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The Influence of Murottal Al- Quran Exposure to Leydig Cell Of Stressed Male Mice (Mus Musculus) Meilina Ratna Dianti; Yen Yen Ari Indrawijaya; Fidia Rizkiah Inayatilah; Alifah Nurin Zuhdina
Journal of Islamic Medicine Vol 6, No 2 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i2.9888

Introduction: Stress is a body's response experienced by a person due to burdened feelings or oppressed in a particular event. Stress may interfere body's homeostasis. One of them is the spermatogenesis process. Healthy stress management is necessary, for example, by doing murottal Al-Qur'an. Reading Al-Qur'an with tartil delivers a beautiful tone and has a relaxing effect and stress release. This research aims to determine the effect of murottal Al-Qur'an on the amount of Leydig cells on male mice (Mus musculus) who are experiencing stress. The compressor used is noise from the road with an intensity of 85dB, given for 12 hours (18.00-06.00) for 21 days. The therapy used was murottal Al-Quran surah Ar-Rahman verses 1-78, which read by Shaykh Abdurrahman Sudais. In this research there were five categories, they are K+ (not given the stressor and murottal therapy), K- (given noise stressors and not given murottal therapy), P1 (given noise stressors for 12-hours and murottal therapy for 1-hour), P2 (given noise stressor for 12-hours and murottal therapy for 2-hours), P3 (given a stress stressor for 12-hours and murottal therapy for 4-hours). Moreover, observations were done on testicular histology preparations with Hematoxylin Eosin staining in olyvia (c) applications. The number of Leydig cells was examined with a 40x magnification microscope. Cell calculations are done manually with the image raster application. The results revealed that murottal Al-Quran is able to significantly affect the number of Leydig cells (p value = 0,000). Lastly, it can be concluded that there is an influence of murottal Al-Quran on the number of Leydig cells in male mice under stress. Keyword : Stress, Noice, Murottal Al-Aquran, Surah Ar-Rahman, Leydig Cell

Analisis Efektivitas Biaya Terapi Kombinasi Insulin dengan Obat Antidiabetes Oral pada Pasien Rawat Jalan Penderita Diabetes Melitus Tipe 2 di RSUD dr. Soehadi Prijonegoro Sragen Daffa Dhiya Ulhaq; Yen Yen Ari Indrawijaya; Arief Suryadinata
Journal of Islamic Pharmacy Vol 7, No 2 (2022): J. Islamic. Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i2.16376

Diabetes melitus tipe 2 (DM 2) adalah penyakit kronis menahun karena resistensi insulin atau akibat dari berkurangnya sekresi insulin oleh sel beta pankreas. Pengobatan DM 2 berupa terapi oral dan insulin. Cost-Effectiveness Analysis adalah metode analisis untuk mengambil keputusan alternatif terbaik dari terapi yang digunakan. Tujuan penelitian ini mengetahui efektivitas biaya terapi kombinasi insulin dengan antidiabetes oral (ADO) pada pasien rawat jalan di RSUD dr. Soehadi Prijonegoro Sragen tahun 2021. Metode penelitian ini non-eksperimental deskriptif dengan pengambilan data secara retrospektif. Data yang diambil yaitu data rekam medis pasien rawat jalan DM 2 di RSUD dr. Soehadi Prijonegoro Sragen tahun 2021. Parameter yang digunakan yaitu kadar gula darah puasa (GDP) dan biaya medis langsung meliputi biaya pendaftaran, biaya jasa dokter, biaya obat, dan biaya laboratorium. Pasien yang memenuhi kriteria inklusi sebanyak 49 pasien. Terdapat 5 macam kombinasi obat antidiabetes yang diberikan kepada pasien yaitu insulin + ADO (61,22%), insulin + 2 ADO (8,16%), 2 insulin + ADO (14,28%), 2 insulin + 2 ADO (4,08%), dan insulin + 3 ADO (4,08%). Efektivitas terapi dilihat dari jumlah GDP normal dibagi jumlah total pemeriksaan GDP dikali 100%. Efektivitas terapi tertinggi 100% dan terendah 0%. Biaya medis langsung tertinggi Rp. 1.066.520,- dengan terapi Apidra + Sansulin + Metformin + Pioglitazone. Terapi antidiabetes dengan biaya rendah dan paling efektif yaitu terapi dengan ACER terendah dan ICER negatif yaitu terapi Sansulin + Metformin dengan ACER sebesar Rp. 4.320,- dan ICER sebesar Rp. -13,381,-.

