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All Journal Jurnal Farmasi Klinik Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pharmacology and Clinical Pharmacy Research Martabe : Jurnal Pengabdian Kepada Masyarakat BULETIN AL-RIBAATH Jurnal Kreativitas PKM Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal) Health Information : Jurnal Penelitian Jurnal Ilmiah Farmako Bahari Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Pharmacy Edu Masda Journal Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Keperawatan dan Kesehatan (JKK) Bengawan :Jurnal Pengabdian Masyarakat Jurnal Komunitas Farmasi Nasional Pharmaceutical Science Journal Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Abdimas Mahakam
Herdaningsih, Sulastri
Akademi Farmasi Yarsi Pontianak
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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UJI AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAUN SAWI PAKCOY (Brassica rapa Linn.) TERHADAP MENCIT PUTIH (Mus musculus L.) JANTAN YANG DI INDUKSI PEPTON 5% Sulastri Herdaningsih; Iis Maghfira Aulia
Jurnal Komunitas Farmasi Nasional Vol. 6 No. 01 (2026): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Abstract

Fever is a condition marked by an increase in body temperature beyond normal limits. This study aims to evaluate the antipyretic effect of ethanol extract from pakcoy mustard leaves (Brassica rapa Linn.) on male white mice (Mus musculus L.) induced with 5% peptone and to determine the effective dose of the extract. Fifteen male mice were divided into five groups: negative control (0.5% Na-CMC), positive control (paracetamol 65 mg/kg body weight), and three treatment groups receiving ethanol extract doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg body weight. All groups were induced using 5% peptone subcutaneously until a rectal temperature increase of ≥0.6°C occurred, followed by oral administration of the test substances. Temperature was recorded every 30 minutes over 4 hours. Statistical analysis revealed significant antipyretic effects in all treatment groups compared to the negative control (p values 0.02, 0.01, 0.04; p < 0.05) at doses 100, 200, and 400 mg/kg body weight respectively. The findings suggest that ethanol extract of pakcoy mustard leaves possesses significant antipyretic activity in male white mice induced with fever. Keywords: Pakcoy Mustard (Brassica rapa Linn.), Antipyretic, White Mice (Mus musculus L.)
Co-Authors Ahmad Muhtadi Ahmad Muhtadi Angelina, Yusta Asmara, Ratna Dewi Lintang Costan Tryono Parulian Rumapea Dian Kartikasari Dian Kartikasari Dikki Saputra Dikki Saputra Ervina Lili Neri Faisal Kholid Fahdi Fauzan Alfikrie Fauzan, Suhaimi Fenny Oktaviyeni Gabby Novikadarti Rahmah Gina Aulia Hairunnisa Hairunnisa Hairunnisa Herman Herman Herman Ibnu Kahtan, Muhammad Ihsanul Arief Iis Maghfira Aulia Inderiyani, Inderiyani Ismi Utari Keri Lestari Khizul Hertiani Kholid Fahdi, Faisal Kurnianto, Erwan Kurniasih, Dwi Maulana, Iksan Maulana, M. Ali Mela Khofifah Mita Mita Mita Muhammad Ibnu Khatan Muharami, Savitri Nurhafizah Nurhafizah Nurul Annisa Olivia Rahman, Ika Ristia Savitri, Elisabeth Wahyu Selvi, Lucia Martisa Yoga Pramana