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All Journal Jesya (Jurnal Ekonomi dan Ekonomi Syariah) Dinasti International Journal of Education Management and Social Science Jurnal PORKES Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Buana Farma Jurnal Pengabdian kepada Masyarakat Bina Darma Jurnal Agricultural Biosystem Engineering Jurnal Farmasi Klinik dan Sains Arfak Chem: Chemistry Education Journal Jurnal Pengabdian Masyarakat Bangsa Journal of Pharmaceutical and Sciences. Indonesian Journal of Community Development Journal in Teaching and Education Area Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Amelia, Ayu
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Journal : Jurnal Buana Farma

 1 
UJI ANTIBAKTERI EKSTRAK BATANG GAHARU (Aquilaria malaccensis) BERBASIS KOLIN KLORIDA:ASAM SITRAT TERHADAP Bacillus cereus dan Shigella dysenteriae Hasan, Nahrul; Marlina, Sri; Amelia, Ayu; Syahputra, Ghalib Syukrillah; Sari, Diani Mega
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1396

Abstract

Infections caused by Bacillus cereus and Shigella dysenteriae are serious health problems as they can lead to gastrointestinal disorders and contribute to the emergence of antibiotic resistance. One potential strategy to overcome this challenge is the discovery of new antibacterial agents derived from natural sources, such as agarwood (Aquilaria malaccensis). This study aimed to evaluate the antibacterial activity of gaharu stem extract using a Natural Deep Eutectic Solvent (NADES) composed of choline chloride and citric acid through the Ultrasound Assisted Extraction (UAE) method. The antibacterial assay was performed using the disc diffusion method with various NADES ratios (1:1, 2:1, 1:2, 1:3, 1:4, and 4:1 g/g), with chloramphenicol as the positive control and 10% DMSO as the negative control. The results indicated that the NADES extract with a 1:4 g/g ratio produced the largest inhibition zones against Bacillus cereus and Shigella dysenteriae. Moreover, the Minimum Inhibitory Concentration (MIC) test showed that the 1:4 NADES extract effectively inhibited bacterial growth at a concentration of 30%. These findings suggest that gaharu stem extract prepared with NADES is a promising, eco-friendly, and potent antibacterial agent.
Co-Authors Adha, Sakinah Nurlaela Ahdiah, Danies Laelatul Cahyono Cahyono Delladari Mayefis Fadillah, Ainun Fahrudin Fahrudin Febriyanti , Eka Febriyanti, Eka Garniwa, Nanang GHALIB SYUKRILLAH SYAHPUTRA, GHALIB SYUKRILLAH Ghiffari, Habibie Deswilyaz Gina Fernanda Gusmali, Desy Maniarti Gustiawati, Resty Habibie Deswilyaz Ghiffari Hansen Nasif Hasan, Nahrul Hesti Marliza Ida Ayu Putu Sri Widnyani Julianto, Tommy Kamalia, Annisa Kiska, Nurul Delima Leni Marlina Maulida, Nova Masripah Mayefis, Delladari Meilanda , Rastria Meilanda, Rastria Muhammad Amin N, Yennizar Novi Susanti Nurchayati Nurchayati Pratiwi, Reri Puspita, Asih Purwandari Wahyoe Rachmayanti, Aprilya Sri Ridwan, Ridwan Rushd, Ibnu Ruslan Abdul Gani Sammulia, Suci Fitriani Sandi Asmara Sari, Diani Mega Sari, Yelly Oktavia Seandi Taroreh, Bangkit Sidiq, Abdullatif Simarni Siska, Dedi Siska, Dedy Sri Budiasih, Sri Sri Hainil, Sri Sri Marlina, Sri SUDARYANTO SUDARYANTO Suhaera, Suhaera Suparjo Syahputra , Ghalib Syukrillah Syukrillah, Ghalib Utami, Rury Trisa Utamii, Rury Trisa Yunaspi, Rakhmi Febrina