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All Journal Global Medical and Health Communication WARTA Jurnal Keperawatan Padjadjaran Smart Medical Journal Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Rheumatology Indonesian Journal of Cardiology Sebatik MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Community Development Journal: Jurnal Pengabdian Masyarakat Nusantara Science and Technology Proceedings Buletin Poltanesa Jurnal Dharma Bhakti Ekuitas Smart Society Empowerment Journal Gema Lingkungan Kesehatan
Nurhasan Agung Prabowo
Department Of Internal Medicine, Faculty Of Medicine, Sebelas Maret University, Surakarta, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Umbilical Cord Mesenchymal Stem Cells Secretome in Osteoarthritis Patients: A Case Report Nurudhin, Arief; Prabowo, Nurhasan Agung; Wedhiningsih, Yulyani; Sunarso, Indrayana
Gema Lingkungan Kesehatan Vol. 23 No. 4 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/

Abstract

We report a case study of a 58-year-old lady diagnosed with symptomatic knee osteoarthritis (OA) who received umbilical cord-derived mesenchymal stem cell (UC-MSC) secretome via intra-articular injections once weekly for a total of five weeks. This treatment significantly reduced pain compared to the control, using a Visual Analog Scale, with pain scores reducing from 7/10 to 3/10. Moreover, the patient showed marked functional capacity improvement, as indicated by a Western Ontario and McMaster Universities Osteoarthritis Index score from 65 to 30. Her Kellgren-Lawrence grade also improved radiographically from 4 to 2 indicating either an initiation of cartilage regeneration or a reduction in degenerative change. These favorable results position the UC-MSC secretome as a novel and safe treatment for knee osteoarthritis, making it a potent non-invasive replacement therapy to classical treatments. The researchers advise that these findings must be confirmed in bigger, controlled trials before the therapeutic effects of UC-MSC secretome can be established in broader patient populations.
The Dynamics of Rainfall and Humidity in Dengue Fever Epidemiology: A Case Study of Surakarta City Nurhasan Agung Prabowo; Tonang Dwi Ardyanto; Risalina Myrtha; Hendrastutik Apriningsih; Frieska Dyanneza; Niken Dyah Aryani Kuncorowati; Adji Suwandono; Laily Shofiyah; Maria Galuh Kamenyangan Sari; Novianto Adi Nugroho
Poltanesa Vol 26 No 2 (2025): December 2025
Publisher : P3KM Politeknik Pertanian Negeri Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51967/tanesa.v26i2.3469

Abstract

Dengue Fever is a significant and recurring public health challenge in tropical urban centers, including the city of Surakarta, Indonesia. The transmission of this vector-borne disease is highly sensitive to local climatic conditions, as high rainfall and humidity create ideal environments for the proliferation of the Aedes aegypti mosquito. This study aims to analyze the epidemiological trends of Dengue Fever in Surakarta from 2021 to 2023 and to determine the influence of key environmental factors on disease transmission dynamics. A descriptive epidemiological study was conducted using secondary data on reported Dengue Fever cases across Surakarta's five sub-districts: Laweyan, Serengan, Pasar Kliwon, Jebres, and Banjarsari. Incidence rates per 100,000 population were calculated and correlated with monthly rainfall and humidity data. The results showed significant fluctuations in incidence, with a major surge in 2022, when 166 total cases were recorded. The district of Laweyan recorded the highest incidence rate that year at 134.59 cases per 100,000 population. This peak strongly correlated with high rainfall and humidity during the first quarter of 2022, which provided optimal mosquito breeding conditions. In contrast, 2021 had the lowest incidence amid drier conditions. These findings confirm a strong association between climatic factors and Dengue Fever transmission in Surakarta. High rainfall and humidity are critical contributors to the disease burden, underscoring the urgent need for integrated, climate-based forecasting within public health surveillance systems to mitigate future outbreaks effectively.
Predictive Value of Neutrophil-to-Limphocyte Ratio for Detecting Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus Patients Gede Abhirama Daniswara; Nurhasan Agung Prabowo; Desy Puspa Putri; Laily Shofiyah
Gema Lingkungan Kesehatan Vol. 24 No. 1 (2026): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v24i1.455

