Nyoman Suci Widyastiti Partiwi, Rina Pipin Ardhianto Pramanti, Naulita Pramudo, Setyo Gundi Prasetyowati Subchan Purwanto Adipireno Purwanto AP Puspito, Rizky Indra Putra, Dominikus Evano Rezya Salsabela Roidlotul Nikmah Annafi Salma S Salma S Salsabila, Gaby Abellia Fairuz Sanjaya Santoso Satrio Adi Wicaksono Selamat Budijitno Setyo Gundi Pramudo Sigid Kirana Lintang Bhima Susiloningsih, Neni Sustika Novianita Assan Talitha Salsabila Tamariska Evelyn Theresia Ilyan Uyun, Fuadah Vega Karlowee Villa Sekar Cita Vonny Folanda Wulansari, Arin Yetty Movieta Nancy Yetty Movieta Nency Yetty Movieta Nency, Yetty Movieta Yola Eka Putri Kurniasari Yuliana Yuliana