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All Journal IAES International Journal of Artificial Intelligence (IJ-AI) e-CliniC Jurnal e-Biomedik Jurnal Bios Logos Jurnal Teknik Informatika JURNAL BIOMEDIK Indonesian Journal of Electrical Engineering and Informatics (IJEEI) Journal of Electronics, Electromedical Engineering, and Medical Informatics Jurnal Ilmiah Tatengkorang Syntax Idea Jurnal Ilmiah Keperawatan Imelda Jurnal Kesehatan Tambusai Medical Scope Journal (MSJ) Jurnal Locus Penelitian dan Pengabdian eJournal Kedokteran Indonesia Jurnal Lentera: Penelitian dan Pengabdian Masyarakat
Angelina Stevany Regina Masengi
Department Of Pharmacology And Therapy, Faculty Of Medicine, Universitas Sam Ratulangi, Manado, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Uji Antiinflamasi Ekstrak Etanol Lidah Buaya (Aloe Vera (L.) Burm. F.) Dengan Metode Stabilisasi Membran Sel Darah Merah In Vitro Rifky Aditya Rahadian; Christi Diana Mambo; Edward Nangoy; Fatimawali Fatimawali; Angelina Stevany Regina Masengi; Jimmy Posangi
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 2 (2025): JURNAL LOCUS: Penelitian & Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i2.3809

Abstract

Inflamasi merupakan respons tubuh terhadap cedera yang berpotensi menjadi kronis jika tidak terkendali. Lidah buaya (Aloe vera (L.) Burm. f.) mengandung senyawa aktif seperti alkaloid, saponin, dan tanin yang memiliki potensi sebagai antiinflamasi. Penelitian ini bertujuan untuk mengkaji aktivitas antiinflamasi ekstrak etanol lidah buaya menggunakan metode stabilisasi membran sel darah merah secara in vitro. Gel lidah buaya diekstraksi menggunakan metode maserasi dengan pelarut etanol 96%. Kandungan fitokimia dianalisis, dan uji antiinflamasi dilakukan pada berbagai konsentrasi ekstrak (50 ppm hingga 800 ppm) dengan spektrofotometer UV-Vis pada panjang gelombang 576 nm. Data dianalisis untuk menghitung persentase inhibisi hemolisis dan IC50. Berdasarkan dari penelitian didapatkan hasil yang menunjukkan bahwa ekstrak etanol lidah buaya memiliki aktivitas antiinflamasi dengan nilai IC50 sebesar 395,263 ppm, lebih rendah dibandingkan kontrol positif natrium diklofenak. Aktivitas tertinggi diperoleh pada konsentrasi 800 ppm dengan persentase inhibisi sebesar 71,28%. Senyawa fitokimia yang dinilai memiliki aktivitas antiinflamasi didapatkan positif dan hasil dari uji antiinflamasi ekstrak etanol lidah buaya dinyatakan positif.  
Evaluasi Drug Related Problems (Drp’s) Pada Pasien Anak Dengan Infeksi Saluran Pernapasan Akut (Ispa) Di Instalasi Rawat Inap Salah Satu Rumah Sakit Tipe C Di Provinsi Sulawesi Utara Injili Anugerah Vastelita Lengkong; Jimmy Posangi; Angelina Stevany Regina Masengi; Suryadi N.N. Tatura; Christi Diana Mambo; Edward Nangoy
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 2 (2025): JURNAL LOCUS: Penelitian & Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i2.3811

Abstract

Infeksi saluran pernapasan akut (ISPA) merupakan penyebab utama morbiditas dan mortalitas penyakit menular pada anak. ISPA terutama terjadi di negara-negara dengan pendapatan perkapita rendah dan menengah termasuk Indonesia. Menurut hasil Riskesdas 2013 periode prevalensi ISPA pada kelompok umur 1-4 tahun yaitu sebesar 25,8 % dan kelompok umur 5-14 tahun adalah 15,4 %. Kejadian masalah terkait obat (DRPs) lebih sering terjadi pada anak dibandingkan dengan orang dewasa. Drug Related Problems (DRPs) merupakan suatu kejadian yang tidak diharapkan dari pengalaman pasien atau diduga akibat terapi obat sehingga potensial mengganggu keberhasilan penyembuhan yang dikehendaki. Penelitian ini bertujuan untuk mengetahui jumlah kejadian dari DRPs yang meliputi ketidaktepatan dosis yaitu dosis kurang dan dosis lebih, indikasi tanpa obat, obat tanpa indikasi, potensial interaksi serta ketidaktepatan pemilihan obat pada terapi pengobatan infeksi saluran pernapasan akut pada pasien anak dengan infeksi saluran pernapasan akut di instalasi rawat inap salah satu rumah sakit tipe C di Provinsi Sulawesi Utara. Penelitian ini bersifat restropektif dimana data diperoleh melalui data sekunder berupa rekam medis pasien periode Juli 2023 sampai Juni 2024 dengan desain penelitian cross-sectional. Teknik pengambilan data berupa total sampling, didapatkan 78 sampel yang sesuai kriteria inklusi. Hasil penelitian Drug related Problems (DRPs) yang terjadi adalah dosis rendah sebanyak 53 %, interaksi obat yaitu sebanyak 47,43 % , dosis tinggi sebanyak 10,25 % , kategori obat tanpa indikasi 1,29 %, serta tidak terdapat DRPs kategori indikasi tanpa obat dan ketidaktepatan pemilihan obat.
The Relationship Between Pesticide Use and Cognitive Impairment in an Agricultural Community of Tomohon City, North Sulawesi Masengi, Angelina Stevany Regina; Mambo, Christi Diana; Nangoy, Edward; Posangi, Jimmy; Lasut, Marthen Theogives; Pertiwi, Junita Maja; Warouw, Finny; Sanggelorang, Yulianty; Sengkey, Daniel Febrian; Mamahit, Juliet Merry Eva
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.961.42

