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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Medula Jurnal Ilmiah KORPUS JURNAL PENDIDIKAN TAMBUSAI Jurnal Ilmu Kedokteran dan Kesehatan Buletin Ilmiah Marina : Sosial Ekonomi Kelautan dan Perikanan Jurnal Medika Malahayati Jurnal Kesehatan Community Development Journal JURNAL PENELITIAN PERAWAT PROFESIONAL Reswara: Jurnal Pengabdian Kepada Masyarakat Ministrate: Jurnal Birokrasi dan Pemerintahan Daerah JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kesehatan Tambusai ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Bina Pengabdian Kepada Masyarakat Journal of Education Research Al-Khidmah Jurnal Pengabdian Masyarakat Jurnal Pengabdian Pada Masyarakat Power, Conflict and Democracy Journal BAHASTRA JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Mayasari, Diana
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Potensi Lada Hitam Sebagai Obat Herbal Terstandar Untuk Disfungsi Ereksi: Literature Review Hasbullah, Faza; Hadibrata, Exsa; Mayasari, Diana
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1390

Abstract

Erectile dysfunction (ED) is a condition that affects men of all ages and backgrounds, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. First-line treatments for ED, such as Phosphodiesterase-5 Inhibitors (PDE5i), often cause side effects and pose contraindications, especially for patients with cardiovascular diseases. Consequently, various studies have been conducted to explore safer natural remedies. One natural substance proven to enhance erectile function is black pepper. This study implement a literature review approach, examining articles from scientific databases published between 2011 and 2025. Piperine, the active compound in black pepper, exhibits significant antioxidant and anti-inflammatory effects, reduces TNF-α levels, and protects nitric oxide (NO) from free radicals. Piperine also enhances testosterone levels by stimulating Leydig cells, contributing to improved erectile function. Moreover, piperine has been shown to increase the expression of the StAR gene, which plays a critical role in testosterone biosynthesis, essential for the erection process. Studies on animal models demonstrated improvements in sexual behavior, testosterone levels, and total penile reflex following black pepper extract administration. Black pepper holds potential as a natural therapy for ED through mechanisms involving increased NO activity, modulation of testosterone hormones, and protection of Leydig cells. While results from animal studies are promising, further research on humans is required to confirm its efficacy and safety.
Penatalaksanaan Pada Anak Perempuan Usia 12 Bulan Penderita Stunting dan Mikrosefali Disertai Pola Asuh Kurang Tepat Melalui Pendekatan Kedokteran Keluarga Di Wilayah Puskesmas Karang Anyar Machmud Aminudin; Mayasari, Diana
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1485

Abstract

Stunting is a condition of short or very short stature based on body length/height according to age that is smaller than -2 Standard Deviation (SD) on the 2006 World Health Organization (WHO) growth curve. Whereas microcephaly is a small head circumference that is below -2 Standard Deviation (SD) based on the mean on gender and age. In this case there was an 11 month old female patient with body weight was: 5.7 kg (W/A: <-3SD); height: 60 cm (H/A: <-3SD); head circumference: 34 cm (HC/A: <-2SD); upper arm circumference: 11 cm with BMI: 15.8 kg/m2. Stunting and microcephaly are correlated in having a big impact on children's growth and development. Therefore, holistic management is needed with a family medicine approach including patient centered, family focused and community oriented to encourage improvements in the patient's condition and family behavior in order to improve the patient's quality of life. Purpose of mplementation of holistic and comprehensive family doctor services by identifying risk factors, clinical problems, and management of stunting and microcephaly patients based on Evidence Based Medicine through a patient centered care and family approach. This study is a case report using primary and secondary sources. Primary data was obtained through anemnesis (alloanamnesis), physical examination and home visits. Secondary data was obtained from the KIA posyandu book. Assessment based on a holistic diagnosis from the beginning, process and end of the study is carried out qualitatively and quantitatively. Key Words: Family Medicine, Microcephaly, Stunting
Eksplorasi Imunoterapi dan Terapi Gen dalam Pengobatan Tumor Otak: Literature Review Hana Muthi'a Putri; Windarti, Indri; Mayasari, Diana; Susianti, Susianti
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1378