The level of community knowledge about the use of antibiotics Hajar Sugihantoro; Ismea Munawaroh; Fidia Rizkiah Inayatillah; Yen Yen Ari Indrawijaya
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.23917

Knowledge and use of antibiotics play a large and important role in the success of treatment, so that they do not cause negative effects, such as the cause of antibiotic resistance. The purpose of this study was to determine the profile and level of knowledge of the community regarding the use of antibiotics in Banyior Village, Sepulu District, Bangkalan Regency, East Java, Indonesia. This research is a cross-sectional descriptive study. The measurement is a closed questionnaire. Data were analyzed using SPSS version 18. The survey was conducted from October 2021 to December 2022 on 325 residents of Banyior Village. The result is that the antibiotic most often used by respondents is amoxicillin with a percentage of 47%. The majority of respondents, 45 percent, get antibiotics from drugstores or stalls. The knowledge level of the general public shows a good level of knowledge of 6.82%, an average level of knowledge of 19.60% and a low level of knowledge of 73.57%. The most widely used antibiotic by respondents in this study was amoxicillin, where the most common way to obtain it was through drug stores/stalls and public knowledge of the use of antibiotics was still low.

Potensi Senyawa Nitazoxanide dan Arbidol sebagai Antivirus SARS-CoV-2 terhadap Reseptor NSP5 (7BQY dan 2GZ7) dan ACE2 (3D0G dan 1R4L) Ami Fini Faqiha; Yen Yen Ari Indrawijaya; Arief Suryadinata; Muhammad Amiruddin; Roihatul Mutiah
Journal of Food and Pharmaceutical Sciences Vol 10, No 1 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3393

Nitazoxanide merupakan obat pro-drug untuk tizoxanide. Obat tersebut diketahui memiliki aktivitas antivirus pada MERS-CoV. Arbidol memiliki aktivitas antivirus pada H3N2 HA yang memiliki kesamaan struktur dengan SARS-CoV-2. Reseptor target spesifik untuk obat-obat Anti SARS-CoV-2 saat ini adalah NSP5 (Nonstructural protein) dan ACE2 (Angiotensin-converting enzyme 2). NSP5 memediasi replikasi dan transkripsi protein-protein virus sedangkan ACE2 sebagai fasilitator transport asam amino dan reseptor tempat terikatnya SARS-CoV maupun SARS-CoV-2. Tujuan penelitian ini adalah untuk mengetahui aktivitas antivirus SARS-CoV-2 dari senyawa Nitazoxanide dan Arbidol secara in silico. Senyawa Nitazoxanide dan Arbidol dipreparasi terlebih dahulu dengan melakukan pengunduhan kode PDB ID, penyiapan struktur 2D dan 3D, penentuan minimal energy, pembuatan kode SMILES serta prediksi sifat fisikokimia dan toksisitas. Setelah dipreparasi, dilanjutkan proses penambatan molekul menggunakan aplikasi PyRx-Vina®. Hasil docking dianalisis dengan perangkat lunak PyMOL® dan Discovery Studio Visualizer®. Hasil profil fisikokimia menunjukkan bahwa senyawa Arbidol dan Nitazoxanide telah memenuhi hukum Lima Lipinski dan masing-masing memiliki nilai LD50 sebesar 1350 mg/kg dan 340 mg/kg. Hasil penambatan senyawa uji dengan reseptor menghasilkan interaksi yaitu ikatan hidrogen, interaksi hidrofobik dan interaksi elektrostatik. Interaksi Nitazoxanide pada reseptor 2GZ7 serta Arbidol pada reseptor 3D0G dan 1R4L menunjukkan perbedaan yang signifikan masing-masing terhadap Lopinavir dan Chloroquine dengan nilai p < 0.05, sehingga senyawa tersebut diprediksi memiliki potensi antivirus lebih baik.

