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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Natur Indonesia JURNAL BIOLOGI INDONESIA Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil Jurnal Akuatiklestari Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Journal of Tropical Marine Science Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Hippocampus: Jurnal Pengabdian Kepada Masyarakat Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan Indonesian Science Education Journal (ISEJ) Jurnal Perikanan Berita Biologi
Widiastuti, Endang Linirin
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Engineering Environmental Science Immunology & microbiology Medicine & Pharmacology Social Sciences Other

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UJI SITOTOKSISITAS TAURIN DAN EKSTRAK ETANOL MAKROALGA COKELAT DENGAN METODE BSLT (Brine Shrimp Lethality Test) Bareta, Ainun Rohmawati; Widiastuti, Endang Linirin; Nurcahyani, Nuning
Berita Biologi Vol 22 No 2 (2023): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2023.660

Abstract

Makroalga cokelat Padina australis dan Sargassum duplicatum diketahui mengandung metabolit sekunder yang bermanfaat bagi kesehatan, salah satunya sebagai bahan baku antikanker. Tujuan dari penelitian ini untuk mengetahui kandungan senyawa bioaktif yang terdapat dalam ekstrak etanol P. australis dan S. duplicatum dari perairan Pantai Dollar Beach Padada, Kec. Ketapang, Lampung Selatan dan perairan Pantai Tegal Mas, Kec. Teluk Pandan, Pesawaran, serta mengetahui toksisitas dari taurin, ekstrak etanol P. australis dan S. duplicatum dengan metode BSLT (Brine Shrimp Lethality Test). Hasil dari penelitian ini menunjukkan bahwa ekstrak etanol P. australis dan S. duplicatum mengandung saponin, steroid, alkaloid dan flavonoid. Toksisitas taurin, ekstrak etanol P. australis dan S. duplicatum tergolong dalam toksisitas rendah terhadap Artemia salina dengan nilai LC50 berturut-turut adalah 133,73 ppm, 176,95 ppm, dan 140,42 ppm.
POTENSI PRODUK ALAMI LAUT DARI EKSTRAK ETANOL Sargassum duplicatum DAN Padina australis SECARA SITOTOKSIK TERHADAP SEL HeLa Saputra, Yosi Dwi; Widiastuti, Endang Linirin; Berliana, Melisa Intan; Nurcahyani, Nuning
Berita Biologi Vol 23 No 1 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2024.661

Abstract

Salah satu penyebab utama kematian wanita Indonesia adalah kanker serviks. Pertumbuhan sel jaringan tubuh yang tidak terkendali yang berubah menjadi tumor adalah akar penyebab penyakit ini. Banyak peneliti sedang menyelidiki beragam bahan kimia alami dari habitat laut sebagai pilihan pengobatan antikanker karena pengobatan kanker serviks memiliki efek samping yang besar dan durasi pengobatan yang panjang. Makroalga merupakan salah satu organisme laut yang dapat berpotensi sebagai sumber obat alami untuk terapi kanker. Bahan aktif seperti flavonoid, alkaloid, saponin dan steroid berpotensi sebagai agen anti kanker yang diduga dapat mempengaruhi siklus sel dalam pertumbuhan kanker melalui mekanisme apoptosis. Penelitian ini bertujuan untuk menganalisis pengaruh senyawa bioaktif yang terkandung didalam ekstrak Sargassum duplicatum dan Padina australis terhadap sitotoksisitas sel kanker serviks, HeLa. Aktivitas sitotoksik terhadap sel HeLa dievaluasi dengan menggunakan metode WST-8 dengan variasi kosentrasi ekstrak etanol 62,5; 125; 250; 500; 1.000; dan 2.000 ppm. Hasil uji sitotoksik memperlihatkan bahwa ekstrak S. duplicatum dan P. australis memiliki aktivitas sitotoksik terhadap sel HeLa. Nilai IC50 Sargassum duplicatum dan Padina australis terhadap sel HeLa masing-masing sebesar 1.108,7 dan 681,1 μg/ml. Hasil penelitian mengindikasikan bahwa S. duplicatum dan P. australis mempunyai aktivitas sitotoksik melawan sel HeLa, sehingga dapat dijadikan sumber obat antikanker serviks.
Analisis Kualitas Air Sebagai Pemicu Eutrofikasi di Habitat Kerang Bulu (Anadara antiquata) di Pesisir Kabupaten Pesawaran Gultom, Andy Sahalatua; Hasani, Qadar; Susanto, Gregorius Nugroho; Sarida, Munti; Widiastuti, Endang Linirin; Santosa, Winarto
Journal of Tropical Marine Science Vol 9 No 1 (2026): Journal of Tropical Marine Science
Publisher : Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/ekvmbn43

