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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biomedical Journal of Indonesia Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Sriwijaya Journal of Surgery JURNAL KESEHATAN: JURNAL ILMIAH MULTI SCIENCES Indonesian Community Empowerment Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research International Archives of Medical Sciences and Public Health Ophthalmologica Indonesiana Indonesian Journal of Pharmacology and Therapy Journal of Medicine and Health
Theodorus
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Religion Humanities Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Counseling of the Use of Herbal Medicines for Health Care to the Community Parisa, Nita; Kamaluddin, M. T.; Theodorus; Saleh, Mgs. Irsan; Lusiana, Evi; Tamzil, Nia Savitri; Wicaksono, Bonanza Abi; Nashif, Arkan Abdullah
Indonesian Community Empowerment Journal Vol. 2 No. 2 (2022): Indonesian Community Empowerment Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/icejournal.v2i2.21

Abstract

Herbal medicine is growing quite rapidly, especially in every area that has traditional medicine using natural ingredients that are believed to treat disease. In addition, the use of herbal medicines is believed to have fewer side effects compared to conventional medicine. WHO also recommends the use of traditional and herbal medicines in efforts to maintain health, as well as prevent and treat diseases ranging from mild to chronic diseases. Based on the various problems faced, the purpose of implementing community service is to increase public knowledge and understanding of medicinal plants, independent health screening, and self-medication, and the role of supplements (vitamins and herbs) in health care and disease prevention efforts.
Efek Ekstrak Daun Kersen (Muntingia calabura L.) terhadap Kadar TNF-α pada Tikus Wistar Model Gout Artritis Akut Parisa, Nita; Tantoro, Valyn T; Adenina, Masayu S; Prananjaya, Bintang A; Saleh, Masagus I; Theodorus
Journal of Medicine and Health Vol 7 No 1 (2025)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v7i1.8629

Abstract

The inflammatory condition, marked by pain, swelling, and elevated TNF-α levels, prompted the exploration of cherry leaves' flavonoids, known for their anti-inflammatory properties. An in vivo experimental study with a pre-and post-test control group design was conducted to compare the efficacy of cherry leaf extract (Muntingia calabura L.) in the Wistar rat model of acute gout arthritis. Five treatment groups (negative control (Na-CMC 0,5%), positive control (Colchicine), cherry leaf extract dose 200mg/kgBW, cherry leaf extract dose 400mg/kgBW, and cherry leaf extract dose 800mg/kgBW) were administered to Wistar rats to compare their ability in reducing TNF-α levels. Results revealed the extract's significant efficacy in reducing TNF-α levels at all doses compared to negative control. There is no significant difference among the three different doses compared to colchicine as a positive control. In conclusion, cherry leaf extract demonstrated significant efficacy as an anti-inflammatory agent by reducing TNF-α levels in acute gout arthritis rat models with the most efficient dose of 200mg/kg BW.
The Relationship between Thoracic Trauma Scoring and Mortality in Blunt Thoracic Trauma Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Ahmat Umar; Marrantiza, Satria; Theodorus
Sriwijaya Journal of Surgery Vol. 6 No. 2 (2023): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v6i2.88

Abstract

Introduction: Closed thoracic trauma is frequently associated with rib fractures and pulmonary contusions. Thoracic trauma can be life-threatening if it is not treated immediately and properly. This study aimed to determine the relationship between thoracic trauma scoring and mortality in blunt thoracic trauma patients in sub-population Indonesia, especially at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This study is a cross-sectional observational study. A total of 70 research subjects participated in this study. Data analysis was carried out using SPSS in univariate and bivariate to determine the relationship between thoracic trauma scoring and mortality. Results: There is a significant relationship between CTS scores and mortality (p = 0.000). Patients with a CTS score ≥ 5 were significantly more at risk of dying than patients with a CTS score < 5 (p = 0.000). Conclusion: There is a relationship between CTS score and blunt trauma patient mortality thorax at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.
Predicting Conversion to Open Cholecystectomy: A Validation Study of the Difficult Laparoscopic Cholecystectomy Scoring System Muhammad Hafidh Komar; Imanuddin, Kiagus Ahmad; Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1137

