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All Journal Jurnal Natur Indonesia JURNAL BIOLOGI INDONESIA Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil Jurnal Akuatiklestari Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Journal of Tropical Marine Science Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Hippocampus: Jurnal Pengabdian Kepada Masyarakat Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan Indonesian Science Education Journal (ISEJ) Jurnal Perikanan Berita Biologi Analit: Analytical And Environmental Chemistry
Widiastuti, Endang Linirin
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Immunology & microbiology Medicine & Pharmacology Social Sciences Other

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Study of content and bioconcentration of heavy metal (Pb,Hg, and Cd) in green mussels (Perna viridis) based on different sizes and ages Krismonita, Bella; Yudha, Indra Gumay; Sarida, Munti; Hasani, Qadar; Widiastuti, Endang Linirin
Depik Jurnal Ilmu Ilmu Perairan, Pesisir, dan Perikanan Vol 12, No 2 (2023): AUGUST 2023
Publisher : Faculty of Marine and Fisheries, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13170/depik.12.2.29824

Abstract

Green mussel (Perna viridis) has filter-feeding habits and a sessile way of life, with the main food components of plankton and organic matter in the waters. These food components can contaminate green mussels when it accumulates heavy metals. Therefore, this study aims to evaluate heavy metals content and the bioconcentration of lead (Pb), mercury (Hg), and cadmium (Cd) in green mussels based on different sizes and ages. The study was conducted on Pasaran Island, Lampung, Indonesia, and used green mussels aged 3, 5, 7 to 9 months as samples, with 2 replications. The AAS (Atomic Absorption Spectrophotometry) method was used in the analysis of Pb, Hg, and Cd, sampling technique used purposive sampling. The result showed that green mussels at different ages and sizes has impact on Pb content, while an increase of one unit of age and size of green mussels has no effect on the metal content of Hg and Cd. Furthermore, the highest bioconcentration of Pb and Hg was obtained at 9 months, while Cd was observed at 3 months. Based on the results of this study it can be concluded that the simple linear regression appropriate a functional relationship between Pb and the different ages and sizes green mussels cultivated on Pasaran Island , while heavy metals Hg and Cd appropriate with a polynomial quadratic approach and almost do not exist in the form of a functional relationship between Hg and Cd with the different ages and sizes green mussels. Even though it contains heavy metals in below the maximum limit, but care needs to be taken in addressing this phenomenon due to its nature heavy metals that can accumulate in living tissue, thus consuming green mussels containing heavy metals even in relatively small amounts is not recommended.Keywords:Filter feederSessileAccumulateOrganic matterContaminate
UJI SITOTOKSISITAS TAURIN DAN EKSTRAK ETANOL MAKROALGA COKELAT DENGAN METODE BSLT (Brine Shrimp Lethality Test) Bareta, Ainun Rohmawati; Widiastuti, Endang Linirin; Nurcahyani, Nuning
Berita Biologi Vol 22 No 2 (2023): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2023.660

Abstract

Makroalga cokelat Padina australis dan Sargassum duplicatum diketahui mengandung metabolit sekunder yang bermanfaat bagi kesehatan, salah satunya sebagai bahan baku antikanker. Tujuan dari penelitian ini untuk mengetahui kandungan senyawa bioaktif yang terdapat dalam ekstrak etanol P. australis dan S. duplicatum dari perairan Pantai Dollar Beach Padada, Kec. Ketapang, Lampung Selatan dan perairan Pantai Tegal Mas, Kec. Teluk Pandan, Pesawaran, serta mengetahui toksisitas dari taurin, ekstrak etanol P. australis dan S. duplicatum dengan metode BSLT (Brine Shrimp Lethality Test). Hasil dari penelitian ini menunjukkan bahwa ekstrak etanol P. australis dan S. duplicatum mengandung saponin, steroid, alkaloid dan flavonoid. Toksisitas taurin, ekstrak etanol P. australis dan S. duplicatum tergolong dalam toksisitas rendah terhadap Artemia salina dengan nilai LC50 berturut-turut adalah 133,73 ppm, 176,95 ppm, dan 140,42 ppm.
POTENSI PRODUK ALAMI LAUT DARI EKSTRAK ETANOL Sargassum duplicatum DAN Padina australis SECARA SITOTOKSIK TERHADAP SEL HeLa Saputra, Yosi Dwi; Widiastuti, Endang Linirin; Berliana, Melisa Intan; Nurcahyani, Nuning
Berita Biologi Vol 23 No 1 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2024.661

