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All Journal Jurnal Ilmiah Farmasi International Journal of Biosciences and Biotechnology Jurnal Farmasi Udayana BIOTROPIA - The Southeast Asian Journal of Tropical Biology Majalah Obat Tradisional Farmasains : Jurnal Ilmiah Ilmu Kefarmasian WIDYABHAKTI Jurnal Ilmiah Populer Jurnal Ilmu Kefarmasian Indonesia Jurnal Karinov Jurnal Aplikasi dan Inovasi Iptek (JASINTEK) Jurnal Ilmiah Medicamento Usadha Abdi Samulang : Jurnal Pengabdian Kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Erna Cahyaningsih
Universitas Mahasaraswati Denpasar
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Journal : Usadha

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Uji Aktivitas Antibakteri Rebusan dan Infusa Daun Jeruju (Achantus illicifolious) terhadap Bakteri Methicilin Resistant Staphylococcus aureus (MRSA) Maria Dewi, Ni Putu; Cahyaningsih, Erna; Arman Anita Dewi, Ni Luh Kade; Surya Rahadi, I Wayan; Sandhi Kusuma Yuda, Putu Era; Santoso, Puguh
Usadha Vol 3 No 1 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i1.7222

Abstract

Infectious diseases are still a health problem throughout the world, including in Indonesia. One cause of infection that needs to be watched out for is resistance to Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria. Continuous use of antibiotics can cause problems with microbial resistance. Indonesia has various plant species that can actually provide benefits but have not been specifically cultivated. Jeruju leaves (Achanthus ilicifolius) from mangrove plants contain bioactive compounds that have the potential to be antibacterial. The aim of this research is to determine the antibacterial activity of Jeruju leaf decoction and infusion against MRSA bacteria. Antibacterial activity testing uses MRSA bacteria. The results of the phytochemical screening of Jeruju leaf infusion contained secondary metabolite compounds in the form of flavonoids, tannins, saponins and quinones. Meanwhile, the results of the phytochemical screening of Jeruju leaf decoction contained secondary metabolites in the form of tannins, saponins and quinones. Based on the results of research conducted on infusions and decoctions of Jeruju leaves at concentrations of 30%, 60% and 90%, they did not have inhibitory power on the antibacterial activity of MRSA, as seen from the inhibition zone. Zero inhibition zone for MRSA bacteria. It can be concluded that the infusion and decoction of Jeruju (Achantus illicifolious) leaves do not have antibacterial activity against MRSA.
Uji Aktivitas Antibakteri Ekstrak Etanol Bulung Sangu (Gracilaria Sp.) Terhadap Bakteri Gram Negatif Pseudomonas aeruginosa Putri, Leoni; Vernandes Sasadara, Maria Malida; Cahyaningsih, Erna; Santoso, Puguh
Usadha Vol 2 No 3 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i3.7262

Abstract

Pseudomonas aeruginosa is a gram-negative bacterium that is pathogenic to humans, especially in causing nosocomial infections. This bacterium has resistance to several classes of antibiotics, one of which is carbapenem and cephalosporin class antibiotics. The development of new antibiotics is an alternative in solving this case. Seaweed is one of the marine biota that has various benefits to be developed due to its primary and secondary metabolite compounds. Secondary metabolites in seaweed are used as a source of bioactive metabolites which have broad antiviral, antifungal and antibacterial activities. Bulung sangu (Gracilaria sp.) is one of the seaweeds that has biological activity as an antibacterial. This study aims to determine the antibacterial effectiveness of 70% ethanol extract of bulung sangu (Gracilaria sp.) on the growth of Pseudomonas aeruginosa bacteria. Sangu bamboo shoots were obtained from the southern Denpasar area (Bali). Bulung sangu viscous extract was extracted using 70% ethanol by ultrasonic method for 5 minutes at 40oC. Phytochemical screening of the extract was carried out to determine the content of secondary metabolite compounds it had. Antibacterial activity testing was carried out using the well diffusion method using 3 extract concentrations namely 4%, 8% and 12%. The positive and negative controls used were chloramphenicol antibiotics and sterile aquadest. Inhibition zones were observed and expressed as mean ± standard deviation (mm). The results were statistically analyzed using Kruskal-Wallis with a 95% confidence level. The inhibition zones generated from the positive control, concentrations of 4%, 8% and 12% could inhibit Pseudomonas aeruginosa bacteria with the following average diameters of the inhibition zones of 25.67mm, 2.00mm, 2.67mm and 2.67mm in the weak inhibition zone category.
Kajian Etnofarmasi Kelompok Masyarakat Banjar Saraseda Tampaksiring Gianyar Bali Puspita Wati, Ni Putu; Anita Dewi, Ni Luh Kade Arman; Suradnyana, I Gede Made; Kusuma Yuda, I Putu Era Sandhi; Cahyaningsih, Erna; Megawati, Fitria
Usadha Vol 2 No 3 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i3.7376

