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All Journal Medula Indonesian Journal of Biological Pharmacy JCOMENT (Journal of Community Empowerment) Pharmacy Reports Sains Medisina E-Amal: Jurnal Pengabdian Kepada Masyarakat
Triyandi, Ramadhan
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Other

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Review: Studi Etnofarmasi Pemanfaatan Tumbuhan Berkhasiat Obat Untuk Penyakit Hipertensi Oleh Beberapa Etnis Di Indonesia Novriana, Dina; Oktoba, Zulpakor; Oktarlina, Rasmi Zakiah; Triyandi, Ramadhan
Sains Medisina Vol 2 No 4 (2024): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v2i4.380

Abstract

Etnofarmasi merupakan bagian dari bidang ilmu farmasi yang mengupayakan pemahaman mendalam tentang penggunaan tumbuhan obat serta mempelajari cara komunitas etnis atau masyarakat tertentu dalam memanfaatkan berbagai jenis tumbuhan obat. Dalam artikel ini dibahas mengenai tumbuhan obat serta metode pengobatan yang digunakan oleh beberapa etnis di Indonesia di antaranya yaitu diantaranya etnis Melayu, Togian, Kutai, Bajo, Moronene, Bugis, Suku Anak Dalam, Kaili Ledo, Dayak Banyandu, Buton, Gorontalo, Mori, Paser, dan Osing. Studi ini diharapkan akan bermanfaat untuk penelitian selanjutnya terutama dalam penemuan obat baru atau alternatif pengobatan dalam penanganan penyakit terutama hipertensi. Metode yang digunakan adalah studi literatur dengan data yang didapatkan  berasal dari artikel dengan alat pencarian informasi literatur Google Scholar dengan rentang tahun artikel yaitu  tahun 2015 sampai  tahun 2023. Hasil yang didapat disimpulkan bahwa terdapat 42 spesies tumbuhan dari 31 famili yang digunakan dalam penanganan hipertensi oleh beberapa etnis di Indonesia.
SUPLEMENTASI EKSTRAK DAUN KELOR (Moringa oleifera L.) TERHADAP ANEMIA DEFISIENSI BESI: ARTIKEL REVIEW Satria, Dzakiyyah Shoofina Jasmine; Triyandi, Ramadhan; Iqbal, Muhammad; Andrifianie, Femmy
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.929

Abstract

Iron is an important component of hemoglobin. The function of iron, which is as a source of energy for muscles so that it can affect physical endurance and the ability to work in adolescents. Iron deficiency can lead to hematological disorders of anemia. Anemia is a body condition in which the number of red blood cells and oxygen transport capacity is insufficient to meet the physiological needs of the body. Moringa leaves can be used as a substitute for iron tablets, because Moringa leaf powder contains 28 mg of iron. The method used in this writing, is literature review by collecting several research articles. This literature source search uses literature research sources in the form of google scholar and Pubmed. The inclusion criteria from the search, namely research articles using Indonesian and English, articles published within the last 10 years (2013-2023), and discussing the topic of moringa oleifera and anemia. The results of this literature search can be concluded that Moringa oleifera supplementation significantly increases serum iron levels.
Perbandingan Efektivitas Obat Antihipertensi Golongan ARB versus CCB terhadap Penurunan Tekanan Darah pada Pasien Hipertensi Nuryanti, Eva; Wardhana, M. Fitra; Damayanti, Ervina; Triyandi, Ramadhan
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1047