Abstract

This study investigates the cognitive effects of pesticide exposure on agricultural workers from a village in Tomohon City, North Sulawesi, Indonesia. Employing a cross-sectional design from July to September 2024. This study assessed the demographic characteristics, pesticide exposure patterns, and cognitive function of 97 participants aged 18 using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA-INA.The findings reveal a clear association between direct and indirect pesticide exposure and cognitive impairment. Direct exposure was linked to slightly lower cognitive scores than indirect exposure, with both groups scoring below established thresholds for normal cognitive function, particularly in memory, attention, and executive functions. Inconsistent use of personal protective equipment was noted among participants, with common immediate symptoms including visual disturbances and memory deficits following pesticide application. These results suggest that minimal pesticide exposure may contribute to cognitive decline, potentially accelerating age-related impairments. The underlying neurotoxic mechanisms likely involve oxidative stress, mitochondrial dysfunction, and neuroinflammation, which disrupt neuronal integrity. These findings underscore the urgent need for enhanced occupational health policies, stricter safety measures, and further research to mitigate the cognitive risks of pesticide exposure in agricultural populations.
OPTIMALISASI PERAN REMAJA DALAM PENCEGAHAN STUNTING MELALUI EDUKASI KESEHATAN DAN PENGKAJIAN STATUS GIZI Sanggelorang, Yulianty; Sebayang, F. Ari Anggraini; Rumayar, Adisti; Masengi, Angelina Stevany Regina
Jurnal Ilmiah Tatengkorang Vol 8 No 2 (2024): Jurnal Ilmiah Tatengkorang
Publisher : Pusat Penelitian dan Pengabdian Kepada Masyarakat, Politeknik Negeri Nusa Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54484/tkrg.v8i2.668

Abstract

Stunting, a manifestation of chronic malnutrition, affects cognitive abilities, academic performance, physical health, and economic potential. The persistence of stunting cases in North Sulawesi, particularly in North Minahasa Regency, becomes a significant issue that requires urgent attention. Health education for adolescents has been proven as an effective intervention in preventing various nutritional problems, including stunting. This Community Partnership Program (CPP) was conducted through health education and anthropometric measurements at SMP Advent Wineru and MTs Biharul Ulum, involving students from these two schools. The CPP activities comprised four stages: preparation, pre-test, health education and anthropometric measurement, and post-test. The education sessions covered basic concepts of stunting, related factors, and the role of adolescents in stunting prevention. Meanwhile, the anthropometric measurements, including weight and height, were conducted to determine nutritional status using the BMI-for-age index. A total of 57 students participated in the program. The results indicated a significant difference of students’ knowledge about stunting, before and after the health education (p-value < 0.05). The anthropometric measurements revealed that 73.7% of the students had normal nutritional status, although issues of undernutrition and overnutrition were still present. This PKM successfully enhanced adolescents' knowledge about stunting and specifically identified nutritional problems within the student population at both locations. Sustainable education and interventions are necessary to improve adolescent health and prevent stunting in the future. Stunting, manifestasi dari kekurangan gizi kronis, berdampak pada kemampuan kognitif, prestasi belajar, kesehatan fisik, dan ekonomi. Masih ditemukannya anak stunting di Sulawesi Utara, khususnya di Kabupaten Minahasa Utara, menjadi permasalahan yang perlu untuk ditanggulangi. Edukasi kesehatan pada remaja menjadi salah satu intervensi yang terbukti efektif dalam dalam pencegahan berbagai masalah gizi, termasuk stunting Program Kemitraan Masyarakat (PKM) dilakukan melalui edukasi kesehatan dan pengukuran antropometri di SMP Advent Wineru dan MTs Biharul Ulum dengan peserta siswa dari kedua sekolah ini. Kegiatan PKM terdiri dari empat tahap: persiapan, pre-test, edukasi kesehatan dan pengukuran antropometri, serta post-test. Penyuluhan meliputi konsep dasar stunting, faktor terkait, dan peran remaja dalam pencegahan stunting. Pengukuran antropometri, berat dan tinggi badan, dilakukan untuk menentukan status gizi menggunakan indeks IMT/U. Sebanyak 57 siswa berpartisipasi dalam kegiatan ini. Hasil menunjukkan terdapat perbedaan yang signifikan pengetahuan siswa tentang stunting pada saat sebelum dan setelah edukasi kesehatan (p-value < 0.05). Pengukuran antropometri menunjukkan bahwa 73.7% siswa memiliki status gizi normal, namun masih terdapat masalah gizi kurang dan lebih. PKM ini berhasil meningkatkan pengetahuan remaja tentang stunting dan mengidentifikasi secara spesifik masalah gizi pada populasi siswa di kedua lokasi kegiatan. Edukasi berkelanjutan dan intervensi diperlukan untuk meningkatkan kesehatan remaja dan mencegah stunting di masa depan
Investigation on low-performance tuned-regressor of inhibitory concentration targeting the SARS-CoV-2 polyprotein 1ab Sengkey, Daniel Febrian; Regina Masengi, Angelina Stevany; Sambul, Alwin Melkie; Tallei, Trina Ekawati; Unsratdianto Sompie, Sherwin Reinaldo
IAES International Journal of Artificial Intelligence (IJ-AI) Vol 14, No 4: August 2025
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijai.v14.i4.pp3003-3013