In Silico Studies on The Potential of Green Tea Catechin Compounds (Camellia sinensis) as Antiviral of SARS CoV-2 Againts Spike Glycoprotein (6LZG) and Main Protease (5R7Y) Futna Naufa; Roihatul Mutiah; Yen Yen Ari Indrawijaya
Journal of Food and Pharmaceutical Sciences Vol 10, No 1 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3580

COVID-19 is a disease caused by SARS CoV-2 by producing structural proteins and non-structural proteins. SARS CoV-2 uses a spike glycoprotein to bind ACE-2 receptors in host cells and uses main protease to replicate. This research aims to screen green tea catechin derivates as an antiviral for SARS CoV-2 through inhibition of spike glycoprotein (6LZG) and main protease (5R7Y). In silico studies carried out are molecular docking, prediction of physicochemical properties, and prediction of toxicity. The potential inhibition was assessed based on binding affinity and interaction of amino acid residues. From the molecular docking process showed that epicatechin and epigallocatechin provide inhibition to spike glycoprotein better than nafamostat indicated by binding affinity of -5.2 kcal/mol and -4.5 kcal/mol, while epigallocatechin gallate and epicatechin gallate provide inhibiton to main protease better than lopinavir with binding affinity of -8.7 kcal/mol and -8.3 kcal/mol. The results of the physicochemical properties prediction showed that only epigallocatechin gallate that did not fulfill five Lipinski's rule. Based on the toxicity class LD50, the derivates of catechin belong to classes 4 and 6. In conclusion, it can be known that epicatechin and epigallocatechin can be developed as an antiviral for SARS CoV-2.

Formulation and Characterization on Self Nanoemulsifying Drug Delivery System of Eleutherine Palmifolia Extract Employing Short, Medium, and Long Chain Triglyceride Rahmi Annisa; Yen Yen Ari Indrawijaya; Dewi Sinta Megawati; Ana Fikrotus Zakia
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 2 (2020): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i2.232

Eleutherine palmifolia (E. palmifolia) is a common plant used as an anticancer drug in Kalimantan, Indonesia. The active compound present in it is naphthoquinone, which has low water solubility and needs to be formulated into SNEDDS preparations to improve its dissolution and bioavailability in the body. The dispersion method is used in the preparation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) and PEG 400 cosurfactants. Furthermore, this study aims to ascertain the effects of oil on the SNEDDS preparations. The results showed that the effect of the preparations on olive oil, VCO, and oleic acid in the organoleptic test produced dark red, clear, and non functional emulsion. The average particle sizes obtained in the AGF media were 61,10, 774,33, and 211,70 nm; in AIF media it amounted to 211,70, 123,65, and 830,22 nm. The pH value for each formula was 6,8, while the average emulsification time for the AGF media was 24,10, 22,53, and 25,75 seconds, and, lastly, for the AIF media, they were 20,96, 19,62, and 23,74 second.

Changes on Serum Troponin T Level before and after Taking Standard Therapy Medication in Heart Failure Patients Indrawijaya, Yen Yen Ari; Suharjono, Suharjono; Aminuddin, Muhammad; Retnowati, Endang; Rahman, Gilang Mauladi
Folia Medica Indonesiana Vol. 56 No. 1 (2020): March
Publisher : Universitas Airlangga

Patients with advanced heart failure (NYHA FC III and IV heart failure) had positive cardiac troponin levels in previous cohort studies. In heart failure, cardiac troponin T (cTnT) is a biomarker that is sensitive to myocardial damage, especially myocardial necrosis. However, there is still little information regarding changes in cTnT levels during standard therapy. This prospective observational study is aimed at evaluating changes in cTnT levels before and after theadministration of standard therapy and evaluating symptom improvement before and after the administration of standard therapy in patients with severe heart failure. Measurement of cTnT levels and symptom improvement parameters before treatment was carried out on the first day of the inpatient and measurement after therapy was carried out on the last day of the inpatient. Sampling was done by consecutive sampling and found 30 patients in the inpatient room of the SMF Cardiovascular Disease, Dr. Soetomo Hospital, Surabaya during the months of May-July 2017. The results of the study obtained the average cTnT levels before therapy 33.48 + 31.88 pg/ml and the average cTnT levels after therapy 46.32 + 52.68 pg/ml. Based on the statistical difference test with the Wilcoxon sign-ranked test, there was no significant change in cTnT levels (p = 0.318). On the parameter of clinical symptom improvement, there was a significant decrease in pulse, respiratory rate, blood pressure, and mean arterial pressure before and after administration of therapy (p <0.05). There was no change in troponin T levels before and after the administration of therapy meant there was no worsening of myocardial necrosis.

