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All Journal International Journal of Public Health Science (IJPHS) Media Kesehatan Masyarakat Indonesia Jurnal Kesehatan Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Pengabdian Pada Masyarakat Manuju : Malahayati Nursing Journal Jurnal Respirasi (JR) Medical Technology and Public Health Journal Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Ilmiah Kesehatan Indonesian Journal of Electrical Engineering and Computer Science Majalah Biomorfologi (Biomorphology Journal) Poltekita: Jurnal Pengabdian Masyarakat Edu Dharma Journal: Jurnal penelitian dan pengabdian masyarakat Indonesian Archives of Biomedical Research (InABR) MEDICINUS
Rosyid, Alfian Nur
Department Of Pulmonary And Respiratory Medicine, Faculty Of Medicine And Hospital, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Terapi Montelukast pada Asma Alfian Nur Rosyid; Arief Bakhtiar; Daniel Maranatha; Muhammad Amin
MEDICINUS Vol. 37 No. 1 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/51tkjy13

Abstract

Asthma is a chronic inflammatory respiratory condition caused by various inflammatory mediators, including those from the arachidonic acid pathway, which serves as a precursor for leukotrienes and prostaglandins. Leukotriene receptor antagonists (LTRAs) have been approved since 1998 as a treatment for asthma. Montelukast is one of the LTRAs that is useful for asthma control, including cases that accompanied by allergic rhinitis. A daily dose of 5-10 mg is recommended for persistent asthma as the preferred controller. LTRAs are not recommended for acute asthma exacerbation due to their relatively slow onset, but they are beneficial in preventing exacerbations. They are also indicated for exercise-induced asthma (EIA), and can be taken 2 hours prior to exercise. Montelukast can be administered as monotherapy or added to LABA-ICS therapy. It is suitable for adults, children, and infants over 1 year of age, preferably taken at night to prevent symptoms in the early morning. Possible side effects include respiratory tract infections, abdominal pain, diarrhea, and neuropsychiatric disorders. Montelukast is considered safe for use during pregnancy and breastfeeding. Physicians should provide comprehensive education for patients regarding medication compliance and the potential risks of side effects. Regular daily use of montelukast is beneficial in preventing acute exacerbations in asthma patients.
Development of an EKA application to help tuberculosis patients improve medication adherence and self efficacy Fuadiati, Lie Liana; Sukartini, Tintin; Makhfudli, Makhfudli; Dewi, Yulis Setiya; Rosyid, Alfian Nur; Qona’ah, Arina
International Journal of Public Health Science (IJPHS) Vol 13, No 1: March 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i1.23309

Abstract

Tuberculosis treatment is carried out daily for a long time, causing boredom with taking medication and reducing medication adherence. It results in drug resistance and more prolonged treatment. In response to the situation, this study developed an android-based application called the education, calendar, and medication alarm (EKA) app to improve medication adherence and self-efficacy of tuberculosis patients. Research and development with four steps: evaluation of health education, medication adherence, and self-efficacy; application development; feasibility test; and application socialization. The sample in this study was 38 respondents. This study also uses morisky medication adherence scale (MMAS-8), self-efficacy, and system usability scale (SUS) questionnaires and evaluation sheets to collect the data. Data analysis was done descriptively. The outcomes of the application feasibility test showed that the EKA application received an acceptable value of 81.5 based on acceptance, B value (81.5) based on value scale, an excellent value (81.5) based on adjective rating, and good score (81.5) based on percentile. Socialization on the use of the application goes well, and the patient gets a good understanding and can use the EKA application easily. It proves that the android-based EKA application tested using the SUS questionnaire can be used as a medium for health education and supports medication adherence and self-efficacy.
Arterial Blood Gas Parameters to Evaluate Oxygenation and Acid-Base Disorders in Corticosteroid-Receiving Severe and Critical COVID-19 Patients Temenggung, Bintang; Setiawan, Herley Windo; Rochmanti, Maftuchah; Rosyid, Alfian Nur
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 2 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I22024.64-69

