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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biomedical Journal of Indonesia Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Sriwijaya Journal of Surgery JURNAL KESEHATAN: JURNAL ILMIAH MULTI SCIENCES Indonesian Community Empowerment Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Social Science, Educational, Economics, Agriculture Research, and Technology (IJSET) Ophthalmologica Indonesiana Indonesian Journal of Pharmacology and Therapy Journal of Medicine and Health
Theodorus
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Predicting Conversion to Open Cholecystectomy: A Validation Study of the Difficult Laparoscopic Cholecystectomy Scoring System Muhammad Hafidh Komar; Imanuddin, Kiagus Ahmad; Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1137

Abstract

Background: Laparoscopic cholecystectomy (LC) has become the gold standard for managing symptomatic gallstone disease. However, a subset of patients requires conversion to open cholecystectomy (OC) due to intraoperative difficulties. The difficult laparoscopic cholecystectomy scoring system (DLCSS) has been proposed to predict the likelihood of conversion. This study aimed to validate the DLCSS in a single-center setting and assess its predictive accuracy for conversion to OC. Methods: A retrospective analysis was conducted on patients who underwent LC at Dr. Mohammad Hoesin General Hospital Palembang, Indonesia, between January and December 2023. Preoperative, intraoperative, and postoperative data were collected. The DLCSS was calculated for each patient, and its correlation with conversion to OC was analyzed using statistical methods. Results: A total of 30 patients were included in the study. The conversion rate to OC was 3.3%. Statistical analysis revealed a weak negative correlation between the DLCSS and conversion to OC (r = -0.318, p = 0.087), suggesting that higher DLCSS scores were associated with a slightly increased likelihood of conversion, although this association was not statistically significant. Conclusion: The DLCSS demonstrated limited predictive value for conversion to OC in our single-center study. Further research with larger sample sizes and diverse patient populations is needed to confirm the utility of the DLCSS in predicting conversion and to identify additional factors that may contribute to intraoperative difficulties during LC.
Correlation of TNF-α with Systemic Lupus Erythematosus Activity in Mohammad Hoesin Hospital Palembang Ismed, Yonis; Kurniati, Nova; Theodorus; Yuniza; Salim, Eddy Mart
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.349

Abstract

Systemic lupus erythematosus (SLE) is a persistent autoimmune disorder marked by immunological dysregulation and widespread inflammation.  Tumor necrosis factor-α (TNF-α), a pivotal pro-inflammatory cytokine, has been associated with the pathophysiology of systemic lupus erythematosus (SLE), although its clinical relevance is still debated.  This study aims to assess the connection between serum TNF-α levels and disease activity, as quantified by the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI), in Indonesian patients with systemic lupus erythematosus (SLE).  A cross-sectional study was performed including 34 patients exhibiting mild-to-moderate systemic lupus erythematosus activity (MEX-SLEDAI ≤12) at Dr. Mohammad Hoesin General Hospital in Palembang, Indonesia.  Individuals with significant active disease were excluded.  Serum TNF-α concentrations were quantified via a commercial ELISA kit, while disease activity was evaluated through MEX-SLEDAI.  Correlation analysis was conducted using Spearman’s rank test, with p < 0.05 being statistically significant.  The average age of participants was 33.6 ± 11.0 years, with 94.1% identifying as female.  The median MEX-SLEDAI score was 3 (range 2–7), and the median TNF-α level was 1.834 pg/mL (range 0.99–8.62).  No substantial connection was detected between serum TNF-α levels and disease activity (r = 0.111, p = 0.533).  This suggests that serum TNF-α levels did not correlate with or forecast clinical disease activity in this investigation.  The results indicate that the efficacy of TNF-α as a biomarker in SLE may be contingent upon contextual factors, especially illness severity.  Additional multicenter and longitudinal studies involving individuals with a broader spectrum of disease activity are necessary to elucidate its clinical significance.
Correlation Between Serum Malondialdehyde Levels and Disease Activity in Patients with Mild to Moderate Systemic Lupus Erythematosus Hartanto, Kristian; Kurniati, Nova; Theodorus; Yuniza; Salim, Eddy Mart
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.350