Abstract

Hyperparameter tuning is a key optimization strategy in machine learning (ML), often used with GridSearchCV to find optimal hyperparameter combinations. This study aimed to predict the half-maximal inhibitory concentration (IC50) of small molecules targeting the SARS-CoV-2 replicase polyprotein 1ab (pp1ab) by optimizing three ML algorithms: histogram gradient boosting regressor (HGBR), light gradient boosting regressor (LGBR), and random forest regressor (RFR). Bioactivity data, including duplicates, were processed using three approaches: untreated, aggregation of quantitative bioactivity, and duplicate removal. Molecular features were encoded using twelve types of molecular fingerprints. To optimize the models, hyperparameter tuning with GridSearchCV was applied across a broad parameter space. The results showed that the performance of the models was inconsistent, despite comprehensive hyperparameter tuning. Further analysis showed that the distribution of Murcko fragments was uneven between the training and testing datasets. Key fragments were underrepresented in the testing phase, leading to a mismatch in model predictions. The study demonstrates that hyperparameter tuning alone may not be sufficient to achieve high predictive performance when the distribution of molecular fragments is unbalanced between training and testing datasets. Ensuring fragment diversity across datasets is crucial for improving model reliability in drug discovery applications.
Co-Authors Abdullah, Rezky Putri Indarwati Achmad, Mardhita Nilamsari Andi Nuraini Mallombasang Arthur Morits Rumagit Bawonte, Trivianto G. Christi D. Mambo Christi Diana Mambo Corry Novita Mahama Daniel Febrian Sengkey Deffianie A. Thomas Diana S. Purwanto Edward Nangoy Edward Nangoy, Edward Elvira Yunita F Ari Anggraini Sebayang Fanny Septiani Farhan Fatimawali . Febrisa Salsabila Feisy Diane Kambey Fellery W. R. Onibala Heilbert Armando Mapaly Imam Jayanto Injili Anugerah Vastelita Lengkong Intan Indah Suryani Irma Antasionasti Jimmy Posangi Jimmy Posangi Jusman, Sri Widia Azraki Kenneth Yosua Rumawas Palilingan Kolang, Indri Claudia Leonardo Delvin Gosal Mamahit, Juliet Merry Eva Mambo, Christi D. Mambo, Christi Diana Mario Esau Katuuk Marthen Theogives Lasut, Marthen Theogives Mawara, Reza Michelly Cantika Mohamad Sadikin Nur Fiat, Daffa Olivia Amelia Waworuntu Ollivia Enggelina Supit Onibala, Aurelia R. Pertiwi, Junita Maja Pinrolinvic Duadelfri Kurnialimki Manembu Purnomo, Nadira Tri Ardianti Rifky Aditya Rahadian Rizal Sengkey Rue, Puella Rumayar, Adisti Salvius Paulus Lengkong Sambul, Alwin Melkie Seran, Ester Sinaulan, Evania A. Suratinoyo, Syifabela Surya Sumantri Abdullah Suryadi N.N. Tatura Ticoalu, Injilia Tirza TRINA EKAWATI TALLEI Umboh, Octavianus Unsratdianto Sompie, Sherwin Reinaldo Warouw, Finny Wawan Mulyawan Waworuntu Waworuntu Yulianty Sanggelorang