Abstract

Highlights: Both severe and critical COVID-19 patients primarily presented with hypoxemia. Severe and critical COVID-19 patients differed through their tendencies towards respiratory alkalosis/metabolic acidosis and respiratory acidosis, respectively.   Abstract Introduction: Increased inflammation and immune dysregulation in severe and critical COVID-19 trigger oxygen and acid-base disorders, possibly mitigated by corticosteroids. Variations in arterial blood gas (ABG) parameters and the influence of corticosteroid administration have become a concern for clinicians. This study aimed to uncover significant differences in temporal arterial blood gas parameters between severe and critical COVID-19 cases undergoing corticosteroid treatment. Methods: This case-control study, which adhered to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines, analyzed severe (n=27) and critical (n=41) COVID-19 patients treated in the high care unit (HCU) and the intensive care unit (ICU) of Universitas Airlangga Hospital, Surabaya, from May to July 2021. Arterial blood gas results were categorized into three evaluations (E1-E3) based on collection days. The International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) for Macintosh version 27.0 was used for statistical analysis, with a p<0.05 considered statistically significant. Results: Hypoxemia through PaO2 and P/F ratios was prominent in both groups throughout E1-E3, with differences only in E1 P/F ratios (p=0.003). While SaO2 stayed normal in severe cases, critical cases were low, with differences in E1 (p=0.012) and E3 (p=0.004). Severe cases maintained normal pH, while critical cases tended towards acidemia, notably differing in E1-E3. Both groups had low HCO3 levels, differing only in E2 (p<0.001). Severe and critical groups exhibited low and high PaCO2 trends, respectively, with distinctions in E2 (p<0.001) and E3 (p=0.003). Conclusion: Hypoxemia was prevalent in both groups. Compensated respiratory alkalosis or metabolic acidosis was common in the severe group, while the critical presented with respiratory acidosis.
Risk Factors of Death in Chronic Obstructive Pulmonary Disease (COPD) Patients at Dr. Soetomo General Academic Hospital, Surabaya, in 2019 Wedhana, Hilmy Indra; Bakhtiar, Arief; Kusuma, Edward; Rosyid, Alfian Nur
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 1 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I12025.14-20

Abstract

Highlights: The highest distribution of chronic obstructive pulmonary disease (COPD) patients’ age and gender was over 60 years old and males. The highest distribution of COPD patients’ comorbidity was infection, with pneumonia being the most common infection.   Abstract Introduction: The distribution of death and risk factors in chronic obstructive pulmonary disease (COPD) patients varies according to disease severity. This study aimed to determine the risk factors of mortality in COPD patients. Methods: This was a retrospective descriptive study with a total sampling method using inclusion and exclusion criteria. Data collection was performed on patients' medical records throughout 2019. The inclusion criteria for this study sample were patients diagnosed with COPD who died in 2019, aged over 25 years old (adults), both male and female. The exclusion criteria were COPD patients with incomplete medical record data. Results: The total number of samples obtained and included in this study was 31 COPD patients (n=31). The characteristics of the patients showed a predominance of males over females, with a ratio of 9:1. Seventeen samples (58.0%) out of 31 were patients aged >66 years old. Comorbidities accounted for 96.8% of the study population. The most prevalent comorbidity was infection (77.41%), with pneumonia accounting for 38.7% of all deaths. Eighteen patients (58.1%) reported having two or more comorbidities, whilst 28 patients (90.3%) scored 0-7 on the Modified Sequential Organ Failure Assessment (mSOFA) when admitted to the hospital. Conclusion: This study found that the group of patients with the mSOFA score of 0-7 with the characteristics of being aged >60 years old, males, and having pneumonia infection had the highest mortality rate among other COPD patients who died.
The Role of Vitamin C Supplementation in Preventing Severity Progression in Mild and Moderate COVID-19 Patients at Universitas Airlangga Hospital Arifandi, Yoga Akbar; Rosyid, Alfian Nur; Indiastuti, Danti Nur; Effendi, Wiwin Is
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 1 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I12025.63-69

