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All Journal Alchemy : Journal of Chemistry Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas Journal of Islamic Medicine Pharmacology and Clinical Pharmacy Research Jurnal Tumbuhan Obat Indonesia
Roihatul Mutiah
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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PROFILE OF ANTICANCER ACTIVITIES OF BROTOWALI (Tinospora crispa L.) PLANTS OFVARIOUS REGIONS IN EAST JAWA Roihatul Mutiah; Laily Nurul Azizah; Rahmi Annisa; Anik Listyana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (531.707 KB) | DOI: 10.24071/jpsc.002020

Abstract

Brotowali (Tinosporacrispa L) is a plant which has potential to be a chemopreventive agent. This study aims to determine the profile of anticancer activity of brotowali stem extracts (Tinosporacrispa L.), from several regions in East Java. The extraction was carried out by maceration method using 80% ethanol solvent. Then, anticancer activity test was carried out on MCF-7 breast cancer cell model using the Microtetrazolium (MTT) Assay method. The results of the anticancer activity test showed that 15 brotowali stem extracts taken from 5 locations in East Java had significant differences in anticancer activity (P 0.05). Brotowali extracts from Kanigoro, Blitar city, had the highest anticancer activity with an IC50 value of 30.64 g / mL.
Network Pharmacology and Component Analysis Integrated Study to Uncovers the Molecular Mechanisms of Lansium parasiticum Bark Extract in Colon Cancer Treatment Mutiah, Roihatul; Briliana, Malich Septi Diajeng; Ahmad, Ananda Rizkia Azizah; Fauziyah, Begum; Janaloka, Nandana Adyuta; Suryadinata, Arief
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.314-324

Abstract

Side effects and risk of resistance are common consequences of colon cancer treatment based on chemotherapy. The medicinal plant originating in Indonesia, Lansium parasiticum bark extract (LPBE), has not been studied much. The purpose of this study is to identify the compounds present in LPBE and explain how the molecular mechanisms of the composite inhibit colon cancer cells. LC-MS/MS Liquid Chromatography Tandem Mass Spectrophotometry has been used to identify compounds in LPBE. The ADMET program is used to determine absorption profiles and bioavailability per oral. The tissue pharmacology approach uses Cytoscape 3.9.1, GeneCards, Disgenet, STRING 2.0.0, SRplot, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway to predict the molecular anti-cancer mechanisms of these compounds. In vitro validation using PyRx Autodock Vina 9.0 and Biovia Discovery Studio with BAX (PDB ID:2YXJ), BCL2 (P DB ID:2W3L) and STAT3 receptors (PDB ID:6NJS). A total of 17 active compounds were identified through LC-MS/MS. The moronic acid compound showed the highest levels of 14.29% followed by 4-Morpholineacetic Acid 12.2% and ursolic aldehyde 8.37%. Pharmacological network analysis showed that the compounder works on the EGFR tyrosine kinase resistance path by targeting the BCL2, BAX, STAT3 genes. The results of the in silico validation support the results of tissue pharmacology findings. Ursolic aldehyde, and Moronic acid showed a higher affinity to the three receptors. Therefore, Lansium parasiticum bark extract (LPBE) is recommended for further study as a candidate anti-cancer drug both in vitro and in vivo.
Formulation and Evaluation of Halal Non-Aromatic Moisture and Protection Cream Preparations for Hajj and Umroh Pilgrims Annisa, Rahmi; Anggraini, Wirda; Purwaningsih, Fauziyah Eni; Salsabila, Dhia Fadhilah; Samah, Moh.Alfin; Mutiah, Roihatul
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.26427

