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Natural Deep Eutectic Solvent–Extracted Old and Young Mangrove Avicennia marina Leaves: Comparative Antibacterial Activity Against Propionibacterium acnes Djamaludin, Heder; Firdaus, Shelina Innasa; Suprayitno, Eddy; Yahya, Yahya; Arisandi, Desy; Ahmad, Mirza Gulam; Tambunan, Jeny Ernawati; Ahmad, Nurul Hawa; Ramli, Nurul Shazini; Kartikaningsih, Hartati
Journal of Tropical Life Science Vol. 15 No. 3
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.15.03.13

Abstract

Acne vulgaris is a common inflammatory skin disorder largely associated with the proliferation of Propionibacterium acnes. Although antibiotics are widely used for acne treatment, the increasing incidence of antibiotic resistance necessitates the exploration of effective natural alternatives. Mangrove plants are known to contain diverse bioactive compounds with antimicrobial potential. This study aimed to evaluate the antibacterial activity of Natural Deep Eutectic Solvent (NADES) extracts derived from young and old leaves of Avicennia marina against P. acnes. Extraction was conducted using citric acid–glucose-based NADES with different molar ratios: P1 (1:1), P2 (2:1), P3 (3:1), and P4 (4:1), to assess the effect of solvent composition on antibacterial performance. Antibacterial activity was determined using inhibition zone assays, while molecular docking analysis was performed to investigate interactions between extracted metabolites and P. acnes target proteins. The results showed that both young and old leaf extracts exhibited significant antibacterial activity, strongly influenced by the NADES formulation. Young leaf extracts produced the largest inhibition zone with the P4 formulation (24.51±0.75 mm) and the smallest with P1 (21.63±0.67 mm). Similarly, old leaf extracts showed maximum inhibition in P4 (37.38±4.34 mm) and minimum inhibition in P1 (22.62±1.40 mm). Increasing the proportion of citric acid enhanced the extraction of bioactive compounds responsible for antibacterial activity. Molecular docking confirmed strong binding affinities between key metabolites and P. acnes target proteins, supporting the experimental findings. Thus, NADES extracts of A. marina leaves, particularly those prepared using a 4:1 citric acid–glucose ratio, demonstrate strong potential as natural antibacterial agents for acne prevention and treatment.
Co-Authors A'yunin, Qurrota A'yunin, Qurrota Abdul Aziz Jaziri Abdul Mulki Purnama Afifa, Faisa Afiyanti, Mufidah Agung Pramana Warih Marhendra Agung Pramana Warih Marhendra, Agung Pramana Warih Agus Susilo Agus Susilo Ahmad, Mirza Gulam Ahmad, Nurul Hawa Al Fatih, Ahmad Nuril Fuad Alif, Muhammad Rizki Mas Alifatul Fatchiyah Alviani, Melinda Nuril Andi Kurniawan Andrew, Mulabbi Anggayasti, Wresti L. Anggraeni, Ike Listya Anies Chamidah Anik M. Hariati Anshary, Muhammad Reza Arifin, Nasrullah Bai Arifin, Sunanto Arisandi, Desy Arning Wilujeng Ekawati Asep Awaludin Prihanto Ashari, Fadhil Muhamad Atikawati, Dini Audina, Nanda Bagyo Yanuwiadi Bambang Semedi Budi Wahono Citra Satrya Utama Dewi Darius Darius Defri Yona Dewa Gede Raka Wiadnya Dian Wahyu Wardani Dini Atikawati Djamaludin, Heder Eddy Suprayitno Fauziyah, Jihan Nur Feni Iranawati Feni Iranawati, Feni Firdaus, Shelina Innasa Fuad, Mochamad Arif Zainul Galih Nugroho Gunawan, Fahdynia Karnira Habibah, Laila Nur Happy Nursyam Hardoko Hardoko Ike Listya Anggraeni Indah Ashlachal Ummah K, Maharani Pertiwi Kasitowati, Rarasrumdyah Ken Audia Pradarameswari Khotibul Umam Al Awwaly Khusaini, Mohammad Kristama, Yoga Sita Kristin Rosalina Kuncoroyekti, Andre Ledhyane Ika Harlyan Lestariadi, Riski Agung Lina Asmara Wati Lina Asmarawat Luchman Hakim M. Choirul Anam Madyasta Anggana Rarassari Maharani Pertiwi Koentjoro Maharani, Sarastria Mimit - Primyastanto Mirna Zena Tuarita Mochamad Arif Zainul Fuad Mufti, Eka Deviana Muhamad Firdaus Muhamad Khafid Rifai Muhammad Fathur Rouf Hasan Muhammad Rizki Mas Alif Muntafi’ah, Salimatul Nasrullah Bai Arifin Nurhanif, Ardhian Eko Nurul Badriyah Nurul Catur Febriana Oktavia, Yoan Oktofani, Rizdya Poerbyanti, Nike Putra, Erwansyah Ilham Pradana Qomariyatus Sholihah Rachman Hartono Ramli, Nurul Shazini Rhytia Ayu Christianty Putri Rifai, Muhamad Khafid Rika Kurniaty Rizki Fadila, Rizki Roosa, Lucy Cynthia Saputra, Nyoman Robby Manik Sari, Safitri Permata Sartika, Fitarina Setyandhinavia, Amilis Setyo Tri Wahyudi Soemarno Soemarno Sri Andayani Sri Andayani Sri Sudaryanti, Sri Subagyo Subagyo Sukoso Sukoso Supirman, S S Supriyadi Supriyadi Surjono Susanto, Dony Tri Syarifah Hikmah Julinda Sari Tambunan, Jenny Ernawati Tambunan, Jeny Ernawati Tian Nur Ma’rifat Toat, Akhmad Prasetyo Ibnu Wahyu Devi Hapsari Wijayanti Wardana, Fitri Candra Wiadnya D.G R Yahya Yahya Yahya Yahya Yanti Suryanti Yanuar, Adi Tiya YOGA DWI JATMIKO Yunita Eka Puspitasari Zaelanie, K Kartini Zaelanie, K Kartinie