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All Journal International Journal of Biosciences and Biotechnology BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Sains dan Teknologi Indonesian Journal of Medicine JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal of Midwifery and Nursing Jurnal Riset Kefarmasian Indonesia Jurnal Aplikasi dan Inovasi Iptek (JASINTEK) Jurnal Ilmiah Medicamento Jurnal WIDYA LAKSMI (Jurnal Pengabdian Kepada Masyarakat) Usadha Alpatih: Jurnal Inovasi Pengabdian Masyarakat Biosaintifika: Journal of Biology & Biology Education Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Creative Power and Ambition (JCPA)
Maria Malida Vernandes Sasadara
Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Produksi Ramah Lingkungan Granul Instan Antioksidan dari Kulit Jeruk Bali (Citrus maxima) Menggunakan Ekstraksi Berbantuan Enzim Yuda, Putu Era Sandhi Kusuma; Ni Kadek Lita; Adinda Puspita Elisabet Lian; Ni Putu Jayanti Putri; I Gusti Ayu Sri Candramukhi Devi Dasi; Intan Alfira Kolifay; Erna Cahyaningsih; Maria Malida Vernandes Sasadara
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i3.13155

Abstract

Pomelo peel (Citrus maxima) is an agricultural by-product rich in bioactive compounds, particularly flavonoids and phenolic compounds, which have potential antioxidant and anti-aging properties. However, the high pectin content in citrus peels can hinder the release of these active compounds. The objective of this study was to improve the extraction efficiency of bioactive compounds from pomelo peel using an environmentally friendly Enzyme-Assisted Extraction (EAE) method employing pectinase enzymes and to formulate the extract into instant effervescent granules. The granules produced using enzymatic extraction, granules prepared without enzymes, and control granules were evaluated through sensory assessment, physical quality analysis, total phenolic content, antioxidant activity (DPPH method), and crude fiber content. The results showed that enzyme-assisted extraction granules (EEG) exhibited significantly higher free radical scavenging activity (49.57 ± 6.10%) compared to non-enzymatic granules (NEG) (28.48 ± 8.67%). EEG also demonstrated a higher total phenolic content (0.027 g/100 g) than NEG (0.017 g/100 g). In addition, EEG showed better sensory acceptance and physical quality, including a more balanced taste, a stronger citrus aroma, and higher fiber content. These findings indicate that the application of the EAE method can enhance phenolic and fiber content, physical quality, and antioxidant activity of instant pomelo peel granules, suggesting their potential development as an environmentally friendly natural antioxidant product.
ETHNOBOTANICAL STUDY OF MEDICINAL PLANT USAGE DURING COVID-19 PANDEMIC: A COMMUNITY-BASED SURVEY IN INDONESIA Nayaka, Ni Made Dwi Mara Widyani; Yuda, Putu Era Sandhi Kusuma; Sanjaya, Dwi Arymbhi; Ernawati, Desak Ketut; Cahyaningsih, Erna; Dewi, Ni Luh Kade Arman Anita; Sasadara, Maria Malida Vernandes
BIOTROPIA Vol. 30 No. 2 (2023): BIOTROPIA Vol. 30 No. 2 August 2023
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2023.30.2.1784

Abstract

Before the availability of a vaccine, Indonesian population relied on traditional medicines to prevent COVID-19. Any species used by indigenous people could lead to further investigations in modern pharmacology, to preserve ancient knowledge, and to plan for plants’ conservation. The study aimed to discover and record species, methods of preparation, route of administration, and motivation in using medicinal plants by the Indonesian population during the COVID-19 pandemic. Participants of survey were selected from the people who live in Java and Bali for responding to an online structured questionnaire. Relative Frequency of Citation (RFC) was employed in the quantitative analysis of the collected data. The pharmacological relevance of the five plants with the highest RFC was further reviewed. The results showed that respondents used 59 plants from 28 families. Five species with the highest RFC were Curcuma longa (0.707), Zingiber officinale (0.674), Cymbopogon citratus (0.269), Kaempferia galanga (0.174), and Curcuma zanthorrhiza (0.165). Most plants were prepared by boiling (77.97%) and administered orally as a single ingredient or mixed with other herbals. Respondents believed that the plants were beneficial as immune-booster (71.26%), maintain good health (24.85%) and stamina (12.28%), and prevent viral infection, including COVID-19 (5.39%). The most commonly used plants might be scientifically based to boost immunity. However, their usage against COVID-19 and the medicinal value of herbal mixtures should be further investigated.
UJI IN VIVO TAHAP PREKLINIS TERHADAP EKSTRAK BATANG PISANG (Musa paradisiaca L.) SEBAGAI ANTIINFLAMASI TOPIKAL Dewi, Ni Luh Kade Arman Anita; Yuda, Putu Era Sandhi Kusuma; Suarnata, I Gede Agus; Sasadara, Maria Malida Vernandes
Jurnal Riset Kefarmasian Indonesia Vol. 3 No. 2 (2021): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v3i2.129