Abstract

Background: Laparoscopic cholecystectomy (LC) has become the gold standard for managing symptomatic gallstone disease. However, a subset of patients requires conversion to open cholecystectomy (OC) due to intraoperative difficulties. The difficult laparoscopic cholecystectomy scoring system (DLCSS) has been proposed to predict the likelihood of conversion. This study aimed to validate the DLCSS in a single-center setting and assess its predictive accuracy for conversion to OC. Methods: A retrospective analysis was conducted on patients who underwent LC at Dr. Mohammad Hoesin General Hospital Palembang, Indonesia, between January and December 2023. Preoperative, intraoperative, and postoperative data were collected. The DLCSS was calculated for each patient, and its correlation with conversion to OC was analyzed using statistical methods. Results: A total of 30 patients were included in the study. The conversion rate to OC was 3.3%. Statistical analysis revealed a weak negative correlation between the DLCSS and conversion to OC (r = -0.318, p = 0.087), suggesting that higher DLCSS scores were associated with a slightly increased likelihood of conversion, although this association was not statistically significant. Conclusion: The DLCSS demonstrated limited predictive value for conversion to OC in our single-center study. Further research with larger sample sizes and diverse patient populations is needed to confirm the utility of the DLCSS in predicting conversion and to identify additional factors that may contribute to intraoperative difficulties during LC.
Correlation of TNF-α with Systemic Lupus Erythematosus Activity in Mohammad Hoesin Hospital Palembang Ismed, Yonis; Kurniati, Nova; Theodorus; Yuniza; Salim, Eddy Mart
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.349

Abstract

Systemic lupus erythematosus (SLE) is a persistent autoimmune disorder marked by immunological dysregulation and widespread inflammation.  Tumor necrosis factor-α (TNF-α), a pivotal pro-inflammatory cytokine, has been associated with the pathophysiology of systemic lupus erythematosus (SLE), although its clinical relevance is still debated.  This study aims to assess the connection between serum TNF-α levels and disease activity, as quantified by the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI), in Indonesian patients with systemic lupus erythematosus (SLE).  A cross-sectional study was performed including 34 patients exhibiting mild-to-moderate systemic lupus erythematosus activity (MEX-SLEDAI ≤12) at Dr. Mohammad Hoesin General Hospital in Palembang, Indonesia.  Individuals with significant active disease were excluded.  Serum TNF-α concentrations were quantified via a commercial ELISA kit, while disease activity was evaluated through MEX-SLEDAI.  Correlation analysis was conducted using Spearman’s rank test, with p < 0.05 being statistically significant.  The average age of participants was 33.6 ± 11.0 years, with 94.1% identifying as female.  The median MEX-SLEDAI score was 3 (range 2–7), and the median TNF-α level was 1.834 pg/mL (range 0.99–8.62).  No substantial connection was detected between serum TNF-α levels and disease activity (r = 0.111, p = 0.533).  This suggests that serum TNF-α levels did not correlate with or forecast clinical disease activity in this investigation.  The results indicate that the efficacy of TNF-α as a biomarker in SLE may be contingent upon contextual factors, especially illness severity.  Additional multicenter and longitudinal studies involving individuals with a broader spectrum of disease activity are necessary to elucidate its clinical significance.
Correlation Between Serum Malondialdehyde Levels and Disease Activity in Patients with Mild to Moderate Systemic Lupus Erythematosus Hartanto, Kristian; Kurniati, Nova; Theodorus; Yuniza; Salim, Eddy Mart
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.350