Abstract

Hypertension is defined as a systolic blood pressure of more than 140 mmHg and a diastolic blood pressure of more than 90 mmHg. Hypertension is a degenerative disease that requires long-term treatment. Hypertension is a silent killer disease because it does not cause symptoms and is only detected during physical examination due to certain diseases so that it can be a major cause of morbidity and mortality. Hypertension management guidelines recommend the use of thiazide/ACEi/ARB/CCB diuretic class drug monotherapy. The purpose of this study is to determine the difference in effectiveness between Calcium Channel Blocker (CCB) and Angiostensin Receptor Blocker (ARB) antihypertensives in reducing blood pressure. The method used in this study is through literature review using a database through Google Schoolar and Pubmed with a time span of 2013-2023 using the PICO method with keywords or keywords tailored to the search topic and articles selected based on inclusion criteria. The results of the literature show that ARB and CCB antihypertensives have similar effectiveness in lowering blood pressure. CCB antihypertensives are vasculoselective. This can be beneficial because CCBs are able to reduce peripheral resistance without reducing heart function so as to reduce the incidence of stroke. However, the use of CCBs can cause edema while ARBs have renoprotective effects or effects that protect the kidneys.
Aktivitas Antioksidan Pada Temulawak (Curcuma xanthorrhiza Roxb.) Dan Jahe Merah (Zingiber officinale var Rubrum) Fadila, Riska Intan; Iqbal, Muhammad; Triyandi, Ramadhan; Rahayu, Ihsanti Dwi
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Temulawak (Curcuma xanthorrhiza Roxb.) or Javanese turmeric is one of the medicine plants from Indonesia, which contains curcuminoid and xanthorrhizol. These compounds have large biological activity, such as antioxidant capacity. The location of this plant grows, affects the variance of the active compound which causes the changes in its activity. This study aims to evaluate antioxidant capacity, total phenolic, and total flavonoid content (TPC and TFC) of the sample collected from different markets, and to classify the samples into different culsters with chemometric techniques. The antioxidant capacity is determined by using DPPH radical scavenging assay. Red ginger (Zingiber officinale var. Rubrum) is a spice plant as well as a plant that functions as a raw material for medicines. In the health sector, red ginger contains compounds that are antioxidants, one of which is phenol compounds. The phenolic compounds present in the red ginger rhizome have the potential to prevent hemolysis and inhibit free radical oxidation reactions in the body. Red ginger (Zingiber officinale var. Rubrum) is a spice plant as well as a plant that functions as a raw material for medicines. In the health sector, red ginger contains compounds that are antioxidants, one of which is phenolic compounds. The phenolic compounds in red ginger rhizomes have the potential to prevent hemolysis and inhibit the process of free radical oxidation in the body. The phenolic compounds in red ginger rhizomes have the potential to prevent hemolysis and inhibit the process of free radical oxidation in the body. Apart from that, red ginger rhizome contains gingerol which has antioxidant, antibacterial, anti-inflammatory, anticarcinogenic, antimutagenic and antitumor activity.
Review Article: Pharmacological Activity of Robusta Coffee Plants (Coffee canephora) Virginia, Jesica; Iqbal, Muhammad; Triyandi, Ramadhan; Andrifianie, Femmy
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1054

Abstract

Coffee canephora or robusta coffee is a tree-shaped cultivated plant belonging to the Rubiaceae family and the Coffea genus. This plant is most widely planted in Indonesia, namely 91% more than Arabica coffee plantations and has great potential in its use as an alternative treatment for various diseases. Robusta coffee contains flavonoids, alkaloids, tannins, saponins and polyphenols. The two main polyphenolic compounds found in coffee are chlorogenic acid and caffeine, which each account for about 90% of all phenols found in coffee. This review article aims to determine the various pharmacological activities found in robusta coffee obtained from experimental studies conducted using electronic databases in the form of Google Scholar, Pubmed, and Mendley. The inclusion criteria in the article search were articles in Indonesian and English published in the last 10 years and the exclusion criteria were articles that could not be accessed in full. The results of the study of 25 articles show that the robusta coffee plant in the seeds, leaves and fruit skin has antibacterial, antioxidant, anticancer, anti-inflammatory, antifungal, antidiabetic, and biolarvicide pharmacological activities.
Artikel Review: Aktivitas Antibakteri dan Antioksidan Tanaman Baru Cina (Artemisia Vulgaris L.) Suci Ainu Sella; Triyandi, Ramadhan; Afriyani, Afriyani; Iqbal, Muhammad
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1071