Abstract

Background: Protective moisturizer cream can be used by Hajj and Umrah pilgrims.They can use sunscreen moisturizer cream as a moisturizer and sunscreen to protect their skin from exposure to the sun because it does not contain alcohol or certain fragrances. Objective: This research aims to determine the halalness of ingredients, the presence or absence of aromatic content, the suitability of physical characteristics, and the effectiveness of the SPF value of halal non-aromatic Sunscreen moisturizer cream preparations using pre-experimental design research methods. Methods: The physical characteristics were evaluated, including organoleptic, homogeneity, spreadability, adhesive power, pH, and viscosity. Results: The organoleptic test results show that the Sunscreen moisturizer cream preparation has a yellowish-white color, is scentless, and has a soft texture. Homogeneity testing shows that this preparation is homogeneous. The spreadability test value of the preparation is 6.50 cm; the sticking power value is 3.77 seconds; the pH value is 5.00; the viscosity value is 5.64 cPs. The research results also show that the preparation contains halal ingredients and does not contain fragrances. Halal non-aromatic sunscreen moisturizer cream. Formula SPF value 38.332 ± 1.526 with ultra protection type. Conclusion: All evaluations of the physical characteristics of the Sunscreen moisturizer cream preparation have met the requirements for a good cream preparation, except for the viscosity test. It contains halal ingredients and has ultraprotective protection against UV light. Keyword : Cream, Sunscreen, Moisturizer, Non Aromatic, Hajj Care
Molecular Insights into Breast Cancer Treatment: An Integrated Approach of Network Pharmacology and Component Analysis for Lansium parasiticum Bark Extract Mutiah, Roihatul; Annisa, Rahmi; Zahiro, Syayida Roisatus
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp96-107

Abstract

Medicinal plants containing multi-components have the potential for multi-target genes, multi-pathways, and various effects on diverse diseases. With the increasing technological advancements, understanding the complex interactions between multi-component substances and biological systems is becoming more crucial. In this context, conventional experimental research might have limitations as it typically focuses on the impact of one component on one gene. The objective of this research is to identify compounds in the bark extract of Lansium parasiticum and elucidate the molecular mechanisms of these compounds in inhibiting the progression of breast cancer cells using a network pharmacology approach. Compound identification in Lansium parasiticum bark extract (LPBE) has been conducted using Liquid Chromatography Tandem Mass Spectrophotometry (LC-MS/MS) technique. ADMET predictions were utilized to determine the absorption and bioavailability profiles. A network pharmacology approach employing Cytoscape 3.9.1, GeneCards, Disgenet, STRING 2.0.0, SRplot, and Kyoto Encyclopedia of Genes and Genomes (KEGG) was used to predict the anti-cancer molecular mechanisms of these compounds. Seventeen active compounds have been successfully identified via LC-MS/MS. Among these, the compounds Moronic Acid, 4-Morpholineacetic Acid, and Ursolic Aldehyde were found in the highest concentrations. The results of the network pharmacology analysis indicate that the compounds in LPBE are involved in three potential pathways for breast cancer treatment: the NF-κß signaling pathway (hsa 04064), microRNA in cancer (hsa05206), and apoptosis (hsa04210). Target genes implicated in these pathways include BAX, BCL2, TNF-α, PARP1, STAT3, NOTCH1, and NF-κß1. It can be concluded that LPBE contains compounds with potential for treating breast cancer, as they are predicted to interact with relevant target pathways and genes. Therefore, further research is highly recommended, particularly in the development of drugs for breast cancer.Keywords: apoptosis, microRNA, NF-κß, TNF-α, STAT3.
Identification of Drug Related Problems (DRPs) Based on Drug and Dosage Selection in Type 2 Diabetes Mellitus Patients Wijaya, Dhani; Rahmadanita, Fathia Faza; Atmaja, Ria Ramadhani Dwi; Syarifuddin, Sadli; Mutiah, Roihatul; Habibah, Atiqoh Nur; Nafisah, Fika Sayyidatun
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.61653