Abstract

Brain tumors are a significant neurological disorder with a high mortality rate, especially in cases of glioblastoma, which is highly aggressive and difficult to treat. Conventional treatment methods, such as surgery, radiation therapy, and chemotherapy, are often not effective enough, particularly in advanced stages. This study aims to explore two innovative approaches, namely immunotherapy and gene therapy, as alternative treatments for brain tumors. Immunotherapy works by enhancing the immune system's ability to fight cancer cells through methods such as checkpoint inhibitors, cancer vaccines, and CAR-T therapy. However, the success of immunotherapy is often hindered by the blood-brain barrier (BBB), which limits the delivery of therapy to the brain. On the other hand, gene therapy offers a solution by modifying genetic material, either to repair damaged genes or to directly destroy cancer cells. Approaches such as the use of oncolytic viruses, CRISPR technology, and nanoparticles have shown promising results in preclinical research and early clinical trials, particularly for glioblastoma. The combination of immunotherapy and gene therapy opens new opportunities to enhance treatment effectiveness by strengthening the immune response and targeting tumors more specifically. However, challenges remain, including treatment resistance, side effects, and limitations in brain delivery methods. Further research is needed to ensure the safety, efficacy, and widespread application of this combination therapy. Immunotherapy and gene therapy have great potential as breakthroughs in the future treatment of brain tumors. Relevant literature, including articles and journals from both national and international sources, were gathered through online searches in various databases, such as Google Scholar, PubMed, and NCBI, and used to compile this article.
Central Obesity as a Risk Factor for Low Back Pain Putri, Reny Arienta; Setiorini, Anggi; Mayasari, Diana; Mustofa, Syazili
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1380

Abstract

Central obesity, or abdominal obesity, is a condition marked by excessive fat accumulation around internal organs, leading to a variety of health complications such as cardiovascular disease, type 2 diabetes, and musculoskeletal disorders, including low back pain (LBP). Central obesity is defined by increased waist circumference, with values greater than 80 cm in women and 90 cm in men. The condition is primarily influenced by factors such as physical inactivity, poor eating habits, and aging. The relationship between central obesity and LBP is supported by studies indicating that abdominal fat increases mechanical load on the lumbar spine, contributing to disc degeneration and pain. Additionally, adipose tissue secretes pro-inflammatory cytokines that exacerbate inflammation and pain sensitization in the spine, leading to LBP. Obesity-related complications, such as muscle weakness and sleep disturbances, can further reduce quality of life. Preventive measures for LBP include physical exercise, weight reduction, and posture correction. Effective treatment options range from pharmacological therapies to physical rehabilitation and alternative medicine approaches. Understanding the link between central obesity and LBP is critical in developing preventive strategies and improving the management of this common condition.
Gambaran Tingkat Stres Kerja Perawat Di Ruang IGD, ICU, Dan NICU RSUD Dr. H. Abdul Moeloek Bandar Lampung Maulida, Syakira Zahra; Mayasari, Diana; Graharti, Risti; Sutarto, Sutarto
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1407

Abstract

Job stress is one of the factors that can lead to decreased performance. Occupations with the highest prevalence of work stress are owned by health workers. Nurses are more prone to stress than other health workers because nurses often have heavier workloads. The impact of stress that arises in the form of physiological, psychological and behavioral responses. the most influential factors causing nurses' work stress are individual and work factors. In addition, nurses in the emergency room and intensive care of hospitals are considered to have higher levels of job stress than other units. The purpose of this study was to determine the description of the level of work stress of emergency room, ICU, and NICU nurses at Dr. H. Abdul Moeloek Hospital Bandar Lampung. The type of research used is descriptive quantitative using primary data in the form of Perceived Stress Scale questionnaire. Sampling using proportional sampling technique with a total sample of 75 people consisting of 26 emergency room nurses, 26 ICU nurses, and 23 NICU nurses and the data will be analyzed univariately and then presented in tabular form. Based on the results of the study, 19 nurses (25.3%) were at a mild stress level and 56 nurses (74.7%) were at a moderate stress level. Levels of job stress that are too low or too high can lead to decreased job satisfaction and achievement so that it is necessary.
Faktor-faktor yang Memengaruhi Menarche Dini pada Remaja Perempuan Hafizha, Syifa; Angraini, Dian Isti; Mayasari, Diana; Perdani, Roro Rukmi Windi
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1452