Abstract

Salah satu penyebab utama kematian wanita Indonesia adalah kanker serviks. Pertumbuhan sel jaringan tubuh yang tidak terkendali yang berubah menjadi tumor adalah akar penyebab penyakit ini. Banyak peneliti sedang menyelidiki beragam bahan kimia alami dari habitat laut sebagai pilihan pengobatan antikanker karena pengobatan kanker serviks memiliki efek samping yang besar dan durasi pengobatan yang panjang. Makroalga merupakan salah satu organisme laut yang dapat berpotensi sebagai sumber obat alami untuk terapi kanker. Bahan aktif seperti flavonoid, alkaloid, saponin dan steroid berpotensi sebagai agen anti kanker yang diduga dapat mempengaruhi siklus sel dalam pertumbuhan kanker melalui mekanisme apoptosis. Penelitian ini bertujuan untuk menganalisis pengaruh senyawa bioaktif yang terkandung didalam ekstrak Sargassum duplicatum dan Padina australis terhadap sitotoksisitas sel kanker serviks, HeLa. Aktivitas sitotoksik terhadap sel HeLa dievaluasi dengan menggunakan metode WST-8 dengan variasi kosentrasi ekstrak etanol 62,5; 125; 250; 500; 1.000; dan 2.000 ppm. Hasil uji sitotoksik memperlihatkan bahwa ekstrak S. duplicatum dan P. australis memiliki aktivitas sitotoksik terhadap sel HeLa. Nilai IC50 Sargassum duplicatum dan Padina australis terhadap sel HeLa masing-masing sebesar 1.108,7 dan 681,1 μg/ml. Hasil penelitian mengindikasikan bahwa S. duplicatum dan P. australis mempunyai aktivitas sitotoksik melawan sel HeLa, sehingga dapat dijadikan sumber obat antikanker serviks.
PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT POTENTIAL OF EXTRACTS ETHANOL MACROALGAE Padina australis FROM TEGAL MAS ISLAND LAMPUNG Alhafizoh, Fatimah; Widiastuti, Endang Linirin; Nurcahyani, Nuning; Juliasih, Ni Luh Gede Ratna; Setyaningrum, Endah
Analit : Analytical and Environmental Chemistry Vol. 9, No. 01 April (2024) Analit : Analytical and Environmental Chemistry
Publisher : Jurusan Kimia FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/analit.v9i01.178

Abstract

In the seas of Lampung, a kind of brown macroalgae known as Padina australis is commonly seen.. Padina australis is widely used in the food industry as a gelling agent, emulsifier, thickener, stabilizer and also in the medical industry. The content of phytochemical compounds that can be developed as phytopharmaceutical agents is one of them as antioxidants. The aim of this study was to analyze the phytochemical content and potential antioxidant activity of the macroalgae Padina australis. The method used was extraction by maceration in 70% ethanol as a solvent. The phytochemical test was performed qualitatively by a color reagent test. The FTIR test was performed to analyze the functional groups of the active ingredients, while the antioxidant test used the DPPH (1,1-diphenyl-2-picrylhydrazil) method. The results obtained show that the ethanol extract of Padina australis contains chemical compounds such as saponins, steroids, tannins, alkaloids, and flavonoids. Padina australis extract shows its potential as an alternative source of natural antioxidant compounds because it is able to reduce free radicals with an IC50 value of 407.96 ppm, which is classified as very weak antioxidant activity. Further research needs to be done to obtain other concentration doses so as to get the best antioxidant activity results that can be developed clinically for health products.    
Co-Authors ', Sutyarso Abdullah Aman Damai Agata, Annisa Agus Budi Utomo Agus Setyawan Alhafizoh, Fatimah Ardiansyah, Budi Khoiri Arifiyanto, Achmad Arlanda, Revilarita Berliana, Melisa Intan Endah Setyaningrum, Endah Endang Nurcahyani Erna Rochana Ernawiati, Eti Gina Dania Pratami, Gina Dania Hartoyo Hartoyo Henni Wijayanti Maharani Indra Gumay Yudha Juliasih, Ni Luh Gede Ratna Khairunnisa, Indah Khasana, Devi Ardiyati Khoirunisa Krismonita, Bella Leni, Yusyam Lestari, Sepnina Like Maya Riantini, Maya Munti Sarida Nababan, Yolanda Nita Sari Nuning Nurcahyani Nurafiah, Eva Nursafitri, Umy Nurul Khasanah, Nurul Pamungkas, Galuh Rara Qadar Hasani Radella Hervidea, Radella Riris Roiska Rohmawati Bareta, Ainun Romaskila, Ulfanida Roselyn, Arini Pradita RR. Ella Evrita Hestiandari Saputra, Yosi Dwi Sari, Mutiara Pradita Supono Supono Susanto, G. Nugroho Susanto, Gregorius Nugroho Susanto, Gregorius Nurgroho Sutyarso Sutyarso , Sutyarso Sutyarso Sutyarso Tugiyono Tugiyono Yuni Astuti