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition characterized by insulin resistance, leading to increased blood glucose levels (hyperglycemia). Insulin resistance is a key factor in the development of nonalcoholic fatty liver disease (NAFLD), a condition defined by excessive hepatic fat accumulation that is not caused by alcohol consumption. NAFLD can progress from simple steatosis to hepatic inflammation and fibrosis. The neutrophil-to-lymphocyte ratio (NLR) is a simple biomarker for systemic inflammation. Elevated NLR values may indicate increased inflammation, such as that observed in NAFLD. This study aimed to determine differences in NLR values in T2DM patients with NAFLD and without NAFLD. This cross-sectional study used secondary data from the medical records of 88 T2DM patients from 2022 to 2024, divided into groups without NAFLD (n=45) and with NAFLD (n=43) based on ultrasonographic liver findings. The Welch t-test was applied to compare NLR values, and receiver operating characteristic (ROC) analysis was used to identify the optimal cut-off value for NLR. The NAFLD group had significantly higher NLR values (mean difference = 3.80; 95% CI: 2.75–5.24; p<0.001), with an AUC of 0.962 (95% CI: 0.915–1.000; p<0.001) and an optimal cut-off value of ≥3.1964 (sensitivity 90.7%; specificity 100%). In conclusion, NLR is significantly elevated in T2DM patients with NAFLD and demonstrates strong discriminatory ability, indicating its potential use as a simple inflammatory biomarker in T2DM managements.
Case Report: Pneumonia Provocate Thyroid Storm in Graves Disease Hermawati, Berty Denny; Prabowo, Nurhasan Agung; Putri, Desy Puspa; Myrtha, Risalina; Apriningsih, Hendrastutik
Smart Medical Journal Vol 6, No 1 (2023): April
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v6i1.68166

Abstract

Introduction: A thyroid crisis is an endocrine emergency involving many organ systems and can be fatal to the patient's survival. Although cases of thyroid crisis are rare, the mortality rate is significant which reaches 20–50%. The presence of comorbidities such as pneumonia infection increases the risk of death dramatically. Infection is a factor that can trigger thyroid crisis and exacerbate thyrotoxicosis. This condition of thyroid crisis most often occurs in people with hyperthyroidism caused by Graves' disease. We present the case of a patient with Graves' disease, aged 22 years, who developed a thyroid crisis due to community-acquired pneumonia infection. This study aims to provide a case report regarding the thyroid crisis due to pneumonia.Results: We carried out a physical and some appropriate supporting examinations to confirm the diagnosis. Wayne's index was 26, indicating hyperthyroidism. Assessment with Burch-Wartofsky obtained a score of 45, indicating suspicion of a thyroid storm. Then supportive care was provided to the patient. The community-acquired pneumonia as a triggering factor was treated with antibiotics. Thyrotoxicosis conditions were treated with antithyroid, beta-blocker, and glucocorticoid drugs. The patient's condition improved after treatment.Conclusion: It is crucial to detect and treat thyroid storm as quickly as possible since it has a high mortality rate. Wayne's score is useful for identifying hyperthyroidism based on clinical symptoms. The Burch-Wartofsky Point Scale scores are used to diagnose thyroid storms. Thyroid storm should be managed according to PERKENI (Perkumpulan Endokrinologi Indonesia) and ATA (American Thyroid Association) recommendations. This case serves as an example of how to make a proper diagnosis and treatment to prevent morbidity and death due to thyroid crisis.
Thyroid Crisis and Diabetic Ketoacidosis in Uncontrolled Diabetes Putri, Desy Puspa; Prabowo, Nurhasan Agung; Hermawati, Berty Denny
Smart Medical Journal Vol 6, No 3 (2023): December
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v6i3.66806