Abstract

Adolescence is a critical phase of rapid growth characterized by the maturation of reproductive organs, known as puberty. In females, puberty is marked by the onset of menstruation, with menarche being the first occurrence of menstruation, typically between the ages of 12 and 14 years. However, the average age of menarche in Indonesia has declined over the years, leading to an increase in early menarche cases. Early menarche occurs at an age of < 11 years (9-10 years) that is primarily driven by elevated estrogen levels in the female body. Factors influencing early menarche include genetics, nutritional status, lifestyle, dietary intake, physical activity, stress management, socioeconomic conditions, sexual behavior, and media exposure. This literature review aims to examine the correlation between these factors and the decreasing age of menarche among adolescent girls in Indonesia. Nutritional status and imbalanced dietary patterns are external factors strongly associated with early menarche. Genetic factors, particularly maternal menarche age, significantly influence the likelihood of early menarche in daughters. Low levels of physical activity contribute to increased ovarian activity and elevated estrogen levels, thereby raising the risk of early menarche. Furthermore, insufficient physical activity is directly linked to early menarche. External influences such as media exposure shape sexual behaviors, which may accelerate menarche onset. Poor stress management also disrupts estrogen regulation, further contributing to early menarche.
Holistic Management Of 8 Years Old Child With Nephrotic Syndrome Through A Family Medicine Approach Simatupang, Devi Fila Delfia BR; Mayasari, Diana
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1671

Abstract

Nephrotic syndrome (NS) is a glomerular disorder of the kidney characterized by massive proteinuria, hypoalbuminemia, edema, and hypercholesterolemia. The global incidence of NS is approximately 1–3 cases per 100,000 children (<16 years), with a prevalence of 6 cases per 100,000 population (2–3 cases per year) in Indonesia. The male-to-female ratio is 2:1. Inappropriate management may result in recurrent relapses, increased risk of complications, and reduced patient well-being. This study represents an application of evidence-based family medicine in managing a patient with nephrotic syndrome, involving the identification of clinical problems, risk factors, and comprehensive management through a patient-centered and family approach. Primary data were obtained through alloanamnesis, physical and supporting examinations, and home visits to complement data on family, psychosocial, and environmental aspects. Evaluation was conducted holistically from the initial to the final stages of the study using both quantitative and qualitative assessments. Disease recurrence can be prevented through non-pharmacological interventions such as patient education on triggering factors. Internal factors identified in this case included a history of infection, age, and lack of awareness regarding relapse risk factors. External factors included insufficient family knowledge about nephrotic syndrome, its potential complications, and the influence of environmental factors in preventing recurrence. The diagnosis was established, and holistic management was carried out using a patient-centered and family approach, supported by relevant theories and recent studies. The patient and family have achieved the adoption stage in behavioral change.
Penatalaksanaan Holistik Pada Penjahit Perempuan Usia 42 Tahun Dengan Carpal Tunnel Syndrome (CTS) Melalui Pendekatan Kedokteran Keluarga di Wilayah Kerja Puskesmas Natar Utami, Putu Urvasi Ari; Mayasari, Diana; Santika, Maya
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1691

Abstract

Carpal Tunnel Syndrome (CTS) is a peripheral nerve disorder caused by compression of the median nerve at the wrist, classified as a musculoskeletal disorder (MSD) with symptoms such as pain, tingling, and numbness, commonly triggered by ergonomic risk factors in the workplace. The management of CTS requires a comprehensive family medicine-based approach to improve treatment outcomes and the patient’s quality of life. This study aims to implement integrated family medicine principles in examining internal and external risk factors, medical problems, and patient management strategies based on Evidence-Based Medicine (EBM) with a patient-centered, family-oriented, and community-based approach. The research method is a descriptive case report using primary data from interviews, physical examinations, and home visits, as well as secondary data from the medical records of Kedaton Primary Health Center, evaluated holistically through quantitative and qualitative methods. The results showed that a 42-year-old female patient, Mrs. M, with CTS was managed comprehensively with analgesics, vitamins, and poster-based educational interventions; evaluation indicated improved symptoms, increased patient understanding as evidenced by pre- and post-test scores, and enhanced family support. In conclusion, the application of family medicine approaches supports holistic and comprehensive management of CTS patients to identify internal and external risk factors, improve therapeutic success, and enhance patient well-being.
Faktor-Faktor Yang Mempengaruhi Mortalitas Pasien Batu Ginjal yang Menjalani Operasi Nefrolitotomi di RSUD Dr. H. Abdul Moeloek Provinsi Lampung Tahun 2017-2021 Purnamasari, Haninovita; Hadibrata, Exsa; Mayasari, Diana; Wintoko, Risal
Medula Vol 16 No 1 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i1.1720

