Article Per Year (5 Year)
p-Index From 2021 - 2026
3.625
P-Index
This Author published in this journals
All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kesehatan Lingkungan indonesia Jurnal Kedokteran Brawijaya Disease Prevention and Public Health Journal Jurnal Kesehatan Masyarakat Althea Medical Journal Medical Laboratory Technology Journal Jurnal Penelitian Kesehatan Suara Forikes SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Ilmu Kedokteran dan Kesehatan Indonesian Journal of Community Services Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Jurnal Kedokteran Raflesia Jurnal Pengabdian Masyarakat Kedokteran Asian Journal of Health and Applied Sciences JKKI : Jurnal Kedokteran dan Kesehatan Indonesia CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Jurnal Ilmiah Sultan Agung Gema Lingkungan Kesehatan Community Empowerment Journal Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Siti Thomas Zulaikhah
Universitas Islam Sultan Agung Semarang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 38 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Althea Medical Journal

 1 
Effect of Cucumber (Cucumis sativus) Extract Cream on Aquaporin-3 and Hyaluronic Acid Levels in Wistar Rats with Xerosis Cutis Suparwi, Ajeng Destian; Harlisa, Pasid; Zulaikhah, Siti Thomas
Althea Medical Journal Vol 13, No 1 (2026)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v13n1.4576

Abstract

Background: Xerosis cutis is characterized by impaired barrier function and reduced hydration markers, including Aquaporin-3 (AQP3) and hyaluronic acid (HA).  Cucumber extract (Cucumis sativus) contains antioxidants and humectants compounds that may improve skin hydration. This study investigated the effects of cucumber extract cream on AQP3 and HA levels in female Wistar rats (Rattus norvegicus) with grade II xerosis cutis.Methods:  This in vivo experimental study used a post-test-only control group design. Twenty-five female Wistar rats were randomly assigned into five groups: healthy control, xerosis control, positive control (10% ceramide), and treatment groups receiving 3% and 5% cucumber extract cream. Xerosis was induced by topical application of 70% acetone followed by 100% ethanol for 5–7 days until grade II xerosis developed.  The creams were then applied topically for 14 days. AQP3 and HA levels were measured using enzyme-linked immunosorbent assay (ELISA).Results: HA levels differed significantly among groups (p=0.016). The 5% cucumber extract cream maintained HA levels comparable to healthy controls (611.25±248.61 vs. 685.26±194.95 ng/L; p=0.394). In contrast, ceramide and 3% cucumber treatments showed lower HA levels relative to healthy controls. AQP3 levels showed no statistically significant differences among groups (p=0.131), although descriptively higher expression was observed in the 5% cucumber-treated group.Conclusion: Cucumber extract cream at 5% concentration helps maintain HA levels and shows a tendency to increase AQP3 expression, suggesting potential benefits for improving skin hydration in xerosis cutis and supporting skin health associated with aging. 
Co-Authors Ali Djamhuri Amellia, Nazzala Luthfin Arif, Mohamad Arrizki Azka Pratama Artanti, Sekar Arum Caesara, Vidya Rahayunda Cahyani, Adhisa Rizky Chodidjah Choirinnisa, Luluk Damayanti, Indy Anindya David Akbar M Dea, Salsabila Ratna Dewa, Yusuf Kusuma Dhanny Rona Etika Egan, Zahir Khan Gaddy Shaquille Eka Norma Anggorowati, Eka Norma Eko Naning Sofyanita Elly Noerhidajati Elly Noerhidayati Elok Faiqoh Endang Surani, Endang Erinda, Adysa Erwin Budi Cahyono Faida, Soraya Nur ferdi ardiansyah, ferdi Fitrianisa, Nadya Ghani, Muhammad Firman Hariyanto, Ropik Iis Aisyah Sutisna Imam Djamaludin Mashoedi Indriatno, Anang Wiwik Isaroh, Nila Latifatul Iwang Yusuf Joko Wahyu Wibowo Joko Wahyu Wibowo Joko Wahyu Wibowo Joko Wahyu Wibowo Joko Wahyu Wibowo Joko Wahyu Wibowo Joko Wahyuwibowo Khairunnisa, Sekarayu Septia Kurniasari, Linda Kurniawan, Yuwono Tulus Lestari, Novi Dian Livana Ph, Livana Lusito Lusito Masyhudi Masyhudi, Masyhudi Maula, Fanindy Ghanif Menik Sahariyani Minidian Fasitasari Minidian Fasitasari Muhammad Saugi Abduh Muhammad Ulil Fuad Mustika Rani Nafisyah, Nafisyah Nisaa, Salsabila Amarti Noorrahman, Handy Triya Nurkhikmah, Eli Octavia, Tania Pasid Harlisa Perez Wahyu Purnasari Prasetijono, Purwito Soegeng Prasetyo Bhakti H Pratami, Rani Windasari Prissanty, Anne Aninditha Pritasari, Alteriana Mydriati Sita Purwito Soegeng Putra, Alexander Vito Dharma Raharja, Mediana Emilia Rahim, Denasa Dwi Sopandita Rahmadhani, Ilham Suci Ratnawati Ratnawati Ratnawati Ratnawati Ratnawati Ratnawati Reza Adityas Trisnadi Rohadi Rohadi Sampurna Sampurna, Sampurna Setyo Trisnadi Shinta, Sopia Silvyana Helmalia Putri Sita, Tiara Laras Sri Priyantini Sulastri, Neng Suparmi Suparmi Suparwi, Ajeng Destian Susilorini Susilorini Taufiqurrachman Nasihun Titiek Sumarawati Wardhana, Naufal Al Faris Widianto, Fadhilla Dimas Yanti, Erica Lidya Yusuf, Iwang