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Andriani, Medi
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Uji Efektivitas Daun Sirih Merah (Piper crocatum) Terhadap Penurunan Kadar Gula Darah Mencit Putih Jantan (Mus musculus) yang Diinduksi Aloksan Andriani, Medi; Putra, Rizki Yulion; Rosyta, Dini Galoh
BIOEDUSCIENCE Vol 8 No 2 (2024): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/13320

Abstract

Background: Hyperglycemia is when blood sugar levels increase excessively from normal sugar levels. High blood sugar levels in the body that exceed normal limits occur when the random blood sugar test value is ≥200 mg/dl and fasting blood sugar is ≥126 mg/dl. One natural ingredient known to lower blood sugar levels is red betel leaf (Piper crocatum). Methods: The method used in this research is the extraction and fractionation of n-hexane, ethyl acetate fraction, n-butanol fraction, and residual water fraction. Results: The results of research that has been carried out by giving fractionated n-butanol is effective in reducing blood sugar levels in male white mice (Mus musculus) that have been induced by alloxan. Conclusions: The positive group was obtained, and the results of administering the n-butanol fraction at a dose of 100 mg/KgBW affected reducing the blood sugar levels of male mice (Mus musculus) which had been induced by alloxan on days 2, 4, and 6, which decreased the most.
Sub-Acute Toxicity Test of Red Betel Leaves (Piper crocatum) on Liver Function in Male White Mice (Mus musculus) Using SGPT Test Andriani, Medi; Putra, Rizky Yulion; Asnadewi, Veni
BIOEDUSCIENCE Vol 8 No 3 (2024): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/14640

Abstract

Background: This research aims to investigate the sub-acute toxicity of red betel leaves (Piper crocatum) on liver function in male white mice (Mus musculus) using a serum glutamic-pyruvic transaminase (SGPT) test on a clinical photometer instrument. Methods: This research aims to investigate the sub-acute toxicity of red betel leaves (Piper crocatum) on liver function in male white mice (Mus musculus) using a test serum Glutamic Pyruvic Transaminase (SGPT) assay on a clinical photometer instrument. In this study, an experimental method was employed using a randomized block design, with 72 mice serving as research subjects and divided into eight treatment groups. Group 1 was given 0.5% Na CMC, group 2 as a positive control; group 3 was given a comparison of metformin; group 4 was given an extract with a dose of 100 mg/KgBB, group 5 was given the N-Hexane fraction with a dose of 100 mg/KgBB, group 6 was given the Ethyl Acetate fraction with a dose of 100 mg/KgBB, group 7 was given the N-Butanol fraction with a dose of 100 mg/KgBB, group 8 was given the Residual Water Fraction with a dose of 100 mg/KgBB, the treatment was carried out for 2, 4, 6 days, in the SGPT test used was serum. Results: The administration of extracts and fractions to animals did not cause Subacute Toxicity effects on the livers of male white mice. Looking at the SGPT (Serum Glutamic Pyruvic Transaminase) parameters, the activity of which was still within normal conditions, namely 25-200 µ/l. Conclusions: did not show any Subacute Toxicity effects as seen from the activity of the SGPT enzyme in the blood of male white mice (Mus musculus).
Co-Authors Aan Putra Abda Abda Afdonil Khomarul Fatta Afrida, Erni Aisa Dinda Mitra Al Fadhilah, Shafira Almira Salsabila, Nandita Almukharomah, Adella Amelda, Mustika Dwi Amelia, Faranita Nur Anandita, Nada Anggelia pratiwi Anggita Septia Meriza Apria, Habibah Aprilia Wulandari Armini Hadriyati Armini Hadriyati Asnadewi, Veni Astari, Wita Athayyah Shabirah Aulia Fatihah, Anya Azhari Putri, Nabila Cupa Munti, Putri Delina Dameria Sibuea, Lasma Desi Ambar Sari Dewi Permata Sari Dewi Permata Sari Dewi, Rasmala Dewi, Rasmala Diah Suci Ramadhani Disty Aldila Wicaksono Erinda Rizki Putri Erni Afrida Fatta, Afdonil Khomarul Fitrawati Fitrawati Fitrawati Fitrawati Haerul Afdal Mubarak, Mohd Hafsari, Winda Galuh Hasanah, Rifdatul Hidayati, Atriani Ibriyanti, Silda Indri Meirista Jelly Permatasari Kirana, Sahla Tahta Kurniadi Rafindra, Meidi Lasma Dameria Sibuea Lili Andriani Lina, Ade Okta Maharani, Juliantika Manik, Feranika Martua, Aris Sahat Meriza, Anggita Septia Mohd Haerul Afdal Mubarak Muchtar, Melayusma Nada Anandita Nandita Almira Salsabila Nasril, Siska Emilia Natari, Rifani Bhakti Nike Nur Ahdiyah Nofrida Saswati nofrida saswati, nofrida Nolasari, Raiza novrianti, wulan nur NR. Umil Hasanah.R Oktaniasih, Putri Oktapiani, Fenti Oliyen Madori Ongki Aleksander Opi Zalita , Tricy Parman Permata Sari, Vira Putra, Rizki Yulion Putra, Rizky Yulion Putri Armellia, Sagita Putri, Elfiana Meirela Putri, Erinda Rizki Putri, Kiki Ananda Putri, Rezky Amelia Rahayu, Rajani Sri Raiza Nolasari Rifdatul Hasanah Rizki, Sri Puri Rizky Yulion Rosyta, Dini Galoh Safitri Nada, Lia Safitri, Desti Rizkyan Sagita Putri Armellia Sandi, Putri Lara Santi Perawati Sanuddin, Mukhlis Saputri, Ghina Nabilla Dwi Sepriani Sepriani Sepriani Sepriani, Sepriani Shabirah, Athayyah Siti Nurhaliza Sri Bintang Sahara Mahaputra Kusumanegara Sri Puri Rizki Sutrisno , Deny Syamsul Arifin Ulfa, Zakia Umairoh, Sarah Umil Hasanah.R, NR. Wita Astari WULANDARI, APRILIA Yasril, Farih Rahma Yuli Hidayati Yuliandani, Yuliandani Yulianis Yulianis Yulianis Yulianis Yulianis Yulianis Yulyana, Zahara Yuni Andriani Zhafirah, Wara