Abstract

This study aims to determine the factors that influence the mortality of kidney stone patients after nephrolithotomy surgery. This study used an descriptive analytic method with a case control approach. The research sample was 84 people, namely 21 cases and 63 controls in the working area of RSUD Dr. H. Abdul Moeloek 2017-2021 and was taken using the consecuetive sampling method. The dependent variable is the mortality of post-nephrolithotomy kidney stone patients. The independent variables were age, sex, Hb levels, decreased kidney function, types of stones, and multiple comorbidities. Statistical analysis using the chi square test. Based on the results of the study the mortality rate for patient with kidney stones after nephrolitotomy surgery was 7,9%. Most of the respondents were aged <60 years (76.2%), male (52.4%), Hb level >10 g/dl (63.1%), creatinine level <1.5 mg/dl (57.1%), non staghorn stones (54.8%), and multiple comorbidities (57.1%). Variables that influence mortality in postoperative kidney stone patients (α=0,05), namely age (p value <0,001),  Hb level (p value=0,003), decreased kidney function (p value=0,001), type of stone (p value=0,043), and multiple comorbidities (p value=0,002). While the unrelated variables is gender (p value=0,207). The factor that has the most dominant influence is Hb levels. Age, Hb level, decreased kidney function, type of stone and multiple comorbidities are influence with mortality in postoperative kidney stone patients at RSUD Dr. H. Abdul Moeloek.
Co-Authors A.T, Minerva Nadia Putri Adhim, Muhammad Risqi Ago, Muhammad Bagus Nitei Agustin, Marchella Aini, Silvina Nur Akramullah, Akramullah Andra, Aditya Anggraeni, Liza Ardhana, Nanda Rizki Asti, Andi Fajar Aulia Dita Maurizka Azhari Aziz Samudra Aziz, Muhammad Irsyad Nurullah Bustomi, Eka Chania Devi, Fryda Liana Dewi Nur Fiana Dian Isti Angraini Djuardi, Attisya Milenty Putri Dwi Indria Anggraini Dwita Oktaria Efriyan Imantika Eliza Techa Fattima, Eliza Techa Eri Dia, Eva Ety Apriliana Eva Eri Dia Fathaniah, Widya Fathia, Nauriel Fauzi Ahmad Muda Fitri, Dilla Syahra Noor Fitria Saftarina Fitriyana, Intan Gunata, Agustina Fadilla Hadibrata, Exsa Hafizha, Syifa Hana Muthi'a Putri Hanna Mutiara, Hanna Harsa, Shenia Verinda Hasbullah, Faza Ihsanti Dwi Rahayu Indri Windarti Irwansyah Irwansyah Isti Anggraini, Dian Isti Angraini, Dian Kussumawati, Risma Lay, Dhivana Anarchia Ria Leonard, Edo Christian Liana Sidharti, Liana Machmud Aminudin Mardiroharjo, Nanang Maulida, Syakira Zahra Mindaudah Murtane, Nyoman Mupu Nareswari, Prasnya Jatu Nova Sabila Novita Carolia Prihatin, yulianah Purnamasari, Haninovita Putra, Muhammad Ferdiansyah Putri A.T, Minerva Nadia Putri, Hanifah Sapto Putri, Reny Arienta Rahmah, Clarisa Rahmat Hidayat Rahmatika, Achisna Rahmawati, Nur Laili Rahmayani, Fidha Ramadhan, Risca Ariska Ramayani, Fidha Rasmi Zakiah Oktarlina ratri mauluti larasati, ratri mauluti larasati Ratu, Sarih Risal Wintoko Risti Graharti Rohmah, Zakiah Nur Roro Rukmi Windi Perdani, Roro Rukmi S, Johns Fatriyadi Santika, Maya Saputri, Chyntia Sari, Merry Indah Setiawan, Gigih Setiorini, Anggi Shinta Nareswari, Shinta Simatupang, Devi Fila Delfia BR Soetardi, Eriza Kultsum R Sofyan Musyabiq Wijaya Sri Waluyo Susianti, Susianti Sutarto Sutarto Syazili Mustofa Tarigan Sibero, Hendra Umroh, Afidatul Utama, WInda Trijayanti Utami, Putu Urvasi Ari Wiguna, Bangkit Adhi Wiwi Febriani Zahrani, Raisha Naomi Zanariah, Zam