Edukasi Vaksinasi Covid-19 dan Peningkatan Daya Tahan Tubuh melalui Suplemen Kesehatan Maimunah, Siti; Ari Indrawijaya, Yen Yen; Ayudianti, Prida; Nur Hasan, Yuliono Trika
JRCE (Journal of Research on Community Engagement) Vol 4, No 1 (2022): Journal of Research on Community Engagement
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jrce.v4i1.15793

At the end of 2019, a corona virus known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was discovered and spread rapidly, resulting in a global pandemic. In February 2020, the World Health Organization (WHO) defined the disease as COVID-19, which stands for Coronavirus Disease 2019. When the immune system or immune system does not function properly, the body will experience a disease that can cause death. Having a good immune system is an effort to deal with COVID-19. Vaccines to prevent SARS-CoV-2 infection are considered to be the most promising approach to curb the pandemic and are being pursued vigorously. Development of Standardized Herbal Medicines and Phytopharmaceuticals in Indonesia, in addition to promoting and protecting the use of native Indonesian medicinal plants, is also for the realization of measures in the community in dealing with controlling the spread of COVID-19 in Indonesia. This service aims to be able to determine the level of knowledge about vaccines, maintaining immunity, and public health supplements around the Faculty of Medicine and Health Sciences, especially Krajan Hamlet, Sumbersekar Village, Dau Regency which is located 9.3 KM from campus III. The measurement of the level of knowledge was carried out by filling out the pretest and posttest by the respondents.

The Influence of Murottal Al- Quran Exposure to Leydig Cell Of Stressed Male Mice (Mus Musculus) Dianti, Meilina Ratna; Indrawijaya, Yen Yen Ari; Inayatilah, Fidia Rizkiah; Zuhdina, Alifah Nurin
Journal of Islamic Medicine Vol 6, No 2 (2022): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2022
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v6i2.9888

Introduction: Stress is a body's response experienced by a person due to burdened feelings or oppressed in a particular event. Stress may interfere body's homeostasis. One of them is the spermatogenesis process. Healthy stress management is necessary, for example, by doing murottal Al-Qur'an. Reading Al-Qur'an with tartil delivers a beautiful tone and has a relaxing effect and stress release. This research aims to determine the effect of murottal Al-Qur'an on the amount of Leydig cells on male mice (Mus musculus) who are experiencing stress. The compressor used is noise from the road with an intensity of 85dB, given for 12 hours (18.00-06.00) for 21 days. The therapy used was murottal Al-Quran surah Ar-Rahman verses 1-78, which read by Shaykh Abdurrahman Sudais. In this research there were five categories, they are K+ (not given the stressor and murottal therapy), K- (given noise stressors and not given murottal therapy), P1 (given noise stressors for 12-hours and murottal therapy for 1-hour), P2 (given noise stressor for 12-hours and murottal therapy for 2-hours), P3 (given a stress stressor for 12-hours and murottal therapy for 4-hours). Moreover, observations were done on testicular histology preparations with Hematoxylin Eosin staining in olyvia (c) applications. The number of Leydig cells was examined with a 40x magnification microscope. Cell calculations are done manually with the image raster application. The results revealed that murottal Al-Quran is able to significantly affect the number of Leydig cells (p value = 0,000). Lastly, it can be concluded that there is an influence of murottal Al-Quran on the number of Leydig cells in male mice under stress. Keyword : Stress, Noice, Murottal Al-Aquran, Surah Ar-Rahman, Leydig Cell

The level of community knowledge about the use of antibiotics Sugihantoro, Hajar; Munawaroh, Ismea; Inayatillah, Fidia Rizkiah; Indrawijaya, Yen Yen Ari
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.23917

Knowledge and use of antibiotics play a large and important role in the success of treatment, so that they do not cause negative effects, such as the cause of antibiotic resistance. The purpose of this study was to determine the profile and level of knowledge of the community regarding the use of antibiotics in Banyior Village, Sepulu District, Bangkalan Regency, East Java, Indonesia. This research is a cross-sectional descriptive study. The measurement is a closed questionnaire. Data were analyzed using SPSS version 18. The survey was conducted from October 2021 to December 2022 on 325 residents of Banyior Village. The result is that the antibiotic most often used by respondents is amoxicillin with a percentage of 47%. The majority of respondents, 45 percent, get antibiotics from drugstores or stalls. The knowledge level of the general public shows a good level of knowledge of 6.82%, an average level of knowledge of 19.60% and a low level of knowledge of 73.57%. The most widely used antibiotic by respondents in this study was amoxicillin, where the most common way to obtain it was through drug stores/stalls and public knowledge of the use of antibiotics was still low.

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