Abstract

Highlights: The administration of different dosages of vitamin C significantly yields different outcomes in preventing the progression of disease severity. Most patients with mild and moderate coronavirus disease (COVID-19) did not demonstrate an escalation in disease severity.   Abstract Introduction: Coronavirus disease (COVID-19) is an infectious disease that increases pro-oxidant elements and decreases antioxidants. Vitamin C functions as a potent antioxidant in humans due to its electron-donating properties.  This study aimed to explain the impact of three distinct vitamin C supplementation dosages in preventing disease severity progression among mild and moderate COVID-19 patients. Methods: This retrospective study used secondary data from 100 medical records (n=100). The subjects were classified into three categories based on the vitamin C dosage. The data were analyzed using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 26.0 for Windows. Results: Most of mild and moderate COVID-19 patients (78%) did not experience increased disease severity. Vitamin C supplementation significantly demonstrated a different outcome in preventing disease severity progression among the three groups (p=0.018). However, it did not significantly show any difference in reducing the duration of hospital stay (p=0.680). Conclusion: The impact of vitamin C supplementation on COVID-19 severity appeared to vary depending on the dosage administered. However, it did not affect the duration of the hospital stay.
Potensi Ekoenzim Daun Kayu Putih (Melaleuca leucadendra) Produksi UMKM Lamongan sebagai Antifungal terhadap Pertumbuhan Jamur Aspergillus flavus Rahma, Rachel Sabila; Retnowati, Wiwin; Rosyid, Alfian Nur
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i3.55368

Abstract

Aspergillus flavus adalah jamur patogen yang menyebabkan aspergillosis, terutama pada individu dengan sistem imun lemah. Resistensi terhadap antijamur sintetis mendorong pencarian alternatif alami yang lebih aman. Daun kayu putih (Melaleuca leucadendra) diketahui memiliki aktivitas antimikroba karena kandungan terpenoid seperti 1,8-cineol. Kabupaten Lamongan, sebagai penghasil daun kayu putih berkualitas, memanfaatkannya dalam produksi ekoenzim melalui fermentasi sederhana oleh UMKM setempat. Penelitian ini bertujuan untuk mengevaluasi potensi antijamur ekoenzim daun kayu putih produksi UMKM Lamongan terhadap Aspergillus flavus menggunakan metode difusi. Ekoenzim difermentasi selama enam bulan, lalu diuji pada berbagai konsentrasi dengan ketokonazol sebagai kontrol positif dan air suling sebagai kontrol negatif. Setelah inkubasi 48 jam, hasil menunjukkan tidak adanya zona hambat pada semua konsentrasi ekoenzim. Hal ini mengindikasikan bahwa ekoenzim tidak memiliki efek antijamur signifikan terhadap Aspergillus flavus, yang mungkin disebabkan oleh rendahnya konsentrasi terpenoid, pH ekoenzim yang relatif tinggi (4,95), serta kemungkinan interaksi antagonistik antar senyawa bioaktif. Faktor lain mencakup kualitas bahan baku, metode fermentasi, dan kondisi lingkungan selama produksi. Penelitian ini merekomendasikan optimalisasi proses fermentasi dan pengujian terhadap patogen lain untuk mengeksplorasi potensi antimikroba ekoenzim kayu putih.
Beban Psikologis dan Kualitas Hidup Pada Pasien Penyakit Paru Obstruktif Kronis: Sebuah Tinjauan Literatur Mochamad Rafi Pratama Hariyanto Putra; Rosyid, Alfian Nur
Jurnal Ilmiah Kesehatan Vol 17 No 2 (2025): Jurnal Ilmiah Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/jik.v17i2.3153

