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Prabowo, Nurhasan Agung
Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta Dan RS Universitas Sebelas Maret
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Role of Gamma-Glutamyl Transferase, High Sensitivity C Reactive Protein and Apolipoprotein B as A Marker of Disease Severity in Psoriasis Shofiyah, Laily; Ardyanto, Tonang Dwi; Prabowo, Nurhasan Agung; Aprilningsih, Hendrastutik; Myrtha, Risalina; Kuncorowati, Niken Dyah Aryani; Suwandono, Adji; Nugroho, Novianto Adi; Sari, Maria Galuh Kamenyangan; Dyanneza, Frieska
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.285

Abstract

Psoriasis can develop into systemic psoriasis, which primarily affects the liver, bile ducts, and cardiovascular system. Assessing the severity of psoriasis was crucial for determining treatment and cardiovascular disease risk. The aim of this study was to determine the role of Gamma-Glutamyl Transferase (GGT), High Sensitivity C-Reactive Protein (HS-CRP), and apolipoprotein B (APO B) in assessing the severity of psoriasis. Methods: This study was a cross-sectional, observational analytic study. A total of 33 psoriasis patients were tested for GGT, HS-CRP, APO B levels, and the Psoriasis Area and Severity Index (PASI) score. Results: The average GGT level was 70.75±56.47 u/L, the average HS-CRP level was 0.91±1.03 mg/L, the average APO B level was 110.09±26.47 mg/dL, and the average PASI score was 11.70±4.54. 12.1% of patients had mild psoriasis, 51.5% had moderate psoriasis, and 36.4% had severe psoriasis. There was a positive and strong correlation between GGT and PASI score, HS-CRP and PASI score, and APO B and PASI score. The multivariate correlation between GGT, HS-CRP, and APO B with PASI score had a value of R = 0.874, F = 31.145, p = <0.001. Conclusion: The multivariate correlation between GGT, HS-CRP, and APO B with PASI scores shows a positive and strong correlation, thus it useful for assessing the severity of psoriasis and evaluating the likelihood of cardiovascular disease.
Co-Authors Adji Suwandono Adji Suwandono Andri Haryanto Anindita, Brigitta Devi Aprilningsih, Hendrastutik Apriningsih, Apriningsih Apriningsih Apriningsih, Hendrastutik Arief Nurudhin Arief Nurudhin Arief Nurudhin Arief Nurudhin Arief Nurudhin Arief Nurudhin Arifin Arifin Asih Anggraeni Astri Tantri Indriani Astri Tantri Indriani Astri Tantri Indriani Berty Denny Hermawati Bryan Arief Aji Rudita Coana Sukma Gautama Desy Puspa Putri Dyanneza, Frieska Evi Nurhayatun Evi Nurhayatun Fatichati Budiningsih Frieska Dyanneza Frieska Dyanneza Frieska Dyanneza Habibah, Sopia Nur Hafi Nurinasari Hartono Hartono Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hermawati, Berty Denny Indriani, Astri Tantri Kuncorowati, Niken Dwi Aryani Kuncorowati, Niken Dyah Aryani Laily Shofiyah Laily Shofiyah Maria Galuh Kamenyangan Maria Galuh Kamenyangan Sari, Maria Galuh Kamenyangan Meirina Mulia Wardani Muchtar Hanafi Myrtha, Risalina Niken Dwi Aryani Kuncorowati Niken Dyah Aryani Kuncorowati Niken Dyah Aryani Kuncorowati Novianto Adi Nugroho Nugroho, Novianto Adi Putri, Desy Puspa Rachmah, Azkia Reviono Reviono Riandini Aisyah Risalina Myrtha Risalina Myrtha Risalina Myrtha Risalina Myrtha Shofiyah, Laily Sri Sulistyowati Sunarso, Indrayana Syahrini Wisdayanti Tamaulina Br Sembiring Tonang Dwi Ardyanto Werdiningsih, Yulyani Wijayanto, Matthew Aldo Yeni Farida Yulyani Werdiningsih Yulyani Werdiningsih Yulyani Werdiningsih Zainal Arifin Adnan Zainal Arifin Adnan