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All Journal Jurnal Akademika Biologi Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan Jurnal Media Gizi Indonesia (MGI) JIP: Jurnal Ilmiah PGMI AFEBI Accounting Review KOMIK (Konferensi Nasional Teknologi Informasi dan Komputer) Jurnal Sistem Informasi Kaputama (JSIK) Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Keluwih: Jurnal Kesehatan dan Kedokteran Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Sains Teknologi dan Sistem Informasi International Journal of Economic, Business, Accounting, Agriculture Management and Sharia Administration (IJEBAS) International Journal of Social Science, Educational, Economics, Agriculture Research, and Technology (IJSET) Islamic Accounting and Finance Review Bandung Conference Series: Islamic Education International Journal of Accounting, Management, Economics and Social Sciences (IJAMESC) Jurnal Riset Manajemen Gudang Jurnal Multidisiplin Ilmu Cendikia Pendidikan Causa: Jurnal Hukum dan Kewarganegaraan Jurnal Media Akademik (JMA) JURNAL MULTIDISIPLIN ILMU AKADEMIK Imajinasi: Jurnal Ilmu Pengetahuan, Seni, dan Teknologi Fatih: Journal of Contemporary Research Mesada: Journal of Innovative Research Taawun: Jurnal Pengabdian kepada Masyarakat
Putri Ramadhani
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Journal : Keluwih: Jurnal Kesehatan dan Kedokteran

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A Case Report Capecitabine-Induce Grade II Hand and Foot Syndrome Nurul Damayanti; Putri Ramadhani; Khusnul Fitri Hamidah; Husin Thamrin
Keluwih: Jurnal Kesehatan dan Kedokteran Vol. 6 No. 2 (2025): Keluwih: Jurnal Kesehatan dan Kedokteran (June)
Publisher : Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/kesdok.V6i2.7305

Abstract

Abstract—Capecitabine has a common side effect of hand and foot syndrome (HFS). It is cutaneous capecitabine’s adverse effect, which generally occurs within 11 to 360 days. In this case report assesses the delayed onset of capecitabine because HFS did not occur within 11-360 days but rather took longer, specifically 720 days. A female patient of 82 years old with a history of breast cancer was diagnosed four years ago. She did not undergo radiation and surgery, only capecitabine tablets as neoadjuvant therapy since April 2021. In August 2023, the patient complained of pain, dryness, and blood in both legs. Analysis of side effects of the drug was carried out using the Naranjo Probability Scale. Therapy management during hospitalization involves stopping capecitabine and performing wound care by applying fusidic acid cream and the patient's complaints improved on the eleventh day of therapy. Capecitabine discontinuation is the most effective strategy to minimize the effect of HFS. Further research is to determine the effectiveness of emollient application as a prevention for HFS. Keywords: adverse effects, capecitabine, hand and foot syndrome Abstrak—Sindrom tangan dan kaki efek samping yang sering terjadi pada penggunaan kapesitabine. Efek samping ini merupakan efek samping pada kulit yang terjadi dalam jangka waktu 11 hingga 360 hari. Pada case report ini efek samping tidak terjadi dalam jangka waktu 11-360 hari, terjadi keterlambatan reaksi yang berlangsung pada 720 hari setelah penggunaan kapesitabin. Seorang pasien perempuan berusia 82 tahun dengan riwayat kanker payudara didiagnosis empat tahun lalu. Pasien tidak menjalani radiasi dan operasi, hanya mengonsumsi tablet kapesitabin sebagai terapi neoadjuvan sejak April 2021. Pada Agustus 2023, pasien mengeluhkan nyeri, kulit kering, dan berdarah pada kedua kakinya. Analisis efek samping obat dilakukan dengan menggunakan Skala Probabilitas Naranjo. Penatalaksanaan terapi selama rawat inap meliputi penghentian kapesitabin dan perawatan luka dengan krim asam fusidat dan keluhan pasien membaik di hari ke-11 terapi. Penghentian kapesitabin merupakan strategi yang paling efektif untuk meminimalkan efek HFS. Penelitian selanjutnya adalah untuk menentukan efektivitas pemberian emolien sebagai pencegahan HFS. Kata kunci: efek samping, kapesitabin, sindrom kaki dan tangan
Co-Authors Abdul Hamid Habbe, Abdul Hamid ACHMAD FAUZI Adi Priyono Ahmad Hariandi Alifa, Sarah Alwin Fau Amir Maniur Silitonga Aninda Muliani Anisa Firma Annisa Rahmah Ghaffari Arliasnyah, Arliasnyah Asha Firnandia Atikah Haura Aulia, Najri Auradian Marta Dani Manesah Daulat Saragi Delra Maulida Risma Dewi Seftiana A Dinanti Amelia Putri Enoh Fadly Anhar Gultom Fitri Rahma Dani Fitrianingsih Fitrianingsih Fitriyani Fitriyani Fuadi Fuadi Helmi Aziz Hendra Ibrahim Husnul Khatimah Icha Widya Putri Imam Mahadi Imelda Mardayanti Indah Putri Santri Indriani Nainggolan Ira Rohaya Sitio Izmi Zakia Hazizah Juanda, Reza Kaldius Ndruru Khusnul Fitri Hamidah Lailatul Husna Lieona Fibra Asha Liza Husnita Machranda Machranda Maulani Al umi MEDIATY MG Isworo Rukmi Mido Irawan Minggu, Ayu Rinathi Muhammad Dedi Irawan Muhammad Farhan Muhammad Ikram Muhammad Lie Kelvin Aidy Muhammad Rifqi Al Husaini Mutiara Rizkia Nabila Azzahra Nelly Astuti Hasibuan Novriza Awwalin Nisa Nur Aisah Nur Fauziah Subati Nurul Aulia Nurul Damayanti Pakulla’, Heriani Pakulla’, Heriani Phasya Isyedwina Febriani Pradita Yulia Dwi Putri Putri Andini Rabiyatul Adawiyah Ratna Ayu Damayanti Razali, Ramadhan Reza Putri Harnefi Rio Andika Rizka Nova Fitria Rizky Fajar Sitepu Rosmayanti Rosmayanti Rosmayanti, Rosmayanti Saidatul Umniyah Solly Aryza Sonia Winda Khairani Sri Pujiyanto Surya Darma Nasution Syarifuddin Syarifuddin Thamrin, Husin Trias Mahmudiono Urfa Trisna Syadawi Vannesah Nara Tasya Halim Vina Ameera Wildan Asykarillah Yanti, Harti Budi Yetti Hidayatillah Yogi Wirandicha Zahra Amalia Zulfa Zulfarina Zulfarina