Claim Missing Document
Check
Articles

Found 34 Documents
Search

Optimasi dan Uji Antibakteri Nanopartikel Perak dengan Bioreduktor Ekstrak Batang Anggrek Merpati (Dendrobium crumenatum Sw.) Keiza Natania Panjaitan; Syamsurizal Syamsurizal; Indri Maharini; Diky Okta Yudha Putra; Prima Septiana
Sinteza Vol. 5 No. 1 (2025): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i1.29574

Abstract

Silver nanoparticles have demonstrated significant antibacterial efficacy against Escherichia coli and Staphylococcus aureus.  using a green synthesis method with plant extracts rich in flavonoids as bioreductor.  The pigeon orchid (Dendrobium crumenatum Sw.) is a plant with potential as a bioreductant, especially its stem, rich in flavonoid compounds. Optimizing heating temperature, extract volume, and silver nitrate concentration is essential for producing silver nanoparticles with optimal properties and enhanced antibacterial activity.  This research conducts optimization by varying the volume of pigeon orchid stem extract, heating temperature, and AgNO3 solution concentration.  The main parameter in the optimization is the Surface Plasmon Resonance (SPR) value. The characterization of silver nanoparticles includes particle size, polydispersity index, zeta potential, FTIR spectra, and antibacterial activity tests against E. coli and S. aureus. The research results show that the optimum conditions for synthesising silver nanoparticles are 1 mL of orchid stem extract, a heating temperature of 60°C, and an AgNO3 concentration of 1.629 mM..  The silver nanoparticles produced have characteristics with an SPR peak at 450 nm, a particle size of 98.267 nm, a polydispersity index of 0.2337, and a zeta potential of -21.9 mV.  Antibacterial tests showed an inhibition zone of 14,71±1,23 mm against S. aureus and 15,28±0,91 mm against E. coli.  These results prove that silver nanoparticles effectively inhibit the growth of gram-positive and gram-negative bacteria.
Pelatihan Pembuatan Permen Gummy Sungkai Sebagai Pengembangan Produk Inovasi di UMKM Nurchery Lestari, Uce; Muhaimin, Muhaimin; Elisma, Elisma; Maharini, Indri; Yuliana, Yuliana; Mekeama, Luri; Perawati, Santi
Jurnal Abdimas Kartika Wijayakusuma Vol 7 No 1 (2026): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v7i1.1207

Abstract

Nurchery adalah Usaha Mikro, Kecil, dan Menengah (UMKM) yang bergerak pada bidang pengolahan minuman serta makanan ringan berbasis herbal. Dalam upaya meningkatkan daya saing dan menciptakan inovasi produk di pasar, dilakukan kegiatan pelatihan dan sosialisasi pembuatan permen gummy yang menggunakan bahan alami dari daun sungkai. Daun sungkai diketahui memiliki manfaat sebagai peningkat daya tahan tubuh sekaligus berperan sebagai antioksidan alami. Kegiatan Pengabdian kepada Masyarakat (PPM) ini bertujuan memperkenalkan teknologi pembuatan permen gummy berbahan alami, meningkatkan keterampilan serta pengetahuan produksi pelaku UMKM, dan membuka peluang diversifikasi produk dengan nilai jual yang lebih tinggi. Metode yang digunakan meliputi sosialisasi manfaat kesehatan daun sungkai, demonstrasi proses pembuatan permen gummy, serta pendampingan dalam pengemasan produk. Hasil kegiatan menunjukkan bahwa pelaku UMKM mampu menerapkan teknologi pembuatan permen gummy sungkai dengan baik dalam kegiatan usahanya, sehingga membuka peluang produk inovatif berbahan alami tersebut untuk diterima di pasar komersial karena memiliki potensi dan nilai jual yang tinggi. Melalui pelatihan ini, diharapkan UMKM Nurchery dapat menghasilkan produk unggulan yang inovatif dan memiliki daya saing lebih kuat dalam industri makanan fungsional.
Green-Synthesized Silver Nanoparticles Using Erythrina subumbrans Leaf Extract: Optimization and Antibacterial Activity Maharini, Indri; Utami, Karen Putri; Rachmawati, Lilis; Fitrianingsih, Fitrianingsih; Pratiwi, Puspa Dwi
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502580

Abstract

The high prevalence of acne and increasing antibiotic resistance necessitate the development of sustainable antimicrobial agents. This study investigated the green synthesis of silver nanoparticles (AgNPs) using Erythrina subumbrans (Hassk.) Merr. leaf extract as a natural bioreductant and stabilizer. The primary objective was to optimize the synthesis process and evaluate the antibacterial efficacy of the resulting nanoparticles specifically against Propionibacterium acnes. Physicochemical and structural characterization were performed using spectroscopic and microscopic techniques to confirm the formation and stability of the nanoparticles. The results successfully demonstrated the synthesis of crystalline, nanoscale AgNPs with plant-derived functional groups facilitating their stabilization. Analytical data indicated a relatively uniform particle size distribution, spherical morphology, and favorable surface characteristics, suggesting high suitability for biomedical integration. Significantly, the synthesized AgNPs exhibited potent antibacterial activity against P. acnes. The underlying mechanism of action is attributed to the disruption of bacterial cell membranes, induction of intracellular reactive oxygen species, and subsequent interference with vital cellular functions. Utilizing E. subumbrans extract offers an eco-friendly, cost-effective, and sustainable alternative to conventional chemical synthesis, reducing the reliance on toxic reagents. These findings highlight the significant potential of plant-mediated AgNPs as innovative antimicrobial agents for dermatological applications. This research provides a robust foundation for the advancement of nanotechnology-based topical treatments. Consequently, further investigation into pharmaceutical formulation development, comprehensive safety assessments, and clinical efficacy trials is highly recommended to establish E. subumbrans-mediated silver nanoparticles as viable therapeutic solutions for managing acne and other skin-related infections in the future.
Optimization Formula and SPF Test of Lotion from Essential Oil of Patchouli Leaves (Pogostemon cablin Benth.) Anjaly Rizkya Fazariana; Fathnur Sani K; Indri Maharini
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008439

Abstract

An increase in the ultraviolet (UV) index poses severe health risks by inducing harmful effects on the skin, such as sunburn, erythema, skin darkening, premature ageing, and skin cancer. These risks are mitigated through sunscreens with high Sun Protection Factor (SPF) values (15). Natural sources of high SPF include patchouli leaf essential oil, which contains flavonoids. Flavonoid compounds with double bonds can absorb UV-A and UV-B rays, protecting against their harmful effects. The purpose of this study was to find the best formula and observe its impact on the physical characteristics of the preparation and SPF activity. Formula optimization used Design Expert software 13 with the simplex lattice design method. The optimized variables were TEA and stearic acid as emulsifying agents. The results of the optimum formula composition consisted of 4% TEA and 5% stearic acid. The optimum skin protection lotion preparation has a yellow color, a distinctive smell of patchouli oil, a semi-solid shape and a thick texture. The pH parameters of 7.7±0.09, adhesion of 2.34±0.06 seconds, spreadability of 6.85±0.02 cm and viscosity of 4503.3±219.39 Cp. Patchouli leaf essential oil and lotion have ultra-category SPF values with oil SPF value of 27.86±1.07 and lotion preparation of 27.65±1.75 preparation is also homogeneous with pH parameters of 7.7±0.09, adhesion of 2.34±0.06 seconds, spreadability of 6.85±0.02 cm and viscosity of 4503.3±219.39 Cp. Patchouli leaf essential oil and lotion have ultra-category SPF values with oil SPF value of 27.86±1.07 and lotion preparation of 27.65±1.75.