Abstract

Introduction: Thyroid crisis is a medical emergency that causes damage to various organs of the body so that proper diagnosis and immediate treatment are needed. Excess thyroid hormone also affects blood sugar metabolism, especially in diabetic patients. The occurrence of thyroid crisis in conjunction with diabetic ketoacidosis (DKA) is rare, and the exact pathogenesis is still being investigated. We report a case of thyroid crisis in a DKA patient.Case Presentation: A 35-year-old woman was brought by her family to the ER due to a loss of consciousness since 6 hours before admission to the hospital. The patient was said to have complained of fever, shortness of breath, palpitations since the previous day. The patient has a history of uncontrolled Type 2 Diabetes Mellitus (DM) since 5 years ago. Physical examination showed somnolence, blood pressure 120/72 mmHg, pulse rate 126 beats per minute, irregular, respiratory rate 28 breaths per minute, fast and deep breaths. Investigations showed blood sugar 320 mg/dL, uncompensated metabolic acidosis, ketonuria. The patient received DKA therapy, but her consciousness and pulse rate had not improved. TSH levels was low with an increase in fT4 levels, with the Burch-Wartofsky score supporting a thyroid crisis. The patient then received treatment for thyroid crisis and her clinical condition showed significant improvement.Conclusion: The occurrence of thyroid crisis along with DKA is a life-threatening emergency. Untreated hyperthyroid induce severe hyperglycemia and causes acute condition in both organs.  
Pelatihan Senam Kaki Buerger Allen di Puskemas Purwodiningratan Febrinasari, Ratih Puspita; Prabowo, Nurhasan Agung; Putri, Desy Puspa; Setyawan, Sigit
Smart Society Empowerment Journal Vol 3, No 2 (2023): Juli
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v3i2.76858

Abstract

Pendahuluan: Prevalensi Diabetes Mellitus (DM) tipe 2 di Indonesia semakin meningkat. Penyakit ini berkaitan dengan timbulnya komplikasi dan hal ini akan menurunkan kualitas hidup pasien. Penurunan komplikasi dilakukan pengobatan farmakologis dan non farmakologis. Salah satu upaya terapi non farmakologis adalah dengan edukasi dan Latihan fisik seperti senam kaki diabetes. Tujuan dari pengabdian ini adalah memberikan edukasi mengenai DM tipe 2 dan pelatian senam kaki Buerger Allen pada penderita DM tipe 2 di puskesmas Purwodiningratan.Metode: Langkah pengabdian yang akan dilakukan meliputi pengumpulan bahan dan materi, perencanaan, dan kegiatan inti.  Setelah kegiatan akan dilakukan pelaporan dan evaluasiHasil dan pembahasan: Penyuluhan dan edukasi sebagai acara inti akan dilakukan pada tanggal 27 Mei 2023 dengan materi: mengenal DM tipe 2 dan gejalanya, mengenal obat-obatan DM tipe 2, olahraga dan aktifitas fisik pada DM tipe 2, komplikasi pada DM tipe 2. Pasien diberikan instruksi senam kaki dan diajarkan oleh para instruktur senam kaki. Selain itu pasien mendapatkan leaflet dan video senam kaki diabetes dengan metode Buerger allen agar dipraktekkan di rumah dan mendapatkan hasil optimal.Kesimpulan: Pengabdian sudah terlaksana dengan baik, masyarakan penderita DM tipe 2 yang menjalani pelatihan mendapatkan penurunan gejala komplikasi DM tipe 2.
Correlation Between Total Cholesterol, HDL, and Non-HDL Cholesterol with Apolipoprotein B in Hyperlipidemia Patients Laily Shofiyah; Maria Galuh Kamenyangan Sari; Novianto Adi Nugroho; Adji Suwandono; Niken Dyah Aryani Kuncorowati; Risalina Myrtha; Hendrastutik Apriningsih; Nurhasan Agung Prabowo; Tonang Dwi Ardyanto; Frieska Dyanneza
Gema Lingkungan Kesehatan Vol. 24 No. 2 (2026): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v24i2.281