Abstract

Herbal medicines and their active ingredients have been a trusted source of treatment since ancient times. Herbal products with raw plant parts or bioactive compounds are increasingly in demand in the treatment of disease. Diseases caused by pathogenic bacteria have become an unresolved problem due to bacterial mutations that cause bacteria to be resistant to antibiotic agents. Long used as a medicinal plant, recent studies show that mugwort (Artemisia vulgaris L.) exhibits antioxidant, hypolipidemic, analgesic, antibacterial, antifungal, and hypotensive properties with chemical compounds such as flavonoids, sesquiterpene lactones, coumarins, acetylene, phenolic acids, organic acids, sterols, vitamins (ascorbic acid), monoterpenes, and sesquiterpenes. The content of mugwort (Artemisia vulgaris L.) can be used as a source of natural antioxidants, which can be used as ingredients for cosmetics, food supplements, and medicines. This plant can inhibit the growth of the bacteria Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Enterococcus sp., Propionibacterium acnes, and Staphylococcus epidermidis. From the literature, it is known that a 0.1% concentration of the test extract was able to inhibit bacterial growth, and a 5% concentration of methanol extract showed the best inhibition of bacterial growth with an inhibitory zone diameter of 24–25 mm. Plant antioxidant activity was tested using the DPPH method and the ORAC method. The best IC50 value was in the methanol extract, namely 4.3 µg/mL, with an ascorbic acid IC50 of 2.9 µg/mL. Meanwhile, the ORAC value was 5700 (µmol trolox EQ/g extract).
Penelusuran Potensi Antioksidan Dalam Beragam Ekstrak Daun Tanaman Obat Di Indonesia Mutiara Hati, Nadia; Triyandi, Ramadhan; Wardhana S, Muhammad Fitra; Andrifianie, Femmy; Iqbal, Muhammad
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1072

Abstract

Antioxidants are substances that are able to absorb or neutralize free molecules, preventing degenerative diseases such as heart disease and cancer by donating electrons to inhibit free radical chain reactions that damage the body. The use of natural medicines is increasingly becoming the main choice in Indonesian society. Even though various types of plants have been used for a long time, their use has not been optimal. In order to summarize and provide information regarding the potential of natural ingredients from various plant extracts which have antioxidant activity, a literature review was carried out. The method used was a database search via Google Scholar for the last 8 years (2015-2023), which produced 170 journals regarding plants with antioxidant activity. Of this number, 20 plants were selected based on the dark green leaves which have antioxidant activity by comparing the IC50 values ​​obtained. Plant extracts contain antioxidant compounds that can fight free radicals, offering a natural alternative to synthetic antioxidants.  Plants with high antioxidant activity often have characteristics such as phytochemical content such as flavonoids, polyphenols, carotenoids, and vitamin C, as well as bright colors such as purple, red, or orange which indicate the content of antioxidant pigments such as anthocyanins, lycopene, or beta-carotene. Apart from that, plants that have a bitter or astringent taste, such as green tea, red grapes, or blueberries, also tend to contain quite high levels of antioxidant compounds, coupled with their habit of growing in harsh or extreme environments and their traditional use in medicine or health supplements.
Potensi Tanaman Obat pada Penyakit Diabetes Melitus Dan Komplikasinya: Artikel Review Elisabeth Elva Monika; Triyandi, Ramadhan; Afriyani, Afriyani; Rahayu, Ihsanti Dwi; Iqbal, Muhammad
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1073

Abstract

Diabetes Mellitus (DM) merupakan kelainan metabolisme yang ditandai dengan hiperglikemia, yang dapat menyebabkan komplikasi mikrovaskuler dan makrovaskuler. Dalam rangka pencegahan dan pengobatannya, penelitian ini bertujuan untuk mengidentifikasi tanaman obat dan kandungannya yang mempunyai efek terhadap pasien diabetes melitus, menganalisis dampak penggunaannya, dan memastikan tanaman mampu mengobati komplikasi diabetes melitus. Dalam tulisan ini, metode yang digunakan adalah mengidentifikasi dan mengevaluasi temuan relevan tanaman obat diabetes melitus dari artikel, memanfaatkan mesin pencari Google dan Google Scholar dengan kriteria inklusi meliputi artikel penelitian yang diterbitkan dalam 10 tahun terakhir (2013 - 2023), full-text. artikel penelitian yang mudah diunduh, dan artikel ditulis dalam bahasa Inggris atau bahasa Indonesia. Hasil literatur ini menunjukkan bahwa beberapa tanaman obat seperti Bawang Putih ( Allium sativum ), Teh Hijau ( Camellia Sinensis ), Daun Kelor ( Moringa Oleifera ), Daun Sirsak ( Annona muricata ), Jahe ( Zingiber officinale ), dan Kumis Kucing ( Orthosiphon stamineus Benth.) ditemukan mengandung berbagai senyawa bioaktif dengan efek positif dalam menurunkan kadar gula darah, melindungi organ yang berhubungan dengan diabetes, dan mengurangi risiko komplikasi. Temuan ini memberikan landasan yang kuat bagi pengembangan terapi herbal sebagai pendekatan alternatif atau komplementer dalam pengobatan diabetes melitus.
Dampak Penggunaan Obat Off Label Terhadap Adverse Drug Reactions (ADR): Studi Pada Pasien Pediatri Nur Hidayah, Fitri; Iqbal, Muhamad; Wardana, Muhammad Fitra; Triyandi, Ramadhan
Medula Vol 14 No 6 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i6.1164

