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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kesehatan Lingkungan indonesia Jurnal Kedokteran Brawijaya Disease Prevention and Public Health Journal Jurnal Kesehatan Masyarakat Medical Laboratory Technology Journal Jurnal Penelitian Kesehatan Suara Forikes SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Ilmu Kedokteran dan Kesehatan Indonesian Journal of Community Services Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Jurnal Kedokteran Raflesia Jurnal Pengabdian Masyarakat Kedokteran Asian Journal of Health and Applied Sciences JKKI : Jurnal Kedokteran dan Kesehatan Indonesia CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Jurnal Ilmiah Sultan Agung Gema Lingkungan Kesehatan Community Empowerment Journal Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Siti Thomas Zulaikhah
Universitas Islam Sultan Agung Semarang
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Journal : Medical Laboratory Technology Journal

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The Effect of Cucumber (Cucumis sativus) Extract Cream on VEGF and IL-10 in Xerotic Rats Yanti, Erica Lidya; Harlisa, Pasid; Zulaikhah, Siti Thomas
Medical Laboratory Technology Journal Vol. 11 No. 2 (2025): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i2.664

Abstract

Xerosis cutis is a chronic dry skin condition aggravated by impaired skin barrier function and increased transepidermal water loss (TEWL). Decreased levels of interleukin-10 (IL-10) and vascular endothelial growth factor (VEGF) contribute to prolonged inflammation and hinder tissue regeneration. Cucumber (Cucumis sativus) contains flavonoids and vitamin C, which possess anti-inflammatory and angiogenic properties, making it a promising candidate for natural topical therapy. This study aimed to determine the effect of cucumber extract cream on IL-10 and VEGF levels in the skin of female Wistar rats with grade II xerosis cutis induced by acetone and ethanol. This experimental research employed a post-test only control group design. A total of 30 Wistar rats were randomly divided into five groups: normal control, negative control, positive control (10% ceramide cream), and two treatment groups receiving cucumber extract cream at concentrations of 3% and 5%. Following the induction of xerosis, the respective creams were applied topically for 14 consecutive days. Results showed that administration of 5% cucumber extract cream significantly increased VEGF levels (715.75 ± 152.65 ng/L) and IL-10 levels (200.35 ± 43.49 pg/mL) compared to the negative control (VEGF 494.29 ± 95.05 ng/L; IL-10 120.62 ± 22.11 pg/mL, p<0.05). The 3% cucumber extract cream also elevated VEGF (522.96 ± 115.48 ng/L) and IL-10 (197.86 ± 31.32 pg/mL), though less effectively than the 5% formulation. Meanwhile, the group treated with ceramide 10% cream showed increases in VEGF (694.87 ± 180.52 ng/L) and IL-10 (140.85 ± 32.42 pg/mL), indicating that cucumber extract at 5% comparable to ceramide therapy. In conclusion, cucumber extract cream, particularly at 5% concentration, significantly enhances IL-10 and VEGF levels in the skin of xerosis cutis model rats. These findings indicate its potential as an effective natural topical therapy for reducing inflammation and promoting skin regeneration in xerosis cutis caused by chemical exposure.
Co-Authors Ali Djamhuri Anang Wiwik Indriatno Arif, Mohamad Arrizki Azka Pratama Caesara, Vidya Rahayunda Cahyani, Adhisa Rizky Chodidjah Choirinnisa, Luluk David Akbar M Dhanny Rona Etika Eka Norma Anggorowati, Eka Norma Eko Naning Sofyanita Elly Noerhidajati Elly Noerhidayati Elok Faiqoh Endang Surani, Endang Erinda, Adysa Erwin Budi Cahyono Faida, Soraya Nur ferdi ardiansyah, ferdi Ghani, Muhammad Firman Hariyanto, Ropik Iis Aisyah Sutisna Imam Djamaludin Mashoedi Indy Anindya Damayanti Isaroh, Nila Latifatul Iwang Yusuf Joko Wahyu Wibowo Joko Wahyu Wibowo Joko Wahyu Wibowo Joko Wahyu Wibowo Joko Wahyu Wibowo Joko Wahyu Wibowo Joko Wahyuwibowo Kurniasari, Linda Lestari, Novi Dian Livana Ph, Livana Lusito Lusito Masyhudi Masyhudi, Masyhudi Maula, Fanindy Ghanif Menik Sahariyani Minidian Fasitasari Minidian Fasitasari Muhammad Saugi Abduh Muhammad Ulil Fuad Mustika Rani Nadya Fitrianisa Nafisyah Nafisyah Naufal Al Faris Wardhana Nazzala Luthfin Amellia Noorrahman, Handy Triya Nurkhikmah, Eli Pasid Harlisa Perez Wahyu Purnasari Prasetyo Bhakti H Prissanty, Anne Aninditha Pritasari, Alteriana Mydriati Sita Purwito Soegeng Purwito Soegeng Prasetijono Putra, Alexander Vito Dharma Raharja, Mediana Emilia Rahim, Denasa Dwi Sopandita Rahmadhani, Ilham Suci Rani Windasari Pratami Ratnawati Ratnawati Ratnawati Ratnawati Ratnawati Ratnawati Reza Adityas Trisnadi Rohadi Rohadi Salsabila Amarti Nisaa Salsabila Ratna Dea Sampurna Sampurna, Sampurna Sekar Arum Artanti Sekarayu Septia Khairunnisa Setyo Trisnadi Shinta, Sopia Silvyana Helmalia Putri Sita, Tiara Laras Sri Priyantini Sulastri, Neng Susilorini Susilorini Tania Octavia Taufiqurrachman Nasihun Titiek Sumarawati Widianto, Fadhilla Dimas Yanti, Erica Lidya Yusuf Kusuma Dewa Yusuf, Iwang Yuwono Tulus Kurniawan Zahir Khan Gaddy Shaquille Egan