Abstract

Inflammation is a normal protective response to tissue injury caused by physical trauma, chemical damage, or microbiological substances. Banana stems (Musa paradisiaca L.) have been empirically believed for their topical anti-inflammatory properties. The purpose of this study was to scientifically evaluate the in vivo preclinical anti-inflammatory activity of banana stems. This research was designed experimentally using twenty-five albino male rats which were divided into five groups: the positive control group which received sodium diclofenac gel, the negative control group which received gel basis preparation without any active ingredient, and three experimental groups which received banana stem extract gel in three different concentrations, 5%, 10%, and 15%. Every five rats of every group were firstly injected with 1% of carrageenan, and the anti-inflammatory effect was evaluated every hour for 4 hours using a plethysmometer. The collected data were statistically evaluated. The results showed that banana stem extract gel with concentrations of 15% produced the best anti-inflammatory effect, compared to other gel concentrations. In conclusion, the preparation of 15% banana stem extract gel can be applied as potential topical anti-inflammatory preparation.
The use of Red Onion (Allium Cepa L.) Skin Extract as an Antioxidant and Anti-Inflammatory in Rats: A Literature Review Study Gede Agus Ari Tirtayasa; Maria Malida Vernandes Sasadara; Putu Era Sandhi Kusuma Yuda; Erna Cahyaningsih; Ni Luh Kade Arman Anita Dewi
Journal of Creative Power and Ambition (JCPA) Vol. 4 No. 01 (2026): Journal of Creative Power and Ambition (JCPA)
Publisher : CV Edujavare Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70610/jcpa.v4i01.1145

Abstract

Red onion peel (Allium cepa L.) is an agricultural by-product that contains high levels of bioactive compounds, particularly flavonoids and quercetin, which are known to possess antioxidant and anti-inflammatory properties. This systematic literature review aims to analyze the scientific evidence regarding the effects of red onion peel extract on antioxidant and anti-inflammatory activities in mouse models. Data were collected from international databases and selected based on relevance to in vivo and in vitro studies published between 2020 and 2025. The findings indicate that red onion peel extract significantly enhances antioxidant defense mechanisms by increasing the activity of superoxide dismutase (SOD), catalase, and total antioxidant capacity (ORAC), while reducing oxidative stress markers such as nitric oxide (NO) and inducible nitric oxide synthase (iNOS). In addition, the extract exhibits strong anti-inflammatory effects through the suppression of pro-inflammatory cytokines, including IL-1α, IL-1β, IL-6, and TNF-α, as well as inhibition of key signaling pathways such as JAK-STAT, NF-κB, and NLRP3/caspase-1. The effectiveness of the extract is influenced by dosage, duration of administration, and extraction method, with higher doses and longer exposure generally producing stronger biological effects. Overall, red onion peel extract shows promising potential as a natural source of antioxidant and anti-inflammatory agents for nutraceutical and therapeutic applications.
Aktivitas Anti-Inflamasi Minyak Herbal Tradisional Dari Bahan Usada Bali Pada Mencit Inflamasi Yang Diinduksi Karagenan Yuda, Putu Era Sandhi Kusuma; Mahardika, I Made Agus; Cahyaningsih, Erna; Sasadara, Maria Malida Vernandes; Nayaka, Ni Made Dwi Mara Widyani; Dewi, Ni Luh Kade Arman Anita
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 3 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i3.60529