Abstract

The blood cockle (Anadara antiquata) is an economically valuable marine species that depends on suitable water quality conditions in its habitat. This study aims to analyze water quality parameters that potentially trigger eutrophication in the habitat of the blood cockle in the coastal waters of Pesawaran Regency, Lampung Province. The study was conducted at three key harvesting sites—Teluk Hurun, Teluk Cikunyinyi, and Teluk Ratai—with sampling carried out four times during September–October 2024. The measured parameters included temperature, pH, salinity, dissolved oxygen (DO), transparency, depth, nitrite, ammonia, phosphate, and total organic matter (TOM). The results showed that several chemical parameters, such as nitrite (up to 0.11 mg/L), phosphate (up to 0.63 mg/L), and TOM (up to 39.14 mg/L), exceeded marine water quality standards based on Government Regulation No. 22 of 2021. The low N/P ratio (<1) at all sites indicates a high potential for eutrophication, with Teluk Ratai identified as the most critical site. These findings highlight the importance of continuous water quality monitoring to support the sustainability of blood cockle habitats and coastal ecosystems.
Analysis of Serum Glutamate Pyruvate Transaminase (SGPT) and Serum Glutamate Oxaloacetate Transaminase (SGOT) Levels in the Blood of Rat Offspring (Rattus norvegicus) Treated with Soybean (Glycine max L.) Extract and Zinc Hafidz, Muhammad Al Hafidz; Busman, Hendri; Kanedi, M. Kanedi; Widiastuti, Endang Linirin
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 14 No. 1 (2026): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v14i1.41788

Abstract

Background: The liver is the largest metabolic organ and plays an important role in the body. Nutritional fulfilment is one factor in maintaining liver health. Liver function can be evaluated by measuring the levels of SGPT and SGOT enzymes in the blood. Soybean juice and zinc can support liver health by keeping SGPT and SGOT enzyme levels normal. Methods: This study was conducted between October and December 2024 at the Zoology Laboratory of the University of Lampung. This study used a Completely Randomized Design (CRD) included four treatment groups. Each treatment included five mice: control (K), treatment 1 (P1)- induced Soybean juice 0,6 mL/kg body weight (P2) induced Soybean 0,3 mL/kg body weight and Zinc 0,3 mL/kg body weight, and (P3) induced Soybean 0,6 mL/kg body weight and Zinc 0,6 mL/kg body weight for 14 days. Normal and homogeneous data were analyzed using analysis of variance (ANOVA) to determine whether the treatment's effect was significant. Differences were considered statistically significant at p < 0.05. Duncan's multiple interval post hoc test (=5%) was used to identify the most effective treatment. Result: Based on the results of the one-way ANOVA test with a 95% confidence interval, the average SGPT and SGOT levels in the K, P1, P2, and P3 treatments differ significantly. The average SGPT levels above show that the P2 and P3 groups experienced a significant decrease compared to the K and P1 treatments. Conclusion: Analysis of variance (ANOVA) showed that administering soya juice and zinc at an optimum dose of 1.2 mL/kg body weight can affect and maintain normal SGPT and SGOT levels.
Co-Authors ', Sutyarso Abdullah Aman Damai Agata, Annisa Agus Budi Utomo Agus Setyawan Alhafizoh, Fatimah Ardiansyah, Budi Khoiri Arifiyanto, Achmad Arlanda, Revilarita Berliana, Melisa Intan Endah Setyaningrum, Endah Endang Nurcahyani Erna Rochana Ernawiati, Eti Gina Dania Pratami, Gina Dania Gultom, Andy Sahalatua Hafidz, Muhammad Al Hafidz Hartoyo Hartoyo Hendri Busman Henni Wijayanti Maharani Indra Gumay Yudha Juliasih, Ni Luh Gede Ratna Kanedi, M. Kanedi Khairunnisa, Indah Khasana, Devi Ardiyati Khoirunisa Krismonita, Bella Leni, Yusyam Lestari, Sepnina Like Maya Riantini, Maya Munti Sarida Nababan, Yolanda Nita Sari Nuning Nurcahyani Nurafiah, Eva Nursafitri, Umy Pamungkas, Galuh Rara Qadar Hasani Radella Hervidea, Radella Riris Roiska Rohmawati Bareta, Ainun Romaskila, Ulfanida Roselyn, Arini Pradita RR. Ella Evrita Hestiandari Santosa, Winarto Saputra, Yosi Dwi Sari, Mutiara Pradita Siswahyudianto Supono Supono Susanto, G. Nugroho Susanto, Gregorius Nugroho Susanto, Gregorius Nurgroho Sutyarso Sutyarso , Sutyarso Sutyarso Sutyarso Tugiyono Tugiyono Yuni Astuti