Abstract

Systemic lupus erythematosus (SLE) is characterized by persistent inflammation and oxidative stress, which contribute to the progression of the disease.   Lipid peroxidation is indicated by malondialdehyde (MDA).   The objective of this investigation was to evaluate the correlation between serum MDA levels and disease activity in patients with mild to moderate systemic lupus erythematosus (SLE).   This investigation was a cross-sectional correlation analysis that employed baseline data from adult patients with systemic lupus erythematosus who were receiving conventional treatment.   Spearman's correlation was employed to determine the relationship between serum MDA levels and disease activity, which was evaluated using the MEX-SLEDAI score.   The study encompassed 38 patients with mild to moderate SLE.   The MEX-SLEDAI score was 3 (range 2–7), and the median serum MDA concentration was 1.42 µmol/L (range 0.90–1.99).   Spearman's correlation analysis demonstrated a moderately positive correlation between serum MDA levels and MEX-SLEDAI scores (r = 0.415, p = 0.010), indicating that elevated oxidative stress is associated with increased disease activity in SLE patients.   A considerable positive correlation between serum malondialdehyde levels and disease activity is statistically significant in patients with mild to moderate systemic lupus erythematosus (SLE).   These results support the existence of oxidative stress in the pathophysiology of lupus and suggest that MDA may serve as a potential biomarker for disease monitoring.
Pemeriksaan helicobacter pylori dengan PCR dari lambung penderita gastritis kronis Novi Triana; Mezfi Unita; Jusuf Fantoni; Theodorus; Yuwono
Majalah Patologi Indonesia Vol. 19 No. 1 (2010)
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAKLatar belakangHelicobacter pylori (H.pylori atau Hp) adalah bakteri yang hidup pada mukus dan epitel lambungmanusia. Bakteri ini merupakan salah satu penyebab terjadinya gastritis, ulkus duodenum danlambung, atau salah satu faktor penyebab keganasan lambung. Di negara berkembang prevalensiH.pylori dilaporkan lebih tinggi dibandingkan negara maju. Angka prevalensi juga tergantung daristatus sosialekonomi, budaya, lingkungan dan genetik. Penelitian ini bertujuan untuk mengetahuiperbandingan nilai sensitifitas dan spesifisitas pemeriksaan PCR dengan pemeriksaan histopatologik dalam mendeteksi H.pylori serta mengetahui nilai dugaan positif dan negatif pemeriksaanPCR.MetodeSampel diambil dari arsip slide dan blok parafin di Laboratorium Patologi Anatomik, dan cairanlambung dari Laboratorium Mikrobiologi Fakultas Kedokteran Universitas Sriwijaya/Rumah SakitDr. Mohammad Hoesin Palembang. Jumlah sampel yang diperlukan untuk penelitian ini sebanyak30 sampel, kemudian dilakukan review oleh spesialis Patologi Anatomik, dilakukan pulasan Giemsadan pemeriksaan PCR untuk cairan lambung.HasilPada penelitian ini didapatkan 30 sampel, tujuh sampel (23,3%) dengan atrofi kelenjar, 5 sampel(16,7%) dengan metaplasia intestinal dan 14 sampel H.pylori positif (46,7%). Hasil pemeriksaansequen DNA H.pylori positif sebanyak 28 orang (93,3%) dan sequen DNA H.pylori negatif sebanyak2 orang (6,7%). Setelah dilakukan uji diagnostik didapati nilai sensitifitas 92,85%, spesifisitas6,25%, prediksi positif 46,4% dan prediksi negatif 50%. Sampel terbanyak (27) adalah gastritiskronik aktif, diikuti oleh gastritis kronik nonaktif.KesimpulanUntuk mengetahui adanya H.pylori pada lambung, pemeriksaan dengan metode PCR ini bisadijadikan pemeriksaan alternatif apabila pasien menolak untuk dilakukan biopsi lambung.
Hubungan Ekspresi Interleukin-17 dan Indeks Proliferasi Ki67 pada Karsinoma Payudara Ika Kartika,; Theodorus; Citra Dewi; Nyiayu Fauziah Kurniawati
Majalah Patologi Indonesia Vol. 30 No. 1, Januari 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.460

Abstract

BackgroundTumor cells have the ability to change the phenotype of inflammatory cells in the tumor environment into protumoral factors. One ofthe mediators produced such as interleukin 17 (IL-17) also plays a role in increasing tumor proliferation and invasion. Similar to IL-17,Ki67 has generally been used as a marker to assess the extent of breast carcinoma proliferation. This is the first study to determinethe relationship of IL-17 expression with Ki67 proliferation index of breast carcinoma patients.MethodsThis is a case series study using 38 paraffin block samples of breast carcinoma patients. The clinicopathological characteristicsdocumented are age, histopathological subtype and grade, TILs (tumor infiltrating lymphocytes) and molecular subtypes. Interleukin17 and Ki67 expressions were assessed using immunohistochemistry examination and data were analysed using the Pearson andSpearman test to assess correlations between the two variables.ResultsGeneral characteristics of the sample in this study were breast cancer patients aged >40 years (73.7%), histopathological subtypesof non-specific invasive carcinoma (84.2%), high tumor rates (78.9%), non-dominant TILs (94.7%) and molecular subtype luminal B(55.3%). There is no relationship between IL-17 expression and Ki67 proliferation index (p 0.72 and OR of 1.417), even though lowerexpression of IL-17 showed a higher Ki67 proliferation index.ConclusionExpression of IL-17 cannot describe the Ki67 proliferation index in breast carcinoma. Studies using another analytical techniques andlarge sample size are suggested to obtain more accurate results.
Analisis Ekspresi Interleukin-17 pada Karakteristik Klinikopatologi Karsinoma Payudara Nyiayu Fauziah Kurniawati; Ika Kartika; Citra Dewi; Theodorus
Majalah Patologi Indonesia Vol. 30 No. 1, Januari 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.461