Abstract

Penyakit Paru Obstruktif Kronik (PPOK) merupakan beban kesehatan utama yang tidak hanya menyebabkan gangguan fisik tetapi juga beban psikologis signifikan berupa depresi, ansietas, dan penurunan kualitas hidup. Tinjauan literatur sistematis ini menganalisis 14 studi dari berbagai negara untuk mengidentifikasi hubungan antara beban psikologis dan kualitas hidup pasien PPOK. Hasil menunjukkan prevalensi depresi 17,6%-57,6% dan ansietas 37,2% pada pasien PPOK, terutama pada lansia. Faktor risiko meliputi gangguan tidur, usia lanjut, status sosial ekonomi rendah, durasi penyakit, dan keparahan klinis. Dampak signifikan meliputi keterbatasan aktivitas fisik, isolasi sosial, dan beban pada caregiver. Intervensi psikologis seperti wawancara motivasional, mindfulness, dan manajemen psikiatri dalam rehabilitasi pulmoner terbukti meningkatkan kualitas hidup dan mengurangi gejala psikologis. Pendekatan biopsikososial yang komprehensif, termasuk asesmen psikologis rutin, layanan multidisiplin, dukungan caregiver, dan kebijakan nasional yang mengakui kesehatan mental, sangat diperlukan untuk penatalaksanaan PPOK yang optimal.
Comparison of Clinical Characteristics of Pulmonary Tuberculosis Patients with and without Diabetes Mellitus at Dr. Soetomo Hospital Idwar, Fadiah Dini Putri; Wahyunitisari, Manik Retno; Wironegoro, Rio; Rosyid, Alfian Nur
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.78117

Abstract

Tuberculosis (TB) is a transmissible infectious condition attributable to Mycobacterium tuberculosis. Common symptoms of tuberculosis include a persistent cough lasting more than two weeks, fever, fatigue, malaise, and unintended weight loss. These symptoms may become more severe in individuals with co-infected Diabetes Mellitus (DM) due to impaired immunity. In 2021, approximately 400,000 people were reported to have TB-DM. Active TB can disrupt glucose tolerance, contributing to TB-DM2. Studies indicate this combination affects disease progression and treatment outcomes from both patients. This study employed an observational design with descriptive and analytical approaches. The study utilized medical record data from individuals diagnosed with TB who were managed at Dr. Soetomo General Academic Hospital in 2023.  There were 245 total patients, comprising 151 TB without DM and 94 TB with DM cases. The analysis demonstrated a statistically significant difference in mean age between the two groups (p = 0.000). In both groups, the majority were male (69.5%; 63.8%). Cough was more frequent in TB with DM patients (p = 0.038). The most common systemic symptom in both groups was weight loss (70.9%; 63.8%). AFB and GeneXpert MTB/RIF assays results showed no significant differences in between. However, significant differences were found in leukocyte, ALT, AST, and BUN levels (p = 0.001; 0.004; 0.019; 0.007). Radiological examinations showed no significant differences. TB patients with and without DM differ significantly in age, symptoms, and several laboratory parameters, suggesting that comorbidity may influence TB characteristics and clinical presentation.
Profile of Patients with Chronic Obstructive Pulmonary Disease (COPD) in Pulmonology Clinic, Universitas Airlangga Hospital, Surabaya, Indonesia, for the Period of January-December 2022 Susila, I Made Dwi Yudiartana Putra; Rosyid, Alfian Nur; Umiastuti, Pirlina; Bakhtiar, Arief
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 17 No. 1 (2026): JANUARY 2026 (IN-PROGRESS ISSUE)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V17I12026.15-21

