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Journal : Medula

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PENGARUH PEMBERIAN EKSTRAK LADA HITAM (Piper nigrum L) TERHADAP LIBIDO (PERILAKU SEKSUAL) MODEL TIKUS PUTIH JANTAN (RATTUS NORVEGICUS) DIABETES MELITUS Isvari, Gusti Ayu Made Prathita; Hadibrata, Exsa; Yunianto, Andi Eka; Susianti
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1284

Abstract

Abstract Diabetes Mellitus causes complications in the form of sexual libido dysfunction. Some of the treatment for libido dysfunction was aphrodisiac (piperin) which consist in black pepper. This study aimed to determine the effect of black pepper (piper nigrum l) extract on male white rat (Rattus norvegicus) libido (sexual behavior) with diabetes mellitus. The study was an experimental laboratory with a post-test only control group design using 30 samples of male white rats (Rattus norvegicus) which divided into 5 groups. Each divided into, control group 1 (K1) consist of normal rats; control group 2 (K2), diabetic rats induced by alloxan 150 mg/kg; treatment group 1 (P1), diabetic rats induced by alloxan 150 mg/kg and given black pepper extract 122.5 mg/kg; treatment group 2 (P2), diabetic rats induced by alloxan 150 mg/kg and given black pepper extract 245 mg/kg; treatment group 3 (P3), diabetic rats induced by alloxan 150mg/kg and given sildenafil 1mg/kg. Libido’s measurement was done by observing intromission latency in second, mount latency in second, mount frequency by its quantity. Kruskal-Wallis test was used to analyzed introducing  latency, whereas mounting latency and mounting frequency was analyzed with One Way ANOVA.  The results showed that introducing latency of group P1 and P2 significantly different compared to group K2 (p=0,003, p=0,003), Mounting latency of group P1 significantly different compared to group K2 (p=0,000) and mounting frequency of group P1 and P2 significantly different compared to group K2 (p=0,000,p=0,006). Black pepper extract enhances male white rat (Rattus norvegicus) libido with diabetes mellitus.
Identifikasi Kandungan Senyawa Aktif dan Penentuan Massa Jenis Ekstrak Etanol Daun Jambu Air (Syzygium aqueum) Naufal, Muhammad Ariq; Susianti; Daulay, Suryani Agustina; Carolia, Novita
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1320

Abstract

Water apple (Syzygium aqueum) is a plant widely utilized by publics for both consumption and medicinal purposes. Traditionally, it is used as an alternative treatment for diarrhea, headaches, and cough. The method to maximize the potential of water apple leaves is by extracting the active compounds in it. These extracts have potential as antioxidants, anti-inflammatory, anti-cholesterol, antidiabetics, and antidiarrheal agents. Previous studies have shown that water apple leaves contain various active compounds such as alkaloids, flavonoids, terpenoids, saponins, and phenolics. This research aimed to analyze the active compounds and determine the density of the water apple leaf extract. The study was conducted as a laboratory-based experimental research at the Botany Laboratory, FMIPA University of Lampung. The method employed was maceration of water apple leaves using 96% ethanol as a solvent, followed by qualitative phytochemical tests and density determination. Qualitative tests conducted included assessments for flavonoids, terpenoids, tannins, saponins, phenolics, alkaloids, and steroids. The density of the extract was determined by measuring the mass of the extract using an analytical balance and dividing it by its volume. The results showed that maceration using 96% ethanol yielded 110.62 grams of extract with a yield percentage of 11.062%. Phytochemical tests revealed the ethanol extract contained flavonoids, phenolics, tannins, saponins, alkaloids, and steroids. The density of the ethanol extract was calculated to be 0.9209 g/mL.
Hubungan Protein Urin dengan Berat Jenis Urin pada Pasien Nefropati Diabetik Putri, Najwa Naraniya; Kurniati, Intanri; Yuningrum, Hesti; Susianti
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1273