Abstract

BackgroundInteraction between cancer cells and tumor microenvironment plays roles in cancer proliferation and invasiveness. Many type ofcytokine produced by inflammatory cells in tumor stroma could stimulate tumor proliferation and invasiveness, such as interleukin-17.The aim of this study is to determine the correlation between IL-17 expression and clinicopathological characteristics of breast cancer.MethodsSerial cases study was performed by enrolling 40 paraffin block of breast cancer patients. Clinicopathological characteirstics werenoted, including age, histopathological subtype and grade, TILs, lymphovascular invasion and molecular subtype. TILs were scoredby denomination area of stromal tissue occupied by mononuclear cells over total stromal area. Expression of IL-17 was examined byusing immunohistochemistry with anti-IL-17 antibody and counted from stromal mononuclear cells cytoplasm staining from five areas.The average value was used as a cut-off point in determining level of expression. Data were analysed by using SPSS v.22.ResultsMajority of the patients were more than 40 years old (75%), histopathological grade III (77.5%), without lymphovascular invasion(62.5%), luminal B molecular subtype (57.5%), and non-dominant TILs (95%). IL-17 expression was not significantly correlated withclinicopathological characteristics with p value=0.079, 0.600, 0.739, 0.883 and 1.000 respectively for age, histological grade,lymphovascular invasion, molecular subtype and TILs.ConclusionInterleukin-17 expression and clinicopathological on characteristics of breast carcinoma between histopathological grade, TILs, andlymphovascular invasion showed no significant differences. There was a tendency that the higher IL-17 expression, the higherhistopathological grade, the lower TILs and positive lymphovascular invasion
PURPLE SWEET POTATO EXTRACT ATTENUATES GENTAMICIN-INDUCED HEPATOTOXICITY IN WISTAR RATS Lusiana, Evi; Theodorus; Putri, Khairunnisa Rizqika Amanda
International Archives of Medical Sciences and Public Health Vol. 7 No. 1 (2026): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v7i1.1474

Abstract

Purple sweet potato extract (Ipomoea batatas L.) has hepatoprotective potential due to its antioxidant properties. This study evaluated the effect of purple sweet potato extract (PSPE) on gentamicin-induced hepatotoxicity in male Wistar rats. Thirty rats were divided into five groups: negative control, positive control, and PSPE-treated groups receiving 50, 100, and 200 mg/kg body weight (BW). Hepatotoxicity was induced using gentamicin for seven days, followed by extract administration for fourteen days. Caspase-3 expression was analyzed using immunohistochemistry, while fibrosis was assessed using Masson’s Trichrome staining and METAVIR scoring. One-way ANOVA showed significant differences in Caspase-3 expression among groups (p ¡ 0.001). PSPE was associated with reduced Caspase-3 expression and attenuated hepatic fibrosis, with the strongest effect observed at 200 mg/kgBW. Histopathological evaluation showed predominantly METAVIR grade F0 fibrosis at doses of 100 and 200 mg/kgBW. These findings suggest potential hepatoprotective effects of PSPE in this preclinical model of gentamicin-inducedhepatotoxicity.
Co-Authors Abda Arif Adenina, Masayu S Agustian, Wisman Agustina Br Haloho Ahmat Umar Alsen Arlan Amanda Putri, Khairunnisa Rizqika Anak Agung Gede Sugianthara Apriani Apriani Ayeshah A Rosdah Bobi Wijaya Citra Dewi Darwin, Nopriansyah Debby Handayati Harahap Dian Puspita Sari Eddy Mart Salim, Eddy Mart Efman Manawan Egha Eka Satyani Belina Evi Lusiana Fitrisyah, Aidyl Gerry Armando H.M.T. Kamaluddin Hardi Darmawan Hartanto, Kristian Ika Kartika Ika Kartika Ika Kartika, Imanuddin, Kiagus Ahmad Ismed, Yonis Jusuf Fantoni kurniati, nova M. T. Kamaluddin M.T. Kamaluddin Marrantiza, Satria Mezfi Unita Mgs. Irsan Saleh, Mgs. Irsan Mgs.Irsan Saleh Muhammad Hafidh Komar Mulawan Umar Nashif, Arkan Abdullah Nita Parisa Novi Triana Novianty Nurwany, Raissa Nyiayu Fauziah Kurniawati PATIYUS AGUSTIANSYAH, PATIYUS Prananjaya, Bintang A Putra, Chani Sinaro Putri, Khairunnisa Rizqika Amanda Qodir, Nur Ramzi Amin, Ramzi Rima Zanaria Rizal Sanif Roni Ferdi Rose Mafiana Rukmana, Cici Chintya Aulia Ruli Robi Ferli Saleh, Masagus I Salni Sastradinata, Irawan Sonata Daniatiek Sutomo Tanzil Syafei, Abdul Tantoro, Valyn T Veny Larasati Wicaksono, Bonanza Abi Windi Astriana Yuniza Yuwono