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All Journal International Journal of Public Health Science (IJPHS) Media Kesehatan Masyarakat Indonesia Jurnal Kesehatan Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Pengabdian Pada Masyarakat Manuju : Malahayati Nursing Journal Jurnal Respirasi (JR) Medical Technology and Public Health Journal Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Ilmiah Kesehatan Indonesian Journal of Electrical Engineering and Computer Science Majalah Biomorfologi (Biomorphology Journal) Poltekita: Jurnal Pengabdian Masyarakat Edu Dharma Journal: Jurnal penelitian dan pengabdian masyarakat Indonesian Archives of Biomedical Research (InABR) MEDICINUS
Rosyid, Alfian Nur
Department Of Pulmonary And Respiratory Medicine, Faculty Of Medicine And Hospital, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Syntax Literate: Jurnal Ilmiah Indonesia

 1 
Drug Utilization Study of Lopinavir And Ritonavir In Covid-19 Patients Aryani, Toetik; D. Puspitasari, Arina; Nafikhah, Wardah Zuhan; Rosyid, Alfian Nur; Astanti, Erika
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.598 KB) | DOI: 10.36418/syntax-literate.v7i12.10447

Abstract

The world pandemic of COVID-19 which caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a very infectious and contagious. Lopinavir and ritonavir is recommended based on guidelines from National Health Commission of China as an antiviral therapy for COVID-19. Both lopinavir and ritonavir inhibit the 3CLpro enzyme’s action, which its role in replication also release of viruses. As protease inhibitor in Human Immunodeficiency Virus (HIV), both lopinavir and ritonavir’s target is a symmetrical bag of C2 where does not exist in 3CLpro enzyme of corona virus. This literature review is needed to determine the outcome of using lopinavir and ritonavir in order to find a conclusion that can be used as a basis for intervening drug administration in patients of COVID-19. A method of narrative review was used in this study which was carried out by searching on Pubmed and Science direct. After doing abstract screening and title based on the inclusion criteria, 13 articles were left to be analyzed. These articles were analyzed using predetermined clinical outcome parameters, namely duration of hospital stay, composite event, clinical symptom score, time to achieve negative RT-PCR, duration of mechanical ventilation, and all-cause mortality. Based on all reviewed articles, the majority of clinical outcome parameters showed that the outcome was no better than standard care or other drugs. From this review, it can be concluded that lopinavir along with ritonavir provide no better clinical outcomes than standard therapy or other drugs in COVID-19’s patients.
Potensi Ekoenzim Daun Kayu Putih (Melaleuca leucadendra) Produksi UMKM Lamongan sebagai Antifungal terhadap Pertumbuhan Jamur Aspergillus flavus Rahma, Rachel Sabila; Retnowati, Wiwin; Rosyid, Alfian Nur
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i3.55368

Abstract

Aspergillus flavus adalah jamur patogen yang menyebabkan aspergillosis, terutama pada individu dengan sistem imun lemah. Resistensi terhadap antijamur sintetis mendorong pencarian alternatif alami yang lebih aman. Daun kayu putih (Melaleuca leucadendra) diketahui memiliki aktivitas antimikroba karena kandungan terpenoid seperti 1,8-cineol. Kabupaten Lamongan, sebagai penghasil daun kayu putih berkualitas, memanfaatkannya dalam produksi ekoenzim melalui fermentasi sederhana oleh UMKM setempat. Penelitian ini bertujuan untuk mengevaluasi potensi antijamur ekoenzim daun kayu putih produksi UMKM Lamongan terhadap Aspergillus flavus menggunakan metode difusi. Ekoenzim difermentasi selama enam bulan, lalu diuji pada berbagai konsentrasi dengan ketokonazol sebagai kontrol positif dan air suling sebagai kontrol negatif. Setelah inkubasi 48 jam, hasil menunjukkan tidak adanya zona hambat pada semua konsentrasi ekoenzim. Hal ini mengindikasikan bahwa ekoenzim tidak memiliki efek antijamur signifikan terhadap Aspergillus flavus, yang mungkin disebabkan oleh rendahnya konsentrasi terpenoid, pH ekoenzim yang relatif tinggi (4,95), serta kemungkinan interaksi antagonistik antar senyawa bioaktif. Faktor lain mencakup kualitas bahan baku, metode fermentasi, dan kondisi lingkungan selama produksi. Penelitian ini merekomendasikan optimalisasi proses fermentasi dan pengujian terhadap patogen lain untuk mengeksplorasi potensi antimikroba ekoenzim kayu putih.
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Anastasya Annisa Karlina Ardi, Bangun Mukti Arifandi, Yoga Akbar Arina Dery Puspitasari Arina Dery Puspitasari Asmahan Farah Adiba Astanti, Erika Bakhtiar, Arief Bakhtiar, Arief Bambang Subakti Zulkarnain Brigitta Dhyah Kunthi Wardhani Brigitta Dhyah Kunthi Wardhani BUDI UTOMO D. Puspitasari, Arina Dava Aulia Dhieo Kurniawan Diah Indriani Duta, Garinda Alma Effendi, Wiwin Is Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Farah Meutia Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fauzul Meiliani Fauzul Meiliani Fauzul Meiliani Fauzul Meiliani Hafidz Alfarobi Handira Nadhifatul Aini Hasanudin Hasanudin Herley Windo Setiawan Idwar, Fadiah Dini Putri Ika Nindya Kadariswantiningsih Indiastuti, Danti Nur Isnin Anang Marhana Izzatul Fitriyah Kusuma, Edward Putra Lie Liana Fuadiati Lily Aina Lily Aina Lily Aina Lily Aina M. Yamin Maftuchah Maftuchah Makhfudli Makhfudli Maranatha, Daniel Mareta Rindang Andarsari Maulana Antiyan Empitu Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Mochamad Rafi Pratama Hariyanto Putra MOCHAMMAD THAHA Muhammad Amin Muhammad Amin Muhammad Rivai Mutiara Rizki Haryati Nafikhah, Wardah Zuhan Nanda Ardianto Nanda Ardianto Nanda Ardianto Nanda Ardianto Natalia Christin Tiara Revita Naura Alya Hirmadiani Nur Rachmawati Maulida Nursalam Nursalam Pharmasinta Putri Hapsari Prastuti Asta Wulaningrum Qona’ah, Arina Rahma, Rachel Sabila Resti Yudhawati Reyna Cesariyani Rahmadianti Rusuldi Riyanarto Sarno Sanchia Callista Raihanah Wiryawan Sarah Mahmudatun Nabila Sensusiati, Anggraini Dwi Sharifa Audi Salsabila Shintami Chusnul Hidayati Soenarnatalina Melaniani Suryantoro, Satriyo Dwi Susila, I Made Dwi Yudiartana Putra Tafana Fadhillah Laili Tamara Nur Budiarti Tamara Nur Budiarti Tamara nUR Budiarti Temenggung, Bintang Tintin Sukartini Sukartini, Tintin Sukartini Toetik Aryani Umiastuti, Pirlina Vatine Adila Wahyunitisari, Manik Retno Wedhana, Hilmy Indra Wironegoro, Rio Wiwin Is Effendi Wiwin Retnowati Yasmin Karimah Ikhsan Yulis Setiya Dewi Yuliza Yuliza Yusuke Suzuki Zedny Norachuriya