Abstract

Peradangan sendi atau artritis merupakan salah satu penyakit inflamasi kronis yang memerlukan penggunaan obat jangka panjang. Penggunaan obat artritis seperti metotreksat dan NSAID dalam waktu lama dapat menimbulkan berbagai efek samping serius, sehingga diperlukan alternatif pengobatan yang relatif lebih aman terutama dari bahan herbal. Penelitian ini dilakukan untuk menguji aktivitas anti-inflamasi minyak herbal tradisional Usada Bali dari bahan Jahe (Zingiber officinale), Kunyit (Curcuma longa), Kencur (Kaemferia galanga), Bangle (Zingiber montanum), Cengkeh (Syzigium aromaticum) dan Kayu Manis (Cinnamomum burmanii) pada mencit inflamasi yang diinduksi karagenan melalui pengujian secara topikal. Mencit dibagi empat kelompok yang terdiri dari kelompok kontrol negatif (pembawa), kontrol positif (Natrium Diklofenak topikal), minyak herbal 150 dan 300 mg/ml. Volume peradangan kaki mencit diukur dengan alat pletismometer setiap jam selama empat jam setelah diinduksi dengan karagenan 0,5% (b/v) subplantar, kemudian diuji secara statistik (Mann-Whitney) dengan taraf kepercayaan 95%. Skrining fitokimia menunjukkan bahwa minyak herbal mengandung senyawa flavonoid, terpenoid dan steroid. Hasil uji aktivitas anti-inflamasi menunjukan adanya penghambatan peradangan yang signifikan (p<0,05) oleh minyak herbal konsentrasi 150 mg/ml maupun 300 mg/ml dengan persentase penghambatan pada jam ke-4 masing-masing sebesar 16,52% dan 11,30%, serta tidak berbeda bermakna dibandingkan kontrol positif (p>0,05). Hasil tersebut menunjukkan adanya potensi  minyak herbal Usada Bali sebagai anti-inflamasi topikal.
Anti-Inflammatory Activity of Ayurvedic Trikatu Herbal Oil and Identification of Its Phytochemical Constituents Using GC-MS Putu Era Sandhi Kusuma Yuda; Ni Luh Kade Arman Anita Dewi; Maria Malida Vernandes Sasadara; Dewa Ayu Ika Pramitha; Erna Cahyaningsih
JST (Jurnal Sains dan Teknologi) Vol. 14 No. 3 (2025): October
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jst-undiksha.v14i3.103115

Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by chronic inflammation, which can lead to progressive joint dysfunction and disability. Long-term use of conventional pharmacological therapies is often associated with serious side effects, highlighting the need for safer and more effective alternative treatments. This study aims to analyze the effectiveness and underlying anti-inflammatory mechanisms of topical Trikatu Herbal Oil (THO) by assessing physiological responses and identifying active compounds through phytochemical analysis and Gas Chromatography–Mass Spectrometry (GC–MS). This research employed an experimental approach using a post-test only control group design. The study subjects consisted of 24 male BALB/c mice aged 2–3 months, weighing 20–30 g. Anti-inflammatory activity was evaluated using a carrageenan-induced paw edema model, in which edema volume was measured hourly for four hours using a plethysmometer. Data were obtained from observations of edema volume changes and GC–MS analysis of the bioactive constituents of THO. Statistical analysis was performed using the Kruskal–Wallis and Mann–Whitney tests at a 95% confidence level. The results demonstrated that Trikatu herbal oil contains β-caryophyllene and fatty acids that play a role in suppressing inflammatory responses. THO at a 20% concentration exhibited the highest anti-inflammatory activity, with an edema inhibition percentage of 56% compared to the control group. These findings confirm that Trikatu herbal oil is significantly effective as a topical anti-inflammatory agent. Implicatively, this study provides a scientific basis for the development of safe, natural-based topical herbal therapies with strong potential as alternatives to long-term synthetic anti-inflammatory treatments.
DNA Barcoding Based on matK Gene and Phytochemistry Analyses of Local Balinese Kayu Tangi ( Lagerstroemia sp.) I Ketut Suada; I Gede Putu Wirawan; Gusti Ketut Asti Dea Ningsih; I Nyoman Wijaya; Lambok Jenny Sagita Munthe; Anak Agung Sagung Intan Gayatri; Maria Malida Vernandes Sasadara; I Made Oka Parwata
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 3 (2024): December 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v16i3.9265

Abstract

Kayu tangi (Lagerstroemia sp.) is one of the medicinal plants that is often used traditionally by Balinese people for treating insomnia, diabetes, and dysentery. This study aims to determine the phylogenetic trees and the active compounds in Lagerstroemia tomentosa extract and its antioxidant activities. The methods used in molecular identification are DNA isolation, PCR, and DNA sequencing. The DNA sample was BLASTed to see its homology with the sequences in GenBank. These sequences were then used for phylogenetic tree analysis. The phytochemical analysis was done using the GC-MS method and the antioxidant activity test used the DPPH (1,1-diphenyl-2-picrylhydrazyl) after being reacted with the tested extract.  The results of molecular identification showed that the samples used were closely related to Lagerstroemia tomentosa species (MW044208.1). The antioxidant activity test results showed an IC50 of 2.1 ugml-1 which is included in the very strong category. The phytochemical test results showed that the most dominant compounds contained in the plant stem bark were furfural (AUC 8.54%), beta-sitosterol (AUC 6.00%), and gamma-sitosterol (AUC 3.81%). Based on PubChem data, these compounds have antioxidant and antimicrobial properties as well as insecticide and herbicide. In conclusion, kayu tangi is very close to  Lagerstroemia tomentosa and it’s potentially used as a medicine with strong antioxidant activities.  
Peningkatan kapasitas masyarakat melalui pelatihan pengembangan Roll-On aromaterapi cempaka sebagai produk wellness di Desa Sibanggede Maria Malida Vernandes Sasadara; Ade Irma Suryani; I Dewa Agung Ayu Diva Candraningrat
ALPATIH: Jurnal Inovasi Pengabdian Masyarakat Vol. 4 No. 3 (2026): September
Publisher : Alpatih Harapan Semesta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70115/alpatih.v4i3.742