Abstract

Pharmacological therapy for type 2 diabetes mellitus involves more than one type of drug, this increases the potential for Drug Associated Problems (DRPs) in terms of selecting the type and dose of the drug. This study aimed to determine the treatment profile and identify the occurrence of DRPs based on drug selection and dosage in patients with type 2 diabetes mellitus. This descriptive observational study was conducted in October 2022 in the medical record room of one general hospital in Batu, East Java. The study sample was obtained by total sampling using 36 medical records of inpatients with type 2 diabetes mellitus without complications. Identification of DRPs based on The Pharmaceutical Care Network Europe (PCNE) V.9.1 guidelines. The results showed that glimepiride (6.45%), insulin (16.13%), a combination of metformin and glimepiride (3.23%), a combination of metformin and insulin (3.23%), and basal-bolus insulin (67.74%) were antidiabetic drugs used by patients. Based on the drug selection, 17 patients were identified as having DRPs where the use of drugs without indication (38.89%) was the most common case. Meanwhile, DRPs based on dose selection were found in 6 patients with 13.89% of cases being too high a drug dose. Based on this study, it can be concluded that there are cases of DRPs based on drug selection and dosage in patients with type 2 diabetes mellitus so improved pharmaceutical services are needed to address this to improve patient safety.
Metabolite Profiling Famili Asteraceae (Kenikir, Bunga Matahari, Krisan) dengan Metode HPTLC dan Principal Component Analysis (PCA) Mutiah, Roihatul; Hayati, Elok Kamilah; Andiartama, Amanda Milano
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.2315

Abstract

Tanaman dari famili Asteraceae di Indonesia memiliki berbagai potensi bioaktif yang tinggi karena kandungan senyawa seperti lakton, alkaloid, dan tanin. Penelitian ini bertujuan untuk menganalisis profil metabolit daun kenikir, bunga matahari, dan krisan yang berasal dari famili Asteraceae dengan pendekatan metabolomik. Ekstrak daun diperoleh melalui ekstraksi ultrasonik dengan etanol 96% dan dianalisis menggunakan High Performance Thin Layer Chromatography (HPTLC). Visualisasi dilakukan dengan menggunakan instrumen TLC Visualizer dan perangkat lunak ImageJ, sehingga menghasilkan densitogram. Profil metabolit dengan HPTLC dan analisis PCA berimplikasi pada penguatan kontrol kualitas dan standarisasi fitokimia melalui autentikasi spesies, identifikasi marker metabolit, serta penjaminan konsistensi mutu produk herbal berbasis Asteraceae. Hasil menunjukkan bahwa terdapat perbedaan jumlah noda dan intensitas warna antar sampel. Hasil PCA menunjukkan sebaran metabolit mengelompok pada area yang berbeda, dengan total variasi 72,5% (PC1 = 56,5% dan PC2 = 15,9%). Analisis Heatmap menunjukkan bahwa ekstrak daun bunga matahari memiliki intensitas senyawa aktif tertinggi, yang ditandai dengan area merah yang lebih pekat akibat nilai AUC tertinggi. Penelitian ini membuktikan bahwa terdeapat perbedaan profil metabolit pada ketiga tanaman yang berasal dari famili yang sama. Kata kunci: Profil Metabolit, Asteraceae, HPTLC, Principal Component Analysis
In Silico Prediction of Isoliquiritigenin and Oxyresveratrol Compounds to BCL-2 dan VEGF-2 Receptors Mutiah, Roihatul; Hariz, Muhammad Fawaz; Indrawijaya, Yen Yen Ari; Ma'arif, Burhan
Indonesian Journal of Cancer Chemoprevention Vol 10, No 2 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss2pp51-59