Abstract

Diabetic nephropathy is one of the main causes of end-stage renal failure or End Stage Renal Disease (ESRD) in patients with type 2 diabetes. Diabetic nephropathy is defined as the presence of albumin or protein of more than 30 mg/day in urine on two examinations within a period of 3-6 months, as well as a decrease in the glomerular filtration rate. Urinalysis examination using the dipstick method is carried out for certain indications or suspicions of complications of diabetes mellitus, one of which is diabetic nephropathy. Dipstick examination can detect protein, pH, glucose, specific gravity, ketones, urobilinogen, nitrite, blood, bilirubin, and leukocyte esterase. The specific gravity of urine depends on the concentration of glucose, urea, and protein particles in the solution. Therefore, the purpose of this study was to determine the relationship between protein in urine and specific gravity in patients with diabetic nephropathy. Observational analytical research was conducted with a cross-sectional approach. This study was conducted at the Medical Records Installation of Dr. H. Abdul Moeloek Hospital. The population of this study was diabetic nephropathy patients treated at Dr. H. Abdul Moeloek Hospital in January-December 2023. The sampling technique used the total sampling technique so that 49 samples were obtained that met the inclusion and exclusion criteria. The data obtained were analyzed using the Spearman correlation test. The results showed a correlation coefficient (r) of 0.589 and a significance p-value = 0.000. There is a relationship between urine protein and urine specific gravity in diabetic nephropathy patients.
Literature Review: Antioxidant Activity of Water Apple Leaves (Syzygium aqueum) Justisia, Adilla; Susianti; Jausal, Anisa Nuraisa; Busman, Hendri
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1321

Abstract

Antioxidant is a complex inhibit, prevent or dampen the reactions of free radicals and oxidants, as well as to prevent tissue damage. Antioxidant works by donating one of its electron to oxidant compounds thereby inhibiting the activity of these oxidant compounds. An imbalance between antioxidants and free radicals, where free radicals are more prevalent, can damage molecular organisms and cause oxidative stress that triggers damage to body cells. Oxidative damage to DNA triggers mutations that initiates cancer, cardiovascular disease, neurodegenerative disorder, autoimmune diseases, aging processes and several hereditary diseases. Currently, the use of natural antioxidants as traditional treatments is widely consumed by the community. Natural antioxidants are found in several plant sources, it is known to be more affordable and have lower side effects, making it as popular treatment choice in the community. One of the plants with a high antioxidant content is the water apple leaf (Syzygium aqueum) which rich in flavonoids, phenolics, and tannins. DPPH (2,2-diphenyl-1-picrylhydrazyl) is a common method to measure antioxidant activity, it works with the principle of hydrogen capture from antioxidants by free radicals. The parameter IC50 is used to represents the sample concentration required to capture 50% of DPPH radicals. Several studies using the DPPH method have shown that water apple leaves have strong antioxidant activity, indicated by its low IC50 value. The lower the IC50 value, the stronger the antioxidant activity.
Transient Ischemic Attack : Tantangan dalam Mendiagnosis Akuba, Nanda Nurrohim; Susianti; Daulay, Suryani Agustina; Berawi, Khairun Nisa
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1360

Abstract

Stroke is a condition characterized by the rapid development of clinical signs of focal and global neurological deficits, which can worsen and persist for 24 hours or more, potentially leading to death, with no clear cause other than vascular. Transient Ischemic Attack (TIA) is a temporary neurological dysfunction caused by a blockade or reduction in blood perfusion to brain tissue, lasting from a few seconds to minutes, and in some cases, up to 24 hours. Diagnosing TIA is challenging because patients typically present after the TIA has resolved, making it crucial to diagnose TIA clinically before confirming the diagnosis with additional examinations such as CT-Scan or MRI. There are meta-analysis studies that describe the role of certain biomarkers in supporting the diagnosis of TIA. Due to the closely related pathomechanisms between TIA and ischemic stroke, almost all the same biomarkers can be used to diagnose both conditions. There are scoring systems used to identify the risk of stroke in patients with TIA, with the ABCD² score being the most commonly used. Rapid assessment and the implementation of adequate therapy reduce the risk of TIA progressing to ischemic stroke.
Co-Authors Aini, Hidayatul Ainin Aniah, Pratiwi Akuba, Nanda Nurrohim Andi Indra Martini Bayu Anggileo Pramesona Betta Kurniawan, Betta Daulay, Suryani Agustina Hadibrata, Exsa Haikal, Fikrian Handini, Ilsa Hendra Tarigan, Sibero Hendri Busman Indri Windarti Intanri Kurniati Isvari, Gusti Ayu Made Prathita ita yuliana Jausal, Anisa Nuraisa Justisia, Adilla Khairun Nisa Malasandi, M. Yuda Muhamad Yogie, Fadli Muhammad Yogie, Fadli Mu’fidatul Nurul Hajjad Naufal, Muhammad Ariq Ningsih, Nadia Novita Carolia Pratiwi, Ainin Aniah Putri, Najwa Naraniya Risal Wintoko Rizki Hanriko Rudiyanto, Waluyo Sapudra, Wawan Sarwadi Sopia, Mira Suharmanto Suryadi Islami Sutyarso Wahid, Solahudin Yatna, Mazhuri Bakti Yunianto, Andi Eka Yuningrum, Hesti