Abstract

  The use of ethnopharmaceutical practices remains widespread in Bali, as this knowledge has been passed down through generations. Although the Balinese people still strongly uphold their traditional healing systems and have long utilized plants as medicinal ingredients, there is still limited research documenting the diversity of plant species recorded in the Usadha manuscripts along with their therapeutic uses. This study aimed to inventory medicinal plants that are still used by the community in Banjar Saraseda, Tampaksiring, Gianyar, Bali. The study employed a descriptive design, with data collected through interviews to obtain information from respondents regarding local plant names, therapeutic uses/indications, parts of the plant utilized, and methods of preparation and application. The data were analyzed descriptively and presented in tables. Based on the ethnopharmacological survey conducted in Banjar Saraseda, Tampaksiring, Gianyar, Bali, a total of 20 medicinal plant species were recorded. The most frequently used plant parts were leaves (75%), followed by rhizomes (15%) and fruits (10%). The primary methods of preparation included boiling (65%), pounding (15%), grating, crushing, brewing, and direct use (each 5%). Based on therapeutic indications, the plants were mainly used to treat fever (20%), muscle pain and gout (20%), hypertension (20%), skin itching (10%), diabetes (10%), and to manage wounds, diarrhoea, haemorrhoids, and gastritis (each 5%). This study demonstrates that the Banjar Saraseda community in Tampaksiring, Gianyar, Bali continues to preserve traditional knowledge in the use of medicinal plants that has been inherited through generations.
Mini Review: Potensi Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp) sebagai Antibakteri Yuda, Putu Era Sandhi Kusuma; Pramesti , Luh Ratih Widhia; Widyani Nayaka , Ni Made Dwi Mara; Anita Dewi, Ni Luh Kade Arman; Cahyaningsih, Erna; Sasadara, Maria Malida Vernandes
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.7036

Abstract

  Infectious diseases by bacteria are one of the problems in the world of health. The therapy that can be given to people with bacterial infections is antibiotics. However, the increasing incidence of antibiotic resistance and bacterial infections requires other antibiotic alternatives such as those sourced from natural materials. Bay leaf (Syzygium polyanthum (Wight) Walp) included in the Myrtaceae family is one of the plants that is widely known among Indonesian people which empirically has properties in curing various diseases. Bay leaves are known to contain secondary metabolite compounds such as flavonoids, tannins, alkaloids, saponins, triterpenoids, steroids, eugenol, and essential oils that function as antibacterials. This literature review aims to discuss the antibacterial activity of bay leaves against gram-positive and gram-negative bacteria as well as the components of active compounds in bay leaves and their mechanism as antibacterials. The method used in the preparation of this review article is the literature study method. This research uses secondary data taken from the results of other researchers' research in the form of scientific articles that have been published in national and international scientific journals with a year limit from 2014 to 2023. Based on the literature study that has been done, it is known that bay leaves have potential as antibacterials against both gram-positive and gram-negative bacteria. The antibacterial activity is known to be related to the content of active compounds such as flavonoids, tannins, alkaloids, saponins, triterpenoids, steroids, phenols, and essential oils.
Kajian Etnofarmasi Kelompok Masyarakat Banjar Subamia Kelong, Tabanan Bali Perayanthi, Reni; Anita Dewi, Ni Luh Kade Arman; Kusuma Yuda, Putu Era Sandhi; Cahyaningsih, Erna; Vernandes Sasadara, Maria Malida; Suradnyana, I Gede Made; Sugiyanto, Milyadi
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7369