Abstract

Hyperlipidemia is a major modifiable risk factor for atherosclerotic cardiovascular disease. Among the available laboratory markers, non-HDL cholesterol and apolipoprotein B have attracted considerable attention as more informative measures of the true atherogenic burden carried by a patient’s blood. 51 hyperlipidemia patients were recruited sequentially for our cross-sectional study at the Clinical Laboratory of UNS Hospital, Sukoharjo. A power calculation for correlation studies (α = 0.05, power = 80%) was used to estimate the sample size. A TMS 30i analyser was used to quantify total cholesterol, HDL, and apo B; non-HDL cholesterol was calculated by subtraction. For every association, Pearson product-moment correlation coefficients with 95% confidence intervals (CIs) were calculated using Fisher's z-transformation. There was a high and positive correlation between total cholesterol and apo B (r = 0.881, 95% CI: 0.803–0.932, p < 0.001). There was no significant correlation between HDL cholesterol and apo B (r = 0.082, 95% CI: −0.196 to 0.349, p = 0.566). Apo B and non-HDL cholesterol had the highest correlation by far (r = 0.938, 95% CI: 0.896–0.963, p < 0.001). In hyperlipidemic, non-HDL cholesterol followed apo B more accurately than any other parameter, supporting its usage as a useful, affordable substitute for apo B in situations when direct measurement is not possible. To strengthen these relationships, larger, prospective, multi-center studies that account for important variables are required.
The Importance of Hyperthyroid Screening in Acute Decompensated Heart Failure with Persistent Tachycardia Despite Optimal Decongestion: A Case Report Risalina Myrtha; Matthew Aldo Wijayanto; Nurhasan Agung Prabowo
Jurnal Kardiologi Indonesia Vol 46 No 4 (2025): October - December, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.2006

Abstract

In “The Importance of Hyperthyroid Screening in Acute Decompensated Heart Failure with Persistent Tachycardia Despite Optimal Decongestion: A Case Report” (Indonesian Journal of Cardiology, 43(3), 123-9. https://doi.org/10.30701/ijc.1328), there is an error noted. An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI is https://doi.org/10.30701/ijc.1328. The error occurs only in the PDF; the DOI listed in the article metadata is already correct.The publisher apologizes for any inconvenience caused by this error.DOI of original article: https://doi.org/10.30701/ijc.1328
Co-Authors Adji Suwandono adji suwandono Andri Haryanto Anindita, Brigitta Devi Aprilningsih, Hendrastutik Apriningsih, Apriningsih Apriningsih Apriningsih, Hendrastutik Arief Nurudhin Arief Nurudhin Arief Nurudhin Arief Nurudhin Arief Nurudhin Arief Nurudhin Arifin Arifin Arsyi Dasa Ramadhan Asih Anggraeni Astri Tantri Indriani Astri Tantri Indriani Astri Tantri Indriani Berty Denny Hermawati Betty Suryawati Bryan Arief Aji Rudita Coana Sukma Gautama Desy Puspa Putri Dyanneza, Frieska Dyanneza, Frieska Evi Liliek Wulandari Evi Nurhayatun Fatichati Budiningsih Gede Abhirama Daniswara Habibah, Sopia Nur Hafi Nurinasari Harioputro, Dhani Redhono Hartono Hartono Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hermawati, Berty Denny I Made Adi Palguna Rama Daffa Indriani, Astri Tantri Kuncorowati, Niken Dwi Aryani Kuncorowati, Niken Dyah Aryani Laily Shofiyah Laily Shofiyah Laily Shofiyah Maria Galuh Kamenyangan Maria Galuh Kamenyangan Sari Maria Galuh Kamenyangan Sari Maria Galuh Kamenyangan Sari, Maria Galuh Kamenyangan Matthew Aldo Wijayanto Meirina Mulia Wardani Muchtar Hanafi Myrtha, Risalina Niken Dwi Aryani Kuncorowati Niken Dyah Aryani Kuncorowati Niken Dyah Aryani Kuncorowati Niken Dyah Aryani Kuncorowati Niken Dyah Aryani Kuncorowati Novianto Adi Nugroho Novianto Adi Nugroho Novianto Adi Nugroho Nugroho, Novianto Adi Putri, Desy Puspa Rachmah, Azkia Ratih Puspita Febrinasari Reviono Reviono Reviono Riandini Aisyah Risalina Myrtha Risalina Myrtha Risalina Myrtha Risalina Myrtha Risalina Myrtha Risalina Myrtha Risalina Myrtha Risalina Myrtha Satrio Budi Susilo Shofiyah Shofiyah, Laily Sri Sulistyowati Sunarso, Indrayana Syahrini Wisdayanti Tamaulina Br Sembiring Tonang Dwi Ardyanto Wedhiningsih, Yulyani Werdiningsih, Yulyani Wijayanto, Matthew Aldo Yeni Farida Yulyani Werdiningsih Yulyani Werdiningsih Yulyani Werdiningsih Zainal Arifin Adnan Zainal Arifin Adnan