Abstract

Highlights: Chronic obstructive pulmonary disease mainly occurs in male patients, elderly patients, and ex-smokers. Classification of COPD patient therapy must be chosen individually for each patient, which sometimes does not comply with existing guidelines.   Abstract Introduction: Chronic obstructive pulmonary disease (COPD) is a disease-causing breathing issue characterized by persistent and progressive airflow obstruction in response to noxious particles or gases and influenced by host factors. This study aimed to describe the profile trends, including age, sex, body mass index (BMI), complaints, physical examination findings, comorbidities, smoking history, exacerbations, COPD assessment test (CAT) score, modified Medical Research Council (mMRC) dyspnea scale, the Global Initiative for Chronic Obstructive Lung Disease (GOLD)-ABE grouping, and pharmacological therapy. Methods: Data collection included variables such as age, sex, BMI, complaints, physical examination, comorbidities, smoking history, exacerbations, CAT score, mMRC dyspnea scale, GOLD-ABE grouping, and pharmacological therapy. Results: A total of 73 patients were included. The sample was dominated by male patients (84.93%), aged 61-70 years old (38.35%), had normal BMI (63.01%), most complained of persistent cough (57.53%), had normal physical examination (97.26%), had no comorbidities (82.19%), ex-smokers (63.01%), and had no exacerbations (39.72%). Most were classified as Group B (50.68%) in the GOLD-ABE Group, medium (54.79%) on the CAT Score, and grade 1 (42.47%) on the mMRC dyspnea scale. Most patients were treated with long-acting β2-agonist (LABA)+inhaled corticosteroid (ICS) (79.45%) and mucolytics (27.40%). Conclusion: Chronic obstructive pulmonary disease predominantly affected elderly male patients, especially aged 61-70 years old, with a history of smoking. Most had a normal BMI, reported persistent cough, and had no comorbidities. Patients were primarily classified under GOLD-ABE Group B with moderate symptoms, while severe exacerbations were rare. Treatment mainly involved LABA+ICS combinations, though adherence to updated guidelines varied. Further research is needed to refine treatment strategies and to explore additional variables to improve management.
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Anastasya Annisa Karlina Ardi, Bangun Mukti Arifandi, Yoga Akbar Arina Dery Puspitasari Arina Dery Puspitasari Asmahan Farah Adiba Astanti, Erika Bakhtiar, Arief Bakhtiar, Arief Bambang Subakti Zulkarnain Brigitta Dhyah Kunthi Wardhani Brigitta Dhyah Kunthi Wardhani BUDI UTOMO D. Puspitasari, Arina Dava Aulia Dhieo Kurniawan Diah Indriani Duta, Garinda Alma Effendi, Wiwin Is Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Eunice Marlene Sicilia Kundiman Farah Meutia Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fatimatuz Zahra Oviary Satryo Fauzul Meiliani Fauzul Meiliani Fauzul Meiliani Fauzul Meiliani Hafidz Alfarobi Handira Nadhifatul Aini Hasanudin Hasanudin Herley Windo Setiawan Idwar, Fadiah Dini Putri Ika Nindya Kadariswantiningsih Indiastuti, Danti Nur Isnin Anang Marhana Izzatul Fitriyah Kusuma, Edward Putra Lie Liana Fuadiati Lily Aina Lily Aina Lily Aina Lily Aina M. Yamin Maftuchah Maftuchah Makhfudli Makhfudli Maranatha, Daniel Mareta Rindang Andarsari Maulana Antiyan Empitu Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Melinda Putri Amelia Rachman Mochamad Rafi Pratama Hariyanto Putra MOCHAMMAD THAHA Muhammad Amin Muhammad Amin Muhammad Rivai Mutiara Rizki Haryati Nafikhah, Wardah Zuhan Nanda Ardianto Nanda Ardianto Nanda Ardianto Nanda Ardianto Natalia Christin Tiara Revita Naura Alya Hirmadiani Nur Rachmawati Maulida Nursalam Nursalam Pharmasinta Putri Hapsari Prastuti Asta Wulaningrum Qona’ah, Arina Rahma, Rachel Sabila Resti Yudhawati Reyna Cesariyani Rahmadianti Rusuldi Riyanarto Sarno Sanchia Callista Raihanah Wiryawan Sarah Mahmudatun Nabila Sensusiati, Anggraini Dwi Sharifa Audi Salsabila Shintami Chusnul Hidayati Soenarnatalina Melaniani Suryantoro, Satriyo Dwi Susila, I Made Dwi Yudiartana Putra Tafana Fadhillah Laili Tamara nUR Budiarti Tamara Nur Budiarti Tamara Nur Budiarti Temenggung, Bintang Tintin Sukartini Sukartini, Tintin Sukartini Toetik Aryani Umiastuti, Pirlina Vatine Adila Wahyunitisari, Manik Retno Wedhana, Hilmy Indra Wironegoro, Rio Wiwin Is Effendi Wiwin Retnowati Yasmin Karimah Ikhsan Yulis Setiya Dewi Yuliza Yuliza Yusuke Suzuki Zedny Norachuriya