Abstract

  Bali is rich in culture and traditions passed down from generation to generation, especially in the ethnopharmacy aspect as a traditional medecine. This research aims to study ethnopharmacy aspects of the application of herbal plants as traditional medicine including plant parts, processing methods, indications, and usage of herbal plants in Banjar Subamia Kelong, Tabanan, Bali. This research was carried out using survey methods, direct observation in the field, and interviews. This research identified 20 types of plants that are generally used by the community in the Banjar Subamia Kelong. The plant parts generally used are leaves (60%), stems (15%), rhizomes (15%) and fruit (10%). Most of the plants are processed by boiling (60%). These medicinal plants are mostly used orally (65%), and the general indication is to treat joint problems, such as muscle pain and gout (25%).
Identifikasi Senyawa Fitokimia dan Uji Aktivitas Antioksidan pada Cascara (Coffea arabica L.) Sasadara, Maria Malida Vernandes; Cahyaningsih, Erna; Yuda, Putu Era Sandhi Kusuma; Handani, Dewa Ayu Sri; Dewi, Ni Luh Kade Arman Anita; Megawati, Fitria; Tirtayasa, Gede Agus Ari
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.12181

Abstract

Cascara refers to the dried husk of coffee cherries. It has garnered significant attention in recent research due to its phytochemical composition and potential health benefits. Several studies have highlighted the presence of bioactive compounds and the antioxidant activity exhibited by cascara. This study aims to investigate the phytochemical content and antioxidant potential of cascara. The cascara was extracted using the maceration method with 96% ethanol, followed by phytochemical screening for alkaloids, flavonoids, tannins, saponins, terpenoids, steroids, and quinones using standard color reactions in test tubes. Antioxidant activity was assessed via the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, with ascorbic acid as a reference compound. The phytochemical profile of the extract was identified using gas chromatography-mass spectrometry (GC-MS). The findings indicated that cascara contains alkaloids, flavonoids, tannins, saponins, and triterpenoids. GC-MS analysis identified caffeine, hexadecanoic acid (methyl ester), and hexadecanoic acid (ethyl ester) as the predominant compounds in cascara. The antioxidant activity test using the DPPH method demonstrated that the ethanol extract of cascara possesses moderate antioxidant potential, with an average IC50 value of 108.49 ± 1.28 ppm. Ascorbic acid, the reference compound used in this study, yielded an IC50 of 2.53 ppm, categorized as very strong. This research underscores cascara’s potential as a valuable source of antioxidants with significant health benefits, influenced by geographic factors affecting its bioactive compound profile. Consequently, cascara holds promise for further development as a raw material for functional health-promoting products.
Review: Pemanfaatan Tanaman sebagai Fitoterapi pada Diabetes Mellitus Dewi, Ni Luh Kade Arman Anita; Prameswari, Putu Nimas Diyah; Cahyaningsih, Erna; Megawati, Fitria; Agustini, Ni Putu Dewi; Juliadi, Debby
Usadha Vol 1 No 3 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v1i3.5562

Abstract

Diabetes is a chronic disease that occurs due to high levels of sugar in the blood, this can occur when the pancreas does not produce enough insulin (a hormone that regulates blood sugar or glucose), or when the body cannot effectively use the insulin it produces. Management of DM patients can be carried out with non-pharmacological and pharmacological therapies. The method used in the journal review was to search for the keyword "diabetes mellitus herbal medicine" for clinical studies on plant-derived products for the treatment of diabetes mellitus. Search terms included “phytotherapy”, “phytochemicals”, “medicinal plant products”, “herbal medicine”, and “diabetes mellitus”. Involving plant-derived compounds and pigmentation as outcome measures were included. In this review article, 30 journals were collected from which the objectives and results of the research in the journal were obtained. The goal is as an alternative management treatment to control blood sugar levels. For some of the compounds we discuss, among others: Flavonoids, Allicin, Lectins, Alkaloids, Andrographolid, Curcumin, Cinnamaldehyde, peptides, Phenolics, Tannins.
Efektivitas Pengobatan Tanaman Herbal dan Terapi Tradisional untuk Penyakit Tulang dan Persendian Cahyaningsih, Erna; Anita Dewi, Ni Luh Kade Arman; Udayani, Ni Nyoman Wahyu; Dwipayanti, Ni Kadek Sari; Megawati, Fitria
Usadha Vol 1 No 3 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v1i3.5596