Abstract

Systemic lupus erythematosus (SLE) is characterized by persistent inflammation and oxidative stress, which contribute to the progression of the disease.   Lipid peroxidation is indicated by malondialdehyde (MDA).   The objective of this investigation was to evaluate the correlation between serum MDA levels and disease activity in patients with mild to moderate systemic lupus erythematosus (SLE).   This investigation was a cross-sectional correlation analysis that employed baseline data from adult patients with systemic lupus erythematosus who were receiving conventional treatment.   Spearman's correlation was employed to determine the relationship between serum MDA levels and disease activity, which was evaluated using the MEX-SLEDAI score.   The study encompassed 38 patients with mild to moderate SLE.   The MEX-SLEDAI score was 3 (range 2–7), and the median serum MDA concentration was 1.42 µmol/L (range 0.90–1.99).   Spearman's correlation analysis demonstrated a moderately positive correlation between serum MDA levels and MEX-SLEDAI scores (r = 0.415, p = 0.010), indicating that elevated oxidative stress is associated with increased disease activity in SLE patients.   A considerable positive correlation between serum malondialdehyde levels and disease activity is statistically significant in patients with mild to moderate systemic lupus erythematosus (SLE).   These results support the existence of oxidative stress in the pathophysiology of lupus and suggest that MDA may serve as a potential biomarker for disease monitoring.
SUSTAINABLE MENTORING IN THE USE OF ONLINE LEARNING PLATFORMS TO ENHANCE THE EFFECTIVENESS OF CHRISTIAN RELIGIOUS EDUCATION TEACHING IN RURAL SCHOOLS [A SYSTEMATIC LITERATURE REVIEW] Esterani; Resti; Daniel Nianda; Theodorus
International Journal of Social Science, Educational, Economics, Agriculture Research and Technology (IJSET) Vol. 4 No. 11 (2025): OCTOBER
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54443/ijset.v5i1.1508

Abstract

This article presents a systematic literature review on continuous mentoring in using online platforms to enhance the effectiveness of Christian Religious Education (CRE) teaching in rural schools. Based on an analysis of 17 empirical articles (2020-2024), this study identifies multidimensional challenges faced by teachers, including limited infrastructure, low digital pedagogy competence, and psychological barriers such as technostress. The synthesis reveals that effective mentoring models are sustainable and contextual, combining instructional coaching for individual support and virtual communities of practice (VCoP) for peer collaboration. This approach significantly enhances complex dimensions of teachers' TPACK particularly Technological Pedagogical Knowledge (TPK) and Technological Content Knowledge (TCK) enabling them to design more interactive, reflective, and contextual online CRE learning. Key success factors include contextualizing materials for low-bandwidth conditions, building trust-based mentor-teacher relationships, and active support from school leadership. The findings provide an evidence-based foundation for policymakers and practitioners to design targeted mentoring programs that improve the quality of online CRE learning in rural areas.
THE ROLE OF SOCIAL MEDIA IN SHAPING CHRISTIAN CHARACTER AMONG GENERATION Z Resti; Esterani; Daniel Nianda; Theodorus
International Journal of Social Science, Educational, Economics, Agriculture Research and Technology (IJSET) Vol. 4 No. 12 (2025): NOVEMBER
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54443/ijset.v4i12.1545

Abstract

The 21st century has witnessed a radical transformation in human communication ecology, with social media evolving from mere connection platforms into a primary lifeworld for young people. Generation Z, growing up in an intrinsically digital environment, internalizes the logic, norms, and rhythms of social media into their identity construction. This study employs a Systematic Literature Review (SLR) method to analyze 32 empirical studies (2019-2024) exploring the role of social media in shaping Christian character among Generation Z. The findings reveal a dual formative role: social media acts as a Curated Sanctuary, providing unprecedented access to spiritual resources, communities, and role models, while simultaneously functioning as an Algorithmic Arena that fosters performative piety, theological reduction, and value conflicts. In response, Generation Z demonstrates active agency through negotiation strategies like content curation, compartmentalization, and digital fasting, leading to the formation of a hybrid habitus. This review proposes a Critical Digital Discipleship Framework as an integrative model emphasizing theological digital literacy, intentional curation, and embodied integration to guide effective character formation in the digital age.
Systemic Neuroinflammatory Signatures in Lumbar Spinal Stenosis: An Exploratory Correlation of Serum IL-1β and hs-CRP with Schizas Morphological Grading Arazy Gifta Prima; Rendra Leonas; Theodorus
Sriwijaya Journal of Surgery Vol. 9 No. 1 (2026): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v9i1.142