Abstract

Isoliquiritigenin and oxyresveratrol are compounds that have been reported to have anticancer activities. This study aimed to predict cytotoxic activity, toxicity and physicochemical properties of the compounds isoliquiritigenin and oxyresveratrol. Prediction of physicochemical properties referred to Lipinski rules of five using the pkCSM online tool. Prediction of compounds toxicity using Protox II online tool while ligand interaction with receptors using Molegro Virtual Docker (MVD). Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) (PDB: 2RL5) and B Cell Lymphoma BCL-2 (PDB: 4AQ3) were used as target cancer receptor proteins. In silico predictive results showed that oxyresveratrol and isoliquiritigenin complied with Lipinski rules of five, predictive values of LD50 between 500-2000 mg/kg respectively 1560 mg/kg and 1048 mg/kg. The docking result was in the form of bound energy described by Rerank Score (RS). A compound having a small RS value was predicted to have greater activity. RS of oxyresveratrol on 2RL5: -73.0413 and 4AQ3: -87.9985, while isoliquiritigenin on 2RL5: -68.0282 and 4AQ3: -78.5041. The cytotoxic activity of oxyresveratrol was also shown by hydrogen bonds in active amino acids (2RL5: Cys 919 in 4AQ3: Tyr 67). From docking results of both compounds, oxyreveratrol had greater activity than isoliquiritigenin to both target cancer receptor proteins and complied Lipinski rules of five and have a low toxicity.Keywords: cytotoxicity, toxicity, isoliquiritigenin, oxyresveratrol, in silico.
Inhibition of Human Epidermal Growth Factor Receptor-2 (HER-2) from Pomelo (Citrus maxima) Flavonoid Compounds: an In Silico Approach Mutiah, Roihatul; Dewi, Tanaya Jati Dharma; Suryadinata, Arief; Qonita, Kesimira
Indonesian Journal of Cancer Chemoprevention Vol 12, No 3 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss3pp148-160

Abstract

Citrus maxima or pomelo is a plant that has potential as an anticancer because it contains flavonoids. One of the targets of breast anticancer receptors is the HER-2 protein. This research aims to determine the anticancer activity, the toxicity of the compound, and the prediction of physicochemical properties of flavonoids contained in Citrus maxima through in silico approach. Flavonoid compounds were screened using SwissADME with Lipinski's rule of five, Torsion, TPSA, and P-Gp Non-Substrate. Compounds that passed the screening were carried out molecular docking to the HER-2 receptor (PDB ID: 3PP0) using the Molegro Virtual Docker (MVD). The HER-2 receptor (GDP ID: 3PP0) was declared valid because it had RMSD<2Å. The results showed that there were 11 flavonoid compounds that passed the screening and had a lower rerank score than the comparison compound Trastuzumab. Toxicity was predicted using the Protox II online tool and the results showed that the flavonoid compounds were in the safe limits, namely classes 5 and 3. Based on this research, it can be concluded that acacetin, diosmetin, honyucitrin, isosinensetin, nobiletin, sinensetin, and tangeretin can be candidates for breast cancer drugs based on natural ingredients.Keywords: breast cancer, Citrus maxima, HER-2, in silico.
Extract of Yellow Root (Arcangelisia Flava (L.) Merr.) from Several Regions in Kalimantan: Alkaloid Content and Cytotoxicity towards WiDr Colorectal Cancer Cells Mutiah, Roihatul; Kirana, Farenza Okta; Annisa, Rahmi; Rahmawati, Ana; Sandra, Ferry
Indonesian Journal of Cancer Chemoprevention Vol 11, No 2 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss2pp84-89

Abstract

Yellow root (Arcangelisia flava (L.) Merr.) has been scientifically known to have potential as an antimalarial, antibacterial, antioxidant, and anticancer. The purpose of this study was to determine the profile of alkaloid content and cytotoxicity of yellow root extract from several regions in Kalimantan. The alkaloid content was tested using the thin layer chromatography (TLC) method with dragendorf reagent. Cytotoxic in vitro test was conducted against WiDr colorectal cancer cells using the 3-(4,5-dimethylthiazol-2-il)-2,5-diphenyltetrazolium bromide (MTT) assay. Yellow roots were collected from Samarinda city, Banjarmasin city, Barito Timur regency, Malinau district, and Balikpapan City. The MTT inhibitory concentration 50 (IC50) of yellow root extracts were 573.308 μg/mL; 582.857 μg/mL; 296.326 μg/mL; 114.119 μg/mL; and 320.162 μg/mL respectively. Results of the compound identification indicated that alkaloid was found in A. flava from all regions. Alkaloids of A. flava extract should be investigated further in order to find possible active agent that could decrease the viability of WiDr colorectal cancer cells.Keywords: Arcangelisia flava, Borneo, colorectal cancer, Kalimantan, WiDr cells.
Exposure of Murattal Al-Quran Audio Enhances Cisplatin Activity on Growth Inhibition and Cell Cycle Modulation on Hela Cells Mutiah, Roihatul; Mustofa, Muhammad Ragib; Indrawijaya, Yen Yen Ari; Hakim, Abdul; Annisa, Rahmi; Susanti, Nurlaili; Nashichuddin, Ach; Zainuddin, Muhammad
Indonesian Journal of Cancer Chemoprevention Vol 10, No 2 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss2pp71-79