Abstract

Bones are the body's framework that causes the body to stand upright, where the muscles are attached to allow the passage of blood vessels, where the bone marrow and nerves protect soft tissues. Traditional medicine is an effort to treat or treat other ways outside of medical science or nursing science. Indonesia is one of the countries that have the potential to develop medicinal plant cultivation and use it as an alternative treatment. This study aims to determine the effectiveness of herbal medicine and traditional therapy for bone and joint diseases. This study uses the method of literature study. The results showed that traditional herbal therapy for ball compresses, lemongrass warm compresses, cinnamon warm compresses, lavender aromatherapy warm water flower compresses, bangle rhizome compresses, and ginger warm compresses can be used for bone and joint diseases. Where there are compounds in herbal plants that have effectiveness as traditional medicine and therapy for bone and joint diseases, namely flavonoids, quercetin, curcumin, 6-gingerol and shogaol, alkaloids, steroids, and saponins.
Aktivitas Antibakteri Ekstrak Tanaman Obat terhadap Methicillin-Resistant Staphylococcus aureus (MRSA) Dwi Widyastrini, Desak Made; Cahyaningsih, Erna; I Gusti Agung Ayu Kusuma Wardani
Usadha Vol 1 No 1 (2021): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Meningkatnya kemunculan infeksi multidrug-resistant yang disebabkan oleh mikroorganisme telah menjadi beban yang signifikan secara global. Mereka telah menghasilkan tingkat kematian, kecacatan dan penyakit yang tinggi di seluruh dunia terutama di negara berkembang. Laporan dari Centre for Disease Control and Prevention (CDC) memperkirakan bahwa lebih dari 2 juta penyakit dan 23.000 kematian per tahun disebabkan oleh patogen resisten antibiotik di Amerika Serikat, salah satunya yaitu Methicillin-Resistant Staphylococcus aureus (MRSA). Tanaman obat telah diakui memiliki efek samping yang minimal dan juga dapat menekan pertumbuhan patogen dengan mekanisme yang berbeda dari antibiotik sintetik yang digunakan saat ini. Tujuan penulisan artikel review ini untuk mempelajari aktivitas antibakteri ekstrak tanaman obat terhadap Methicillin-Resistant Staphylococcus aureus (MRSA). Metode yang digunakan dalam penyusunan artikel review ini yaitu studi literatur melalaui beberapa basis data yang kemudian diskrining dengan beberapa kriteria. Hasil review mengatakan bahwa vankomisin sebelumnya merupakan obat yang digunakan secara luas untuk pengobatan infeksi MRSA. Hal ini tidak lagi terjadi dengan munculnya strain S. aureus dengan sensitivitas vankomisin yang berkurang sehingga membatasi pilihan pengobatan konvensional untuk infeksi MRSA. Saat ini, banyak peneliti telah melaporkan aktivitas antibakteri dari banyak ekstrak tanaman pada MRSA. Konsentrasi hambat minimum (MIC) dan konsentrasi bakterisida minimum (MBC) digunakan untuk menilai aktivitas antibakteri ekstrak dari tanaman obat. Berdasarkan hasil dapat disimpulkan bahwa tanaman obat dapat digunakan sebagai kandidat alternatif untuk pengembangan obat yang dapat menghentikan atau mengendalikan infeksi dari MRSA.
Produksi Ramah Lingkungan Granul Instan Antioksidan dari Kulit Jeruk Bali (Citrus maxima) Menggunakan Ekstraksi Berbantuan Enzim Yuda, Putu Era Sandhi Kusuma; Ni Kadek Lita; Adinda Puspita Elisabet Lian; Ni Putu Jayanti Putri; I Gusti Ayu Sri Candramukhi Devi Dasi; Intan Alfira Kolifay; Erna Cahyaningsih; Maria Malida Vernandes Sasadara
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i3.13155