Abstract

Introduction: The clinical-radiological paradox in lumbar spinal stenosis (LSS) suggests that anatomical compression alone fails to explain symptom severity. Emerging evidence points to a bio-active stenotic environment driven by chronic neuroinflammation. This study aimed to investigate whether the morphological severity of stenosis, graded by the Schizas classification, correlates with systemic inflammatory biomarkers (Interleukin-1β and high-sensitivity C-reactive protein) after strictly controlling for pharmacological confounders. Methods: A prospective, cross-sectional exploratory pilot study was conducted on 30 patients with degenerative LSS. To isolate stenosis-induced inflammation, strictly non-obese patients (BMI <30 kg/m²) underwent a verified 7-day NSAID/steroid washout period. Stenosis severity was graded on MRI using the Schizas classification. Due to small sample size in extreme stenosis, Grades C and D were merged into a severe stenosis cohort. Serum IL-1β and hs-CRP were quantified via ELISA. Statistical analysis utilized Kruskal-Wallis tests and bootstrapped multivariate linear regression (1,000 resamples) to control for Age, BMI, and multicollinearity (VIF). Results: The cohort was stratified into Grade A (n=10), Grade B (n=11), and Severe Grade C/D (n=9). Systemic inflammatory markers demonstrated a significant stepwise elevation corresponding to morphological severity. Median IL-1β levels rose from 5.60 (IQR 4.9–6.4) pg/mL in Grade A to 11.20 (IQR 9.1–13.8) pg/mL in the Severe group (p<0.001). Similarly, hs-CRP increased from 2.15 mg/L to 4.90 mg/L (p=0.003). Bootstrapped regression confirmed that Schizas severity remained a significant independent predictor of IL-1β (β=0.46, p=0.012) and CRP (β=0.49, p=0.009) with acceptable variance inflation factors (VIF < 2.5), validating the model despite age-related correlations. Conclusion: Morphological severity of the dural sac significantly correlates with systemic inflammatory burden. Severe mechanical compression appears to induce a spillover effect, creating a detectable peripheral inflammatory signature. These biomarkers may serve as objective adjuncts to MRI in conflicting clinical scenarios.
Co-Authors Abda Arif Adenina, Masayu S Agustian, Wisman Agustina Br Haloho Ahmat Umar Akbar Rizky Wicaksana Alsen Arlan Amanda Putri, Khairunnisa Rizqika Anak Agung Gede Sugianthara Anugerah Onie Widhiatmo Apriani Apriani Arazy Gifta Prima Arie Hasiholan Lumban Tobing Ayeshah A Rosdah Bobi Wijaya Charita Ulfah Widyawan Citra Dewi Daniel Nianda Darwin, Nopriansyah Debby Handayati Harahap Dian Puspita Sari Eddy Mart Salim, Eddy Mart Efman Manawan Egha Eka Satyani Belina Esterani Evi Lusiana Fitrisyah, Aidyl Gerry Armando H.M.T. Kamaluddin Hardi Darmawan Hartanto, Kristian Ika Kartika Ika Kartika, Imanuddin, Kiagus Ahmad Ismail Bastomi Ismed, Yonis Jaya Ndaru Prasetio Jayawarsa, A.A. Ketut Jusuf Fantoni kurniati, nova Larasati, Veny M. T. Kamaluddin M.T. Kamaluddin Marrantiza, Satria Mezfi Unita Mgs. Irsan Saleh, Mgs. Irsan Mgs.Irsan Saleh Muhammad Hafidh Komar Muhammad Rizqi Firyal Muhammad Yufimar Riza Fadilah Mulawan Umar Nashif, Arkan Abdullah Nita Parisa Novi Triana Novianty Nurwany, Raissa Nyiayu Fauziah Kurniawati PATIYUS AGUSTIANSYAH, PATIYUS Prananjaya, Bintang A Putra, Chani Sinaro Qodir, Nur Ramzi Amin, Ramzi Rendra Leonas Resti Rima Zanaria Rizal Sanif Roni Ferdi Rose Mafiana Rukmana, Cici Chintya Aulia Ruli Robi Ferli Saleh, Masagus I Salni Sastradinata, Irawan Satya Agusmansyah Sonata Daniatiek Sutomo Tanzil Syafei, Abdul Tantoro, Valyn T Wicaksono, Bonanza Abi Windi Astriana Yuniza Yuwono