Abstract

Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan kapasitas masyarakat melalui pelatihan pengembangan roll-on aromaterapi minyak cempaka sebagai produk wellness, yang mencakup formulasi, pengemasan, dan branding. Metode pelaksanaan meliputi pelatihan praktik (hands-on) pembuatan roll-on aromaterapi, edukasi mengenai pengemasan dan branding produk, serta evaluasi menggunakan pretest–posttest dan observasi keterampilan peserta selama praktik. Hasil kegiatan menunjukkan bahwa pelatihan secara signifikan meningkatkan pengetahuan peserta mengenai formulasi, proses produksi, higienitas, pengemasan, dan branding produk. Selain itu, sebagian besar peserta mampu mempraktikkan proses pembuatan roll-onaromaterapi secara mandiri, mulai dari penimbangan bahan, pencampuran, hingga pengisian produk ke dalam kemasan. Kegiatan ini juga meningkatkan pemahaman peserta mengenai pentingnya identitas produk dan kemasan dalam mendukung pengembangan produk wellness berbasis potensi lokal. Secara keseluruhan, program berhasil meningkatkan kapasitas masyarakat Desa Sibanggede dalam mengolah minyak atsiri cempaka menjadi produk bernilai tambah dan memberikan dasar bagi pengembangan produk wellness berbasis sumber daya lokal yang berpotensi dikembangkan pada skala usaha mikro, kecil, dan menengah (UMKM)
Co-Authors Ade Irma Suryani Ade Irma Suryani Adinda Puspita Elisabet Lian Agung Ari Chandra Wibawa Anak Agung Sagung Intan Gayatri Anak Agung Vivi Noviyanti Anita Dewi, Ni Luh Kade Arman Apriliani, Ni Luh Putri Buana, Komang Dirga Mega Budayasa, I Putu Gede Candraningrat, I Dewa Agung Ayu Diva Darmawan, I Wayan Agus Debby Juliadi Desak Ketut Ernawati Dewa Ayu Arintini Kusuma Dewa Ayu Ika Pramitha Dewi Ani Anjani Dewi, Ni Kadek Dwi Purnama Dwi Arymbhi Sanjaya Erna Cahyaningsih Gede Agus Ari Tirtayasa Gusti Ketut Asti Dea Ningsih Handani, Dewa Ayu Sri I Dewa Agung Ayu Diva Candraningrat I Dewa Gede Agung Pandawana I Dewa Made Adi Baskara Joni I Gede Putu Wirawan I GEDE PUTU WIRAWAN I Gusti Ayu Sri Candramukhi Devi Dasi I Ketut Suada I Made Oka Parwata I Nyoman Wijaya I Putu Tangkas Suwantara I Wayan Mahardika Saputra Indriani, Felia Riska Intan Alfira Kolifay Kusuwa Wardani, I Gusti Agung Ayu Lambok Jenny Sagita Munthe Luh Dita Sukriani Luh Putri Dianti Laksmi MADE SRITAMIN Mahardika, I Made Agus Megawati, Fitria Mendra, Ni Nyoman Yudianti Ni Kadek Jessica Agustin Ni Kadek Lita Ni Ketut Ayu Parwati Pooja Ni Luh Gede Erica Fridayana Ni Luh Gede Wiwin Pebriani Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Sintya Ni Made Dwi Mara Widyani Nayaka Ni Made Renita Putri Ni Nyoman Ayu Puspita Sari Ni Nyoman Ita Trisnadewi Ni Nyoman Wahyu Udayani Ni Nyoman Zelina Aswindari Ni Putu Arie Leony Kertita Ni Putu Jayanti Putri Ni Putu Lilis Adnyani Ni Wayan Rias Samidya Partama, I GD. Yudha Perayanthi, Reni Pramesti , Luh Ratih Widhia Prawitasari, Putu Putri Puguh Santoso puguh santoso, puguh Putra, I Made Agus Sunadi Putri, Leoni Putri, Ni Kadek Dila Pratiwi Putri, Ni Kadek Nisa Leoni Putu Era Sandhi Kusuma Yuda Suarnata, I Gede Agus Sugiyanto, Milyadi Suradnyana, I Gede Made Wardani, I Gusti Agung Ayu Kusuma WAYAN ADIARTAYASA Widyani Nayaka , Ni Made Dwi Mara Wiranata, I Gede Wulaningtyas, Ni Ketut Maha Yanti, Ni Kadek Pradnya Yundari, Yundari