Abstract

Pomelo peel (Citrus maxima) is an agricultural by-product rich in bioactive compounds, particularly flavonoids and phenolic compounds, which have potential antioxidant and anti-aging properties. However, the high pectin content in citrus peels can hinder the release of these active compounds. The objective of this study was to improve the extraction efficiency of bioactive compounds from pomelo peel using an environmentally friendly Enzyme-Assisted Extraction (EAE) method employing pectinase enzymes and to formulate the extract into instant effervescent granules. The granules produced using enzymatic extraction, granules prepared without enzymes, and control granules were evaluated through sensory assessment, physical quality analysis, total phenolic content, antioxidant activity (DPPH method), and crude fiber content. The results showed that enzyme-assisted extraction granules (EEG) exhibited significantly higher free radical scavenging activity (49.57 ± 6.10%) compared to non-enzymatic granules (NEG) (28.48 ± 8.67%). EEG also demonstrated a higher total phenolic content (0.027 g/100 g) than NEG (0.017 g/100 g). In addition, EEG showed better sensory acceptance and physical quality, including a more balanced taste, a stronger citrus aroma, and higher fiber content. These findings indicate that the application of the EAE method can enhance phenolic and fiber content, physical quality, and antioxidant activity of instant pomelo peel granules, suggesting their potential development as an environmentally friendly natural antioxidant product.
Co-Authors Adinda Puspita Elisabet Lian Agrippina Wiraningtyas, Agrippina Agustini, Ni Putu Dewi Anak Agung Putu Gede Bagus Arie Susandya Anita Dewi, Ni Luh Kade Arman Apriliani, Ni Luh Putri Artini, Ni Putu Eka Darmawan, I Wayan Agus Darmayanti, Gusti Ayu Putu Eka Debby Juliadi Desak Ketut Ernawati Dewi , Ni Luh Kade Arman Anita Dewi, Ni Kadek Dwi Purnama Dwi Arymbhi Sanjaya Dwi Widyastrini, Desak Made Dwipayanti, Ni Kadek Sari Elis Suwarni Fitria Megawati Gusti Ayu Made Indah Siantari Gusti Ayu Putu Eka Darmayanti Gusti Ayu Putu Yosinta Sasmita Handani, Dewa Ayu Sri I Gusti Ayu Sri Candramukhi Devi Dasi I Made Agus Sunadi Putra I Putu Tangkas Suwantara Indah Muthia Susanthi Indriani, Felia Riska Intan Alfira Kolifay Irlangga, I Gusti Ngurah Agustia Adi Surya Taksu Irma Rubianti Kusuma Yuda, I Putu Era Sandhi Kusuma Yuda, Putu Era Sandhi Luh Risma Putri Rahayu Made Agus Deny Mahendra Putra Maria Daniela Tupa Hokor Maria Dewi, Ni Putu Maria Malida Vernandes Sasadara Maria Malida Vernandes Sasadara Megawati, Fitria Ni Kadek Lita Ni Luh Ayu Mega Ratnasari Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Sintya Ni Made Dharma Shantini Suena Ni Made Dwi Mara Widyani Nayaka Ni Made Wiwik Setiawati Ni Nyoman Wahyu Udayani Ni Putu Anggun Cipta Rosalita Jelantik Ni Putu Dewi Agustini Ni Putu Eka Artini Ni Putu Jayanti Putri Ni Putu Udayana Antari Ni Putu Yuni Winariyanthi Olahairullah, Olahairullah Perayanthi, Reni Pramesti , Luh Ratih Widhia Prameswari, Putu Nimas Diyah Puguh Santoso Puguh Santoso Puguh Santoso puguh santoso, puguh Puspita Wati, Ni Putu Putra Hilmi Prayitno Putra, I Made Agus Sunadi Putri, Leoni Putri, Ni Kadek Dila Pratiwi Putri, Ni Kadek Nisa Leoni Putu Eka Pasmidi Ariati Putu Era Sandhi K.Yuda Putu Era Sandhi Kusuma Yuda Sandhi Kusuma Yuda, Putu Era Sasadara, Maria Malida Sasadara, Maria Malida Vernandes Sugiyanto, Milyadi Suradnyana, I Gede Made Surya Rahadi, I Wayan Susanthi, Indah Muthia Suwarni, Elis Tirtayasa, Gede Agus Ari Vernandes Sasadara, Maria Malida Wardani, I Gusti Agung Ayu Kusuma Widyani Nayaka , Ni Made Dwi Mara Wiguna, Putu Dony Saputra Winariyanthi, Ni Putu Yuni Yanti, Ni Kadek Pradnya