Abstract

Cancer is a disease characterized by abnormal cell mechanisms. The development of alternative cancer treatments is still needed. One of them is the music therapy. The music therapy uses sound vibrations to improve healing. Al-Quran, the Holy book of muslims, recites with measured recitation produces beautiful tones. Reading and recitating of Al-Quran is an important form of worship for which a Muslim can expect reward and benefit in the Hereafter. Al-Fatihah is one of surahs in Al-Qur'an that is often read by Muslims and used as a prayer for healing. The purpose of this study was to determine the effect of cytotoxic activity and cell cycle modulation on Hela cells with exposure of murattal Al-Quran and cisplatin combination. Audio exposure murattal Al-Fatihah and its combination with cisplatin to HeLa cells were tested using the MTT method assay. Induction of apoptosis and modulation of cell cycle evaluated by flow cytometry method. Treatment used 30 minutes Audio Murattal (AM), Cisplatin 10 µg/mL (Cis), and the combination of AM + Cis caused a decrease in the viability of HeLa cells respectively 80.14%, 69.86%, and 64.32%. The results of flow cytometry explained that in treatment of AM there was inhibition in the G2-M phase and induction of apoptosis in the M5 phase. Whereas in treatment AM + Cis inhibition occurs in the S, G2-M phase, and induction of apoptosis in the M5 phase. Audio Murattal Al-Quran presents cytotoxic effects on HeLa cells and to provide a synergistic impact on cisplatin so that disclosure therapy murattal can be recommended for supporting therapy in the treatment of cancer (supportive therapy).Keywords: Al-Quran, Audio murottal, HeLa Cells, Cell Viability, Flow cytometry
Co-Authors Abdul Hakim Ach. Nashichuddin Ahmad, Ananda Rizkia Azizah Amrulloh, Muhammad Firman Andiartama, Amanda Milano Anik Listiyana Anik Listyana Annisa, Rahmi Arief Suryadinata Aty Widyawaruyanti Begum Fauziyah Briliana, Malich Septi Diajeng Dhani Wijaya, Dhani Elok Kamilah Hayati Erna Susanti Fathia Faza Rahmadanita Ferry Sandra Habibah, Atiqoh Nur Hadya, Chorida Muhjatul Hariz, Muhammad Fawaz Huwaida, Fadhila Isma Indradewa, Rhian Irawati, Santia Janaloka, Nandana Adyuta Kirana, Farenza Okta Laily Nurul Azizah Lestari, Nia Ayu Ma'arif Z.A, Burhan Ma'arif, Burhan Ma'arif, Burhan Minggarwati, Trian Sidha Muhammad Zainuddin Mustofa, Muhammad Ragib Nafisah, Fika Sayyidatun Nurlaili Susanti Octavia, Nur Ika Purwaningsih, Fauziyah Eni Qonita, Kesimira Rahmi Annisa Ramadhani D.A., Ria Retno Susilowati Ria Ramadhani Dwi Atmaja Risma Aprinda Kristanti Sadli Syarifuddin Salsabila, Dhia Fadhilah Salsabilla, Farida Rahma Samah, Moh.Alfin Siti Zulaikah Sukardiman Sukma, Yolanda Cahyaning Suyadinata, Arief Tanaya Jati Dharma Dewi Taufik, Imam Ulfah, Jauza Weka Sidha Bhagawan Wirda Anggraini Yen Yen Ari Indrawijaya Zahiro, Syayida Roisatus