Abstract

Limited types of drugs that can be used in the age range of children aged 0-2 years have resulted in treatment of patients using off-label drugs. Unwanted drug reactions (ROTD) are a health problem in society that occurs especially in the pediatric population. ROTD in children can have relatively more severe effects when compared to adults. Research on off-label drug use has been carried out in several places in Indonesia but most of it is limited to the percentage of off-label drug use and it is also not known further about its influence on the emergence of ROTD, namely information on drug labeling, efficacy and safety in the pediatric population is limited. Limited information results in many off-label drug prescribing in pediatric patients. Several studies aim to obtain an overview of off-label drug use in pediatric patients. A review of this literature is that off-label drug use in pediatric patients is still an issue that needs attention. With a better understanding of off-label drug use, steps can be taken to improve the safety and effectiveness of treatment in pediatric patients.
Review Artikel: Aktivitas Farmakologi Daun Alpukat (Persea americana Mill.) Rahmadhita, Elmira; Iqbal, Muhammad; Oktoba, Zulpakor; Nurmasuri, Nurmasuri; Triyandi, Ramadhan
Medula Vol 14 No 7 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i7.1174

Abstract

Indonesia possesses abundant natural resources, including the abundant fish, which are considered an alternative to modern diets. Fish, particularly alpaca, have high economic value and potential for local consumption. Alpaca is rich in protein, selenium, minerals, and anti-inflammatory properties that can help maintain health and prevent kidney damage.Alpukat (Persea america Mill.) is a rich, commercially valuable, and potentially beneficial food source for local consumption. Research has shown that alpaca can help prevent kidney damage by providing essential nutrients like potassium, magnesium, vitamin E, flavonoid, saponin, alkaloid, steroid, vitamin E, mineral, natrium, tanin, alkaloida, quersetin, polifenol, asam lemak tidak jenuh, zat filantik, and kalium. Alpukat also contains flavonoid and quersetin, which help prevent cholesterol accumulation and reduce the risk of lipid oxidation. Flavonoid and quersetin also help prevent glucosa absorption and oxidative stress, which can lead to cancer and other health issues. Alpukat also contains potassium with diuretic effects, which can be used for treating ginkgo biloba, kencing biloba, tinggi, and sakit kepala. Diuretik, a substance that increases urine volume and excretion of waste, can help prevent kidney damage. In conclusion, Indonesia has a rich and diverse food supply, including various types of fish, which have significant economic and health benefits.
Co-Authors AA Sudharmawan, AA Afriyani Agustine Sesunan, Dyah Surya Akbar, Muhamad Farhan Akbar, Muhammad Farhan Andrifianie, Femmy Atri Sri Ulandari Bayu Anggileo Pramesona Betta Kurniawan, Betta Cantika, Diana Helen Damayanti, Ervina Defri, Carisa Nabila Elisabeth Elva Monika Fadila, Riska Intan Hakim, Fatiyah Kamilah Hasmal, Aditia Leo Hasyimi, Meifia Ihsanti Dwi Rahayu Junando, Mirza Larrassati, Vanesya Naya Lia Puspitasari Muhamad Iqbal Muhammad Iqbal Mutiara Hati, Nadia Novriana, Dina NUR AFRIYANI Nur Hidayah, Fitri Nuryanti, Eva Oktoba, Zulpakor Pasaribu, Risma Kristina Uli Rahayu, Anis Dwi Rahayu, Anisa Dwi Rahmadhita, Elmira Ramadhana Komala Rasmi Zakiah Oktarlina Ronalda Budyantara Satria, Dzakiyyah Shoofina Jasmine Sormin, Merris Hartati Suci Ainu Sella Suri, Nurma Virginia, Jesica Wardana, Muhammad Fitra Wardhana S, Muhammad Fitra Wardhana, M. Fitra Warman, Ressalia Shoumadani Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yuviana, Yuviana Zulfikar